Patents by Examiner Dennis M White

Patent number: 8697008
Abstract: A method and device for periodically perturbing the flow field within a microfluidic device to provide regular droplet formation at high speed.
Type: Grant
Filed: March 9, 2010
Issued: April 15, 2014
Assignee: Eastman Kodak Company
Inventors: Andrew Clarke, Nicholas J. Dartnell, Christopher B. Rider
Patent number: 8697005
Abstract: Multiplex binding assay assemblies are disclosed. The assemblies include at least one assay bar that has a top side, a bottom side, and at least one well accessible from the top side of the assay bar, with each well including a side surface, a bottom surface, an open top end. Each well also includes at least one secondary container, with each secondary container including a capillary tube that (i) begins at a location within an interior volume of the well and (ii) ends at a location beneath the bottom side of the assay bar. The assemblies further include a guiding track, which includes a set of two rails, with each rail having its own separate groove. Such grooves are configured to run parallel to each other with a distance between such grooves, with a first groove configured to receive a protruding element (or an end) of a first side of the assay bar, and a second groove configured to receive a protruding element (or an end) of a second side of the assay bar.
Type: Grant
Filed: August 2, 2011
Issued: April 15, 2014
Inventor: Pierre F. Indermuhle
Patent number: 8691151
Abstract: This invention provides an apparatus for particle sorting, particle patterning, and methods of using the same. The sorting or patterning is opto-fluidics based, in that particles are applied to individual chambers in the device, detection and/or analysis of the particles is carried out, such that a cell or population whose removal or conveyance is desired is defined, and the cell or population is removed or conveyed via application of an optical force and flow-mediated conveyance or removal of the part.
Type: Grant
Filed: August 27, 2007
Issued: April 8, 2014
Assignee: Massachusetts Institute of Technology
Inventors: Joseph Kovac, Joel Voldman
Patent number: 8685745
Abstract: A multilayered optical sensing patch, for the measurement of conditions, such as pH, oxygen level, etc, within containers, is provided. The multilayered optical sensing patch of the present invention is comprised of a heat sealable polymer substrate layer, and a polymeric sensing membrane later attached thereto. The polymer sensing membrane layer is formed of a porous polymer support membrane, and an optical sensing composition (comprising a reactive indicator) covalently bonded thereto. The heat sealable polymer substrate layer is capable of being securely bonded to the inner layer of bioreactor bags, as well as the porous polymer support substrate layer. Further, the porous polymer support membrane layer provides a firm supporting structure for the polymeric sensing layer, thereby protecting the optical sensing composition disposed therein from degradation/damage.
Type: Grant
Filed: October 26, 2011
Issued: April 1, 2014
Assignee: Polestar Technologies, Inc.
Inventor: James A. Kane
Patent number: 8673215
Abstract: The invention relates to the test device for platelet aggregation detection comprising: —an element (1) for receiving a blood sample—a capillary tube (3) connected at a first end (31) to said element (1) and at a second end (32) to a pressure lowering device (5) to pump said blood sample through said capillary tube (3)—at least a pair of facing electrodes (8) on the capillary tube—a device for measuring an impedance between said pair of facing electrodes. The invention also relates to a process for using this device, comprising: a) receiving a blood sample and pumping it through the capillar tube (3) b) determining a dynamic change of the value of the impedance between at least one pair of electrodes (8).
Type: Grant
Filed: October 16, 2008
Issued: March 18, 2014
Assignee: Centre National de la Recherche Scientifique
Inventors: Francine Rendu, Daniel Fruman, Jaime Levenson
Patent number: 8652409
Abstract: Fluid analyte sensors include a photoelectrocatalytic element that is configured to be exposed to the fluid, if present, and to respond to photoelectrocatalysis of at least one analyte in the fluid that occurs in response to impingement of optical radiation upon the photoelectrocatalytic element. A semiconductor light emitting source is also provided that is configured to impinge the optical radiation upon the photoelectrocatalytic element. Related solid state devices and sensing methods are also described.
Type: Grant
Filed: November 5, 2012
Issued: February 18, 2014
Assignee: Valencell, Inc.
