Patents by Inventor Su-Chun Zhang

Su-Chun Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Myelinating oligodendrocyte precursor populations
    Patent number: 8658424
    Abstract: A method of differentiating embryonic stem cells into oligodendroglial precursor cells and oligodendroglial cells by culturing a population of cells comprising a majority of cells that are characterized by a neural tube-like rosette morphology and are Pax6+/Sox1+ into a population of cells that are PDGFR?+.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: February 25, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Baoyang Hu, Zhong-Wei Du
  • Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
    Patent number: 8597945
    Abstract: A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of retinoic acid, wherein the cells express Hoxb4, but not Otx2 or Bf1.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: December 3, 2013
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xue-Jun Li
  • METHOD OF GENERATING MYELINATING OLIGODENDROCYTES
    Publication number: 20130011917
    Abstract: A method of differentiating embryonic stem cells into oligodendroglial precursor cells and oligodendroglial cells by culturing a population of cells comprising a majority of cells that are characterized by a neural tube-like rosette morphology and are Pax6+/Sox1+ into a population of cells that are PDGFR?+.
    Type: Application
    Filed: June 28, 2012
    Publication date: January 10, 2013
    Inventors: Su-Chun Zhang, Baoyang Hu, Zhong-Wei Du
  • Method of generating myelinating oligodendrocytes
    Patent number: 8227247
    Abstract: A method of differentiating embryonic stem cells into oligodendroglial precursor cells and oligodendroglial cells by culturing a population of cells comprising a majority of cells that are characterized by a neural tube-like rosette morphology and are Pax6+/Sox1+ into a population of cells that are PDGFR?+.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: July 24, 2012
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Baoyang Hu, Zhong-Wei Du
  • Method of In Vitro Differentiation of Neural Stem Cells, Motor Neurons and Dopamine Neurons From Primate Embryonic Stem Cells
    Publication number: 20120184032
    Abstract: A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of retinoic acid, wherein the cells express Hoxb4, but not Otx2 or Bf1.
    Type: Application
    Filed: February 27, 2012
    Publication date: July 19, 2012
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xue-Jun Li
  • Controlling The Potential Of Primate Neural Stem Cells By Regulating Pax6
    Publication number: 20120157510
    Abstract: A transcription factor both necessary and sufficient for human neuroectoderm specification, Pax6, as well as applications thereof, is disclosed.
    Type: Application
    Filed: January 27, 2012
    Publication date: June 21, 2012
    Inventors: Su-Chun Zhang, Xiaoqing Zhang
  • Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
    Patent number: 8153424
    Abstract: A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of retinoic acid, wherein the cells express Hoxb4, but not Otx2 or Bf1.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: April 10, 2012
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xue-Jun Li
  • Production of primate neural stem cells through expression of pax6
    Patent number: 8133731
    Abstract: A transcription factor both necessary and sufficient for human neuroectoderm specification, Pax6, as well as applications thereof, is disclosed.
    Type: Grant
    Filed: August 3, 2010
    Date of Patent: March 13, 2012
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xiaoqing Zhang
  • Directed Differentiation of Primate Pluripotent Stem Cells Into Functional Basal Forebrain Cholinergic Neurons (BFCNs) and Medium Spiny Gabaergic Projection Neurons
    Publication number: 20120040393
    Abstract: Methods of efficiently converting primate pluripotent stem cells to GABA neurons or cholinergic neurons, as well as applications thereof, are disclosed.
    Type: Application
    Filed: August 10, 2011
    Publication date: February 16, 2012
    Inventors: Su-Chun Zhang, Yan Liu, Lixiang Ma
  • Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
    Publication number: 20110275152
    Abstract: A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+.
    Type: Application
    Filed: May 6, 2011
    Publication date: November 10, 2011
    Inventors: Su-Chun Zhang, Xue-Jun Li
  • Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
    Patent number: 7972850
    Abstract: A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF 9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: July 5, 2011
    Assignee: Wisonsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xue-jun Li
  • Gene recombination exchange system for stable gene modification in human ES cells
    Patent number: 7947501
    Abstract: A method of creating a human pluripotent transgenic stem cell, wherein heterologous DNA is inserted into specific “hot-spots” in the genome where stable and high gene expression may occur, is disclosed. In one embodiment, the method comprises the steps of: (a) selecting a pluripotent stem cell line, and (b) inserting heterologous DNA at an insertion site selected from the group consisting of insertion site one and insertion site two to form a transgenic cell line. In another embodiment, the heterologous DNA is an exchange cassette and the transgenic cell line formed is a master cell line.
