Patents Assigned to BioCardia, Inc.
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Patent number: 11828757Abstract: Autologous bone marrow cells (BMC) are transplanted to a heterologous site in a patient after a sample of the patient's BMC has been tested and found to have a phenotypic profile which meets minimum criteria for transplantation. The phenotypic profile may be obtained by screening a sample of bone marrow cells (BMC) from the patient for the phenotypic profile, such as a CD profile, the phenotype profile may be assessed to determine the likelihood that the BMC will be suitable for transplantation to the heterologous tissue site without enriching particular phenotypic population(s) of the BMC.Type: GrantFiled: July 30, 2020Date of Patent: November 28, 2023Assignee: BioCardia, Inc.Inventors: Peter Altman, Cheryl Wong Po Foo
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Publication number: 20230233805Abstract: A bi-directional steerable catheter adapted for delivery into a patient's vasculature. The pull wires which are used to tension the deflectable segment of the steerable catheter are wound in parallel around the axis of the steerable catheter on opposite sides of the steerable catheter.Type: ApplicationFiled: April 3, 2023Publication date: July 27, 2023Applicant: BioCardia, Inc.Inventors: Wai Hsueh, Ken Vien, James B. Ross
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Patent number: 11642377Abstract: The present disclosure provides use of neurokinin 1 receptor (NK1R) as a marker for identifying and/or isolating multipotential cells. The present disclosure provides cell populations enriched by methods of the present disclosure and therapeutic uses of these cells and agents derived from these cells.Type: GrantFiled: September 26, 2019Date of Patent: May 9, 2023Assignee: BioCardia, Inc.Inventors: Ian McNiece, Peter Altman
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Patent number: 11617859Abstract: A bi-directional steerable catheter adapted for delivery into a patient's vasculature. The pull wires which are used to tension the deflectable segment of the steerable catheter are wound in parallel around the axis of the steerable catheter on opposite sides of the steerable catheter.Type: GrantFiled: September 11, 2021Date of Patent: April 4, 2023Assignee: BioCardia, Inc.Inventors: Wai Hsueh, Ken Vien, James B. Ross
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Publication number: 20220305237Abstract: A needle-injection catheter includes a catheter body having a distal end, a proximal end, a stiff proximal portion, a flexible distal portion, and a delivery lumen extending therethrough. In a first embodiment, a straight injection needle extends coaxially from a distal tip of the flexible portion of the catheter body, and a plurality of penetration limiting elements positioned circumferentially about a base of the straight injection needle and configured to fold radially inwardly against a shaft of the needle when constrained in a tubular lumen and to extend radially outwardly when unconstrained. In a second embodiment, a helical needle extends from the distal tip of the flexible portion of the catheter body. The helical needle has at least one helical delivery lumen connected to receive an injectable substance from the delivery lumen of the catheter body.Type: ApplicationFiled: June 2, 2022Publication date: September 29, 2022Applicant: BioCardia, Inc.Inventors: Wai Hsueh, Olin Jay Palmer, Scott Comiso, James B. Ross, Ken Vien, Julio Argentieri, Peter Altman
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Patent number: 11357463Abstract: Fluoroscopic imaging of a patient's heart is performed by positioning a patient in a sterile field and imaging the heart using a x-ray fluoroscopy system within the sterile to produce a two-dimensional image. The two-dimensional image is simultaneously displayed on an operative display within or adjacent the sterile filed and on a display of a remote image processor outside the operative field. The two-dimensional image of the remote display is manually marked or annotated to show anatomical or treatment information which is simultaneously shown on the operative display.Type: GrantFiled: January 8, 2014Date of Patent: June 14, 2022Assignee: BIOCARDIA, INC.Inventors: Cheryl Wong Po Foo, David Sanderson, Peter Altman
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Publication number: 20220168544Abstract: A bi-directional steerable catheter adapted for delivery into a patient's vasculature. The pull wires which are used to tension the deflectable segment of the steerable catheter are wound in parallel around the axis of the steerable catheter on opposite sides of the steerable catheter.Type: ApplicationFiled: September 11, 2021Publication date: June 2, 2022Applicant: BioCardia, Inc.Inventors: Wai Hsueh, Ken Vien, James B. Ross
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Publication number: 20210315532Abstract: Fluoroscopic imaging of a patient's heart is performed by positioning a patient in a sterile field and imaging the heart using a x-ray fluoroscopy system within the sterile to produce a two-dimensional image. The two-dimensional image is simultaneously displayed on an operative display within or adjacent the sterile filed and on a display of a remote image processor outside the operative field. The two-dimensional image of the remote display is manually marked or annotated to show anatomical or treatment information which is simultaneously shown on the operative display.Type: ApplicationFiled: June 24, 2021Publication date: October 14, 2021Applicant: BioCardia, Inc.Inventors: Cheryl Wong Po Foo, David Sanderson, Peter Altman
