Abstract: Systems and methods for isolating and/or desiccating a portion of a drug delivery tract of a drug delivery apparatus to reduce water vapor content therein are provided. For example, there is provided a metered dose inhaler for delivering aerosolized medicament or other matter to a user. The aerosolized medicament or other matter may be discharged from a discharge passageway within the inhaler into an inhalation passageway for inhalation by a user, and the inhaler may comprise a seal member operative to selectively isolate the discharge passageway from the inhalation passageway and external environment during inactivity. The inhaler may further comprise a desiccant material arranged to withdraw moisture from the isolated discharge passageway. In other instances, desiccant material may be arranged to withdraw moisture from the discharge passageway of the inhaler without isolating the discharge passage during inactivity.

Abstract: A room 100 in a building has a living etc. space 101 of volume V that is an enclosed space. Ventilation of an air flow F is performed from the outside to the living etc. space 101. Entering/exiting of air as an air current between the inside of the living etc. space 101 and the outside is eliminated, and at least a part of the boundary between the living etc. space 101 and the outside is configured from a gas exchange membrane 310 having a diffusion constant D, a thickness L, and an area A for gas molecules of interest. When air inside the living etc. space 101 is sufficiently agitated and the concentration of gas molecules constituting the air is made spatially uniform, ?(t) is controlled so as to vary according to ? ? ( t ) = ? o - BL AD ? ( 1 - exp ? ( - [ AD ? / ? L ] ? t ? / ? V ) ) ( 9 ) B(m3/s) is the gas consumption amount inside the living etc. space 101, ?1 (t) is the gas concentration inside the living etc.

Abstract: Systems and methods for isolating and/or desiccating a portion of a drug delivery tract of a drug delivery apparatus to reduce water vapor content therein are provided. For example, there is provided a metered dose inhaler for delivering aerosolized medicament or other matter to a user. The aerosolized medicament or other matter may be discharged from a discharge passageway within the inhaler into an inhalation passageway for inhalation by a user, and the inhaler may comprise a seal member operative to selectively isolate the discharge passageway from the inhalation passageway and external environment during inactivity. The inhaler may further comprise a desiccant material arranged to withdraw moisture from the isolated discharge passageway. In other instances, desiccant material may be arranged to withdraw moisture from the discharge passageway of the inhaler without isolating the discharge passage during inactivity.

Abstract: A flow of gases in a respiratory therapy system can be conditioned to achieve more consistent output from sensors configured to sense a characteristic of the flow. The flow can be mixed by imparting a tangential, rotary, helical, or swirling motion to the flow of gases. The mixing can occur upstream of the sensors. The flow can be segregated into smaller compartments to reduce turbulence in a region of the sensors.

Abstract: A square bottle that includes a mouth portion, a shoulder portion, a body portion, and a bottom portion provided to be continuous in this order from the top to the bottom in a bottle axis direction, wherein in the body portion a plurality of panel surface portions are provided to be continuous with each other with corner portions therebetween in a circumferential direction around a bottle axis and in the body portion a first peripheral groove straddling at least the corner portions in the circumferential direction is formed, and a ridge portion straddling the corner portions in the circumferential direction is formed on an inner surface defining the first peripheral groove.

Abstract: Methods and systems are provided for delivering anesthetic agent to a patient. In one embodiment, a liquid anesthetic agent container includes a base region, an interior of the base region configured to hold liquid anesthetic agent, an adapter region, and a capillary force vaporizer (CFV) housed in the adapter region. The adapter region includes a coupling end configured to couple to a patient breathing circuit to supply anesthetic agent vaporized by the CFV to a patient.

Abstract: A gas conduit for respiratory apparatus includes a lumen for passage of a breathable gas to a patient and a flexible conduit wall surrounding the lumen. The flexible conduit wall has a humidification apparatus for delivering water vapour into the gas passing through the lumen.

Abstract: A patient communication system having a medical sensing device operable to collect medical data, a network communication module operable to transmit the medical data onto a data network, a controller operable route the first medical sensing data to the network communication module, and a power source operable to provide power to the first medical sensing device, the controller, and the network communication module.

