Patents by Examiner Dennis M White
  • Patent number: 9393563
    Abstract: The present application relates to: a strip for lateral flow assay, comprising a support, a medium for development, a sample pad comprising a subpad, and an absorption pad; and a cartridge for lateral flow assay, comprising the same. According to the present application, the strip adopts a novel sample loading method, thereby obtaining reproducible results irrespective of the volume of an injected sample, and it is possible to readily change the amount of a sample, as necessary, thereby improving the reproducibility of measured results and convenience.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: July 19, 2016
    Assignee: BODITECHMED. INC
    Inventors: Byeong Chul Kim, Ki Tae Park, Hyun Jeong Kim
  • Patent number: 9395331
    Abstract: A method and apparatus for microfluidic processing by programmably manipulating a packet. A material is introduced onto a reaction surface and compartmentalized to form a packet. A position of the packet is sensed with a position sensor. A programmable manipulation force is applied to the packet at the position. The programmable manipulation force is adjustable according to packet position by a controller. The packet is programmably moved according to the programmable manipulation force along arbitrarily chosen paths.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: July 19, 2016
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Frederick F. Becker, Peter Gascoyne, Xiaobo Wang, Jody Valentine Vykoukal, Giovanni De Gasperis
  • Patent number: 9389211
    Abstract: The present invention relates to a device for investigating, measuring and/or detecting properties of chemical and/or biological fluids as well as to a device for performing these procedures and a system comprising a holder for holding at least one of said devices. A device for detecting properties of chemical and/or biological fluids may comprise a tubular structure with a cavity for accommodating the fluid, the tubular structure comprising a magnetizable and/or magnetic material, wherein the tubular structure comprises a segment that is transparent to light of wavelength 200 nm to 2000 nm.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: July 12, 2016
    Assignees: Nanotemper Technologies GmbH, Hirschmann Laborgerate GmbH & Co. KG
    Inventors: Stefan Duhr, Philipp Baaske, Hans-Jurgen Bigus
  • Patent number: 9383294
    Abstract: Hydrophilic articles and methods of using such articles are described. The hydrophilic articles include a hydrophilic layer comprising sintered, acidified silica nanoparticles attached to a substrate. A spacer layer attached to a first portion of the hydrophilic layer defines at least one fluid transport channel bounded on one side by a second portion of the hydrophilic layer. The nanoparticles may include one or both of spherical and elongated nanoparticles.
    Type: Grant
    Filed: October 30, 2012
    Date of Patent: July 5, 2016
    Inventors: Raymond J. Kenney, Theresa J. Gerten, Daniel P. Decabooter, Naiyong Jing, Garry W. Lachmansingh
  • Patent number: 9383351
    Abstract: A test strip to assist in determining the concentration of an analyte in a fluid sample comprises a base, at least one tab and a break line. The base includes a capillary channel and a test element. The capillary channel is in fluid communication with the test element. The test element is adapted to receive the fluid sample. The at least one tab is removably attached to the base. The capillary channel extends from the base into a portion of the tab. The break line intersects the capillary channel in which an inlet to the capillary channel is exposed along the break line when the tab is separated from the base.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: July 5, 2016
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventor: Roger Fleming
  • Patent number: 9377401
    Abstract: A biological sensing structure includes a mesa integrally connected a portion of a substrate, wherein the mesa has a top surface and a sidewall surface adjacent to the top surface. The biological sensing structure includes a first light reflecting layer over the top surface and the sidewall surface of the mesa. The biological sensing structure includes a filling material surrounding the mesa, wherein the mesa protrudes from the filling material. The biological sensing structure includes a stop layer over the filling material and a portion of the first light reflecting layer. The biological sensing structure includes a second light reflecting layer over a portion of the stop layer and a portion of the top surface of the mesa. The biological sensing structure includes an opening in the second light reflecting layer to partially expose the top surface of the mesa.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: June 28, 2016
    Assignee: Taiwan Semiconductor Manufacturing Company, Ltd.
