Abstract: The present invention relates to the use of a molecule selected from an Annelid globin, an Annelid globin protomer, and an Annelid extracellular haemoglobin, to treat acute respiratory distress syndrome.

Abstract: This invention relates to a method for analysing a sample of cells of a patient or an of an organoid, comprising: a first step of mixing of cells of a patient or an of an organoid with at least one molecule chosen from an Annelid globin, an Annelid globin protomer and an extracellular Annelid haemoglobin, optionally, a second step for preparation of the mixture obtained in the first step, and a third step of analysing the mixture obtained in the first step or in the second step.

Abstract: The present invention relates to isolated haemoglobin from worms belonging to the Nereididae family and its use in cell culture medium, in preservation solutions and as artificial oxygen carrier for transfusion.

Abstract: The invention relates to the use of a haemoglobin for the preparation of dressings and to the resulting dressings.

Abstract: The present invention relates to a method for monitoring the oxygenation of a graft, comprising: a) mixing an organ storage solution preferably with at least one molecule chosen from extracellular hemoglobin from annelids, its globins and its globin protomers, in order to obtain a composition, in a sealed container; b) immersion of the graft in the composition obtained in a); c) the introduction of an oxygen probe in the composition obtained in a), or in the composition of step b); and d) the closure of the hermetic container, steps c) and d) being carried out simultaneously or in any order. It also relates to a method for determining the viability of a graft.

Abstract: The invention relates to a lyophilisate or to a powder including i) at least one globin, a globin protomer or an extracellular hemoglobin from annelids, and ii) at least one biological material from annelids that is different from said globin, from said protomer and from said hemoglobin.

Abstract: The present invention relates to a lyophilizate comprising at least one globin, one globin protomer or one extracellular hemoglobin of annelids, and a stabilizer chosen from disaccharides, polyols and antioxidants. The present invention also relates to a composition comprising: a solution comprising at least one globin, one globin protomer or one extracellular hemoglobin of annelids, and a stabilizer chosen from disaccharides, polyols and antioxidants. Finally, the present invention relates to a process for preparing the lyophilizate.

Abstract: The present invention relates to the use of a molecule chosen from among the oxygen transporters of marine invertebrate animals, preferably from a globin, a globin protomer, or an extracellular hemoglobin of Annelids, as a bactericide, in particular for preventing and/or treating periodontal disease.

Abstract: Disclosed is a method for preserving an organ in a donation after brain death donor or a donation after cardiac death donor comprising administering to the donor a composition comprising at least one globin, one globin protomer or one extracellular hemoglobin of Annelida, a stabilizing solution and/or a solution for conserving organs, said composition having a temperature of between 0° C. and 37° C. Also disclosed is a method for conserving an organ in situ in a donation after brain death donor or a donation after cardiac death donor using normothermic ECMO or double-balloon triple-lumen catheter techniques or any other similar technique.

Abstract: A method for maintaining stem cells in the undifferentiated state by mixing the stem cells with at least one extracellular hemoglobin, globin or globin protomer from annelids.

Abstract: The invention relates to the use of a haemoglobin for the preparation of dressings and to the resulting dressings.

Abstract: The invention relates to a lyophilisate or to a powder including i) at least one globin, a globin protomer or an extracellular hemoglobin from annelids, and ii) at least one biological material from annelids that is different from said globin, from said protomer and from said hemoglobin.

Abstract: A method for treating cancer using at least one globin, a globin protomer or an extracellular haemoglobin of annelids.

Abstract: The invention relates to the use of a haemoglobin for the preparation of dressings and to the resulting dressings.

Abstract: The present invention relates to a lyophilizate comprising at least one globin, one globin protomer or one extracellular hemoglobin of annelids, and a stabilizer chosen from disaccharides, polyols and antioxidants. The present invention also relates to a composition comprising: a solution comprising at least one globin, one globin protomer or one extracellular hemoglobin of annelids, and a stabilizer chosen from disaccharides, polyols and antioxidants. Finally, the present invention relates to a process for preparing the lyophilizate.

Abstract: The invention relates to the use of at least one globin and/or at least one globin protomer and/or at least one naturally extracellular native hemoglobin for the preservation of organs, tissues, organ and tissue cells and cell cultures.

Abstract: A method for maintaining stem cells in the undifferentiated state by mixing the stem cells with at least one extracellular hemoglobin, globin or globin protomer from annelids.

Abstract: The invention relates to the use of a composition comprising at least one globin, one globin protomer or one extracellular hemoglobin of Annelida, a stabilizing solution and/or a solution for conserving organs, said composition having a temperature of between 0° C. and 37° C., for preserving an organ in a donation after brain death donor or a donation after cardiac death donor. The invention also relates to a method for conserving an organ in situ in a donation after brain death donor or a donation after cardiac death donor using normothermic ECMO or double-balloon triple-lumen catheter techniques or any other similar technique.

Abstract: The present invention relates to isolated haemoglobin from worms belonging to the Nereididae family and its use in cell culture medium, in preservation solutions and as artificial oxygen carrier for transfusion.

Abstract: The present invention relates to the use of a high molecular weight extracellular hemoglobin for the manufacture of a medicament for treating and/or preventing diseases by inhibition of calcium. Advantageously, the extracellular hemoglobin is obtained from Annelids. In particular, the invention concerns the use of a high molecular weight extracellular hemoglobin for the manufacture of a medicament for treating and/or preventing cardiovascular diseases, such as hypertension, angina such as angina pectoris, Raynaud's disease, arteriopathy, tachycardia, vasospasm, ischemia, myocardial infarction, congestive heart failure, arrhythmia or cerebrovacular accident.