Abstract: A reaction and distribution system may include a distributor securable near or in a path correspond to a breathing passage such as the nostrils or the mouth of a user for delivering nitric oxide therapy thereto. The distributor may contain an internal reactor for creating the nitric oxide from reactants. Alternative embodiments may include an inhaler for delivering nitric oxide into the mouth of a user. The inhaler may contain a reaction chamber monolithic or contiguous with the inhaler for creating the nitric oxide from reactants.

Abstract: A nebulizer has an aperture plate, a mounting, an actuator, and an aperture plate drive circuit (2-4). A controller measures an electrical drive parameter at each of a plurality of measuring points, each measuring point having a drive frequency; and based on the values of the parameter at the measuring points makes a determination of optimum drive frequency and also an end-of-dose prediction. The controller performs a short scan at regular sub-second intervals at which drive current is measured at two measuring points with different drive frequencies. According to drive parameter measurements at these points the controller determines if a full scan sweeping across a larger number of measuring points should be performed. The full scan provides the optimum drive frequency for the device and also an end of dose indication.

Abstract: A simulated smoking device (1) comprising a simulated cigarette having a substantially cylindrical cigarette-like shape and a refill device (2, 50) having a substantially cuboid housing with a cigarette pack-like shape containing refill gas (32, 59) for the simulated cigarette and having means for selectively retaining the simulated cigarette. The simulated cigarette may be retained wholly within the housing. It may be retained at a location different from the refill location. A dose counter may be provided to give a visual indication of the doses in the refill device.

Abstract: A nebulizer adapter kit including a T-shaped adapter having cylindrical upper and lower portions and a safety cap on the lower portion. A direct flow valve on and in fluid communication with each of the proximal end and a channel stemming from a nebulizer medicine reservoir separate from the nebulizer machine. The direct flow valve is in operational and fluid communication with a direct flow tube. A shut-off valve is between and in fluid communication with the direct flow tube and a mouthpiece. A drip-reduction ring on the adapter bottom end inserts within an upper outlet of the nebulizer machine. A gas source is attachable to and in fluid communication with the nebulizer machine to convert liquid therapy medication into a mist, which is formed within the direct flow valve, rather than inside the nebulizer machine.

Abstract: An inhaler is provided that includes a controller, a driver, an atomizer and one or more sensors for detecting information about a velocity of inhalation of a user of the inhaler. The controller is configured to dispense an inhalant from the inhaler during an inhalation of the user based on information about the velocity of inhalation of the user. Such information can include a duration of maximum inhalation velocity or an increase or maximum in the acceleration in inhalation velocity. Embodiments of the inhaler can be used to enhance the delivery of drugs and therapeutic agents for those patients having a weakened respiratory system who are unable to take a deep or full breadth, e.g., patients having asthma or COPD. Embodiments of the inhaler can be used to deliver a variety of drugs and therapeutic agents including agents for the treatment of asthma, diabetes, epilepsy and heart disease.

Abstract: A humidifier includes a heating element including a porous structure of electrically resistive and thermally conductive material configured to substantially vaporise liquid that is passed through the porous structure. The porous structure has a liquid inlet and a vapour outlet. The humidifier further includes an outer housing surrounding at least a portion of the porous structure for containing the liquid and vapour within the porous structure. The porous structure includes a first electrical connector and a second electrical connector, the first and second connectors being configured for receiving electrical power and applying a voltage across the porous structure to generate heat.

Abstract: Described are gas flow disruption alarms. The alarms can include a gas inlet; a gas outlet configured to couple to a gas delivery device; and a vibration member between the gas inlet and the gas outlet configured to produce an audible sound when a gas delivery device is removed from the gas outlet.

Abstract: A spirometer comprises a housing defining a fluid flow pathway extending between a first end and a second end, a first opening along the pathway and a second opening longitudinally spaced along the pathway from the first opening. A flow chamber defining a fluid flow pathway is disposed within the housing between the first opening and the second opening, the flow chamber including an elongated resistive element along the central longitudinal axis of the flow chamber for defining a flow passage through the flow chamber between the resistive element and the inner surface of the flow chamber. The flow chamber conditions fluid flow for accurate sensing of the fluid flow over a range. A pressure sensor is disposed within the housing in fluid communication with the first opening and the second opening for sensing a pressure differential between the first opening and the second opening and producing an electric signal that corresponds with the rate of fluid flow through the housing.

