Patents by Examiner Dennis M White
  • Patent number: 9598722
    Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: March 21, 2017
    Assignee: GENMARK DIAGNOSTICS, INC.
    Inventors: David Walter Wright, Dominic Aiello, Peter Kroehl, Jon Faiz Kayyem, Darren Scott Gray
  • Patent number: 9597681
    Abstract: A sensor element comprising a tape-shaped mount film; and a plurality of film-shaped sensors bonded on one surface of the mount film, wherein the front and rear film-shaped sensors are spaced at a predetermined distance in a lengthwise direction of the mount film, and a crosswise length of each film-shaped sensor is shorter by a predetermined quantity than a crosswise length of the mount film.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: March 21, 2017
    Assignee: ARKRAY, Inc.
    Inventors: Yuji Kurata, Hisashi Kaneda
  • Patent number: 9594065
    Abstract: Apparatus for detecting deterioration of an NOx selective reduction catalyst in an exhaust passage of an internal combustion engine with improved accuracy, includes an NOx purification rate calculation unit for calculating the NOx purification rate in the NOx selective reduction catalyst based on the NOx concentration in the exhaust gas flowing into and out of the NOx selective reduction catalyst. A determination as to whether the NOx selective reduction catalyst is deteriorated is made based on the NOx purification rate at a time when the temperature of the NOx selective reduction catalyst is equal to or higher than a temperature (Tc0) at which the NOx purification rate will start to decrease with a rise in the temperature of the NOx selective reduction catalyst if the degree of deterioration of the NOx selective reduction catalyst is at the upper limit of an allowable range.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: March 14, 2017
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Taiga Hagimoto, Daisuke Shibata
  • Patent number: 9594253
    Abstract: The present invention provides a spectral apparatus for spectrally separating light including a predetermined wavelength, including a slit that the light enters, a first optical system configured to collimate the light from the slit, a transmissive type diffraction element configured to diffract the light from the first optical system, and a second optical system including a first mirror configured to reflect the light diffracted by the transmissive type diffraction element, and a second mirror configured to reflect the light reflected by the first mirror and diffracted by the transmissive type diffraction element, and configured to make the light reciprocally travel between the first mirror and the second mirror via the transmissive type diffraction element.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: March 14, 2017
    Assignees: CANON KABUSHIKI KAISHA, The University of Tokyo
    Inventors: Takashi Sukegawa, Yohei Kobayashi, Akira Ozawa, Mamoru Endo, Makoto Gonokami
  • Patent number: 9586204
    Abstract: The present disclosure proposes a design of a biomedical paper sensor which can determine the concentration of biological materials in fluids such as blood, urine, and saliva. The sensor contains a plurality of axially radiating test zones, each test zone separated from other test zones by wax ink barriers formed by a process that produces thin walls. Each test zone can contain a unique test reagent, or a unique concentration of a test reagent, and can also be identified by printed text. The region of the device outside of the test zone area is printed with a uniform reference color. Benefits of the invention include increased accuracy in the measurement of the concentration of biological materials due to the larger test zone area. Benefits also include the integration of the reference or calibration color which simplifies the calibration needed for quantification of the concentration.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: March 7, 2017
    Assignee: Xerox Corporation
    Inventors: Wei Hong, Jing Zhou, Mandakini Kanungo, Xing Liu, Nancy Y. Jia, Sarah J. Vella, Laura Lu
  • Patent number: 9581593
    Abstract: There is provided a fluid test strip, comprising a micro-sensor formed on a substrate surface and a reagent deposition site formed on the substrate surface, operate to control the size and location of a reagent deposition. There is also provided a method of forming fluid test strip, comprising forming a micro-sensor on a substrate surface and forming a reagent deposition site on the substrate surface, operable to control the size and location of a reagent deposition.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: February 28, 2017
    Assignee: Microvisk Limited
    Inventors: Robert Ibbotson, Vladislav Djakov, Richard Dunn
  • Patent number: 9568404
    Abstract: Disclosed are devices or apparatus and methods for membrane-, bead- or cell-based biomolecule analysis, where a detectable signal can be measured after affinity binding and/or enzymatic reaction occurs on the membranes, beads or cells. The apparatus or device can rapidly separate the beads or cells from the liquid solution without using centrifugation, vacuum, or magnetic force. The apparatus or device includes a sample well for receiving a sample containing cells or beads, as well as other aqueous solutions, a porous filter membrane at the bottom of the well which is capable of retaining the cells or beads on its upper surface by size exclusion, and an absorbing plug in touch with the filter membrane for removing the liquid solution. Multiple devices can be arranged in a multi-well array in a plate so that signals from multiple assays can be directly analyzed in a plate reader or an imaging instrument.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: February 14, 2017
    Inventor: Junyu Mai
  • Patent number: 9561503
    Abstract: A sensor element comprising a tape-shaped mount film; and a plurality of film-shaped sensors bonded on one surface of the mount film, wherein the front and rear film-shaped sensors are spaced at a predetermined distance in a lengthwise direction of the mount film, and a crosswise length of each film-shaped sensor is shorter by a predetermined quantity than a crosswise length of the mount film.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: February 7, 2017
    Assignee: ARKRAY, Inc.
