Patents by Inventor Howard J. Leonhardt

Howard J. Leonhardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11878161
    Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of Collagen Type XVII Alpha 1 chain (COL17A1), a useful protein, by tissues. Also described are methods of COL17A1 in cells.
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: January 23, 2024
    Inventor: Howard J. Leonhardt
  • Patent number: 11849910
    Abstract: Methods of heart valve decalcification may include mechanically removing calcium deposits on a heart valve, and removing debris from the mechanical decalcification via suction. The mechanical removal of the calcium deposits may be accomplished with a burr and/or an ultrasonic device. In some embodiments, mechanical removal of the calcium deposits may be accomplished with a handheld mechanical decalcification device comprising a bur extending from a hand piece. A catheter system for removing plaque deposits from a heart valve may include at least one mechanical decalcification device configured for cleaning the edges of heart valve leaflets, and at least one active aspiration device. The at least one mechanical decalcification device may comprise a bur and/or an ultrasonic device. The system may additionally include a deployable net apparatus configured to encompass at least a portion of a heart valve.
    Type: Grant
    Filed: April 7, 2020
    Date of Patent: December 26, 2023
    Assignee: VALVUBLATOR INC.
    Inventors: Howard J. Leonhardt, Brett M. Burton, Kapil K. Sharma, Betty Vowles
  • Patent number: 11819688
    Abstract: A skin regeneration therapy combining precise bioelectric signals, light, and biologics for skin treatment and regeneration. Precise bioelectric signals give clear instructions to the stimulated cell DNA/RNA to produce specific regenerative proteins on demand. Bioelectric signals give clear instructions to cell membranes on what to let in and what to let out and serve as an equivalent or surrogate of environmental stimuli to cause a cell action in response.
    Type: Grant
    Filed: July 6, 2021
    Date of Patent: November 21, 2023
    Assignee: Leonhardt Ventures LLC
    Inventors: Howard J. Leonhardt, Jorge Genovese
  • Publication number: 20230347144
    Abstract: Age is an important predictor of neuromuscular recovery after peripheral nerve injury. Insulin-like growth factor 1 (IGF-1) is a potent neurotrophic factor that is known to decline with increasing age. The purpose of this study was to determine if locally delivered IGF-1 would improve nerve regeneration and neuromuscular recovery in aged animals. Young and aged rats underwent nerve transection and repair with either saline or IGF-1 continuously delivered to the site of the nerve repair. After 3 months, nerve regeneration and neuromuscular junction morphology were assessed. In both young and aged animals, IGF-1 significantly improved axon number, diameter, and density. IGF-1 also significantly increased myelination and Schwann cell activity and preserved the morphology of the postsynaptic neuromuscular junction (NMJ), These results show that aged regenerating nerve is sensitive to IGF-1 treatment.
    Type: Application
    Filed: July 5, 2023
    Publication date: November 2, 2023
    Inventors: Howard J. Leonhardt, Jorge Genovese
  • Publication number: 20230293268
    Abstract: Described are a device, system, and method for bioelectric stimulation to accelerate bone integration of an implant and/or bone graft in order to aid healing. Specifically described are devices and methods for enhancing bone integration of a body implant (e.g., a dental implant) or bone graft by modulating (e.g., stimulating) the controlled expression and/or release of selected proteins, which proteins promote osteogenesis and osseointegration via specific bioelectric signals delivered via, e.g., a specialized mouthpiece, electrodes, and/or wireless means. The description particularly relates to the acceleration of the healing of dental implants and/or bone grafts via promoting bone osteointegration more quickly with bioelectric stimulation.