Abstract: The present invention relates to a source container and to a vapor-deposition reactor. The source container according to one embodiment of the present invention comprises: a container comprising an inner wall for delimiting a first space for holing a source material, and a second space which is adjacent to the first space and is for the mixing of vapor emitted from the source material and a carrier gas taken into the inside thereof; a carrier gas inflow pathway which connects the outside of the container second space; a mixed gas discharge pathway which connects the outside of the container and the second space; and a flow-limiting member which expands inside the second space, and provides a first flow barrier surface between the inflow port and the discharge port.

Abstract: A respiratory assistance apparatus includes a flow generator and a humidifier. The humidifier includes a humidification chamber. The humidification chamber comprises a water tub that is configured to receive a volume of water. A lid is hingedly coupled to the water tub for enclosing a volume contained within the water tub.

Abstract: A stand-alone chamber or multi-chamber inhalation system has at least two alternative vaporized test liquid supply systems for passive or self-administered delivery of vaporized test fluid and air to one or more test chambers based on operator selection of delivery on and off times in a passive mode or actuation of an actuator in the chamber by a test animal in a self-administered mode. In one case, a multiple inhalation chamber system has two or more separate test fluid delivery systems and provides options for selective passive uniform drug delivery to multiple chambers or selective delivery of two or more different drugs to different groups of chambers from different delivery systems so that two different drugs or different concentrations of delivered drugs can be tested simultaneously.

Abstract: The present invention provides a gas water bottle adaptor that is suitable for attachment to a water bottle and to a bottle cap. The adaptor can include a gas inlet on one side thereof suitable for attachment to the gas connection of an endoscope. A sealing member can be affixed to the adaptor to prevent leakage of any fluid (e.g., liquid or gas) that is inside of the water bottle. The adaptor may be used in endoscopy methods and is particularly useful for adding a secondary gas source to a water bottle.

Abstract: Described are gas flow disruption alarms. The alarms can include a gas inlet; a gas outlet configured to couple to a gas delivery device; and a vibration member between the gas inlet and the gas outlet configured to produce an audible sound when a gas delivery device is removed from the gas outlet.

Abstract: A simulated smoking device (1) comprising a simulated cigarette having a substantially cylindrical cigarette-like shape and a refill device (2, 50) having a substantially cuboid housing with a cigarette pack-like shape containing refill gas (32, 59) for the simulated cigarette and having means for selectively retaining the simulated cigarette. The simulated cigarette may be retained wholly within the housing. It may be retained at a location different from the refill location. A dose counter may be provided to give a visual indication of the doses in the refill device.

Abstract: The invention concerns a product consisting of distilled water or of an aqueous solution hypotonic or substantially isotonic with respect to blood plasma or, less preferably, hypertonic with respect to blood plasma, to be administered on the nasal mucosa according to a specific operation mode in order to cause an inflammation of an irritative kind, for use in a treatment of stimulation of the endogenous production of inflammatory mediators, in the therapy and prevention of neurological disorders, in particular of degenerative disorders of the central and peripheral nervous system. The inflammatory mediators the endogenous production of which is stimulated comprise NGF, neurotrophin-3, neurotrophin-4, serotonin, substance P, heparin, ECF-A.

Abstract: A nebulizer dispenser has a T-piece, a body sealingly coupled to the T-piece and configured to contain a liquid medication, and a breathing piece sealingly coupled to the T-piece. The dispenser also has a ball-and-socket joint coupled between the T-piece and either the breathing piece or the body. The ball-and-socket joint allows relative rotational motion of the T-piece in a pitch axis, a yaw axis, and a roll axis.

Abstract: A concentric split flow filter may be configured to remove odor and/or bacteria from pumped air used to collect urine and fecal waste products. For instance, filter may be designed to effectively fill the volume that was previously considered wasted surrounding the transport tube of a waste management system. The concentric split flow filter may be configured to split the air flow, with substantially half of the air flow to be treated traveling through a first bed of filter media and substantially the other half of the air flow to be treated traveling through the second bed of filter media. This split flow design reduces the air velocity by 50%. In this way, the pressure drop of filter may be reduced by as much as a factor of 4 as compare to the conventional design.

