Patents by Examiner Dennis M White

Patent number: 8815181
Abstract: A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber (2), especially of an assay apparatus, the apparatus comprising: one or more respective storage chambers (5,6) for containing the one or more liquid reagents and arranged generally above the reaction or test chamber (2); and a plunger element (4) arranged and operable for insertion into the mouth of a selected storage chamber so as to displace a selected reagent from therewithin into the reaction or test chamber (2) generally therebelow by gravitational liquid overflow from the mouth of the chamber. The apparatus may conveniently be provided as a discrete delivery unit, with the storage chambers (5,6) pretilled with the selected reagents.
Type: Grant
Filed: October 23, 2012
Issued: August 26, 2014
Assignee: The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland
Inventor: David James Squirrell
Patent number: 8784749
Abstract: This invention provides a digital microfluidic manipulation device and a manipulation method thereof. This device comprises a PDMS membrane having a surface comprising a plurality of hydrophobic microstructures; a plurality of air chambers arranged in an array and placed under the PDMS membrane; and a plurality of air channels, each of which connects to a corresponding one of the plurality of air chambers. When a suction force is transmitted via one of the plurality of air channels to the corresponding air chamber, a portion of the PDMS membrane above the air chamber deforms toward the air chamber, so that the surface morphology and the contact angle of the liquid/solid interface of the surface comprising the plurality of hydrophobic microstructures are altered and thereby to drive droplets.
Type: Grant
Filed: December 21, 2012
Issued: July 22, 2014
Assignee: National Taiwan University
Inventors: Jing-Tang Yang, Chao-Jyun Huang, Chih-Yu Hwang
Patent number: 8778279
Abstract: The present disclosure relates to microfluidic devices adapted for facilitating cytometry analysis of particles flowing therethrough. In certain embodiments, the microfluidic devices have onboard sterilization capabilities. In other embodiments, microfluidic devices have integral collection bags and methods for keeping the microfluidic channels clean.
Type: Grant
Filed: July 6, 2010
Issued: July 15, 2014
Assignees: Sony Corporation, Sony Corporation of America
Inventor: Gary P. Durack
Patent number: 8778283
Abstract: A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber (2), especially of an assay apparatus, the apparatus comprising: one or more respective storage chambers (5,6) for containing the one or more liquid reagents and arranged generally above the reaction or test chamber (2); and a plunger element (4) arranged and operable for insertion into the mouth of a selected storage chamber so as to displace a selected reagent from therewithin into the reaction or test chamber (2) generally therebelow by gravitational liquid overflow from the mouth of the chamber. The apparatus may conveniently be provided as a discrete delivery unit, with the storage chambers (5,6) prefilled with the selected reagents.
Type: Grant
Filed: January 25, 2010
Issued: July 15, 2014
Assignee: The Secretary of State for Defence
Inventor: David James Squirrell
Patent number: 8765058
Abstract: The invention concerns an analyzer, typically for analyzing body fluids, which has one or several exchangeable cassettes (consumables) that contain operating liquids, operating materials and/or consumables and can be inserted into corresponding holders of the analyzer, wherein the analyzer has a system for exchanging ambient air which has a filter unit on the inlet side of the analyzer to filter the ambient air that needs to be exchanged. The filter unit is integrated into at least one of the exchangeable cassettes in order to minimize the amount of maintenance for the analyzer.
Type: Grant
Filed: November 12, 2008
Issued: July 1, 2014
Assignee: Roche Diagnostics Operations, Inc.
Inventors: Wolfgang Sprengers, Berndt Ebner, Andreas Riegelnegg
Patent number: 8765077
Abstract: Multiplex binding assay assemblies are disclosed. The assemblies generally include at least one assay bar that includes a top side, a bottom side, and at least one well accessible from the top side of the assay bar. Each well includes a side surface, a bottom surface, an open top end, and at least one secondary container, with each secondary container including a capillary tube that (i) begins at a location within an interior volume of the well and (ii) ends at a location beneath the bottom surface of the assay bar. The assemblies further include a dispenser bar that is adapted to be positioned adjacent to the top side of the assay bar, which includes one or more reservoirs that are configured to provide one or more reagents to the at least one secondary container located in each well of the assay bar.
