Patents by Examiner Dennis M White
  • Patent number: 9630181
    Abstract: The present invention is such a plug application and removal device that mist which is generated upon plug removal of a sample container or a reagent container is not peripherally scattered, or is such a sample processing device that mist which is generated upon dispensing of a sample or a reagent into a container is not mixed to another container. A plug application and removal device has a container holding mechanism that holds a container housing liquid inside and applied with a plug, and has a plug application and removal mechanism that removes or applies the plug from/to the container. The plug application and removal device has: a control mechanism for controlling movement of liquid or mist spilled out of the container upon a process of removal or application of the plug by the plug application and removal mechanism.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: April 25, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Yoshihiro Nagaoka, Kenichi Takahashi, Toshiki Yamagata, Shigeki Yamaguchi
  • Patent number: 9623440
    Abstract: A method for at least partially applying a hydrophilic polymer to a measurement channel of a sensor cartridge is provided, which sensor cartridge can be replaceably inserted in an analyzer. The measurement channel comprises at least one sensor element. The method comprises inserting the sensor cartridge into the analyzer, introducing an aqueous solution containing chitosan or a chitosan derivative into the measurement channel of the sensor cartridge, and following a residence time replacing the aqueous chitosan solution with a gaseous or liquid medium, wherein residues of the chitosan or chitosan derivatives remain on the inside surface of the measurement channel and hydrophilize the surface.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: April 18, 2017
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Wolfgang Hofmann, Taghi Noormofidi, Doris Zahrl
  • Patent number: 9624540
    Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include integrated illumination elements and optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: April 18, 2017
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Paul Lundquist, Stephen Turner
  • Patent number: 9625916
    Abstract: Described embodiments provide devices, systems and methods for sequencing liquid flow in response to a driving force by entrapping and releasing gas between volumes of liquid in a controlled manner. In one particular form, a centrifugal “lab on a disk” device is provided to drive liquid flow and sequencing by virtue of the centrifugal force and in one particular form a radially inward bend conduit is used in connection with controllably trapping and releasing gas between liquid volumes.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: April 18, 2017
    Assignee: Biosurfit, S.A.
    Inventors: João Garcia Da Fonseca, Nuno Reis, Tânia Tenreiro, Sandro Miguel Pinto Bordeira
  • Patent number: 9625465
    Abstract: A diagnostic system is provided herein that includes an instrument comprising an electrochemiluminescence (ECL) detector, and a cartridge configured to fit within a portion of the instrument, wherein the cartridge includes at least one reagent including an ECL label and a blood collection holder. Also provided herein is a system that includes a diagnostic instrument, which includes a pump, an ECL detector, an incubator, a magnet, and an output device, and a cartridge configured to fit within a portion of the diagnostic instrument, a sample holder configured to fit within the cartridge, and a closed fluidic loop between the diagnostic instrument and the cartridge when the cartridge is fit within a portion of the diagnostic instrument, wherein the cartridge is configured to accept a sample from the sample holder and place the sample in fluidic communication with the diagnostic instrument via the closed fluidic loop.
    Type: Grant
    Filed: May 15, 2013
    Date of Patent: April 18, 2017
    Assignee: DEFINED DIAGNOSTICS, LLC
    Inventors: Richard Alan Cook, Sang Cho, Charles Quentin Davis, Kevin E Dorsey, Jason Charles Harley, Jonathan Leland, Rober Krikor Matikyan, Sjef Otten, Jeffrey Howard Peterman, Brian B Thomas
  • Patent number: 9623409
    Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: April 18, 2017
    Assignee: CUE INC.
