Patents by Inventor David S. Newburg

David S. Newburg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9567361
    Abstract: The invention provides compositions and methods for utilizing synthetic human milk oligosaccharides as prebiotics.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: February 14, 2017
    Assignees: Glycosyn LLC, Trustees of Boston College
    Inventors: David S Newburg, John M. McCoy, Massimo Merighi, Matthew Ian Heidtman, Zhuoteng Yu
  • Publication number: 20150306120
    Abstract: A method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides.
    Type: Application
    Filed: April 30, 2015
    Publication date: October 29, 2015
    Applicants: Children's Hospital Medical Center, The General Hospital Corporation, Instituto Nacional de Ciencias Medicas Y Nutricion
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo M. Ruiz-Palacios
  • Publication number: 20150265661
    Abstract: Provided herein are prebiotic compositions comprising a combination of oligosaccharides such as sialyated oligosaccharides and fusocylated oligosaccharides, and uses thereof in stimulating the proliferation of beneficial intestinal micro biota, for example, of bifidobacteria, and/or in decreasing the abundance of enteric pathogens. The prebiotic compositions can further contain a probiotic, which can be a population of bifidobacteria, lactobacilli, Bacteriodes fragilis, Bacteriodes thetaiotaomicron, Enterococcus faecalis (pro biotic strains thereof), Staphylococcus epidermides, Enterobacter aerogenes, Enterobacter cloacae, or related bacteria having similar functions.
    Type: Application
    Filed: March 13, 2013
    Publication date: September 24, 2015
    Applicant: Trustees of Boston College
    Inventors: David S. Newburg, Zhuoteng Yu
  • Patent number: 9132142
    Abstract: An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: September 15, 2015
    Assignees: The General Hospital Corporation, Instituto Nacional de Ciencias Medicas Y Nutricion, Children's Hospital Medical Center
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo M. Ruiz-Palacios
  • Patent number: 9132143
    Abstract: An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).
    Type: Grant
    Filed: September 23, 2014
    Date of Patent: September 15, 2015
    Assignees: The General Hospital Corporation, Instituto Nacional de Ciencias Medicas Y Nutricion, Children's Hospital Medical Care
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo M. Ruiz-Palacios
  • Patent number: 9034847
    Abstract: A method of inhibiting inflammation in a subject comprising the administration of milk oligosaccharides or glycoconjugates containing milk oligosaccharides is disclosed.
    Type: Grant
    Filed: July 2, 2010
    Date of Patent: May 19, 2015
    Assignees: Children's Hospital Medical Center, The General Hospital Corporation, Instituto Nacional de Ciencias Medicas Y Nutricion
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo M. Ruiz-Palacios
  • Publication number: 20150079055
    Abstract: An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).
    Type: Application
    Filed: September 23, 2014
    Publication date: March 19, 2015
    Applicants: Children's Hospital Medical Center, The General Hospital Corporation, Instituto Nacional de Ciencias Medicas Y Nutricion
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo M. Ruiz-Palacios
  • Publication number: 20140140970
    Abstract: An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).
    Type: Application
    Filed: October 2, 2013
    Publication date: May 22, 2014
    Applicants: Children's Hospital Medical Center, Instituto Nacional de Ciencias Medicas Y Nutricion, The General Hospital Corporation
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo M. Ruiz-Palacios
  • Patent number: 8574850
    Abstract: An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: November 5, 2013
    Assignees: Instituto Nacional de Ciencias Medicas Y Nutricion, The General Hospital Corporation, Children's Hospital Medical Center
    Inventors: Ardythe L. Morrow, Guillermo Ruiz-Palacios, David S. Newburg
  • Publication number: 20130012472
    Abstract: Compositions comprising a milk-derived oligosaccharide such as trifucosyl(1,2-1,2-1,3)-lacto-N-octoase (TFiLNO) and uses thereof for inhibiting invasion of gastrointestinal pathogen into intestinal epithelial cells or for treating an infectious disease (e.g., a disease caused by a gastrointestinal pathogen such as an ETEC) or an inflammatory diseases such as inflammatory bowel disease.
