Patents by Inventor Su-Chun Zhang

Su-Chun Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160152950
    Abstract: Methods for expanding proliferating populations of neuronal subtype-specific progenitors and creating substantially pure populations of motor neurons are provided herein. In particular, the present invention provides methods for maintaining the unique gene profile and differentiation potential of neuronal subtype-specific progenitors, such as motor neuron progenitors and hindbrain serotonergic neural progenitors.
    Type: Application
    Filed: February 5, 2016
    Publication date: June 2, 2016
    Inventors: Su-Chun Zhang, Zhongwei Du
  • Publication number: 20150285822
    Abstract: Methods and compositions relating to motor neurons derived from induced pluripotent stem cells of subjects having a neurodegenerative disease, where the motor neurons exhibit phenotypes characteristic of the neurodegenerative disease, are provided herein. In particular, the present invention provides methods for screening putative therapeutic agents and methods for diagnosing living subjects as having a neurodegenerative disease. In addition, the present invention provides therapeutic gene transfer methods for treating or preventing a neurodegenerative disease in a subject in need thereof.
    Type: Application
    Filed: April 1, 2015
    Publication date: October 8, 2015
    Inventors: Su-Chun Zhang, Hong Chen
  • Patent number: 9080151
    Abstract: A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF 9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+.
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: July 14, 2015
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xue-jun Li
  • Patent number: 8895302
    Abstract: Methods of efficiently converting primate pluripotent stem cells to GABA neurons or cholinergic neurons, as well as applications thereof, are disclosed.
    Type: Grant
    Filed: August 10, 2011
    Date of Patent: November 25, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Yan Liu, Lixiang Ma
  • Patent number: 8895301
    Abstract: A transcription factor both necessary and sufficient for human neuroectoderm specification, Pax6, as well as applications thereof, is disclosed.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: November 25, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xiaoqing Zhang
  • Publication number: 20140248696
    Abstract: Methods for expanding proliferating populations of neuronal subtype-specific progenitors are provided herein. In particular, the present invention provides methods for maintaining the unique gene profile and differentiation potential of neuronal subtype-specific progenitors, such as motor neuron progenitors and hindbrain serotonergic neural progenitors.
    Type: Application
    Filed: February 28, 2014
    Publication date: September 4, 2014
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Zhong-wei Du, Jianfeng Lu
  • Patent number: 8658424
    Abstract: A method of differentiating embryonic stem cells into oligodendroglial precursor cells and oligodendroglial cells by culturing a population of cells comprising a majority of cells that are characterized by a neural tube-like rosette morphology and are Pax6+/Sox1+ into a population of cells that are PDGFR?+.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: February 25, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Baoyang Hu, Zhong-Wei Du
  • Patent number: 8597945
    Abstract: A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of retinoic acid, wherein the cells express Hoxb4, but not Otx2 or Bf1.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: December 3, 2013
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xue-Jun Li
  • Publication number: 20130011917
    Abstract: A method of differentiating embryonic stem cells into oligodendroglial precursor cells and oligodendroglial cells by culturing a population of cells comprising a majority of cells that are characterized by a neural tube-like rosette morphology and are Pax6+/Sox1+ into a population of cells that are PDGFR?+.
    Type: Application
    Filed: June 28, 2012
    Publication date: January 10, 2013
    Inventors: Su-Chun Zhang, Baoyang Hu, Zhong-Wei Du
  • Patent number: 8227247
    Abstract: A method of differentiating embryonic stem cells into oligodendroglial precursor cells and oligodendroglial cells by culturing a population of cells comprising a majority of cells that are characterized by a neural tube-like rosette morphology and are Pax6+/Sox1+ into a population of cells that are PDGFR?+.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: July 24, 2012
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Baoyang Hu, Zhong-Wei Du
  • Publication number: 20120184032
    Abstract: A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of retinoic acid, wherein the cells express Hoxb4, but not Otx2 or Bf1.
    Type: Application
    Filed: February 27, 2012
    Publication date: July 19, 2012
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xue-Jun Li
  • Publication number: 20120157510
    Abstract: A transcription factor both necessary and sufficient for human neuroectoderm specification, Pax6, as well as applications thereof, is disclosed.
    Type: Application
    Filed: January 27, 2012
    Publication date: June 21, 2012
    Inventors: Su-Chun Zhang, Xiaoqing Zhang
  • Patent number: 8153424
    Abstract: A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of retinoic acid, wherein the cells express Hoxb4, but not Otx2 or Bf1.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: April 10, 2012
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xue-Jun Li
  • Patent number: 8133731
    Abstract: A transcription factor both necessary and sufficient for human neuroectoderm specification, Pax6, as well as applications thereof, is disclosed.
    Type: Grant
    Filed: August 3, 2010
    Date of Patent: March 13, 2012
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xiaoqing Zhang
  • Publication number: 20120040393
    Abstract: Methods of efficiently converting primate pluripotent stem cells to GABA neurons or cholinergic neurons, as well as applications thereof, are disclosed.
    Type: Application
    Filed: August 10, 2011
    Publication date: February 16, 2012
    Inventors: Su-Chun Zhang, Yan Liu, Lixiang Ma
  • Publication number: 20110275152
    Abstract: A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+.
    Type: Application
    Filed: May 6, 2011
    Publication date: November 10, 2011
    Inventors: Su-Chun Zhang, Xue-Jun Li
  • Patent number: 7972850
    Abstract: A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF 9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: July 5, 2011
    Assignee: Wisonsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xue-jun Li
  • Patent number: 7947501
    Abstract: A method of creating a human pluripotent transgenic stem cell, wherein heterologous DNA is inserted into specific “hot-spots” in the genome where stable and high gene expression may occur, is disclosed. In one embodiment, the method comprises the steps of: (a) selecting a pluripotent stem cell line, and (b) inserting heterologous DNA at an insertion site selected from the group consisting of insertion site one and insertion site two to form a transgenic cell line. In another embodiment, the heterologous DNA is an exchange cassette and the transgenic cell line formed is a master cell line.
    Type: Grant
    Filed: February 6, 2009
    Date of Patent: May 24, 2011
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Zhong-wei Du
  • Publication number: 20110034536
    Abstract: A transcription factor both necessary and sufficient for human neuroectoderm specification, Pax6, as well as applications thereof, is disclosed.
    Type: Application
    Filed: August 3, 2010
    Publication date: February 10, 2011
    Inventors: SU-CHUN ZHANG, XIAOQING ZHANG
  • Publication number: 20100159595
    Abstract: A method of differentiating embryonic stem cells into oligodendroglial precursor cells and oligodendroglial cells by culturing a population of cells comprising a majority of cells that are characterized by a neural tube-like rosette morphology and are Pax6+/Sox1+ into a population of cells that are PDGFR?+.
    Type: Application
    Filed: December 18, 2008
    Publication date: June 24, 2010
    Inventors: Su-Chun Zhang, Baoyang Hu, Zhong-Wei Du