    Type: Application
    Filed: March 20, 2023
    Publication date: September 21, 2023
    Inventors: Howard J. Leonhardt, Tom Newman
  • Patent number: 11691007
    Abstract: Described is a method of treating a subject diagnosed with cancer, breast cancer, bone cancer, lung cancer, osteoporosis, multiple myeloma, and a combination of any thereof by applying a bioelectric signal or signals that upregulate the expression of Osteoprotegerin (“OPG”) and thus beneficially effect the subject's OPG/RANKL/RANK pathway.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: July 4, 2023
    Assignee: Leonhardt Ventures LLC
    Inventors: Howard J. Leonhardt, Jorge Genovese
  • Publication number: 20230201563
    Abstract: A minimally invasive circulatory support platform that utilizes an aortic stent pump or pumps is described. The platform uses a low profile catheter-based techniques and provides temporary and chronic circulatory support depending on the needs of the patient. Also described is a catheter-based temporary assist pump to treat patients with acute decompensated heart failure and provide circulatory support to subjects undergoing high risk percutaneous coronary intervention. Further described is a wirelessly powered circulatory assist pump for providing chronic circulatory support for heart failure patients. The platform and system are relatively easy to place, have higher flow rates than existing systems, and provide improvements in the patient's renal function.
    Type: Application
    Filed: March 6, 2023
    Publication date: June 29, 2023
    Inventor: Howard J. Leonhardt
  • Publication number: 20230191128
    Abstract: Described is a low voltage, pulsed electrical stimulation device for modulating (e.g., downregulating) expression of fatty-acid-binding protein 4 (“FABP4”) protein(s) by cellular tissues. In certain embodiments, the device is further programmed or alternatively programmed to produce a bioelectric signal or signals that upregulate expression of, for example, klotho by the tissues.
    Type: Application
    Filed: December 13, 2022
    Publication date: June 22, 2023
    Inventors: Howard J. Leonhardt, Jorge Genovese
  • Publication number: 20230146898
    Abstract: A minimally invasive circulatory support device, system, and related methods. The circulatory assist devices, systems, and methods use low profile catheter-based techniques and provide temporary and chronic circulatory support depending on the needs of the patient. The circulatory assist device, systems, and methods include a stent cage and an impeller. The stent cage is formed of a first material that is sufficiently rigid to expand radially outward and press against an artery wall is sufficiently deformable to collapse within the outer sheath. The impeller includes at least one blade formed of a second material that is sufficiently rigid to expand and retain shape while rotating and assisting blood to flow within the artery and is sufficiently deformable to collapse within the outer sheath with the stent cage.
    Type: Application
    Filed: October 27, 2022
    Publication date: May 11, 2023
    Inventor: Howard J. Leonhardt
  • Publication number: 20230133737
    Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of growth differentiation factor 10 (“GDF10”), a useful protein, by tissues. Also described are methods of enhancing expression of GDF10 in cells, particularly a method of stimulating the expression and/or release of GDF10 in a cell having a gene encoding GDF10, wherein the method includes applying a bioelectric signal produces, as measured at the level of the target cells or tissues being stimulated 2 mA to 4 mA direct current positive to the cell (e.g., directly, indirectly, or wirelessly). Applications in the treatment of cerebral strokes, brain injuries, paralysis, brain cancer, Alzheimer's disease, dementia, anxiety, Parkinson's disease, and/or essential tremors are also disclosed.
    Type: Application
    Filed: October 31, 2022
    Publication date: May 4, 2023
    Inventors: Howard J Leonhardt, Kelsie Leonhardt
  • Patent number: 11602627
    Abstract: A minimally invasive circulatory support platform that utilizes an aortic stent pump or pumps. The platform uses a low profile catheter-based techniques and provides temporary and chronic circulatory support depending on the needs of the patient. Also described is a catheter-based temporary assist pump to treat patients with acute decompensated heart failure and provide circulatory support to subjects undergoing high risk percutaneous coronary intervention (“PCI”). Further described is a wirelessly powered circulatory assist pump for providing chronic circulatory support for heart failure patients. The platform and system are relatively easy to place, have higher flow rates than existing systems, and provide improvements in the patient's renal function.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: March 14, 2023
    Assignee: Second Heart Assist, Inc.
    Inventor: Howard J. Leonhardt
  • Publication number: 20230071154
    Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of Brain-Derived Neurotrophic Factor (“BDNF”), a useful protein, by tissues. Also described are methods of enhancing expression of BDNF in cells, particularly a method of stimulating the expression and/or release of BDNF in a cell having a gene encoding BDNF, wherein the method includes applying a bioelectric signal of from about 10 Hz to about 100 Hz (e.g., 5 Hz, 10 Hz, 40 Hz, 100 Hz, or 110 Hz) to the cell (e.g., directly, indirectly, or wirelessly). Applications in the treatment of Alzheimer's disease, depression, schizophrenia, and post-traumatic stress disorder are also disclosed.