Type: Grant
Filed: August 2, 2011
Issued: July 1, 2014
Inventor: Pierre F. Indermuhle
Patent number: 8747747
Abstract: A reader for mechanical actuation of fluids within a test cartridge. The instrument interface including multiple independently-controlled plungers aligned to respective fluidic pouches on a test cartridge that is inserted into a testing apparatus embodying the instrument interface. The plungers include tips for applying mechanical force to the respective fluidic pouches.
Type: Grant
Filed: December 20, 2011
Issued: June 10, 2014
Assignee: Abbott Point of Care Inc.
Inventor: Seth Hunter
Patent number: 8747779
Abstract: A microfluidic cartridge including on-board dry reagents and microfluidic circuitry for determining a clinical analyte or analytes from a few microliters of liquid sample; with docking interface for use in a host workstation, the workstation including a pneumatic fluid controller and spectrophotometer for monitoring analytical reactions in the cartridge.
Type: Grant
Filed: October 13, 2011
Issued: June 10, 2014
Assignee: Micronics, Inc.
Inventors: Isaac Sprague, John E. Emswiler, C. Frederick Battrell, Joan Haab, Sean M. Pennell, Justin L. Kay, Zane B. Miller, Troy D. Daiber
Patent number: 8747773
Abstract: Embodiments of the invention relate to portable detection apparatus, comprising one or more detector regions adapted to visually indicate the presence or amount of an analyte in a beverage. The detection apparatus is shaped substantially the same as a consumer product.
Type: Grant
Filed: August 11, 2011
Issued: June 10, 2014
Inventor: Maryse Thomas
Patent number: 8734723
Abstract: A gas sensor cell using a liquid crystal composite material is provided. The gas sensor cell has recovery capability and can be reused. Upon gas adsorption, the liquid crystal composite material has visually detectable color changes and changes in electrical properties to facilitate the measurement of gas concentration from low to high.
Type: Grant
Filed: August 30, 2013
Issued: May 27, 2014
Assignee: Industrial Technology Research Institute
Inventors: Chin-Kai Chang, Hui-Lung Kuo
Patent number: 8721990
Abstract: Disclosed is an assay device for the determination of the presence and/or extent if an analyte in a liquid sample over an extended concentration range comprising a first assay and a second assay, wherein the first assay for an analyte comprises a first flow-path having a sole detection zone capable of immobilizing a labelled binding reagent and the second assay for said analyte comprises a second flow-path having a sole detection zone capable of immobilizing a labelled binding reagent, wherein the presence of labelled binding reagent at the detection zones provides an indication of the presence and/or extent of analyte in said liquid sample.
Type: Grant
Filed: April 9, 2008
Issued: May 13, 2014
Assignee: Alere Switzerland GmbH
Inventors: Balbir Raj, Saji Eapen, Ezra Linley
Patent number: 8722417
Abstract: An apparatus is provided for sensing an analyte in a fluid.
Type: Grant
Filed: January 20, 2007
Issued: May 13, 2014
Assignee: Invoy Technologies, L.L.C.
Inventor: Lubna Ahmad
Patent number: 8716028
Abstract: The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
Type: Grant
Filed: December 31, 2012
Issued: May 6, 2014
Assignee: Nalco Company
Inventors: Amy Tseng, Brian V. Jenkins, Robert M. Mack
Patent number: 8709356
Abstract: The present invention relates to systems and methods for minimizing or eliminating diffusion effects. Diffused regions of a segmented flow of multiple, miscible fluid species may be vented off to a waste channel, and non-diffused regions of fluid may be preferentially pulled off the channel that contains the segmented flow. Multiple fluid samples that are not contaminated via diffusion may be collected for analysis and measurement in a single channel. The systems and methods for minimizing or eliminating diffusion effects may be used to minimize or eliminate diffusion effects in a microfluidic system for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules.
Type: Grant
Filed: April 12, 2010
Issued: April 29, 2014
Assignee: Canon U.S. Life Sciences, Inc.