    Inventors: Hung-Hua Lin, Li-Cheng Chu, Ming-Tung Wu, Yuan-Chih Hsieh, Lan-Lin Chao, Chia-Shiung Tsai
  • Patent number: 9377457
    Abstract: A cartridge and method for conducting a labeled molecular affinity binding test such as antibody/antigen, ligand/receptor, and colorometric reactions, and other chemical reactions for which one or more analytes is present in a liquid sample formate. A progressive compression structure progressively forces a liquid flow out of a conjugate pad toward a reaction region to more thoroughly and rapidly mix the liquid, encouraging specific first affinity binding to the analytes in question. A specially dimensioned constricting passageway surrounding the reaction region including the result zones provides an additional siphoning force to the flow. These combined forces rapidly and more evenly guide the flow of liquid through the reaction region so that the rushed rate of uptake of analytes at the strip lines are more evenly distributed, adhesive attachment of non-specific molecules is largely avoided, vastly improving sensitivity and specificity, and providing quantitative results in some tests.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: June 28, 2016
    Inventors: Naishu Wang, David F. Zhou
  • Patent number: 9364826
    Abstract: The present invention discloses an arrangement provided with a chip body having a fluid channel and configured such that an end portion of the fluid channel is opened in a surface of the chip body, and a sheet-like seal member which covers at least the opening in the surface of the chip body for bringing the inside of the fluid channel to a sealed state. The seal member is constituted of laminated sheet members including a first sheet member having a ductility and an elasticity capable of forming a hole therein with use of a nozzle member, and a second sheet member having a lower ductility than the first sheet member. The sheet members adjoining each other are adhered to each other by an adhesive or a tackifier. The second sheet member is disposed on the chip body side than the first sheet member.
    Type: Grant
    Filed: January 18, 2012
    Date of Patent: June 14, 2016
    Assignee: KONICA MINOLTA, INC
    Inventor: Shigeru Wada
  • Patent number: 9360490
    Abstract: A single device to collect, transfer, and measure salivary nitric oxide analyte and metabolite, nitrite, a biomarker for nitric oxide, as well as, a method to assess the effects of diet and exercise on changing an individual's nitric oxide status and health.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: June 7, 2016
    Assignee: Berkeley Test, LLC
    Inventors: Natalie Green, Juliana Green
  • Patent number: 9360479
    Abstract: This invention describes a device for assaying a dry or small volume liquid sample on a lateral flow capillary assay by utilizing a supplementary non-sample aqueous solution that will push the sample up the assay without diluting or significantly diluting the original sample. This invention enables a sample to be assayed rapidly and/or on-site when the sample is in dried or solid form, or when the liquid volume is too small to complete an assay. As an option, the device can display a colored signal when a sufficient amount of liquid sample has been collected or added to the device. The minimal liquid volume requirement of the device significantly reduces the sample collection time to a matter of seconds and resolves situations in which fluids available for collection are not abundant. Therefore, this invention allows the lateral flow test device to be a more rapid, efficient, and versatile apparatus.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: June 7, 2016
    Inventor: Daniel Wang
  • Patent number: 9346048
    Abstract: A chemical assay device includes a hydrophilic substrate and one or more hydrophobic structures that extend from a first side of the hydrophilic substrate to a second side of the hydrophilic substrate. A hydrophobic structure in the hydrophilic substrate forms a fluid barrier wall that extends from the first side of the hydrophilic substrate to the second side of the hydrophilic substrate with a deviation of less than 20° from a perpendicular axis between the first side and the second side.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: May 24, 2016
    Assignee: Xerox Corporation
    Inventors: Jing Zhou, Mandakini Kanungo, Nancy Y. Jia, Wei Hong
  • Patent number: 9340839
    Abstract: This invention describes an advanced cooling system for a laboratory instrument to maintain laboratory samples at a predetermined temperature. The advanced cooling system uses an algorithm that incorporates information from at least one sensor and other operational parameters including thermal effects from the operation of the instrument.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: May 17, 2016
    Assignee: Forward Biotech, Inc.
    Inventors: Brendan Hart, Brian Kolb, David Grinnell, Ian Glasgow
  • Patent number: 9330580
    Abstract: A wick for use in determining sufficiency of an amount of analyte fluid provided to an analyte test section of an assay device is provided. The wick comprises a primary wick portion attached or attachable to the analyte test section so as to be in fluid communication therewith. The primary wick portion has a receiving surface adapted for receiving the analyte fluid and is configured to draw the analyte fluid from a first area to a second area of the primary wick portion. The assay wick further comprises an indicator portion having a contrasting visual characteristic. The indicator surface is covered by at least a portion of the primary wick portion, which comprises a wicking material that becomes more light transmissive when wetted by the analyte fluid. The contrasting visual characteristic is viewable through the at least a portion of the primary wick portion only when the at least a portion of the primary wick portion is suffused by the analyte fluid.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: May 3, 2016
    Assignee: Essentra Porous Technologies Corp.
