Abstract: Various implementations include a fluidic oscillator having at least one control port. The at least one control port is for introducing a control fluid into the fluidic oscillator or suctioning the fluid stream from the fluidic oscillator. The introduction of a control fluid into the fluidic oscillator or suction of the fluid stream from the fluidic oscillator alters the frequency and sweeping angle of the oscillating fluid stream as it exits the fluidic oscillator. Various other implementations include a fluidic oscillator having a first control port defined by the first portion of the outlet nozzle and a second control port defined by the second portion of the outlet nozzle. The introduction of a control fluid into the fluidic oscillator or suction of the fluid stream from the fluidic oscillator through the control ports alters the exit angle of the oscillating fluid stream as it exits the fluidic oscillator.

Abstract: Disclosed herein is a contact lens comprising a lenticular in a superior portion of the contact lens wherein the contact lens attaches to an upper eyelid of a wearer by the lenticular interacting with an upper tarsal plate of the upper eyelid of a wearer, said interaction allows the contact lens to translate upwards in downgaze and maintain rotational stability. In one aspect, the lenticular has a top surface, said top surface having a shape selected from the group consisting of flat, flat with rounded corners, concave, convex or tapered having a thicker portion closer to an edge of the contact lens, or combinations thereof. In another aspect, the lenticular is comprised of a plurality of lenticular sections. In yet another aspect, the lenticular is anatomically-shaped.

Abstract: Disclosed herein is a contact lens comprising a rounded, minus-carrier, lenticular-like curve over a central, upper portion of the lens that allows the contact lens to translate upwards in downgaze.

Abstract: In one aspect, the disclosure relates to methods and compositions for treatment of cancer cachexia. In a further aspect, the composition is a pharmaceutical composition comprising a class I/IIB HDAC inhibitor and an androgen. In a still further aspect, the method of treatment comprises administering a class I/IIB HDAC inhibitor and an androgen to a subject or patient who has been diagnosed as having cancer cachexia. In some aspects, the class I/IIB HDAC inhibitor is a compound known as AR-42.

Abstract: Disclosed are aluminum alloys with high iron content and methods of making and using.

Abstract: An example assembly for use with a vacuum system and an esophageal positioning device esophageal positioning device includes an introducer, in which the esophageal positioning device includes a handle, a first segment, a second segment and an articulation driving mechanism. The first segment being coupled to the handle. The second segment being pivotally connected to the first segment. The articulation driving mechanism being configured to pivot the second segment about the first segment upon articulation.

Abstract: A multiband antenna comprises a dielectric substrate with a first surface defining an annular ledge and a central recess with a plurality of pockets. A MIMO radiator body is disposed in the central recess having a first surface defining a plurality of lobes which are disposed in respective ones of the plurality of pockets and having a second surface defining an outer rim and a central shelf A radiator ring is disposed at the annular ledge so that the radiator ring and the outer rim converge along an annular gap therebetween. A plurality of MIMO feed lines provide external connection to respective lobes. The MIMO radiator body and the radiator ring provide a substantially horizontally-directed radiation pattern (e.g., for terrestrial signals). At least one low-profile radiator on the central shelf provides a substantially circularly polarized or vertically-directed radiation pattern for receiving signals radiated from a satellite.

Abstract: In one aspect, the disclosure relates to compositions and methods for dispersing exiting Salmonella biofilms and inhibiting formation of Salmonella biofilms. In various aspects, the disclosed compositions can be used in methods of treating a persistent Salmonella infection, including an asymptomatic infection. Such infections can colonize a variety of tissues, including the gall-bladder. Also disclosed are methods of treating typhoid fever. Also disclosed are methods for mitigating or preventing secondary outbreaks of typhoid fever by treating asymptomatic subjects who had been symptomatic for typhoid fever at a previous time. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: The present disclosure relates to synthetic oncolytic viruses comprising a lipid nanoparticle comprising one or more types of lipid and a self-amplifying replicon RNA comprising a sequence that encodes an immunomodulatory molecule.

Abstract: Disclosed is a general, reversible bicyclization strategy to increase both the proteolytic stability and cell permeability of peptidyl drugs. A peptide drug is fused with a short cell-penetrating motif and converted into a conformationally constrained bicyclic structure through the formation of a pair of disulfide bonds. The resulting bicyclic peptide has greatly enhanced proteolytic stability as well as cell-permeability. Once inside the cell, the disulfide bonds are reduced to produce a linear, biologically active peptide. This strategy was applied to generate a cell-permeable bicyclic peptidyl inhibitor against the NEMO-IKK interaction.