Inventors: Brian Murphy, Scott Corey, Alex Flamm, Ben Lane, Conrad Laskowski, Chad Schneider
Patent number: 8703070
Abstract: Apparatus for immunoassay includes: a cartridge, including at least one test unit; a pin-film assembly, having a second sealing film, a plurality of pierce mechanisms, and a first actuation unit; a plurality of magnetic particles; at least one first magnetic unit; and at least one second magnetic unit. The test unit includes a plurality of fluid chambers, a plurality of pin chambers, a microchannel structure, a buffer chamber, a detection chamber and a waste chamber. The first actuation unit drives the pierce mechanisms to enable a working fluid to flow into the detection chamber storing the magnetic particles. As the second magnetic unit has a magnetic force larger than that of the first magnetic unit and can move reciprocatingly between a third position and a fourth position, the magnetic particles are driven to move reciprocatingly inside the detection chamber, thereby fully mixing the magnetic particles with the working fluid.
Type: Grant
Filed: November 2, 2012
Issued: April 22, 2014
Assignee: Industrial Technology Research Institute
Inventors: Shaw-Hwa Parng, Chih-Wen Yang, Yu-Yin Tsai, Yi-Chau Huang
Patent number: 8697005
Abstract: Multiplex binding assay assemblies are disclosed. The assemblies include at least one assay bar that has a top side, a bottom side, and at least one well accessible from the top side of the assay bar, with each well including a side surface, a bottom surface, an open top end. Each well also includes at least one secondary container, with each secondary container including a capillary tube that (i) begins at a location within an interior volume of the well and (ii) ends at a location beneath the bottom side of the assay bar. The assemblies further include a guiding track, which includes a set of two rails, with each rail having its own separate groove. Such grooves are configured to run parallel to each other with a distance between such grooves, with a first groove configured to receive a protruding element (or an end) of a first side of the assay bar, and a second groove configured to receive a protruding element (or an end) of a second side of the assay bar.
Type: Grant
Filed: August 2, 2011
Issued: April 15, 2014
Inventor: Pierre F. Indermuhle
Patent number: 8697008
Abstract: A method and device for periodically perturbing the flow field within a microfluidic device to provide regular droplet formation at high speed.
Type: Grant
Filed: March 9, 2010
Issued: April 15, 2014
Assignee: Eastman Kodak Company
Inventors: Andrew Clarke, Nicholas J. Dartnell, Christopher B. Rider
Patent number: 8691151
Abstract: This invention provides an apparatus for particle sorting, particle patterning, and methods of using the same. The sorting or patterning is opto-fluidics based, in that particles are applied to individual chambers in the device, detection and/or analysis of the particles is carried out, such that a cell or population whose removal or conveyance is desired is defined, and the cell or population is removed or conveyed via application of an optical force and flow-mediated conveyance or removal of the part.
Type: Grant
Filed: August 27, 2007
Issued: April 8, 2014
Assignee: Massachusetts Institute of Technology
Inventors: Joseph Kovac, Joel Voldman
Patent number: 8685745
Abstract: A multilayered optical sensing patch, for the measurement of conditions, such as pH, oxygen level, etc, within containers, is provided. The multilayered optical sensing patch of the present invention is comprised of a heat sealable polymer substrate layer, and a polymeric sensing membrane later attached thereto. The polymer sensing membrane layer is formed of a porous polymer support membrane, and an optical sensing composition (comprising a reactive indicator) covalently bonded thereto. The heat sealable polymer substrate layer is capable of being securely bonded to the inner layer of bioreactor bags, as well as the porous polymer support substrate layer. Further, the porous polymer support membrane layer provides a firm supporting structure for the polymeric sensing layer, thereby protecting the optical sensing composition disposed therein from degradation/damage.
Type: Grant
Filed: October 26, 2011
Issued: April 1, 2014
Assignee: Polestar Technologies, Inc.
Inventor: James A. Kane
Patent number: 8673215
Abstract: The invention relates to the test device for platelet aggregation detection comprising: —an element (1) for receiving a blood sample—a capillary tube (3) connected at a first end (31) to said element (1) and at a second end (32) to a pressure lowering device (5) to pump said blood sample through said capillary tube (3)—at least a pair of facing electrodes (8) on the capillary tube—a device for measuring an impedance between said pair of facing electrodes. The invention also relates to a process for using this device, comprising: a) receiving a blood sample and pumping it through the capillar tube (3) b) determining a dynamic change of the value of the impedance between at least one pair of electrodes (8).
Type: Grant
Filed: October 16, 2008
Issued: March 18, 2014
Assignee: Centre National de la Recherche Scientifique
Inventors: Francine Rendu, Daniel Fruman, Jaime Levenson