Patents by Examiner Dennis M White
Patent number: 8961898
Abstract: The present invention provides a bilayer membrane produced using a microchannel capable of easily forming bilayer membranes such as planar lipid bilayer membranes in large quantities, and a production method thereof. A process for producing a bilayer membrane of the present invention comprises forming a state where two liquid phases or liquid and gaseous phases each containing amphipathic molecules are alternately arranged in a microchannel, discharging one of the two liquid phases or the gaseous phase of the liquid and gaseous phases through branch minichannels formed in the wall on one side or in the walls on both sides to contact the remaining liquid phases adjacent to each other, and thereby forming a side-by-side arrangement of bilayer membranes comprising the amphipathic molecules.
Filed: March 28, 2008
Issued: February 24, 2015
Assignee: Tokyo Institute of Technology
Inventors: Takasi Nisisako, Takahiro Baba
Patent number: 8945472
Abstract: The present invention provides a biosensor system comprising a light source, a cartridge adapted to be illuminated by said light source, a light detector adapted for detecting a signal originating from the cartridge, an illumination control means adapted to vary the illumination of the cartridge between at least two different states, a means for generating a first oscillation with a first frequency, and a means for generating a second oscillation with a second frequency, wherein the frame rate of the light detector is triggered by the first oscillation and the illumination control means is triggered by the second oscillation.
Filed: December 18, 2008
Issued: February 3, 2015
Assignee: Koninklijke Philips N.V.
Inventors: Josephus Arnoldus Henricus Maria Kahlman, Bart Michiels
Patent number: 8945486
Abstract: A microwell device is provided. The device includes a plate having a upper surface. The upper surface has first and second recesses formed therein. Each recess has an outer periphery. First and second portions of microwells are formed in upper surface of the plate. The first portion of microwells are spaced about the outer periphery of the first recess and the second portion of microwells spaced about the outer periphery of the first recess. A first barrier is about a first portions of the microwells for fluidicly isolating the first portion of the microwells and a second barrier about a second portions of microwells for fluidicly isolating the second portion of the microwells.
Filed: March 8, 2013
Issued: February 3, 2015
Assignee: Wisconsin Alumni Research Foundation
Inventors: Jay W. Warrick, John Yin, Stephen M. Lindsay
Patent number: 8945939
Abstract: The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
Filed: November 18, 2013
Issued: February 3, 2015
Assignee: Ecolab USA Inc.
Inventors: Amy M. Tseng, Brian V. Jenkins, Robert Mack
Patent number: 8940248
Abstract: A kit comprising a carrier and vessels arranged on the carrier, wherein different reagents are contained in different vessels, the vessels are arranged with an openable closing device on top of the carrier, the carrier has a footprint on the bottom side for being placed on a base, and the carrier has bottom positioning means for being positioned on at least one workplace of an automated laboratory system for microtiter plates according to the SBS standard.
Filed: April 29, 2013
Issued: January 27, 2015
Assignee: Eppendorf AG
Inventors: Judith Lucke, Jens-Peter Kroog, Helmut Knofe
Patent number: 8940234
Abstract: Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator's frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator's frequency response.
Filed: April 11, 2012
Issued: January 27, 2015
Assignee: Intel Corporation
Inventors: Yuegang Zhang, Andrew A. Berlin, Qing Ma, Li-Peng Wang, Valluri Rao, Mineo Yamakawa
Patent number: 8940237
Abstract: An optic light guide test sensor comprises a light guide, a reagent-coated membrane, and a mesh layer. The reagent-coated membrane and the mesh layer are attached to the light guide at an output end of the light guide. The light guide test sensor is adapted to be used to test the level of an analyte in a biological fluid sample when used with a readhead. A method of manufacturing the light guide test sensor involves providing a plurality of light guides, providing a strip of reagent-coated membrane, and providing a strip of mesh layer. The reagent-coated membrane and mesh layer are attached to the light guides by ultrasonic welding. The reagent-coated membrane and mesh layer may also be attached to the light guides by adhesive.