Abstract: Systems, methods, and computer program products for controlling use of sensitive data. A heartbeat signal conveying a context identifier is transmitted into areas where access to sensitive data is granted to authorized users. In response to receiving a request to access the sensitive data, access may be granted if the context identifier in the request matches the context identifier in the heartbeat and denied otherwise. If the requestor has exceeded an access threshold, access may be granted at a reduced rate. This reduced rate may be achieved by reducing a rate at which encryption keys are provided to the requestor. An access control layer positioned between an application layer and a communication layer allows the application layer to use plaintext of the sensitive data while protecting the sensitive data as ciphertext in the communication layer.

Abstract: Disclosed are methods and compositions related to immunoconjugates. Particularly disclosed are immunoconjugates that comprise the Fc portion of IgG3 as well as Factor VII light chain or Factor VII. Also disclosed is an immunoconjugate protein, wherein said immunoconjugate protein comprises a hybrid Fc region of an IgG1 and an IgG3 immunoglobulin conjugated to Factor VII. These immunoconjugates can target Tissue Factor (TF) expressing cells.

Abstract: Various implementations include, an out-of-plane feedback-type fluidic oscillator. including a first portion, a second portion, a middle portion coupled between the first portion and the middle portion, and an axis of rotation. The middle portion includes a first side, a second side opposite and spaced apart from the first side, and a middle plane, an interaction chamber, a fluid supply inlet, an outlet nozzle, a first feedback a channel, and a second feedback channel. The first side is coupled to the first portion, and the second side is coupled to the second portion. The first side, the second side, and the middle plane extend circumferentially around the axis of rotation. The middle plane is disposed equally distanced from the first side and the second side. The fluid stream oscillates as it flows through the interaction chamber such that the fluid stream oscillates as the fluid stream exits the outlet nozzle.

Abstract: Systems, methods, and computer program products for delivering information to an individual, group, or device. The information is carried by audio signals beyond the audible frequency range of human hearing, but within the frequency range of an audio system. The information is modulated onto an ultrasonic frequency and embedded into an audio signal transmitted by the audio system. Each individual, group member, or device may have or be coupled to a receiver configured to receive an acoustic signal transmitted by the audio system that includes the modulated ultrasonic frequency. The receiver extracts the information from the modulated ultrasonic frequency and provides the information to the individual, group member, or device.

Abstract: Anticachexin C1 inhibits the TNF?-TNF? receptor interaction. In this work, analogs of anticachexin C1 are disclosed. The resulting bicyclic peptides inhibit TNF? TNF?-induced cell death, NF-?B activation, and c-Jun N-terminal kinase (JNK) signaling in cultured mammalian cells. Methods of using the bicyclic peptide anticachexin C1 analogs to treat cancer, inflammatory disorders and immune disorders are also described.

Abstract: Shown herein are small molecule compounds that can be used to increase the overall quality of a coffee beverage. The flavor enhancing compounds can be combined with coffee at any stage of its processing to increase the cup score of a coffee beverage. In some embodiments, the flavor enhancing compounds include one or more caffeic ester compounds, for instance caffeic acid esterified with a cyclitol or related compound.

Abstract: Disclosed herein are methods and platforms for increasing utility and efficacy of a cellular vaccine. Specifically, disclosed are steps that optimize ex vivo B cell expansion and boost host in vivo immunity. Also disclosed is a platform for enhancing effectiveness of antigen presentation and antigen-specific immune responses. Also disclosed is a method for enhancing effectiveness of APCs in a subject. Also disclosed are vaccines and kits based on the platform.

Abstract: Various implementations include a method of manufacturing one or more devices. The method includes obtaining a base portion of a non-shape-memory metal, disposing one or more shape-memory metal portions along the base portion, and joining at least a first layer of the non-shape-memory metal to the base portion using ultrasonic additive manufacturing. The shape-memory metal portions are disposed along a first base surface of the base portion. The shape-memory metal portions have a first portion contacting the base portion and a second portion spaced apart from the first portion and extending from the base portion. The first layer is joined to the base portion using ultrasonic additive manufacturing and has a first layer surface that is joined to the first base surface. The first layer surface contacts the shape-memory metal portions when the first layer is joined to the base portion.