Patents by Inventor Howard J. Leonhardt

Patent number: 8308708
Abstract: A catheter-based deployment system for deploying cellular material (22) into the heart muscle (25). The deployment system includes a guiding catheter (19) and a needle assembly (31) capable of sliding within the guiding catheter. The needle assembly (31) terminates in a tip (34) having at least one side with an opening (43) in communication with a lumen (20) disposed within the needle assembly (31). Once the guiding catheter (19) is positioned, the needle assembly (31) is advanced until the tip (34) penetrates the muscle wall (25). At a predetermined depth the cellular material (22) may be deployed into the muscle wall (25) via a push rod (46) disposed through the lumen of the needle assembly (31).
Type: Grant
Filed: February 5, 2010
Issued: November 13, 2012
Assignee: Abbott Cardiovascular Systems Inc.
Inventors: Howard J Leonhardt, Robert D. Lashinski
Patent number: 8133267
Abstract: The present invention relates to an apparatus for deploying an endoluminal prosthesis for engrafting a blood vessel. The apparatus includes a bifurcated graft that is able to conform to the interior surface of the blood vessel and can be deployed through a single entry site.
Type: Grant
Filed: March 1, 2010
Issued: March 13, 2012
Assignee: Medtronic Vascular, Inc.
Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
Application number: 20100217383
Abstract: The present invention relates to an apparatus for deploying an endoluminal prosthesis for engrafting a blood vessel. The apparatus includes a bifurcated graft that is able to conform to the interior surface of the blood vessel and can be deployed through a single entry site.
Type: Application
Filed: March 1, 2010
Issued: August 26, 2010
Assignee: Medtronic Vascular, Inc.
Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
Application number: 20100137835
Abstract: A catheter-based deployment system for deploying cellular material (22) into the heart muscle (25). The deployment system includes a guiding catheter (19) and a needle assembly (31) capable of sliding within the guiding catheter. The needle assembly (31) terminates in a tip (34) having at least one side with an opening (43) in communication with a lumen (20) disposed within the needle assembly (31). Once the guiding catheter (19) is positioned, the needle assembly (31) is advanced until the tip (34) penetrates the muscle wall (25). At a predetermined depth the cellular material (22) may be deployed into the muscle wall (25) via a push rod (46) disposed through the lumen of the needle assembly (31).
Type: Application
Filed: February 5, 2010
Issued: June 3, 2010
Inventors: Howard J. Leonhardt, Robert D. Lashinski
Patent number: 7699885
Abstract: The present invention relates to an apparatus for deploying an endoluminal prosthesis for engrafting a blood vessel. The apparatus includes a bifurcated graft that is able to conform to the interior surface of the blood vessel and can be deployed through a single entry site.
Type: Grant
Filed: June 30, 2004
Issued: April 20, 2010
Assignee: Medtronic Vascular, Inc.
Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
Patent number: 7686799
Abstract: A catheter-based deployment system for deploying cellular material (22) into the heart muscle (25). The deployment system includes a guiding catheter (19) and a needle assembly (31) capable of sliding within the guiding catheter. The needle assembly (31) terminates in a tip (34) having at least one side with an opening (43) in communication with a lumen (20) disposed within the needle assembly (31). Once the guiding catheter (19) is positioned the needle assembly (31) is advanced until the tip (34) penetrates the muscle wall (25). At a predetermined depth the cellular material (22) may be deployed into the muscle wall (25) via a push rod (46) disposed through the lumen of the needle assembly (31).
Type: Grant
Filed: July 13, 2001
Issued: March 30, 2010
Assignee: Abbott Cardiovascular Systems Inc.
Inventors: Howard J Leonhardt, Robert D Lashinski
Patent number: 7483749
Abstract: The present invention provides a method for enhancing regeneration of the myocardium. The method comprises the steps of applying electrical stimulation to an injury site in the myocardium. The method can be used in combination with implantation of myogenic cells into the injury site. The electrical stimulation may be applied before or after the implantation.
Type: Grant
Filed: March 28, 2005
Issued: January 27, 2009
Assignee: Bioheart, Inc.