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Patent number: 11141568Abstract: A bi-directional steerable catheter adapted for delivery into a patient's vasculature. The pull wires which are used to tension the deflectable segment of the steerable catheter are wound in parallel around the axis of the steerable catheter on opposite sides of the steerable catheter.Type: GrantFiled: August 27, 2018Date of Patent: October 12, 2021Assignee: BioCardia, Inc.Inventors: Wai Hsueh, Ken Vien, James B. Ross
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Publication number: 20210164978Abstract: Autologous bone marrow cells (BMC) are transplanted to a heterologous site in a patient after a sample of the patient's BMC has been tested and found to have a phenotypic profile which meets minimum criteria for transplantation. The phenotypic profile may be obtained by screening a sample of bone marrow cells (BMC) from the patient for the phenotypic profile, such as a CD profile, the phenotype profile may be assessed to determine the likelihood that the BMC will be suitable for transplantation to the heterologous tissue site without enriching particular phenotypic population(s) of the BMC.Type: ApplicationFiled: July 30, 2020Publication date: June 3, 2021Applicant: BioCardia, Inc.Inventors: Peter ALTMAN, Cheryl WONG PO FOO
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Patent number: 10874831Abstract: A steerable guide sheath system adapted for delivery into a patient's vasculature. The pull wire which is used to tension the deflectable portion of the sheath is wrapped or twisted around the axis of the sheath.Type: GrantFiled: October 6, 2015Date of Patent: December 29, 2020Assignee: BIOCARDIA, INC.Inventors: Daniel C. Rosenman, Daniel Kayser, Peter A. Altman
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Publication number: 20200398029Abstract: A needle-injection catheter includes a catheter body having a distal end, a proximal end, a stiff proximal portion, a flexible distal portion, and a delivery lumen extending therethrough. In a first embodiment, a straight injection needle extends coaxially from a distal tip of the flexible portion of the catheter body, and a plurality of penetration limiting elements positioned circumferentially about a base of the straight injection needle and configured to fold radially inwardly against a shaft of the needle when constrained in a tubular lumen and to extend radially outwardly when unconstrained. In a second embodiment, a helical needle extends from the distal tip of the flexible portion of the catheter body. The helical needle has at least one helical delivery lumen connected to receive an injectable substance from the delivery lumen of the catheter body.Type: ApplicationFiled: September 2, 2020Publication date: December 24, 2020Applicant: BioCardia, Inc.Inventors: Wai Hsueh, Olin Jay Palmer, Scott Comiso, James B. Ross, Ken Vien, Julio Argentieri, Peter Altman
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Patent number: 10780248Abstract: A needle-injection catheter includes a catheter body having a distal end, a proximal end, a stiff proximal portion, a flexible distal portion, and a delivery lumen extending therethrough. In a first embodiment, a straight injection needle extends coaxially from a distal tip of the flexible portion of the catheter body, and a plurality of penetration limiting elements positioned circumferentially about a base of the straight injection needle and configured to fold radially inwardly against a shaft of the needle when constrained in a tubular lumen and to extend radially outwardly when unconstrained. In a second embodiment, a helical needle extends from the distal tip of the flexible portion of the catheter body. The helical needle has at least one helical delivery lumen connected to receive an injectable substance from the delivery lumen of the catheter body.Type: GrantFiled: August 9, 2018Date of Patent: September 22, 2020Assignee: BioCardia, Inc.Inventors: Wai Hsueh, Olin Jay Palmer, Scott Comiso, James B. Ross, Ken Vien, Julio Argentieri, Peter Altman
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Patent number: 10632281Abstract: A system and method for delivering a drug to a target site within a patient's body. The system and method include a steerable guide catheter and a drug delivery catheter. The steerable guide catheter has a first extension tube and a second extension tube that are joined together and form a shoulder. The delivery catheter has a distal docking segment and a proximal docking segment. The guide catheter is inserted into the patient's body, then the delivery catheter is inserted into the guide catheter. The distal docking segment engages the first extension tube, the proximal docking segment engages the second extension tube, and the shoulder limits the distance the delivery catheter can be inserted into the guide catheter. Also, once the delivery catheter is inserted it can be rotated to attach the helical tip to the target site. The guide catheter also includes a steering mechanism as well as a friction mechanism which controls the tension on the steering mechanism.Type: GrantFiled: April 21, 2014Date of Patent: April 28, 2020Assignee: BioCardia, Inc.Inventors: Daniel C. Rosenman, Peter A. Altman, Brian K. Hakim, Daniel J. Kayser, Robert E. Maston, Douglas McEtchin