Abstract: The present invention is directed to a Continuous Positive Airway Pressure Device as an apparatus configured to provide positive airway pressure in a respiratory circuit that comprises a container configured to be filled to a preselected level with liquids; a drop tube assembly comprising a hollow gas tube rotatably mounted in said container having an upper end extending a static distance outwardly of the container and connected to a respiratory circuit downstream of a user, and a hollow drop tube reciprocally movable upwardly and downwardly in the liquid in response to rotational movement of the gas tube. The container is provided with a gas vent and a liquid fill port.

Abstract: A vapor inhalation device includes a first body portion defining a first chamber and a second body portion defining a second chamber provided at least partially within the first chamber, where the second body portion has at least one aperture placing the second chamber in fluid communication with the first chamber. An intake conduit defines a first air passageway from an exterior of the first body portion to within the second chamber. An output conduit has a proximal end located within the first chamber, a distal end opposite the proximal end and located at the exterior of the first body portion, is physically coupled to the first body portion at a location different from the proximal end of the output conduit, and defines a second air passageway extending from within the first chamber to the exterior of the body portion.

Abstract: A simulated smoking device (1) comprising a simulated cigarette having a substantially cylindrical cigarette-like shape and a refill device (2, 50) having a substantially cuboid housing with a cigarette pack-like shape containing refill gas (32, 59) for the simulated cigarette and having means for selectively retaining the simulated cigarette. The simulated cigarette may be retained wholly within the housing. It may be retained at a location different from the refill location. A dose counter may be provided to give a visual indication of the doses in the refill device.

Abstract: Methods of generating oxygen (O2) are described in which ferrate(VI) is combined with an acid.

Abstract: Disclosed herein is an anesthetic vaporizer comprising a refrigeration system configured to cool a liquid anesthetic to less than 0° C. and to the anesthetic's temperature of minimal alveolar concentration. Further disclosed are methods of administering a liquid anesthetic comprising cooling the liquid anesthetic to less than 0° C. and to the anesthetic's temperature of minimal alveolar concentration.

Abstract: A gas mist inhaler includes a gas supply device for supplying a gas containing oxygen, carbon dioxide, or a mixed gas of oxygen and carbon dioxide, a gas mist generation device connected to the gas supply device for storing a liquid inside thereof and generating a gas mist prepared by pulverizing and dissolving the liquid stored in the gas mist generation device and the gas supplied from the gas supply device, and an inhalation member connected to the gas mist generation device and containing an inhalation port of inhaling the gas mist into a living organism.

Abstract: A personal vapor inhaling unit is disclosed. An electronic flameless vapor inhaler unit that may simulate a cigarette has a cavity that receives a cartridge in the distal end of the inhaler unit. The cartridge brings a substance to be vaporized in contact with a wick. When the unit is activated, and the user provides suction, the substance to be vaporized is drawn out of the cartridge, through the wick, and is atomized by the wick into a cavity containing a heating element. The heating element vaporizes the atomized substance. The vapors then continue to be pulled by the user through a mouthpiece and mouthpiece cover where they may be inhaled.

Abstract: A drug delivery device is disclosed which produces aerosolized particles of pharmaceutically active drug for delivery to a patient by inhalation. The device includes a liquid feeding source such as a channel to which formulation is added at one end and expelled through an exit opening. The feeding channel is surrounded by a pressurized chamber into which gas is fed and out of which gas is expelled from an opening. The opening from which the gas is expelled is positioned directly in front of the flow path of liquid expelled from the feeding channel. Various parameters are adjusted so that pressurized gas surrounds liquid flowing out of the feeding channel in a manner so as to maintain a stable capillary microjet of liquid until the liquid exits the pressure chamber opening and is aerosolized into particles having a uniform diameter in the range of about 1 to 5 microns.

Abstract: An inhaler (1) is proposed (see FIG. 1), for the inhalation of a formulation (2) from capsules (3) that each contain one dose of the formulation. The capsules are preferably each emptied in a capsule chamber (4) by being set in motion by a stream of air flowing through the capsule chamber. The stream of air can be generated by the inhalation of a user or patient and/or can be generated actively generated by the inhaler. For simple handling, the inhaler has a means for, in particular, automatic filling, emptying and/or cleaning of the capsule chamber, if the latter is used more than once. Alternatively, the inhaler has a large number of capsule chambers that each preferably already contain a capsule and re preferably used just once.