Inventors: Howard J. Leonhardt, Juan C. Chachques
Patent number: 7341062
Abstract: The present invention provides a method for repairing damaged myocardium. The method comprises using a combination of cellular cardiomyoplasty and electrostimulation for myogenic predifferentiation of stem cells and to synchronize the contractions of the transplanted cells with the cardiac cells. The method comprises the steps of obtaining stem or myogenic cells from a donor, culturing and electrostimulating the isolated cells in vitro, and implanting the cells into the damaged myocardium.
Type: Grant
Filed: May 17, 2004
Issued: March 11, 2008
Assignee: Bioheart, Inc.
Inventors: Juan C. Chachques, Howard J. Leonhardt
Patent number: 6852116
Abstract: A method for deploying an endoluminal prosthesis by introducing into a bifurcated vessel a sheath introducer having therein a bifurcated graft with a primary and contralateral limb. The contralateral limb being radially retained independent of the sheath introducer. The graft being positionable by an insertion catheter. When the graft is in position within the vessel, a retaining device about the contralateral limb is broken and the graft takes the shape of the vessel.
Type: Grant
Filed: February 20, 2002
Issued: February 8, 2005
Assignee: World Medical Manufacturing Corporation
Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
Application number: 20040236403
Abstract: The present invention relates to an apparatus for deploying an endoluminal prosthesis for engrafting a blood vessel. The apparatus includes a bifurcated graft that is able to conform to the interior surface of the blood vessel and can be deployed through a single entry site.
Type: Application
Filed: June 30, 2004
Issued: November 25, 2004
Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
Patent number: 6767358
Abstract: The present invention relates to an apparatus for deploying and endoluminal prosthesis. The apparatus includes a flexible compressible push rod that allows the catheter to be easily maneuvered through tortuous vessels while providing sufficient deployment force.
Type: Grant
Filed: September 12, 2001
Issued: July 27, 2004
Assignee: World Medical Manufacturing Corporation
Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
Patent number: 6690970
Abstract: A biological pacemaker and implantation catheter for restoring normal or near normal heartbeat function without a mechanical pacemaker. The biological pacemaker is provided by a bridge of implantation cells, such as nerve cells, stem cells or ganglion cells, that are introduced into an area of electrical malfunction, such as an impaired SA node or a blocked AV node. The implantation cells grow to form a conductive cell bridge around the malfunction area so that a new pathway is provided for the electrical signals responsible for triggering heart beat contractions. The implantation catheter has a central nerve cell injection needle connected to a syringe or the like via a cell injection tube, and two elongated lateral stabilizing needles. The catheter is inserted into a blood vessel in a patient's leg, arm, shoulder or the like, and advanced until the catheter's distal end is located above the malfunction area.
Type: Grant
Filed: October 6, 2000
Issued: February 10, 2004
Inventors: Syde A. Taheri, Howard J. Leonhardt
Application number: 20040010231
Abstract: A catheter-based deployment system for deploying cellular material (22) into the heart muscle (25). The deployment system includes a guiding catheter (19) and a needle assembly (31) capable of sliding within the guiding catheter. The needle assembly (31) terminates in a tip (34) having at least one side with an opening (43) in communication with a lumen (20) disposed within the needle assembly (31). Once the guiding catheter (19) is positioned the needle assembly (31) is advanced until the tip (34) penetrates the muscle wall (25). At a predetermined depth the cellular material (22) may be deployed into the muscle wall (25) via a push rod (46) disposed through the lumen of the needle assembly (31).
Type: Application
Filed: July 15, 2003
Issued: January 15, 2004
Inventors: Howard J Leonhardt, Robert D Lashinski
Patent number: 6572645
Abstract: A multi-stage stent graft for implantation into a blood vessel is disclosed. Each stage or layer may comprise radially compressible spring stents with or without a fabric covering, or may comprise a foamed tube. The various stages or layers may also have an adhesive coated thereon. The multi-stage stented graft and the adhesive coatings provide a surface for the ingrowth of cells and promote healing. Also disclosed is a coaxial delivery system for the delivery and endovascular assembly of the multi-stage stented graft during one trip into the vasculature.