Inventors: Steven Francis LeBoeuf, Jesse Berkley Tucker, Michael Edward Aumer
Patent number: 8647575
Abstract: A blood glucose meter includes a front attachment part to which a test piece is attached, a measurement part for measuring a component of blood collected via a blood guide passage in the test piece, and a monitor for displaying the measurement results obtained by the measurement part. When the device is placed on a horizontal plane by referring to the display face of the monitor as the upper side and the opposite side as the lower side and placing the display face of the monitor upward, the central axis of the test piece extends obliquely downward toward the front side. The blood glucose meter comprises a main part provided with the monitor and a linking part between the main part and the front attachment part. The top face of the linking part is placed roughly parallel to the central axis line and is provided with an ejector lever.
Type: Grant
Filed: November 19, 2009
Issued: February 11, 2014
Assignee: Terumo Kabushiki Kaisha
Inventor: Hirotaka Ohashi
Patent number: 8632730
Abstract: In one aspect, a diagnostic test system includes a receptacle, optical detectors, and a logic circuit. Each of the optical detectors has a corresponding view in the receptacle and produces an electrical signal at a respective detector output in response to light from the corresponding view. The logic circuit includes logic inputs that are respectively coupled to the detector outputs and that produce an output logic signal corresponding to a logical combination of signals received at the logic inputs. In another aspect, respective detection signals are produced in response to light received from respective ones of multiple views of the test strip, and at least one output logic signal corresponding to a respective logical combination of the detection signals is generated.
Type: Grant
Filed: November 22, 2005
Issued: January 21, 2014
Assignee: Alverix, Inc.
Inventors: John F. Petrilla, Daniel B. Roitman
Patent number: 8628729
Abstract: Three-dimensional microfluidic devices including by a plurality of patterned porous, hydrophilic layers and a fluid-impermeable layer disposed between every two adjacent patterned porous, hydrophilic layers are described. Each patterned porous, hydrophilic layer has a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic regions within the patterned porous, hydrophilic layer. The fluid-impermeable layer has openings which are aligned with at least part of the hydrophilic region within at least one adjacent patterned porous, hydrophilic layer. Microfluidic assay device, microfluidic mixer, microfluidic flow control device are also described.
Type: Grant
Filed: March 27, 2009
Issued: January 14, 2014
Assignee: President and Fellows of Harvard College
Inventors: Emanuel Carrilho, Andres W. Martinez, Katherine A. Mirica, Scott T. Phillips, Adam C. Siegel, Benjamin Wiley, George M. Whitesides
Patent number: 8609043
Abstract: The present invention relates to the use of a container, made of an inorganic additive containing plastic material, for reducing physical/chemical interaction between the container and an oil, fat and/or wax containing formulation contained therein.
Type: Grant
Filed: August 6, 2012
Issued: December 17, 2013
Assignee: M & P Patent Aktiengesellschaft
Inventor: Claudia Mattern
Patent number: 8609044
Abstract: A micro vial assembly for performing microwave-assisted chemical reactions on small reaction mixture volumes is disclosed, wherein a reaction vessel (10) is sealed through a diaphragm (30) that is capped over an open end of the reaction vessel. The reaction vessel mouths in an end plane of a sleeve (20) surrounding the reaction vessel, the diaphragm being clamped for sealing the open end of the vessel by means of a cap (40) which is secured to the sleeve. The sleeve provides a radial extension of the reaction vessel in order to bridge the radial distance between a wall of the reaction vessel and other components in a system for performing microwave-assisted chemical reactions.
Type: Grant
Filed: December 18, 2003
Issued: December 17, 2013
Assignee: Biotage AB
Inventors: Johan Ulin, Per-Gunnar Eriksson, Fredrik Ekdahl
Patent number: 8563320
Abstract: A use composition monitor determines the concentration of peracid and/or peroxide in a use composition using a kinetic assay procedure. A sample mixture containing a sample of the use composition, a diluent and at least one reagent is prepared and analyzed using, for example, an optical detector. A reduced-turbulence optical detector can be used to improve collected response data. A reduced-turbulence optical detector can include a cell body disposed about a length of transparent tubing. The cell body positions one or more emitter/receiver pairs about the transparent tubing. Thus, tube junctions are eliminated and sample flow within the tube is substantially turbulence free.
Type: Grant
Filed: February 15, 2012
Issued: October 22, 2013
Assignee: Ecolab USA Inc.