    Type: Application
    Filed: July 5, 2012
    Publication date: January 10, 2013
    Applicant: Boston College
    Inventors: David S. NEWBURG, Yingying HE
  • Publication number: 20120294840
    Abstract: The invention provides compositions and methods for utilizing synthetic human milk oligosaccharides as prebiotics.
    Type: Application
    Filed: May 11, 2012
    Publication date: November 22, 2012
    Inventors: David S. Newburg, John M. McCoy, Massimo Merighi, Matthew Ian Heidtman, Zhuoteng Yu
  • Patent number: 8314061
    Abstract: Methods for treating various disorders by orally administering adiponectin or a biologically active fragment thereof are described.
    Type: Grant
    Filed: January 9, 2007
    Date of Patent: November 20, 2012
    Assignees: Children's Hospital Medical Center, University of Massachusetts
    Inventors: Ardythe L. Morrow, Lisa J. Martin, David S. Newburg
  • Publication number: 20120202753
    Abstract: A method of inhibiting inflammation in a subject comprising the administration of milk oligosaccharides or glycoconjugates containing milk oligosaccharides is disclosed.
    Type: Application
    Filed: July 2, 2010
    Publication date: August 9, 2012
    Applicants: Instituto Nacional de Ciencias Medicas Y Nutricion, The General Hospital Corporation d/b/a Massachusetts General Hospital, (CCHMC)
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo M. Ruiz-Palacios
  • Publication number: 20110207659
    Abstract: Oligosaccharides and oligosaccharides linked to backbones such as proteins, methods for making such oligosaccharides and methods for using them to treat and/or prevent various disorders are described.
    Type: Application
    Filed: February 22, 2011
    Publication date: August 25, 2011
    Applicants: Children's Hospital Medical Center, University of Massachusetts, Instituto Nacional de Ciencias Medicas Y Nutricion
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo M. Ruiz-Palacios
  • Publication number: 20110177035
    Abstract: An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).
    Type: Application
    Filed: January 14, 2011
    Publication date: July 21, 2011
    Inventors: Ardythe L. Morrow, Guillermo M. Ruiz-Palacios, David S. Newburg
  • Patent number: 7893041
    Abstract: Oligosaccharides and oligosaccharides linked to backbones such as proteins, methods for making such oligosaccharides and methods for using them to treat and/or prevent various disorders are described.
    Type: Grant
    Filed: December 6, 2004
    Date of Patent: February 22, 2011
    Assignees: Children's Hospital Medical Center, Instituto Nacional De Ciencias Medicas Y Nutricion, University of Massachusetts
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo M. Ruiz-Palacios
  • Patent number: 7871785
    Abstract: An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1 , H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: January 18, 2011
    Assignees: Children's Hospital Medical Center, The General Hospital Corporation, Instituto Nacional De Ciencias Medicas y Nutricion
    Inventors: Ardythe L. Morrow, Guillermo M. Ruiz-Palacios, David S. Newburg
  • Publication number: 20100279308
    Abstract: A glycan-detecting device containing a sample pad, a membrane in communication with the sample pad, a labeled lectin, an immobilized lectin of the same type, and an immobilized antibody specific to the lectin.
    Type: Application
    Filed: March 8, 2010
    Publication date: November 4, 2010
    Inventors: Ardythe L. Morrow, David S. Newburg, Guillermo Ruiz-Palacios
  • Publication number: 20090197806
    Abstract: Methods for treating various disorders by orally administering adiponectin or a biologically active fragment thereof are described.
    Type: Application
    Filed: January 9, 2007
    Publication date: August 6, 2009
    Inventors: Ardythe L. Morrow, Lisa J. Martin, David S. Newburg
  • Publication number: 20090191551
    Abstract: An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range of values. Among the secretor antigens which can be measured are: the H-1, H-2, Lewisb and Lewisy antigens and derivatives thereof (e.g., a sialylated form of Lewis a, Lewis x, Lewis b, Lewis y; H-1, H-2, Lewis a, Lewis x, Lewis b or Lewis y).
    Type: Application
    Filed: September 5, 2008
    Publication date: July 30, 2009
    Inventors: Ardythe L. Morrow, Guillermo M. Ruiz-Palacios, David S. Newburg