Filed: January 22, 2013
Issued: January 27, 2015
Assignee: Bayer HealthCare LLC
Inventors: Jeffery S. Reynolds, Steven C. Charlton, Sung-Kwon Jung, Suny J. George
Patent number: 8932874
Abstract: The invention is directed towards methods and compositions for identifying the amount of ammonium acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of ammonium acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of ammonium acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the ammonium acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
Filed: July 2, 2014
Issued: January 13, 2015
Assignee: Nalco Company
Inventors: Amy M. Tseng, Brian V. Jenkins, Robert M. Mack
Patent number: 8920749
Abstract: A microchip capable of sending liquid in a micro flow channel to a predetermined place irrespective of the pressure difference and sending a mixture of two or more liquid masses to a predetermined place even if the channel structure is simple. The microchip comprises an intermediate reservoir portion provided in a micro flow channel and adapted for temporarily holding liquid sent through the micro flow channel. The microchip is characterized in that the intermediate reservoir portion has a side channel, the volume of the intermediate reservoir portion is smaller than the total volume of the liquid sent into the intermediate reservoir portion, the side channel is provided for communication of a micro flow channel on the upstream side of the intermediate reservoir portion with a micro flow channel on the downstream side thereof, and the cross-section area of the side channel is smaller than that of the micro flow channel.
Filed: August 14, 2013
Issued: December 30, 2014
Assignee: Konica Minolta Medical & Graphic, Inc.
Inventors: Youichi Aoki, Akihisa Nakajima, Kusunoki Higashino, Yasuhiro Sando, Yoshikazu Kurihara
Patent number: 8920723
Abstract: A sample support structure comprising a sample support manufactured from a semiconductor material and having one or more openings therein. Methods of making and using the sample support structure.
Filed: November 16, 2007
Issued: December 30, 2014
Assignee: Protochips, Inc.
Inventors: John Damiano, Jr., Stephen E. Mick, David P. Nackashi
Patent number: 8916110
Abstract: A device and a process are proposed for separating constituents of a sample fluid, wherein the sample fluid is supplied by capillary force to a receiving region (7) for metering, stopping or delaying the sample fluid and the sample fluid is pre-treated with a soluble chemical (13) in the receiving region (7) before the sample fluid is supplied to a separating device (5) for separating off constituents of the sample fluid.
Filed: July 5, 2011
Issued: December 23, 2014
Assignee: Boehringer Ingelheim Microparts GmbH
Inventors: Tobias Rodenfels, Gert Blankenstein
Patent number: 8911681
Abstract: A wetness indicator material may be used on a substrate to form a wetness sensor. The sensor may show either the presence or absence of an aqueous-based fluid or water-containing medium, such as vaginal fluid or urine in a personal hygiene article. The wetness sensor may be incorporated into the article. The wetness indicator material includes a standard colorant that does not change color when wetted. The standard colorant increases the range of hues exhibited by the wetness indicator material.
Filed: September 12, 2011
Issued: December 16, 2014
Assignee: Kimberly-Clark Worldwide, Inc.
Inventors: Xuedong Song, Karen Meloy Goeders, Ning Wei
Patent number: 8900515
Abstract: The present invention provides a biosensing device, comprising an input unit, an analysis unit, a process unit, and a set unit for storing resulting data values as the basis for calibrating the biosensing device, to set up the calibration parameters of a strip of the biosensing device.
Filed: November 25, 2011
Issued: December 2, 2014
Assignee: Health & Life Co., Ltd.
Inventor: Meng Yi Lin
Patent number: 8883079
Abstract: A water-quality monitoring system for an aquatic environment that includes a monitoring unit and a chemical indicator wheel designed and configured to be submerged in the water being monitored. The chemical indicator wheel includes a holder that supports a number of chemical indicators selected for use in measuring levels of constituents of the water. When in use, the wheel is drivingly engaged with a monitoring/measuring unit that includes at least one reader for reading the chemical indicators. In some embodiments, each apparatus includes a plurality of immobilized-dye-based chemical indicators that undergo an optically detectable physical change as levels of one or more constituents of the water change. Also disclosed are a variety of features that can be used to provide the monitoring system with additional functionalities.
Filed: December 13, 2012
Issued: November 11, 2014
Assignee: Step Ahead Innovations, Inc.
Inventor: James E. Clark
Patent number: 8865071
Abstract: A test tape device is disclosed herein for use with a replaceable analytical tape cassette, where the device includes a housing having a cassette compartment covered by a cassette door and a housing opening for sample application, a protective cover that can be moved between a closed position covering the housing opening and a release position allowing access to the housing opening and a door lock for retaining the cassette door in the closed position, wherein the protective cover is coupled with the door lock via an interlocking mechanism, such that the door lock can only be unlocked in the release position of the cover.
