Patents by Inventor Geoffrey Goldspink

Geoffrey Goldspink has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180271942
    Abstract: The invention relates to the use of a Mechano Growth Factor (MGF) polypeptide or a polynucleotide encoding an MGF polypeptide in the manufacture of a medicament for the prevention or limitation of myocardial damage in response to ischemia or mechanical overload of the heart by preventing or limiting apoptosis in the myocardium.
    Type: Application
    Filed: March 13, 2018
    Publication date: September 27, 2018
    Inventors: Geoffrey Goldspink, Paul Goldspink
  • Patent number: 9919031
    Abstract: The invention relates to the use of a Mechano Growth Factor (MGF) polypeptide or a polynucleotide encoding an MGF polypeptide in the manufacture of a medicament for the prevention or limitation of myocardial damage in response to ischemia or mechanical overload of the heart by preventing or limiting apoptosis in the myocardium.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: March 20, 2018
    Assignee: THE BOARD OF TRUSTEES OF UNIVERSITY OF ILLINOIS
    Inventors: Geoffrey Goldspink, Paul Goldspink
  • Publication number: 20130210723
    Abstract: The invention relates to the use of a Mechano Growth Factor (MGF) polypeptide or a polynucleotide encoding an MGF polypeptide in the manufacture of a medicament for the prevention or limitation of myocardial damage in response to ischemia or mechanical overload of the heart by preventing or limiting apoptosis in the myocardium.
    Type: Application
    Filed: September 21, 2012
    Publication date: August 15, 2013
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Geoffrey Goldspink, Paul Goldspink
  • Publication number: 20080039390
    Abstract: The invention relates to the use of a Mechano Growth Factor (MGF) polypeptide or a polynucleotide encoding an MGF polypeptide in the manufacture of a medicament for the prevention or limitation of myocardial damage in response to ischemia or mechanical overload of the heart by preventing or limiting apoptosis in the myocardium.
    Type: Application
    Filed: March 20, 2007
    Publication date: February 14, 2008
    Applicants: UNIVERSITY COLLEGE LONDON, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Geoffrey Goldspink, Paul Goldspink
  • Publication number: 20060211606
    Abstract: This invention relates to biologically active polypeptides derived from the E peptide that forms the C-terminus of the insulin-like growth factor I (IGF-I) splice variant known as mechano growth factor (MGF). These peptides are modified to improve their stability compared to the naturally occurring E peptide.
    Type: Application
    Filed: March 20, 2006
    Publication date: September 21, 2006
    Inventors: Geoffrey Goldspink, Shi Yang, Paul Goldspink
  • Publication number: 20060058239
    Abstract: The invention relates to the treatment of neurological disorders with the Insulin-like Growth Factor I (IGF-I) isoform known as mechano growth factor (MGF).
    Type: Application
    Filed: September 19, 2005
    Publication date: March 16, 2006
    Inventors: Ian Johnson, Geoffrey Goldspink
  • Publication number: 20050048028
    Abstract: The invention relates to the use of a Mechano Growth Factor (MGF) polypeptide or a polynucleotide encoding an MGF polypeptide in the manufacture of a medicament for the prevention or limitation of myocardial damage in response to ischemia or mechanical overload of the heart by preventing or limiting apoptosis in the myocardium.
    Type: Application
    Filed: February 6, 2003
    Publication date: March 3, 2005
    Inventors: Geoffrey Goldspink, Paul Goldspink
  • Patent number: 6821946
    Abstract: The invention provides a method of treating nerve damage involving administering to the damaged nerve an effective non-toxic amount of an MGF (mechano-growth factor) Insulin-like Growth Factor I (IGF-I) isoform which includes amino acid sequences encoded by nucleic acid sequences of IGF-I exons 4, 5 and 6 in the reading frame of MGF and having the ability to reduce motoneurone loss by 20% or greater in response to nerve avulsion.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: November 23, 2004
    Assignees: University College London, East Grinstead Medical Research Trust
    Inventors: Geoffrey Goldspink, Giorgio Terenghi
  • Publication number: 20030008836
    Abstract: The present invention provides an expression cassette comprising, operably linked, (i) a myosin light chain enhancer, (ii) a promoter selected from a myosin heavy chain promoter and a viral promoter and (iii) a polynucleotide sequence of interest. The expression cassette can be used in methods of medical treatment and vaccination.
    Type: Application
    Filed: December 5, 2001
    Publication date: January 9, 2003
    Applicant: University College London
    Inventor: Geoffrey Goldspink
  • Publication number: 20020083477
    Abstract: The invention provides a method of treating nerve damage comprising administering to a subject in need thereof an effective non-toxic amount of an MGF (mechano-growth factor) Insulin-like Growth Factor I (IGF-I) isoform comprising amino acid sequences encoded by nucleic acid sequences of IGF-I exons 4, 5 and 6 in the reading frame of MGF and having the ability to reduce motoneurone loss by 20% or greater in response to nerve avulsion, by localisation of said MGF at the site of said damage.
    Type: Application
    Filed: May 10, 2001
    Publication date: June 27, 2002
    Inventors: Geoffrey Goldspink, Giorgio Terenghi
  • Publication number: 20020025577
    Abstract: The present invention provides an expression cassette comprising, operably linked, (i) a myosin light chain enhancer, (ii) a promoter selected from a myosin heavy chain promoter and a viral promoter and (iii) a polynucleotide sequence of interest. The expression cassette can be used in methods of medical treatment and vaccination.
    Type: Application
    Filed: March 17, 2000
    Publication date: February 28, 2002
    Inventor: GEOFFREY GOLDSPINK
  • Patent number: 6221842
    Abstract: The invention provides pharmaceutical compositions comprising particular isoforms of human insulin-like growth factor I (IGF-I). An isofoim of the invention is an IGF-I polypeptide corresponding to the mechanical-stimulation-specific, stretch-inducible IGF-I isoform present in stretched rabbit EDL muscle, the polypeptide comprising peptides encoded by IGF-I exons 4, 5 and 6 when transcribed in the reading frame of the stretched rabbit EDL muscle isoform and the polypeptide having the ability to induce growth of muscle tissue. The isoforms of the invention have utility in treating muscular disorders, especially muscular dystrophy. Methods of treatment of such muscular disorders in humans and animals with the isoforms of the invention are also provided.
    Type: Grant
    Filed: October 29, 1998
    Date of Patent: April 24, 2001
    Assignee: University College London
    Inventor: Geoffrey Goldspink