    Inventors: Yuji Kurata, Hisashi Kaneda
  • Patent number: 9561506
    Abstract: Fluidic devices and methods including those that provide storage and/or facilitate fluid handling of reagents are provided. Fluidic devices described herein may include channel segments positioned on two sides of an article, optionally connected by an intervening channel passing through the article. The channel segments may be used to store reagents in the device prior to first use by an end user. The stored reagents may include fluid plugs positioned in linear order so that during use, as fluids flow to a reaction site, they are delivered in a predetermined sequence. The specific geometries of the channel segments and the positions of the channel segments within the fluidic devices described herein may allow fluid reagents to be stored for extended periods of time without mixing, even during routine handling of the devices such as during shipping of the devices, and when the devices are subjected to physical shock or vibration.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: February 7, 2017
    Assignee: OPKO Diagnostics, LLC
    Inventors: Jason Taylor, Vincent Linder
  • Patent number: 9562253
    Abstract: A method includes obtaining a sample from a patient; applying, to the sample, a reagent to cause bacterial cells to release adenosine triphosphate (ATP) when the sample includes the bacterial cells; applying another reagent that reacts with the ATP to form a colorimetric agent; detecting whether the sample changes in appearance as observed by an unaided eye of a practitioner when a concentration of the agent is greater than a threshold; identifying a time period from when the other reagent is applied to when the change in appearance is detected; and determines a severity, of a bacterial infection, based on the time period. The severity corresponds to a severity level when the time period is less than a duration of a point of care visit by a first amount, or a higher severity level when the time period is less than the duration by more than the first amount.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: February 7, 2017
    Assignee: POINT OF CARE DIAGNOSTICS, LLC
    Inventor: Ronald Turner
  • Patent number: 9557317
    Abstract: Systems, apparatus, methods, and kits are provided for automated mass spectrometric analysis of small volumes of liquid samples, such as biological samples. The systems, apparatus, and kits may be used in facilities where high throughput of samples, as well as reliable and repeatable assay results with little training of staff, are needed. Such facilities include hospital emergency wards.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: January 31, 2017
    Assignee: PureHoney Technologies, Inc.
    Inventor: Can Ozbal
  • Patent number: 9551707
    Abstract: A nanopore structure includes an aperture extending from a first surface to a second surface of a substrate, the aperture having a wall comprising gold ions embedded in the substrate, the wall defining a first diameter; a first deoxyribonucleic acid (DNA) layer including a thiolated DNA strand covalently bonded to the embedded gold ions within the wall of the aperture; and a second DNA layer hydrogen bonded to the first DNA layer, the second DNA layer defines a substantially cylindrical nanopore that defines a second diameter within the wall of the aperture, the second DNA layer including a single-stranded DNA strand; wherein the second diameter is less than the first diameter.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: January 24, 2017
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Yann Astier, Joshua T. Smith
  • Patent number: 9545635
    Abstract: Provided are pipette tip trays for use in biotechnology applications. In certain embodiments, provided are pipette tip trays having one or more of the following features: (i) lacking an external hinge between the lid and the rack, and (ii) having snap plate fasteners configured to releasably secure a snap plate to a base.
