Patents by Examiner Dennis M White

Patent number: 9034264
Abstract: The present application provides apparatus and methods for determining the density of a fluid sample. In particular, it provides a sensor device which can be loaded with a fluid sample such as blood, and which further comprises at least one oscillating beam member or resonator. Exposure of the blood sample to clotting agents allows a clotting reaction to commence. The device allows the density of the sample fluid to be monitored with reference to the oscillation of the vibrating beam member, thus allowing the monitoring of the clotting of the fluid sample.
Type: Grant
Filed: August 22, 2014
Issued: May 19, 2015
Assignee: Highland Biosciences Limited
Inventor: Richard Day
Patent number: 9028772
Abstract: A method may involve forming one or more photoresist layers over a sensor located on a structure, such that the sensor is covered by the one or more photoresist layers. The sensor is configured to detect an analyte. The method may involve forming a first polymer layer. Further, the method may involve positioning the structure on the first polymer layer. Still further, the method may involve forming a second polymer layer over the first polymer layer and the structure, such that the structure is fully enclosed by the first polymer layer, the second polymer layer, and the one or more photoresist layers. The method may also involve removing the one or more photoresist layers to form a channel through the second polymer layer, wherein the sensor is configured to receive the analyte via the channel.
Type: Grant
Filed: June 28, 2013
Issued: May 12, 2015
Assignee: Google Inc.
Inventors: Huanfen Yao, Jeffrey George Linhardt, Babak Parviz
Patent number: 9028756
Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.
Type: Grant
Filed: August 30, 2013
Issued: May 12, 2015
Assignee: Sysmex Corporation
Inventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
Patent number: 9029159
Abstract: A method of operating the automated sample workcell for processing one or more biological samples is presented. The method comprises receiving one or more biological samples. Each biological sample is contained in a sample tube. Each sample tube is a tube type. If a test order was received for at least one of the biological samples, the test order being indicative of one or more first processing steps, the workcell can automatically execute the one or more first processing steps. If the test order was not received, one or more second processing steps can be determined based on the tube type of the sample tube that contains the at least one biological sample and the one or more second processing steps can then be executed.
Type: Grant
Filed: April 12, 2012
Issued: May 12, 2015
Assignee: Roche Diagnostics Operations, Inc.
Inventors: Frederic Furrer, Joerg Haechler, Andrzej Knafel
Patent number: 9023291
Abstract: The present invention is directed toward a colorimetric detection kit comprising a unit containing chemical reagents and a sample collector for collecting a sample analyte from a surface and a separate unit for visualizing a possible reaction of the chemical reagent and sample, the unit holding the chemical reagents and sample collector being placeable on the visualization unit, whereby when the chemical reagents are released, they are directed onto the sample collector for reaction and the reacted reagents absorbed on a visualization media, such that the presence of a specified analyte in the sample results in a color change in the visualization media.
Type: Grant
Filed: October 23, 2012
Issued: May 5, 2015
Assignee: The United States of America as Represented by the Secretary of The Army
Inventors: James A. Genovese, Edward Rychwalski, III, Kevin Ridgley, Richard Kreis, Kevin M Murphy
Patent number: 9023281
Abstract: Chemical indicator apparatuses containing one or more chemical indicators for use in monitoring the quality of water in an aquatic environment. The apparatuses are designed and configured to be submersible in the water that is being monitored. In some embodiments, each apparatus includes a plurality of immobilized-dye-based chemical indicators that undergo a physical change as levels of one or more constituents of the water change. Such indicators can be read by one or more suitable optical readers. These and other embodiments are designed and configured to be movable by a corresponding monitoring/measuring apparatus, for example, via a magnetically coupled drive. Also disclosed are a variety of features that can be used to provide a chemical indicator apparatus with additional functionalities.
Type: Grant
Filed: December 13, 2012
Issued: May 5, 2015
Assignee: Step Ahead Innovations, Inc.
Inventor: James E. Clark
Patent number: 8999264
Abstract: A coating formula and method for surface coating non-porous surfaces. Microfluidic devices including said coating achieve desired properties including increased hydrophilicity, improved adhesion, stability and optical clarity.
Type: Grant
Filed: September 26, 2011
Issued: April 7, 2015
Assignee: Siemens Healthcare Diagnostics Inc.
