Patents by Inventor Su-Chun Zhang

Su-Chun Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090239305
    Abstract: A method of creating a human pluripotent transgenic stem cell, wherein heterologous DNA is inserted into specific “hot-spots” in the genome where stable and high gene expression may occur, is disclosed. In one embodiment, the method comprises the steps of: (a) selecting a pluripotent stem cell line, and (b) inserting heterologous DNA at an insertion site selected from the group consisting of insertion site one and insertion site two to form a transgenic cell line. In another embodiment, the heterologous DNA is an exchange cassette and the transgenic cell line formed is a master cell line.
    Type: Application
    Filed: February 6, 2009
    Publication date: September 24, 2009
    Inventors: Su-Chun Zhang, Zhong-wei Du
  • Patent number: 7588937
    Abstract: A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF 9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: September 15, 2009
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xue-jun Li
  • Publication number: 20080227137
    Abstract: A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of retinoic acid, wherein the cells express Hoxb4, but not Otx2 or Bf1.
    Type: Application
    Filed: October 31, 2007
    Publication date: September 18, 2008
    Inventors: Su-Chun Zhang, Xue-Jun Li
  • Publication number: 20080206865
    Abstract: A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF 9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+.
    Type: Application
    Filed: November 8, 2006
    Publication date: August 28, 2008
    Inventors: Su-Chun Zhang, James A. Thomson, Ian David Duncan, Xue-jun Li
  • Publication number: 20050095706
    Abstract: A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF 9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+.
    Type: Application
    Filed: August 27, 2004
    Publication date: May 5, 2005
    Inventors: Su-Chun Zhang, James Thomson, Ian Duncan, Xue-jun Li
  • Patent number: 6887706
    Abstract: A method of differentiating embryonic stem cells into neural precursor cells is disclosed. In one embodiment the method comprises the steps of (a) obtaining an embryonic stem cell culture, (b) propagating the stem cells, (c) forming embryoid bodies from the stem cells, and (d) culturing the embryoid bodies in a medium containing an effective amount of fibroblast growth factor 2, wherein neural precursor cells will be generated and isolated.
    Type: Grant
    Filed: October 3, 2001
    Date of Patent: May 3, 2005
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, James A. Thomson, Ian David Duncan
  • Patent number: 6613756
    Abstract: A method of treating multiple sclerosis is disclosed. In one embodiment, the method comprises the step of treating a multiple sclerosis patient with a tetracycline derivative, wherein the multiple sclerosis symptoms of the patient are diminished.
    Type: Grant
    Filed: May 3, 2001
    Date of Patent: September 2, 2003
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ian D. Duncan, Su-Chun Zhang
  • Publication number: 20030068819
    Abstract: A method of differentiating embryonic stem cells into neural precursor cells is disclosed. In one embodiment the method comprises the steps of (a) obtaining an embryonic stem cell culture, (b) propagating the stem cells, (c) forming embryoid bodies from the stem cells, and (d) culturing the embryoid bodies in a medium containing an effective amount of fibroblast growth factor 2, wherein neural precursor cells will be generated and isolated.
    Type: Application
    Filed: October 3, 2001
    Publication date: April 10, 2003
    Inventors: Su-Chun Zhang, James A. Thomson, Ian David Duncan
  • Publication number: 20020022608
    Abstract: A method of treating multiple sclerosis is disclosed. In one embodiment, the method comprises the step of treating a multiple sclerosis patient with a tetracycline derivative, wherein the multiple sclerosis symptoms of the patient are diminished.
    Type: Application
    Filed: May 3, 2001
    Publication date: February 21, 2002
    Inventors: Ian D. Duncan, Su-Chun Zhang