Abstract: A microfluidic dispenser device of inhalable substances includes a casing, housed in which are a driving circuit and a microfluidic cartridge having a tank that contains a liquid to be delivered. The microfluidic cartridge is provided with at least one nebulizer controlled by the driving device. The nebulizer includes: a substrate; a plurality of chambers formed on the substrate and fluidically coupled to the tank for receiving the liquid to be delivered; and a plurality of heaters, which are formed on the substrate in positions corresponding to respective chambers, are thermally coupled to the respective chambers and are separated from the respective chambers by an insulating layer, and are controlled by the driving device. Each chamber is fluidically connected with the outside by at least one respective nozzle.

Abstract: An apparatus such as a fluid mixer, suitable for use with a respirator, including a venturi nozzle for flow of a pressure-controlled fluid; an ambient fluid aperture in fluid communication with the venturi nozzle; a fluid port; a pressure force multiplier in fluid communication with the fluid port; and a valve moveable relative to the venturi nozzle between a start flow position and a stop flow position; where the pressure force multiplier is configured such that fluid forced into the fluid port actuates the valve relative to the venturi nozzle; and where the pressure force multiplier is configured such that fluid withdrawn from the fluid port actuates the valve relative to the venturi nozzle. An attachment device, connector, and method of using an apparatus suitable for a ventilator is also disclosed.

Abstract: The invention relates to a liquid reservoir/wick portion and to an electronic smoking device comprising a liquid reservoir/wick portion. In order to avoid different liquids undesirably mixing in a wick of the electronic smoking device, the liquid reservoir/wick portion comprises a wick. The wick comprising a liquid receiving side coupled to a liquid storage volume of the liquid reservoir/wick portion, and a liquid supply side coupled to an atomizing element of the electronic smoking device.

Abstract: A dental syringe tip system for attachment to a dental syringe. The dental syringe tip system can include components such as an outer core, an inner core, and a carrier which can be combined in a multitude of combinations to achieve different fluid flow characteristics, such as discharge pressure and discharge pattern, through the dental syringe tip. The outer core and inner core can have passages designed to modify fluid flow characteristics. In addition, the outer core and inner core can have additional connectors for receiving fluids from sources other than a dental syringe. Some or all of the components can be separate to be assembled by a manufacturer or an end-user. Assembly of multiple components can be facilitated by retention features located on the components.

Abstract: An electronic pipe includes a battery, an electronic module, a combustible material reservoir, and a heating element inside the combustible material reservoir. The pipe transmits an electric current from the battery to the heating element and the heating element is design to initiate a combustion reaction in the combustible material reservoir, at least partially combusting the combustible material for inhalation purposes.

Abstract: It is provided an electronic smoking device (1) with a housing (2) including an atomizer (6) and a liquid reservoir (4). The atomizer (6) comprises a heating wire (8) and at least a first contact finger (9) adapted to supply a first electrical potential to the heating wire (8). The first contact finger (9) is adapted to contact the heating wire (8) at a plurality of different contact portions (P1, P2, P3, P4) thereby altering the heating characteristics of the atomizer (6) which vaporizes liquid (5) supplied from the reservoir (4) to generate an aerosol (7).

Abstract: The present disclosure provides an aerosol generator and an aerosol inhaling device which are capable of regulating easily the flavor of an aerosol inhaled by a user. The aerosol generator includes two chambers configured for generating an aerosol, an air outlet passage, a first branch and a second branch. The two chambers both define an air inlet and an air outlet. The first branch and the second branch are in communication with one of the two air outlets respectively. Airflows in the first and second branches are converged in the air outlet passage before being expelled. At least one of the first and second branches has provided thereon a regulating switch configured for regulating a rate of an airflow passing through the branch, the regulating switch being capable of rotating around a shaft under an external force to control an airflow passing through the first branch or second branch.