    Inventors: Bennett C. Ward, Jian Xiang, Stacey L. Tibbs, Yelena N. Rogova
  • Patent number: 9326914
    Abstract: Device (1a, 1b, 1c, 1d; 40) for extracting, storing and/or processing blood or other substances of human or animal origin, and for applying blood compounds or other biological compounds, which comprises a body (2; 41) inside which a piston (3; 42) is capable of moving longitudinally and is separable at least in part, where the body (2; 41) is provided with an internal space (9; 51) that may be connected to the outside by means of a conduit (6; 50) at a first end (4; 48) of the body (2; 41), where the body (2; 41) and the piston (3; 43) may be blocked longitudinally in at least one position to allow the creation of different degrees of vacuum. The device has multiple uses and is extremely versatile.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: May 3, 2016
    Assignee: BIOTECHNOLOGY INSTITUTE, I MAS D, S.L.
    Inventor: Eduardo Anitua Aldecoa
  • Patent number: 9316583
    Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: April 19, 2016
    Assignee: SYSMEX CORPORATION
    Inventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
  • Patent number: 9304084
    Abstract: Devices, systems, kits, and methods for detecting and/or identifying a plurality of spectrally labeled bodies well-suited for performing multiplexed assays. By spectrally labeling the beads with materials which generate identifiable spectra, a plurality of beads may be identified within the fluid. Reading of the beads is facilitated by restraining the beads in arrays, and/or using a focused laser.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: April 5, 2016
    Assignee: Life Technologies Corporation
    Inventors: Stephen Empedocles, Andrew Watson, Jian Jin
  • Patent number: 9297762
    Abstract: Devices, systems, kits, and methods for detecting and/or identifying a plurality of spectrally labeled bodies well-suited for performing multiplexed assays. By spectrally labeling the beads with materials which generate identifiable spectra, a plurality of beads may be identified within the fluid. Reading of the beads is facilitated by restraining the beads in arrays, and/or using a focused laser.
    Type: Grant
    Filed: August 17, 2015
    Date of Patent: March 29, 2016
    Assignee: Life Technologies Corporation
    Inventors: Stephen Empedocles, Andrew Watson, Jian Jin
  • Patent number: 9291620
    Abstract: Provided is an in vitro diagnostic tool configured to quantitatively or qualitatively detect a suspected substance in a test solution, the tool including: a first porous layer having a first surface and a second surface; a base sheet bonded to the first surface; a second porous layer bonded to the second surface; and a reagent configured to react with the suspected substance and carried in at least a part of the second porous layer, wherein: the first porous layer has a matrix structure of first nanofibers formed by electrostatic spinning; the second porous layer has a matrix structure of second nanofibers formed by electrostatic spinning; and a fiber diameter of the second nanofibers is smaller than a fiber diameter of the first nanofibers.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: March 22, 2016
    Assignee: Panasonic Intellectual Property Management Co., Ltd.
    Inventors: Yuki Yoshioka, Takahiro Kurokawa
  • Patent number: 9284520
    Abstract: Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or disk. Fluidics channels between containers allow the performance of different techniques for sample preparation, such as lysing, washing and elution. Different functional elements, such as grinders or mixers, may be attached to the containers.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: March 15, 2016
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Imran R. Malik, Erika F. Garcia, Xiomara Linnette Madero, Axel Scherer
  • Patent number: 9279771
    Abstract: A three-dimensional porous photonic structure, whose internal pore surfaces can be provided with desired surface properties in a spatially selective manner with arbitrary patterns, and methods for making the same are described. When exposed to a fluid (e.g., via immersion or wicking), the fluid can selectively penetrate the regions of the structure with compatible surface properties. Broad applications, for example in security, encryption and document authentication, as well as in areas such as simple microfluidics and diagnostics, are anticipated.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: March 8, 2016
    Assignee: President and Fellows of Harvard College
    Inventors: Joanna Aizenberg, Ian B. Burgess, Lidiya Mishchenko, Benjamin Hatton, Marko Loncar