    Inventors: Ayub Khattak, Clinton Sever, Paul Nelson, Ryan Cooper, Thomas Congdon, Justin Demartino, Raphael Shapiro, Mark Duncan
  • Patent number: 9626315
    Abstract: A multisite sensing system including two or more analyte sensors, an interface device, and a shared bus. The interface device may be configured to receive a power signal and generate power for powering the analyte sensors and to convey data signals generated by the analyte sensors. The shared bus connected to the interface device and each of the analyte sensors and configured to provide the power generated by the interface device to the analyte sensors and to provide the data signals generated by the analyte sensors to the interface device. The interface device may be an inductive element. The shared bus may be a two wire, multiplexed bus. The analyte sensors may be spatially separated for analyte sensing at least two different locations. The analyte sensors may generate data signals indicative of the presence and/or amount of the same analyte or of one or more different analytes.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: April 18, 2017
    Assignee: Senseonics, Incorporated
    Inventor: Andrew DeHennis
  • Patent number: 9624531
    Abstract: Apparatuses for preparing a sample are disclosed herein. The apparatuses include a chamber, a first valve at least partially disposed in the first chamber, a second valve at least partially disposed in the first chamber, and a pump comprising an actuator and nozzle.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: April 18, 2017
    Assignee: LUMINEX CORPORATION
    Inventors: Jesus Ching, David Hsiang Hu, Steve Jia Chang Yu, Phillip You Fai Lee
  • Patent number: 9618456
    Abstract: A humidity indicating card includes a humidity indicator and a security device.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: April 11, 2017
    Assignee: Desiccare, Inc.
    Inventors: Sammie Joe Glorioso, Benjamin Edward Blankenhorn
  • Patent number: 9616425
    Abstract: A chemical assay device includes a hydrophilic substrate and one or more hydrophobic structures that extend from a first side of the hydrophilic substrate to a second side of the hydrophilic substrate. A hydrophobic structure in the hydrophilic substrate forms a fluid barrier wall that extends from the first side of the hydrophilic substrate to the second side of the hydrophilic substrate with a deviation of less than 20° from a perpendicular axis between the first side and the second side. The hydrophobic material in the first hydrophobic structure occupies more than 50% of a void volume fraction of the hydrophilic substrate.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: April 11, 2017
    Assignee: Xerox Corporation
    Inventors: Jing Zhou, Mandakini Kanungo, Nancy Y. Jia, Wei Hong
  • Patent number: 9610037
    Abstract: Devices and systems for sampling and profiling microbiota of skin are described which include a replaceable microbe sampling unit including a substrate and a location information storage component, the substrate including a microbe-capture region configured to capture at least one type of microbe from one or more regions of a skin surface of an individual, and the location information storage component configured to store information associated with the location of said one or more regions of the skin surface of the individual.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: April 4, 2017
    Assignee: Elwha LLC
    Inventors: Michael H. Baym, Roderick A. Hyde, Jordin T. Kare, Eric C. Leuthardt, Gary L. McKnight, Tony S. Pan, Elizabeth A. Sweeney, Clarence T. Tegreene, Lowell L. Wood, Jr.
  • Patent number: 9611573
    Abstract: A nonwoven fabric includes a fiber including a first portion and a second portion connected to the first portion. A first fiber diameter of the first portion is smaller than a reference fiber diameter. A second fiber diameter of the second portion is equal to or greater than the reference fiber diameter. The reference fiber diameter is smaller than 1 ?m. A ratio of a maximum fiber diameter of the second portion to a length of a linear line connecting both end portions of the second portion is from 1/10 to 1/3.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: April 4, 2017
    Assignee: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.
    Inventors: Yuki Yoshioka, Takayoshi Yamaguchi, Takahiro Kurokawa
  • Patent number: 9606140
    Abstract: An acceleration sensitive indicator for indicating a centrifugation status of a biological sample, a sample container comprising the indicator, a centrifuge for centrifuging samples and an analytical system for analyzing centrifuged samples are disclosed. The indicator comprises at least one closed chamber, formed between two opposite surfaces, that comprises an indication zone that comprises at least two fluid transfer zones or at least one particle transfer zone. The at least one fluid transfer zone comprises a solid carrier phase and a fluid stabilized in the solid carrier phase or at least one non-stabilized non-Newtonian fluid having thixotropic and/or shear thinning properties. The at least one particle transfer zone comprises a particle stabilizing fluid comprising stabilized dispersed particles. The fluid or particles have a distribution with respect to the indication zone changeable upon application of a g-force above a threshold value, the change of distribution indicating the centrifugation status.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: March 28, 2017
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Geza Burghardt, Michael Glauser, Oliver Gutmann, Daniel Mueller, Edwin Oosterbroek, Roger Sandoz, Emad Sarofim, Goran Savatic
  • Patent number: 9606116
    Abstract: A flexible, integrated, urine-based diagnostic device designed such that one or more diagnostic channels are integrated into the body of the device. Each diagnostic channel is designed to contain an immunoassay to detect the presence of a selected analyte so that the device can return a visible readout indicating the presence of the analyte. The flexibility of the device aids the user in the sample collection process.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: March 28, 2017
    Assignee: LIA DIAGNOSTICS, INC.