    Type: Application
    Filed: August 26, 2022
    Publication date: March 9, 2023
    Inventors: Howard J. Leonhardt, Kelsie Leonhardt, Sejal Chaudhari
  • Publication number: 20220409894
    Abstract: Described is precise bioelectrical stimulation of a subject's cellular tissue with a selected bioelectric signal to modulate the expression of a peptide by the cellular tissue. More specifically, the application relates to a device that delivers a programmed bioelectric signal or signals, and associated methods for the controlled modulation of a peptide, such as vascular endothelial growth factor (VEGF) and/or hypoxia-inducible factor 1-alpha (HIF1?), or manipulation of stem cells, via precise bioelectrical signals and sequences useful in, for example, orthodontic and other procedures. The bioelectric signals have preferably been further optimized by selecting a desired pulse width for the peptide(s) to be expressed.
    Type: Application
    Filed: June 27, 2022
    Publication date: December 29, 2022
    Inventors: Howard J. Leonhardt, John Marchetto
  • Publication number: 20220370791
    Abstract: Described is a low voltage, pulsed electrical stimulation device for modulating expression of BMP9 protein(s) by cellular tissues.
    Type: Application
    Filed: May 16, 2022
    Publication date: November 24, 2022
    Inventors: Howard J. Leonhardt, Jorge Genovese
  • Publication number: 20220331576
    Abstract: A minimally invasive circulatory support platform that utilizes an aortic stent pump or pumps. The platform uses a low profile catheter-based techniques and provides temporary and chronic circulatory support depending on the needs of the patient. Further described is a wirelessly powered circulatory assist pump for providing chronic circulatory support to, for example, heart failure patients. The platform and system are relatively easy to place, have higher flow rates than existing systems, and provide improvements in the patient's renal function.
    Type: Application
    Filed: March 18, 2022
    Publication date: October 20, 2022
    Inventor: Howard J. Leonhardt
  • Patent number: 11471686
    Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of klotho, a useful protein, by tissues. Also described are methods of enhancing expression of klotho in cells.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: October 18, 2022
    Assignee: Leonhardt Ventures LLC
    Inventor: Howard J. Leonhardt
  • Patent number: 11446488
    Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of klotho, a useful protein, by tissues. Also described are methods of enhancing expression of klotho in cells and treating a subject's kidneys.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: September 20, 2022
    Assignee: Leonhardt Ventures LLC
    Inventor: Howard J. Leonhardt
  • Patent number: 11433231
    Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of sonic hedgehog (“Shh”), a useful protein, by tissues. Also described are methods of enhancing expression of sonic hedgehog in cells, particularly a method of stimulating the expression and/or release of Shh in a cell having a gene encoding Shh, wherein the method includes applying a bioelectric signal of less than 50 Hz (e.g., 5 Hz, 10 Hz, or 20 Hz) at a pulse width duration of, e.g., 1 ms, to the cell (e.g., directly, indirectly, or wirelessly), and wherein the amount of Shh expression enhanced by this bioelectric signal is greater than that seen with a prior art bioelectric muscle stimulation or bioelectric muscle contraction alone as may be determined by, e.g., by an analysis of the upregulation of mRNA level/GAPDH fold gene expression in the cell.
    Type: Grant
    Filed: April 13, 2020
    Date of Patent: September 6, 2022
    Assignee: LEONHARDT VENTURES LLC
    Inventor: Howard J. Leonhardt
  • Publication number: 20220226643
    Abstract: Described is a low voltage, pulsed electrical stimulation device (bioelectric stimulator associated with electrodes) for controlling expression of S100 protein(s) by cellular tissues. The bioelectric stimulator is useful in methods to treat a subject suffering from bladder, heart, and/or nerve tissue damage.
    Type: Application
    Filed: January 7, 2022
    Publication date: July 21, 2022
    Inventor: Howard J. Leonhardt
  • Patent number: D957646
    Type: Grant
    Filed: May 3, 2021
    Date of Patent: July 12, 2022
    Assignee: ORTHODONTICELL, INC.
    Inventors: Howard J. Leonhardt, John Joseph Marchetto, Alex Richardson