Type: Grant
Filed: July 19, 2001
Issued: June 3, 2003
Assignee: Medtronic Ave, Inc.
Inventor: Howard J. Leonhardt
Patent number: 6435190
Abstract: A method of autogenous cell patch cardio myoplasty using noninvasive thoracoscopy is disclosed. A patient's greater omentum is separated from its point of attachment to either the greater curvature of the stomach or the transverse colon. All open blood vessels in the greater omentum are ligated to permanently arrest bleeding. The greater omentum is introduced into the left pleural cavity through an opening in the diaphragm. Muscle grafts are removed from skeletal muscle tissue of the patient and an opening is formed in the pericardium to expose an area of damaged myocardium. Following attachment of the skeletal muscle grafts to either the greater omentum or the damaged myocardium area, preferably using an advanced muscle graft implantation system, the greater omentum is wrapped around the heart and attached thereto in order to reinforce the muscle grafts and enrich them with blood flow from the greater omentum.
Type: Grant
Filed: June 14, 2000
Issued: August 20, 2002
Inventors: Syde A. Taheri, Howard J. Leonhardt
Application number: 20020077634
Abstract: The present invention relates to an apparatus for deploying and endoluminal prosthesis. The apparatus includes a flexible compressible push rod that allows the catheter to be easily maneuvered through tortuous vessels while providing sufficient deployment force.
Type: Application
Filed: February 20, 2002
Issued: June 20, 2002
Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
Application number: 20020065545
Abstract: The present invention relates to an apparatus for deploying and endoluminal prosthesis. The apparatus includes a flexible compressible push rod that allows the catheter to be easily maneuvered through tortuous vessels while providing sufficient deployment force.
Type: Application
Filed: September 12, 2001
Issued: May 30, 2002
Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
Application number: 20020029075
Abstract: A multi-stage stent graft for implantation into a blood vessel is disclosed. Each stage or layer may comprise radially compressible spring stents with or without a fabric covering, or may comprise a foamed tube. The various stages or layers may also have an adhesive coated thereon. The multi-stage stented graft and the adhesive coatings provide a surface for the ingrowth of cells and promote healing. Also disclosed is a coaxial delivery system for the delivery and endovascular assembly of the multi-stage stented graft during one trip into the vasculature.
Type: Application
Filed: July 19, 2001
Issued: March 7, 2002
Assignee: Medtronic AVE, Inc.
Inventor: Howard J. Leonhardt
Patent number: 6334869
Abstract: An apparatus and method for engrafting a blood vessel are disclosed. The apparatus includes a tubular graft having radially compressible annular spring portions for biasing proximal and distal ends of the graft into conforming fixed engagement with an interior surface of the vessel, with bifurcated and adjustable length embodiments being disclosed. Apparatus for deploying the graft includes an insertion catheter having a nitinol core wire, a controllable tip balloon-at a remote end thereof for dilation and occlusion of the vessel, and a controllable graft balloon in the vicinity of the tip balloon for fixedly seating the spring portions into conformance with the interior surface of the vessel. A spool apparatus for adjusting or removing an improperly placed graft, and a micro-emboli filter tube, are usable with the deployment apparatus. A method of percutaneously implanting a graft, including a single-entry method for percutaneously implanting a bifurcated graft, are also disclosed.
Type: Grant
Filed: March 14, 2000
Issued: January 1, 2002
Assignee: World Medical Manufacturing Corporation
Inventors: Howard J. Leonhardt, Syde A. Taheri, Trevor Greenan
Patent number: 6280467
Abstract: A multi-stage stent graft for implantation into a blood vessel is disclosed. Each stage or layer may comprise radially compressible spring stents with or without a fabric covering, or may comprise a foamed tube. The various stages or layers may also have an adhesive coated thereon. The multi-stage stented graft and the adhesive coatings provide a surface for the in growth of cells and promote healing. Also disclosed is a coaxial delivery system for the delivery and endovascular assembly of the multi-stage stented graft during one trip into the vasculature.
Type: Grant
Filed: February 25, 1999
Issued: August 28, 2001
Assignee: World Medical Manufacturing Corporation
Inventor: Howard J. Leonhardt
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