Inventors: Eugene Tokhtuev, Christopher Owen, Anna Pilipchenko, Paul Schilling, Daniel Kamben
Patent number: 8557195
Abstract: A sensor substrate includes a base and fibrous projections on an upper surface of the base. The fibrous projections have fixed ends fixed to the upper surface of the base and free ends opposite to the fixed ends, respectively. The fibrous projections provide a fixed end-side region including the fixed ends and a free end-side region including the free ends. The total surface area at which the fibrous projections in the fixed end-side region is larger than that in the free end-side region.
Type: Grant
Filed: September 14, 2012
Issued: October 15, 2013
Assignee: Panasonic Corporation
Inventors: Masaya Nakatani, Makoto Takahashi, Takuya Oka
Patent number: 8545760
Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.
Type: Grant
Filed: September 28, 2007
Issued: October 1, 2013
Assignee: Sysmex Corporation
Inventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
Patent number: 8518342
Abstract: The present invention relates generally to the field of analysis, for example biological analysis.
Type: Grant
Filed: June 24, 2005
Issued: August 27, 2013
Assignee: Biomerieux
Inventors: David Mosticone, Pascal Montes, Jean-Claude Raymond, Bruno Colin, Cecile Paris
Patent number: 8507289
Abstract: The present invention provides a test strip for measuring a concentration of an analyte of interest in a biological fluid, wherein the test strip may be encoded with information that can be read by a test meter into which the test strip is inserted.
Type: Grant
Filed: July 16, 2012
Issued: August 13, 2013
Assignee: Roche Diagnostics Operations, Inc.
Inventors: Henning Groll, Michael J. Celentano
Patent number: 8501093
Abstract: A portable handheld medical diagnostic device includes a housing forming a protective enclosure. A main circuit board is located in the protective enclosure. The main circuit board includes a controller facilitating a physiologic measurement. A display device is connected to the main circuit board that displays information related to the physiologic measurement. An electronic skin is on the housing. The electronic skin comprises a liquid crystal material and is configured to display a color.
Type: Grant
Filed: June 11, 2009
Issued: August 6, 2013
Assignee: Roche Diagnostics Operations, Inc.
Inventors: Paul S. Rutkowski, Robert G. Davies, Mark Mears
Patent number: 8491851
Abstract: A detection system in a portable assay reader device is enabled or activated after a user applies a manual force to a portion of the reader device, to an object supporting the assay test strip, or to the assay test strip itself. The movement moves a switch from an open state to a closed state. The closed state enables a detection system to monitor one or more test regions in the assay test strip for a reaction. The detection system can include one or more imagers, one or more electrical detectors, one or more magnetic detectors, or one or more optical detectors that monitor the one or more test regions for applicable visible, electrical, magnetic, or optical reactions, respectively. The one or more imagers or detectors transmit data to a processing device to determine the results of a test.
Type: Grant
Filed: November 30, 2006
Issued: July 23, 2013
Assignee: Alverix, Inc.
Inventors: Brenton A. Baugh, Robert Sean Murphy
Patent number: 8486349
Abstract: A microfluidic-based flow assay and methods of manufacturing the same are provided. Specifically, the microfluidic flow assay includes a micropatterned surface that induces clot formation and an array of microfluidic channels though which blood flows. The micropatterned surface contains two clotting stimuli, one for inducing platelet adhesion and another for inducing the coagulation cascade.
Type: Grant
Filed: March 10, 2011
Issued: July 16, 2013
Assignee: Colorado School of Mines
Inventors: Keith Benjamin Neeves, Ryan R. Hansen
Patent number: 8475716
Abstract: An embodiment of the invention described herein is directed to a detection system utilizing at least one radiofrequency identification (RFID) sensor comprising: an RFID sensor comprising: a substrate; an antenna; a sensor material selected to be sensitive to one of chemical or biological environment; and a reader, wherein said reader is configured to measure a signal in the form of a complex impedance from said RFID tag wherein said signal comprises a plurality of frequencies and a frequency shift of the maximum of the imaginary part of the complex impedance, a frequency shift of the minimum of the imaginary part of the complex impedance, a frequency shift of the maximum of the real part of the complex impedance, and changes in magnitude of the real part of the complex impedance; and, wherein said complex impedance is related to a nature and a concentration of analyte species derived from multivariate analysis.
Type: Grant
Filed: October 18, 2012
Issued: July 2, 2013
Assignee: General Electric Company
Inventors: Radislav Alexandrovich Potyrailo, William Guy Morris