Abstract: Provided herein are media, methods, kits, primers and oligonucleotide probes for use in the molecular detection of pathogens. These may be used in combination for the rapid, high-throughput screening PCR-based techniques to simultaneously detect multiple pathogens. The multiplex-detection methods have improved sensitivity and specificity for the detection of multiple pathogens simultaneously. Real-time PCR assaying techniques using such primers include microarrays and multiplex arrays, the latter optionally simultaneously with oligonucleotide TaqMan probes.

Abstract: A computer system and method generates one or more commenting features on a canvas, wherein each commenting feature carries at least one comment from a given source. Each commenting feature can include a pin component and a comment body element. The pin component is associated with a corresponding location on the canvas. The computer system and method enable the user to move the comment body element about at least a region of the canvas to view the at least one comment from the given source, while rendering the pin component to coincide with the corresponding associated location of the canvas.

Abstract: An apparatus is disclosed comprising a first device for generating aerosol, smoke or vapour from one or more regions of a target, an inlet conduit to an ion analyser or mass spectrometer, the inlet conduit having an inlet through which the aerosol, smoke or vapour passes, and a Venturi pump arrangement arranged and adapted to direct the aerosol, smoke or vapour towards the inlet.

Abstract: A system for three-dimensional printing is disclosed. The system comprises: a rotary tray configured to rotate about a vertical axis; a printing head, each having a plurality of separated nozzles; and a controller configured for controlling the inkjet printing head to dispense, during the rotation, droplets of building material in layers, such as to print a three-dimensional object on the tray.

Abstract: A phase change memory (PCM) cell includes an electrode, a heater electrically connected to the electrode, a PCM material electrically connected to the heater, a second electrode electrically connected to the PCM material, an electrical insulator surrounding the PCM material, and a shield positioned between the PCM material and the electrical insulator, the shield comprising a reactive-ion-etching-resistant material.

Abstract: The invention relates to methods for synthesizing amanitin derivatives having an amino group attached to position 6? of the central tryptophan moiety. The invention furthermore relates to an amanitin derivative having an amino group attached to position 6? of the central tryptophan moiety, conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates.

Abstract: The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.

Abstract: Systems and method are provided for an internal combustion engine with boosted operation. In an example, this includes operating the engine with boosted intake pressure via a supercharger and with supercharger flow regulated by a vacuum actuated bypass valve, and in response to a supercharger outlet temperature greater than a first threshold, increasing a blow through air passing from the engine intake to engine exhaust without combustion in a cylinder of the engine due to engine intake and exhaust valves having positive valve overlap; and then in response to the supercharger outlet temperature greater than a second, higher, threshold, limiting engine airflow.

Abstract: Exemplary embodiments are directed to a system and method for continuous downlinking communication from a surface location to a bottom hole assembly during drilling operations. The system transmits harmonic pressure wave fluctuations generated by a modulator, which is disposed outside of a surface-located fluid line with a flap rotatably disposed entirely inside of the fluid line encoding data by harmonics. One letter of the combinatorial frequencies signal alphabet can have more than 200 different orthogonal frequencies components; each component represents a unique combination of downlinking command purpose and value. For deepest portion of a long trajectory well, the system uses a narrow frequency range (2-3 Hz) with two letters resulting in more than 250 combinations. The system provides continuous automatic downhole control of the signal-to-noise ratio to achieve robust decoding of downlinking signals with a transmission data rate ten times faster as compared to 1-2 bits per minute in the industry.

Abstract: The disclosure relates to a regulating device for regulating the steering angle for a vehicle, comprising a first controller unit with a controller superposed thereon, the controller having a feedback path and a prefilter. The feedback path provides a first adjustment variable based on actual steering angle information which is provided by the first controller unit as an output variable and the prefilter provides a second adjustment variable based on nominal steering angle information. The controller is configured to form input information for the first controller unit based on the first and the second adjustment variables, wherein the feedback path has a first correction element, the transfer behavior of which can be adjusted. The prefilter has a second correction element, the transfer behavior of which can be adjusted. The controller is configured such that at least the controller gain of the first controller unit can be adjusted.

Abstract: Techniques are described herein that are capable of synthesizing a computer program to include idiomatic function(s) and semantically-meaningful variable(s) using programming by example. For instance, an intent of a user to synthesize a computer program to include functionality configured to generate sample output(s) from respective input(s) is determined based at least in part on receipt of the sample input(s) and the respective sample output(s) from the user. Based at least in part on the determined intent, the computer program is synthesized to include the idiomatic function(s) by configuring the idiomatic function(s) to have the target functionality and to conform to a convention of the target domain-specific language associated with a textual representation of the computer program to be displayed to the user. Non-semantically-meaningful variable(s) included among the idiomatic function(s) are replaced with the respective semantically-meaningful variable(s).