    Type: Grant
    Filed: February 6, 2009
    Date of Patent: May 24, 2011
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Zhong-wei Du
  • CONTROLLING THE POTENTIAL OF PRIMATE NEURAL STEM CELLS BY REGULATING PAX6
    Publication number: 20110034536
    Abstract: A transcription factor both necessary and sufficient for human neuroectoderm specification, Pax6, as well as applications thereof, is disclosed.
    Type: Application
    Filed: August 3, 2010
    Publication date: February 10, 2011
    Inventors: SU-CHUN ZHANG, XIAOQING ZHANG
  • METHOD OF GENERATING MYELINATING OLIGODENDROCYTES
    Publication number: 20100159595
    Abstract: A method of differentiating embryonic stem cells into oligodendroglial precursor cells and oligodendroglial cells by culturing a population of cells comprising a majority of cells that are characterized by a neural tube-like rosette morphology and are Pax6+/Sox1+ into a population of cells that are PDGFR?+.
    Type: Application
    Filed: December 18, 2008
    Publication date: June 24, 2010
    Inventors: Su-Chun Zhang, Baoyang Hu, Zhong-Wei Du
  • Gene recombination exchange system for stable gene modification in human ES cells
    Publication number: 20090239305
    Abstract: A method of creating a human pluripotent transgenic stem cell, wherein heterologous DNA is inserted into specific “hot-spots” in the genome where stable and high gene expression may occur, is disclosed. In one embodiment, the method comprises the steps of: (a) selecting a pluripotent stem cell line, and (b) inserting heterologous DNA at an insertion site selected from the group consisting of insertion site one and insertion site two to form a transgenic cell line. In another embodiment, the heterologous DNA is an exchange cassette and the transgenic cell line formed is a master cell line.
    Type: Application
    Filed: February 6, 2009
    Publication date: September 24, 2009
    Inventors: Su-Chun Zhang, Zhong-wei Du
  • Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
    Patent number: 7588937
    Abstract: A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF 9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: September 15, 2009
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xue-jun Li
  • METHOD OF IN VITRO DIFFERENTIATION OF NEURAL STEM CELLS, MOTOR NEURONS AND DOPAMINE NEURONS FROM PRIMATE EMBRYONIC STEM CELLS
    Publication number: 20080227137
    Abstract: A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of retinoic acid, wherein the cells express Hoxb4, but not Otx2 or Bf1.
    Type: Application
    Filed: October 31, 2007
    Publication date: September 18, 2008
    Inventors: Su-Chun Zhang, Xue-Jun Li
  • Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
    Publication number: 20080206865
    Abstract: A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF 9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+.
    Type: Application
    Filed: November 8, 2006
    Publication date: August 28, 2008
    Inventors: Su-Chun Zhang, James A. Thomson, Ian David Duncan, Xue-jun Li
  • Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
    Publication number: 20050095706
    Abstract: A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF 9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+.
    Type: Application
    Filed: August 27, 2004
    Publication date: May 5, 2005
    Inventors: Su-Chun Zhang, James Thomson, Ian Duncan, Xue-jun Li
  • Method of in vitro differentiation of transplantable neural precursor cells from primate embryonic stem cells
    Patent number: 6887706
    Abstract: A method of differentiating embryonic stem cells into neural precursor cells is disclosed. In one embodiment the method comprises the steps of (a) obtaining an embryonic stem cell culture, (b) propagating the stem cells, (c) forming embryoid bodies from the stem cells, and (d) culturing the embryoid bodies in a medium containing an effective amount of fibroblast growth factor 2, wherein neural precursor cells will be generated and isolated.
    Type: Grant
    Filed: October 3, 2001
    Date of Patent: May 3, 2005
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, James A. Thomson, Ian David Duncan