Filed: June 5, 2013
Issued: October 21, 2014
Assignee: Roche Diagnostics Operations, Inc.
Inventors: Hao-Chih Lin, Wen Tsung Wang
Patent number: 8858884
Abstract: A sterilization indicator system and method of using the system to determine efficacy of a sterilization process. The system includes a vial having a first compartment containing spores of one or more species of microorganism; a second compartment containing a growth medium with a disaccharide, an oligosaccharide or a polysaccharide in which the vial is free of monosaccharide; an enzyme, capable of acting upon the monosaccharide to yield reaction products and electron transfer, disposed on two or more electrodes adapted to carry an electrical signal resulting from the electron transfer, the pair of electrodes positioned to contact the combined contents of the first compartment and the second compartment during incubation; and an apparatus linked or linkable to the electrodes and adapted to detect and measure the electrical signal resulting from electron transfer when the enzyme acts upon the monosaccharide.
Filed: March 15, 2013
Issued: October 14, 2014
Assignee: American Sterilizer Company
Inventors: Phillip P. Franciskovich, Tricia A. Cregger
Patent number: 8845981
Abstract: A device for volumetric metering a liquid biologic sample is provided. The device includes an initial chamber, a second chamber, a third chamber, a first valve, a second valve and a third valve. The chambers are each configured so that liquid sample disposed in the respective chamber is subject to capillary forces. Each chamber has a volume, and the volume of the initial chamber is greater than the volume of either the second or the third chambers. The valves each have a burst pressure. The burst pressure of the first valve is greater than the third burst pressure. The first valve is in fluid communication with the second chamber. The second valve is disposed between, and is in fluid communication with, the initial chamber and the third chamber. The third valve is in fluid communication with the third chamber.
Filed: December 28, 2012
Issued: September 30, 2014
Assignee: Abbott Point of Care, Inc.
Inventor: Manav Mehta
Patent number: 8845968
Abstract: The present application provides apparatus (300, 400) and methods for determining the density of a fluid sample. In particular, it provides a sensor device which can be loaded with a fluid sample such as blood, and which further comprises at least one oscillating beam member or resonator (108, 109, 110). Exposure of the blood sample to clotting agents allows a clotting reaction to commence. The device allows the density of the sample fluid to be monitored with reference to the oscillation of the vibrating beam member, thus allowing the monitoring of the clotting of the fluid sample.
Filed: December 27, 2007
Issued: September 30, 2014
Assignee: Highland Biosciences Limited
Inventor: Richard Day
Patent number: 8815181
Abstract: A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber (2), especially of an assay apparatus, the apparatus comprising: one or more respective storage chambers (5,6) for containing the one or more liquid reagents and arranged generally above the reaction or test chamber (2); and a plunger element (4) arranged and operable for insertion into the mouth of a selected storage chamber so as to displace a selected reagent from therewithin into the reaction or test chamber (2) generally therebelow by gravitational liquid overflow from the mouth of the chamber. The apparatus may conveniently be provided as a discrete delivery unit, with the storage chambers (5,6) pretilled with the selected reagents.
Filed: October 23, 2012
Issued: August 26, 2014
Assignee: The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland
Inventor: David James Squirrell
Patent number: 8784749
Abstract: This invention provides a digital microfluidic manipulation device and a manipulation method thereof. This device comprises a PDMS membrane having a surface comprising a plurality of hydrophobic microstructures; a plurality of air chambers arranged in an array and placed under the PDMS membrane; and a plurality of air channels, each of which connects to a corresponding one of the plurality of air chambers. When a suction force is transmitted via one of the plurality of air channels to the corresponding air chamber, a portion of the PDMS membrane above the air chamber deforms toward the air chamber, so that the surface morphology and the contact angle of the liquid/solid interface of the surface comprising the plurality of hydrophobic microstructures are altered and thereby to drive droplets.
Filed: December 21, 2012
Issued: July 22, 2014
Assignee: National Taiwan University
Inventors: Jing-Tang Yang, Chao-Jyun Huang, Chih-Yu Hwang