Abstract: Actuator for an inhaler for delivering medicament by inhalation. The actuator comprises a main body comprising a tubular member for receiving a canister containing medicament and having a valve stem extending therefrom, and an outlet assembly, as a part formed separately of the main body, comprising a mouthpiece for guiding medicament to the mouth of a user and a nozzle block for receiving the valve stem of the canister and delivering medicament from the canister into the mouthpiece. At least a part of the outlet assembly is configured so as to deform and optionally break on withdrawal of the outlet assembly from the main body so as to prevent re-use of the outlet assembly.

Abstract: A blister pack for use with inhalation therapy inhalers comprises an elongate bottom element having an overlying top element defining a plurality of spaced top crowned areas containing powder or liquid medications or drugs.

Abstract: Methods and devices for creating a supersaturated liquid solution having dissolved gas with hyperbaric partial pressures and aerosolizing the supersaturated solution via a nebulizer. High partial pressures of the dissolved gas may be maintained before, during, and after the aerosolization process. Thus, the hyperbaric partial pressures may be retained in the aerosol particles even after the particles are exposed to ambient barometric pressure. The aerosolized particles may be inhaled to improve oxygenation and blood flow to the lung or alternatively, the aerosolized particles can be topically applied to accelerate wound healing. Nebulizers may produce aerosol particles in some embodiments have mass median aerodynamic diameters of between about 0.25 and about 5 microns, thereby allowing sufficient deposition in the lung parenchyma, proximal to alveoli.

Abstract: A device and a process for the heating and humidification of gas, especially respiratory gas. Fluid from a fluid reservoir is supplied to a sprinkling type chamber where, for the purpose of humidification, it is moved through the gas. The point is that the fluid is heated by a temperature controlled heater to a preset temperature. In addition to the description of the device, a description of the process underlying the operation of the device is described.

Abstract: The present invention prevents liquid droplets from colliding with each other and prevents changes in the liquid droplet size, and prevents degeneration of medicinal solutions from occurring in the center portion where the flow rate of the airflow is maximum inside the airflow path. Inside an inhalation flow path of a flow path mouthpiece unit having a mouthpiece at one end, a cylindrical structure is disposed, and the cross-section of the inhalation flow path is made ring-shaped. The surface of the structure is provided with medicine ejection portions, and the medicinal liquids are supplied from a reservoir provided inside the structure. Even when the medicine ejection portions are simultaneously driven, this structure prevents the liquid droplets from colliding with each other to change the liquid droplet size and the like.

Abstract: The invention concerns an apparatus for supplying a respiratory gas, a humidifying apparatus, a respiratory gas tube and a connecting apparatus therefor. The apparatus of the invention includes a blowing device for delivering the respiratory gas, a housing device which has a bottom region, a top surface region and a side region extending upwardly between the top surface region and the cover region, as well as a connecting device for connecting a humidifying apparatus for humidifying the respiratory gas, wherein the connecting device is arranged in the side region of the apparatus in such a way that the humidifying apparatus can be laterally coupled thereto. The humidifying apparatus according to the invention is distinguished by a partial amount discharge device for passing a partial amount of the liquid pre-stored in a liquid storage space into a humidifying region.

Abstract: A nebulizer includes a piezoelectric transducer for aerosolizing a drug solution in a disposable cup module disposed above the transducer. Acoustic waves generated by the transducer propagate sequentially through transmitting medium, a first barrier, coupling medium, and a second barrier that forms part of the cup module, and into the interior of the cup module. The transducer at least partially comprises silver. The silver fluidly contacts the transmitting medium to discourage bacteria growth in the transmitting medium. The device includes electronics components that drive the transducer and measure an electrical characteristic associated with the transducer during operation. The electronics components measure changes in the electrical characteristic to determine when the drug solution level falls below a predetermined threshold, and deactivates the device accordingly.

Abstract: Aerosol therapy device comprising a nebuliser (10) for generating an aerosol and forming an aerosol flow, a first nosepiece (11) for introducing the aerosol flow into one of the two nostrils (12) of a user, a pressure fluctuation source for generating a pressure fluctuation (DS), a second nosepiece (14) for introducing the pressure fluctuation into the other of the two nostrils (15) of the user in order to superimpose the pressure fluctuation and the aerosol flow, and a sensor system comprising a first pressure sensor (19) for detecting the signal of the pressure fluctuation that arrives at the first nosepiece (11), and an evaluation means (18) that concludes the degree of closure of the velum of the user based on the signal.