Inventor: Michael J. Pugia
Patent number: 8999262
Abstract: A time indicating label for attachment to a tube, the label comprising: (A) An impermeable facesheet optionally adapted to accepting a graphic before or after attachment of the label to a tube, (B) An activation layer comprising a polymer matrix and an activating agent, the activation layer in contact with the facesheet, (C) A release liner impermeable to the activating agent and in contact with the activation layer, (D) A timing layer comprising a film-forming polymer and a pigment, the timing layer in contact with the release liner, (E) A dye layer comprising a film-forming polymer and an organic solvent soluble dye and in contact with the timing layer, and (F) A base layer comprising a material impermeable to the activating agent and dye and in contact with both the dye layer and the activation layer.
Type: Grant
Filed: March 15, 2013
Issued: April 7, 2015
Assignee: Brady Worldwide, Inc.
Inventors: Richard S. Roehr, Matthew M. Kasper, Adam D. Scheuer
Patent number: 8992860
Abstract: The present invention relates to systems and methods for minimizing or eliminating diffusion effects. Diffused regions of a segmented flow of multiple, miscible fluid species may be vented off to a waste channel, and non-diffused regions of fluid may be preferentially pulled off the channel that contains the segmented flow. Multiple fluid samples that are not contaminated via diffusion may be collected for analysis and measurement in a single channel. The systems and methods for minimizing or eliminating diffusion effects may be used to minimize or eliminate diffusion effects in a microfluidic system for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules.
Type: Grant
Filed: April 14, 2014
Issued: March 31, 2015
Assignee: Canon U.S. Life Sciences, Inc.
Inventors: Brian Murphy, Scott Corey, Alex Flamm, Ben Lane, Conrad Laskowski, Chad Schneider
Patent number: 8986611
Abstract: A sample analysis apparatus configured to automatically press a start button upon installation of a sample tube is provided. The sample analysis apparatus includes: a body of the sample analysis apparatus; a door housing which may be provided in an opened state or a closed state, and configured to be coupled to the body of the sample analysis apparatus by a hinge; a tube accommodating unit included in the door housing and configured to accommodate the sample tube; a start button included in the body of the sample analysis apparatus and configured to start analysis of the sample; and an operating member positioned at a first position which is distant from the start button the sample tube is not installed in the tube accommodating unit, and a second position which is configured to operate the start button when a sample tube is installed and the door housing is closed.
Type: Grant
Filed: August 2, 2012
Issued: March 24, 2015
Assignee: Samsung Electronics Co., Ltd.
Inventors: Yong Koo Lee, Tae Soo Kim, In Duk Hwang, Seock Woo Jang, Chul Ho Yun
Patent number: 8986625
Abstract: A method for sampling a sulphur-containing solid product including supplying a gas flow comprising hydrogen sulphide, bringing the gas flow into contact with a solid reagent and reacting the solid reagent with the hydrogen sulphide contained in the gas flow, the reaction fixing the sulphur of the hydrogen sulphide by forming a sulphur-containing solid product which is different in color from the solid reagent, and recovering the sulphur-containing solid product. The invention also relates to a device suitable for the implementation of this method.
Type: Grant
Filed: August 27, 2013
Issued: March 24, 2015
Assignee: Total S.A.
Inventors: Daniel Dessort, Robert Le Van Loï, Nadine Loubere
Patent number: 8974751
Abstract: Sample liquid is collected in a chamber downstream of a separating device. Adjoining the chamber are a plurality of channels which guide the sample liquid to one or more investigating regions.
Type: Grant
Filed: July 5, 2011
Issued: March 10, 2015
Assignee: Boehringer Ingelheim Microparts GmbH
Inventors: Tobias Rodenfels, Gert Blankenstein
Patent number: 8968677
Abstract: An improved apparatus and method for dispersion of a labeling conjugate in a diagnostic assay, the result being a one-step assay. By eliminating a conjugate pad as in conventional lateral diagnostic devices, and forming a frazil ice pellicle (FIP), rehydration and flow are improved resulting in better reproducibility, improved sensitivity, and reduced costs of individual assay devices. The formation of a frazil ice film formed on a super cooled surface of a sample receiving means simplifies assay assembly. Lyophilization of the FIP improves the release of a sample/analyte/label matrix into a macro channel as in a direct flow assay, while at the same time allowing reagents to mix and flow, thereby optimizing the assay performance. The reagents of the conjugate and the formation of the FIP stabilize the conjugate proteins and provide extended shelf life to the diagnostic assay device.
Type: Grant
Filed: January 22, 2013
Issued: March 3, 2015
Assignee: Quantum Design International, Inc.