    Type: Grant
    Filed: March 17, 2011
    Date of Patent: January 17, 2017
    Assignee: BIOTIX, INC.
    Inventors: Arta Motadel, Peter Paul Blaszcak
  • Patent number: 9543118
    Abstract: A nanopore structure includes an aperture extending from a first surface to a second surface of a substrate, the aperture having a wall comprising gold ions embedded in the substrate, the wall defining a first diameter; a first deoxyribonucleic acid (DNA) layer including a thiolated DNA strand covalently bonded to the embedded gold ions within the wall of the aperture; and a second DNA layer hydrogen bonded to the first DNA layer, the second DNA layer defines a substantially cylindrical nanopore that defines a second diameter within the wall of the aperture, the second DNA layer including a single-stranded DNA strand; wherein the second diameter is less than the first diameter.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: January 10, 2017
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Yann Astier, Joshua T. Smith
  • Patent number: 9535036
    Abstract: Provided are a multiple discrimination device and a method of manufacturing the same. According to the multiple discrimination device, a three-dimensional micro ferromagnetic pattern is optimally designed and arranged to allow a magnetic force applied to a discrimination-target particle to be discriminated to be well controlled to perform discrimination well. The method employs a semiconductor processing technology, thereby precisely manufacturing and allowing mass production.
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: January 3, 2017
    Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Dae-Sik Lee, Jeong Won Park, Seong-Mok Cho, Moon Youn Jung
  • Patent number: 9527077
    Abstract: A disposable, point-of-care diagnostic cartridge has a base with a reaction chamber and an inlet and a fluidic channel extending therebetween. An apparatus is fixed to the base. The apparatus includes a flexible upper layer having a reservoir containing fluid therein; a flexible lower layer, and a rigid substrate sandwiched between the upper and lower layers. The upper layer is fixed to the substrate with a first adhesive having a first bond force. The lower layer has a valve member in fluid communication with a through port in the base and the base inlet. The valve member has a closed state to seal off the through port and the inlet from fluid communication and an open state to bring the through port and the inlet into fluid communication. The valve member is moveable from the closed state to the open state under a force less than the first bond force.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: December 27, 2016
    Inventor: David W. Wright
  • Patent number: 9522397
    Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: December 20, 2016
    Assignee: CUE INC.
    Inventors: Ayub Khattak, Clinton Sever
  • Patent number: 9518985
    Abstract: The present invention provides a semi-quantitative lateral flow assay device and method for generating semi-quantitative data from a lateral flow assay. The device comprises a thin, porous hydrophilic substrate wherein the substrate includes a star-shaped or other geometry taken in plan view having a liquid sample-receiving central region and multiple arms that extend or radiate out from the central region. Each arm includes a reaction zone formed by the presence of an analyte-capturing agent wherein the reaction zone of each arm is located at a different distance from the central region such that the analyte in the sample is captured accumulates in different quantities at at least some of the reaction zones of the arms in a manner that can be analyzed to yield semi-quantitative data from lateral flow assays.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: December 13, 2016
    Assignee: STC.UNM
    Inventor: Scott A. Sibbett
  • Patent number: 9500664
    Abstract: A system, including method and apparatus, for generating droplets suitable for droplet-based assays. The disclosed systems may include either one-piece or multi-piece droplet generation components configured to form sample-containing droplets by merging aqueous, sample-containing fluid with a background emulsion fluid such as oil, to form an emulsion of sample-containing droplets suspended in the background fluid. In some cases, the disclosed systems may include channels or other suitable mechanisms configured to transport the sample-containing droplets to an outlet region, so that subsequent assay steps may be performed.
    Type: Grant
    Filed: December 30, 2011
    Date of Patent: November 22, 2016
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Kevin D. Ness, Christopher F. Kelly, Donald A. Masquelier
  • Patent number: 9480981
    Abstract: An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface and an outlet for driving out the sample fluid. The device further comprises an interface assembly comprising: a third layer, a fourth layer, a fifth layer, and a flow path. The interface assembly is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer of the interface assembly and the outlet is in contact with the flow path of the interface assembly for driving out the sample fluid from the integrated device.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: November 1, 2016
    Assignee: General Electric Company
    Inventors: Ralf Lenigk, Erin Jean Finehout, Xuefeng Wang