Abstract: A nebulizer includes a receptacle for containing a liquid, a liquid-drawing tube, and a hollow cover including a partition plate dividing an interior of the cover into first and second chambers, first and second conduits each having an inlet end adapted to be connected to a compressed gas supply tube, and an outlet end communicated with the first chamber, and a mist output tube communicating fluidly with the second chamber. A nebulizing unit is connected to the outlet end of the first conduit and the liquid-drawing tube for directing a first compressed gas from the first conduit to the liquid exiting from the tube to convert the liquid into a mist. The second conduit introduces into the first chamber a second compressed gas which entrains the mist when flowing to the second chamber and exiting through the mist output tube.

Abstract: Containers for incrementally dispensing pressurized contents are described. The containers comprise a vessel suited to contain pressurized contents, a port integral with the vessel and through which pressurized contents contained in the vessel can be released from the vessel, preferably incrementally in approximately equal amounts, and a measuring device disposed in or otherwise associated with the vessel such that the quantity or amount of contents in the vessel can be measured or assessed. The measuring device senses ambient conditions in the vessel and, directly or with other components, indicates, for example, the amount of pressurized contents remaining in the vessel and displaying it to an observer. Devices for incrementally dispensing pressurized contents from such containers are also described.

Abstract: The device and a process for the heating and humidification of gas, especially respiratory gas. Fluid from a fluid reservoir is supplied to a sprinkling type chamber where, for the purpose of humidification, it is moved through the gas. The point is that the fluid is heated by a temperature controlled heater to a preset temperature. In addition to the description of the device, a description of the process underlying the operation of the device is described.

Abstract: A blister pack for use with inhalation therapy inhalers comprises an elongate bottom element having an overlying top element defining a plurality of spaced top crowned areas containing powder or liquid medications or drugs.

Abstract: A nebulizer for efficiently and reliably delivering aerosolized fluid to an inhaling patient is disclosed. The nebulizer includes a fixed diverter and a movable fluid orifice or fluid pathway connected with an actuator for responding to an inhalation or a manual actuation and beginning the nebulization process. Also provided is a method of providing nebulization including the steps of moving a fluid orifice or fluid pathway connected to an actuator so that the fluid orifice or fluid pathway reaches a nebulizing position during inhalation.

Abstract: A medical breathing assistance apparatus (20) for supplying pressurised gases to a patient is disclosed. The breathing assistance apparatus (20) comprises a heating chamber (29) and a pressure chamber (27) both adapted to contain water, and at least one pressure adjusting means (24,25,26). The pressure chamber (27) is connected to the heating chamber (29) and the pressure adjusting means (24,25,26) is located between the heating chamber (29) and a gases supplying means (23) supplying gas to both the pressure chamber (27) and heating chamber (29). The pressure adjusting means (24,25,26) is adapted to convert pressurised gases from the gases supply means (23) to two different pressures, one to each of the heating chamber (29) and the pressure chamber (27), so that water flows from said pressure chamber (27) to the heating chamber (29).

Abstract: Containers for incrementally dispensing pressurized contents are described. The containers comprise a vessel suited to contain pressurized contents, a port integral with the vessel and through which pressurized contents contained in the vessel can be released from the vessel, preferably incrementally in approximately equal amounts, and a measuring device disposed in the vessel. The measuring device senses ambient conditions in the vessel and, directly or with other components, indicates, for example, the amount of pressurized contents remaining in the vessel and displaying it to an observer; methods for comparing the amount of contents actually released from the vessel compared to a theoretical constant; and methods for time logging (alone or in conjunction with the logging of other data) the actuation of the dispensing valve for comparison to a prescribed method. Devices (including metered dose inhalers) for incrementally dispensing pressurized contents from such containers are also described.

Abstract: A dosing device with an electromechanical interface is provided. The dosing device includes delivery means, a medium reservoir and an applicator, on the one hand, and a control unit and electrical energy store, on the other hand, in separate structural units. Guide means are provided for fitting one of the structural units into the other structural unit. The guide means has an electromechanical interface for coupling and/or uncoupling relative to the control unit and/or energy store without using tools.