    Inventors: Bethany Ann Edwards, Frances Melina DiMare
  • Patent number: 9598722
    Abstract: In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: March 21, 2017
    Assignee: GENMARK DIAGNOSTICS, INC.
    Inventors: David Walter Wright, Dominic Aiello, Peter Kroehl, Jon Faiz Kayyem, Darren Scott Gray
  • Patent number: 9597681
    Abstract: A sensor element comprising a tape-shaped mount film; and a plurality of film-shaped sensors bonded on one surface of the mount film, wherein the front and rear film-shaped sensors are spaced at a predetermined distance in a lengthwise direction of the mount film, and a crosswise length of each film-shaped sensor is shorter by a predetermined quantity than a crosswise length of the mount film.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: March 21, 2017
    Assignee: ARKRAY, Inc.
    Inventors: Yuji Kurata, Hisashi Kaneda
  • Patent number: 9594253
    Abstract: The present invention provides a spectral apparatus for spectrally separating light including a predetermined wavelength, including a slit that the light enters, a first optical system configured to collimate the light from the slit, a transmissive type diffraction element configured to diffract the light from the first optical system, and a second optical system including a first mirror configured to reflect the light diffracted by the transmissive type diffraction element, and a second mirror configured to reflect the light reflected by the first mirror and diffracted by the transmissive type diffraction element, and configured to make the light reciprocally travel between the first mirror and the second mirror via the transmissive type diffraction element.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: March 14, 2017
    Assignees: CANON KABUSHIKI KAISHA, The University of Tokyo
    Inventors: Takashi Sukegawa, Yohei Kobayashi, Akira Ozawa, Mamoru Endo, Makoto Gonokami
  • Patent number: 9594065
    Abstract: Apparatus for detecting deterioration of an NOx selective reduction catalyst in an exhaust passage of an internal combustion engine with improved accuracy, includes an NOx purification rate calculation unit for calculating the NOx purification rate in the NOx selective reduction catalyst based on the NOx concentration in the exhaust gas flowing into and out of the NOx selective reduction catalyst. A determination as to whether the NOx selective reduction catalyst is deteriorated is made based on the NOx purification rate at a time when the temperature of the NOx selective reduction catalyst is equal to or higher than a temperature (Tc0) at which the NOx purification rate will start to decrease with a rise in the temperature of the NOx selective reduction catalyst if the degree of deterioration of the NOx selective reduction catalyst is at the upper limit of an allowable range.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: March 14, 2017
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Taiga Hagimoto, Daisuke Shibata
  • Patent number: 9586204
    Abstract: The present disclosure proposes a design of a biomedical paper sensor which can determine the concentration of biological materials in fluids such as blood, urine, and saliva. The sensor contains a plurality of axially radiating test zones, each test zone separated from other test zones by wax ink barriers formed by a process that produces thin walls. Each test zone can contain a unique test reagent, or a unique concentration of a test reagent, and can also be identified by printed text. The region of the device outside of the test zone area is printed with a uniform reference color. Benefits of the invention include increased accuracy in the measurement of the concentration of biological materials due to the larger test zone area. Benefits also include the integration of the reference or calibration color which simplifies the calibration needed for quantification of the concentration.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: March 7, 2017
    Assignee: Xerox Corporation
    Inventors: Wei Hong, Jing Zhou, Mandakini Kanungo, Xing Liu, Nancy Y. Jia, Sarah J. Vella, Laura Lu
  • Patent number: 9581593
    Abstract: There is provided a fluid test strip, comprising a micro-sensor formed on a substrate surface and a reagent deposition site formed on the substrate surface, operate to control the size and location of a reagent deposition. There is also provided a method of forming fluid test strip, comprising forming a micro-sensor on a substrate surface and forming a reagent deposition site on the substrate surface, operable to control the size and location of a reagent deposition.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: February 28, 2017
    Assignee: Microvisk Limited
    Inventors: Robert Ibbotson, Vladislav Djakov, Richard Dunn