Inventors: Ronald T. LaBorde, Nicholas J. Neild
Patent number: 8961898
Abstract: The present invention provides a bilayer membrane produced using a microchannel capable of easily forming bilayer membranes such as planar lipid bilayer membranes in large quantities, and a production method thereof. A process for producing a bilayer membrane of the present invention comprises forming a state where two liquid phases or liquid and gaseous phases each containing amphipathic molecules are alternately arranged in a microchannel, discharging one of the two liquid phases or the gaseous phase of the liquid and gaseous phases through branch minichannels formed in the wall on one side or in the walls on both sides to contact the remaining liquid phases adjacent to each other, and thereby forming a side-by-side arrangement of bilayer membranes comprising the amphipathic molecules.
Type: Grant
Filed: March 28, 2008
Issued: February 24, 2015
Assignee: Tokyo Institute of Technology
Inventors: Takasi Nisisako, Takahiro Baba
Patent number: 8945472
Abstract: The present invention provides a biosensor system comprising a light source, a cartridge adapted to be illuminated by said light source, a light detector adapted for detecting a signal originating from the cartridge, an illumination control means adapted to vary the illumination of the cartridge between at least two different states, a means for generating a first oscillation with a first frequency, and a means for generating a second oscillation with a second frequency, wherein the frame rate of the light detector is triggered by the first oscillation and the illumination control means is triggered by the second oscillation.
Type: Grant
Filed: December 18, 2008
Issued: February 3, 2015
Assignee: Koninklijke Philips N.V.
Inventors: Josephus Arnoldus Henricus Maria Kahlman, Bart Michiels
Patent number: 8945939
Abstract: The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
Type: Grant
Filed: November 18, 2013
Issued: February 3, 2015
Assignee: Ecolab USA Inc.
Inventors: Amy M. Tseng, Brian V. Jenkins, Robert Mack
Patent number: 8945486
Abstract: A microwell device is provided. The device includes a plate having a upper surface. The upper surface has first and second recesses formed therein. Each recess has an outer periphery. First and second portions of microwells are formed in upper surface of the plate. The first portion of microwells are spaced about the outer periphery of the first recess and the second portion of microwells spaced about the outer periphery of the first recess. A first barrier is about a first portions of the microwells for fluidicly isolating the first portion of the microwells and a second barrier about a second portions of microwells for fluidicly isolating the second portion of the microwells.
Type: Grant
Filed: March 8, 2013
Issued: February 3, 2015
Assignee: Wisconsin Alumni Research Foundation
Inventors: Jay W. Warrick, John Yin, Stephen M. Lindsay
Patent number: 8940234
Abstract: Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator's frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator's frequency response.
Type: Grant
Filed: April 11, 2012
Issued: January 27, 2015
Assignee: Intel Corporation
Inventors: Yuegang Zhang, Andrew A. Berlin, Qing Ma, Li-Peng Wang, Valluri Rao, Mineo Yamakawa
Patent number: 8940237
Abstract: An optic light guide test sensor comprises a light guide, a reagent-coated membrane, and a mesh layer. The reagent-coated membrane and the mesh layer are attached to the light guide at an output end of the light guide. The light guide test sensor is adapted to be used to test the level of an analyte in a biological fluid sample when used with a readhead. A method of manufacturing the light guide test sensor involves providing a plurality of light guides, providing a strip of reagent-coated membrane, and providing a strip of mesh layer. The reagent-coated membrane and mesh layer are attached to the light guides by ultrasonic welding. The reagent-coated membrane and mesh layer may also be attached to the light guides by adhesive.
Type: Grant
Filed: January 22, 2013
Issued: January 27, 2015
Assignee: Bayer HealthCare LLC
Inventors: Jeffery S. Reynolds, Steven C. Charlton, Sung-Kwon Jung, Suny J. George


Patent number: 8940248
Abstract: A kit comprising a carrier and vessels arranged on the carrier, wherein different reagents are contained in different vessels, the vessels are arranged with an openable closing device on top of the carrier, the carrier has a footprint on the bottom side for being placed on a base, and the carrier has bottom positioning means for being positioned on at least one workplace of an automated laboratory system for microtiter plates according to the SBS standard.
Type: Grant
Filed: April 29, 2013
Issued: January 27, 2015
Assignee: Eppendorf AG
Inventors: Judith Lucke, Jens-Peter Kroog, Helmut Knofe
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