Abstract: An apparatus can include a generally planar portion approximately in a plane. The apparatus can also include a lip portion extending in a direction generally orthogonal to the plane. The generally planar portion is joined to the lip portion at a circumferential edge of the generally planar portion to form a cover for a beverage container. Likewise, a method can include providing contact information on a disposable cover adapted to cover a beverage container. The contact information is not necessarily provided by the manufacturer of the beverage or beverage container. The method can also include receiving contact from a user of the disposable cover. The method can further include coordinating the delivery of a service to the user of the disposable cover responsive to the contact received from the user.

Abstract: Methods, apparatuses, and computer program products are described herein that are configured to be embodied as a natural language document orchestrator. In some example embodiments, a method is provided that comprises generating natural language text. The method of this embodiment may also include executing document orchestration requests from a scripted input language file.

Abstract: Provided are anti-syndecan-2 antibodies and compositions comprising said antibody and methods useful for treating acute respiratory distress syndrome, including coronavirus disease 2019-induced acute respiratory distress syndrome, in a subject in need thereof. The method comprises administering to the subject an effective amount to treat the acute respiratory distress syndrome of an syndecan-2 disrupting agent. The syndecan-2 disrupting agents may include at least one of the anti-syndecan-2 antibodies and/or at least one syndecan-2 disrupting peptide.

Abstract: Exemplary embodiments are directed to a system and method for continuous downlinking communication from a surface location to a bottom hole assembly during drilling operations. The system transmits harmonic pressure wave fluctuations generated by a modulator, which is disposed outside of a surface-located fluid line with a flap rotatably disposed entirely inside of the fluid line encoding data by harmonics. One letter of the combinatorial frequencies signal alphabet can have more than 200 different orthogonal frequencies components; each component represents a unique combination of downlinking command purpose and value. For deepest portion of a long trajectory well, the system uses a narrow frequency range (2-3 Hz) with two letters resulting in more than 250 combinations. The system provides continuous automatic downhole control of the signal-to-noise ratio to achieve robust decoding of downlinking signals with a transmission data rate ten times faster as compared to 1-2 bits per minute in the industry.

Abstract: Embodiments of the present disclosure relate to methods of finding optimized analog measurement hardware settings of a measurement system for a target measurement. The method can include one or more of the following steps: applying initial settings to the measurement system; varying the settings over a power sweep while processing a test signal used for the target measurement or a representative signal; performing the target measurement during the power sweep, thereby determining a hardware contribution of the measurement system over the power sweep; and identifying the respective settings that lead to a minimum hardware contribution of the measurement system at various powers.

Abstract: Apparatuses and methods are provided for generating one or more images using an example apparatus. An example apparatus includes a plurality of pixel elements fabricated on two or more substrates, wherein each pixel element comprises a plurality of compound refractive lenses. Each compound refractive lens comprises a plurality of concave lenses and each compound refractive lens defines a proximal end and distal end. Each pixel element further comprises a plurality of photon counting detectors, wherein each photon counting detector is configured to receive a beam exiting from the distal end of a particular compound refractive lens.

Abstract: A method for managing an automation system involving asynchronous and synchronous zones, the method including: determining when a moving element enters a merge zone between an asynchronous zone and a synchronous zone; calculating additive jerk to be applied to the moving element, In some cases, the additive jerk is based on predetermined compensation profiles; determining if the master position change is different than a base logged; if so, interpolating additive jerk based on movement characteristics of the moving element; in either event, applying the additive jerk to the moving element; and determining if the merge is completed and, if yes, ending the merge and continue with synchronous operation but, if no, returning to calculating the additive jerk and repeat. A system including a processor/controller and a memory including instructions, which when executed by the processor/controller, perform the method.

Abstract: Methods, systems, and computer program products for gathering electronic signatures to be applied to collaboration system content objects (e.g., contracts, letters, insurance claims, riders, etc.). A collaboration system monitors changes made to the collaboration system content objects during electronic signature processing. A module of the content management system is configured to associate one or more instances of e-signing metadata to one or more of the stored content objects of the content management system. The e-signing metadata indicates whether or not a particular portion of the one or more of the stored content objects has been e-signed by a designated e-signatory. A collaborator who is not one of the designated e-signatories makes a change to one or more of the stored content objects (e.g., contracts, letters, insurance claims, riders, etc.). The change is remediated on-the-fly and the e-signing process continues without having to restart the e-signing process from the beginning.

Abstract: This disclosure relates generally to using machine learning models to generate current time-series features using machine learning and validate time-series machine learning model output. At least one aspect is directed to a system with one or more processors, coupled to memory, to segment a time series range into a first segment for an instance of time, the segment associated with a value for a target feature and a timestamp for the value, segment the time series range into an input segment associated with a plurality of input features and a segment timestamp less than or equal to the timestamp, generate a model trained with input comprising values for the target feature and timestamps for the values less than or equal to the segment timestamp, and transform at least one of the input features based at least on the model.