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Patent number: 10520505Abstract: Autologous bone marrow cells (BMC) are transplanted to a heterologous site in a patient after a sample of the patient's BMC has been tested and found to have a phenotypic profile which meets minimum criteria for transplantation. The phenotypic profile may be obtained by screening a sample of bone marrow cells (BMC) from the patient for the phenotypic profile, such as a CD profile, the phenotype profile may be assessed to determine the likelihood that the BMC will be suitable for transplantation to the heterologous tissue site without enriching particular phenotypic population(s) of the BMC.Type: GrantFiled: March 2, 2018Date of Patent: December 31, 2019Assignee: BioCardia, Inc.Inventors: Peter Altman, Cheryl Wong Po Foo
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Publication number: 20190151614Abstract: A bi-directional steerable catheter adapted for delivery into a patient's vasculature. The pull wires which are used to tension the deflectable segment of the steerable catheter are wound in parallel around the axis of the steerable catheter on opposite sides of the steerable catheter.Type: ApplicationFiled: August 27, 2018Publication date: May 23, 2019Applicant: BioCardia, Inc.Inventors: Wai Hsueh, Ken Vien, James B. Ross
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Patent number: 10071226Abstract: A needle-injection catheter includes a catheter body having a distal end, a proximal end, a stiff proximal portion, a flexible distal portion, and a delivery lumen extending therethrough. In a first embodiment, a straight injection needle extends coaxially from a distal tip of the flexible portion of the catheter body, and a plurality of penetration limiting elements positioned circumferentially about a base of the straight injection needle and configured to fold radially inwardly against a shaft of the needle when constrained in a tubular lumen and to extend radially outwardly when unconstrained. In a second embodiment, a helical needle extends from the distal tip of the flexible portion of the catheter body. The helical needle has at least one helical delivery lumen connected to receive an injectable substance from the delivery lumen of the catheter body.Type: GrantFiled: September 30, 2014Date of Patent: September 11, 2018Assignee: BioCardia, Inc.Inventors: Wai Hsueh, Olin Jay Palmer, Scott Comiso, James B. Ross, Ken Vien, Julio Argentieri, Peter Altman
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Patent number: 10035982Abstract: A method for expanding mesenchymal cells derived from autologous bone marrow in autologous culture medium which can be used in a clinical setting, and a business method for performing such expansions in the future as a service for patients. A method for expanding mesenchymal cells derived from autologous bone marrow in autologous culture medium including a diagnostic kit for the autologous cell therapy to determine whether a patient will respond to the autologous cell therapy for treatment of a disease, in which said kit comprising a system for detecting gene and protein expression comprising at least two isolated DNA molecules wherein each isolated DNA molecule detects expression of a gene that is differentially expressed in the tissue of the patient that is intended to be the source of the autologous cell therapy.Type: GrantFiled: July 31, 2017Date of Patent: July 31, 2018Assignee: BioCardia, Inc.Inventors: Didier Rouy, Peter A. Atlman, Benjamin Koziner
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Patent number: 9945854Abstract: Autologous bone marrow cells (BMC) are transplanted to a heterologous site in a patient after a sample of the patient's BMC has been tested and found to have a phenotypic profile which meets minimum criteria for transplantation. The phenotypic profile may be obtained by screening a sample of bone marrow cells (BMC) from the patient for the phenotypic profile, such as a CD profile, the phenotype profile may be assessed to determine the likelihood that the BMC will be suitable for transplantation to the heterologous tissue site without enriching particular phenotypic population(s) of the BMC.Type: GrantFiled: September 1, 2017Date of Patent: April 17, 2018Assignee: BioCardia Inc.Inventors: Peter Altman, Cheryl Wong Po Foo
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Publication number: 20180085552Abstract: A steerable endoluminal device adapted for delivery into a patient's vasculature. The device includes a tubular member having a distal deflection portion that extends to the distal end and a main body portion that extends from the deflectable portion to the proximal end, the tubular member further including a stiff portion extending along the distal deflection portion, and being formed of polymeric material, which is disposed circumferentially adjacent to the stiff portion. The stiff portion is made of a material that has an elastic modulus greater than the elastic modulus of the polymeric material. A pull wire extends between the proximal end and the distal end of the tubular member and is attached to the distal deflection portion to control deflection of the distal deflection portion of the tubular member.Type: ApplicationFiled: October 3, 2017Publication date: March 29, 2018Applicant: BioCardia, Inc.Inventor: Aaron J. Miller