Abstract: An automatic detection system is provided for detecting disruptions in the flow of liquid from a liquid container or containers to a dispensing apparatus. Two embodiments of the system are disclosed. In the first embodiment, a single liquid container is utilized. In the second embodiment, two liquid containers are utilized. In both embodiments, an optical sensor is employed to detect a disruption in the flow of liquid from the liquid containers to the dispensing apparatus.

Abstract: An electronic cigarette vaporizer includes a heating element, an air pressure sensor and a microcontroller; the microcontroller stores, processes or determines the extent of each inhalation using signals from the air pressure sensor. The microcontroller can calculate the approximate e-liquid consumption from the extent of each inhalation or provide data that enables an external processor to calculate approximate e-liquid consumption. The extent of an inhalation is a function of one or more of: duration; peak flow rate; average flow rate.

Abstract: An assembly for nasal irrigation for the handheld irrigation of a user's nasal cavity comprising a housing with a refill chamber containing irrigating fluid, an applicator, an actuator for forcing irrigating fluid from the refill chamber through the applicator into the user's nasal cavity during operation, and a solution port for refilling the refill chamber. Some embodiments of the present invention may further comprise a system for nasal irrigation that includes the assembly for nasal irrigation or handheld irrigator, as well as a solution assembly structured for dispensing irrigating fluid to the handheld irrigator, a docking station for removably housing the handheld irrigator, a solution assembly and a refill control, including a check valve.

Abstract: An electronic cigarette vaporizer includes a heating element, an air pressure sensor and a microcontroller; the microcontroller stores, processes or determines the extent of each inhalation using signals from the air pressure sensor. The microcontroller can calculate the approximate e-liquid consumption from the extent of each inhalation or provide data that enables an external processor to calculate approximate e-liquid consumption. The extent of an inhalation is a function of one or more of: duration; peak flow rate; average flow rate.

Abstract: A dual chamber nebulizer apparatus for atomizing and administering a first and second liquid medicine includes a housing having first and second chambers for holding the first and second liquid medicines. An atomizer member is situated in the housing and configured to atomize liquid into vapor. An air flow member is coupled to the housing and in fluid communication with the atomizer, the flow member having an inlet port for receiving a compressed air flow to the atomizer member. First and second aspiration tubes are in communication with the atomizer member and extend into first and second chambers, respectively. The atomizer member includes a junction in communication with the first and second aspiration tubes, the valve selectively allowing both of the liquid medicines to be drawn through respective aspiration tubes and directed to the atomizer member when the compressed airflow is directed to the atomizer member.

Abstract: An electronic cigarette vaporizer that includes an IMU (inertial measurement unit). The IMU enables the vaporizer to detect when it is being lifted up and out of a case in which it has been stored so that it can change state. The change of state can be to turn on and to start heating an atomizing element. Data from the IMU may also enable the vaporizer to tell if it is not being used and so can power down.

Abstract: An electronic cigarette vaporizer system includes a case and a vaporizer that is stored in the case; the system includes a non-contact sensor that detects release or withdrawal of the vaporizer from the case. When withdrawal of the vaporizer is detected, then the vaporizer electronic circuitry changes state, e.g. to a ready mode, or a pre-heating mode in which an inhalation detector is activated or to a heating mode, where an atomizing unit in the vaporizer is at least partly activated so that the vaporizer is fully heated when the first inhalation is taken.

Abstract: An electronic cigarette vaporizer that includes a heating element, a power source and an electronics module that manages the delivery of power, current or voltage to the heating element; the electronics module controls or delivers pulses of power, current or voltage to the heating element, such as PWM (pulse width modulation) with a high frequency 1-10 KHz switching frequency. The duty cycle of the PWM can be approximately 90% when heating; and 1-10% duty during a preheat; and 0% when the vaporizer is idle.

Abstract: An electronic pipe includes a first pipe section having an electronic module and a first connector element that communicates with the electronic module. A second pipe section is attached to the first pipe section, the second pipe section including a combustible material reservoir having a passageway that communicates with a mouthpiece receiver, with an aperture located on a surface of the second pipe section, the aperture communicating with the combustible material reservoir so that a fluid exterior to the electronic pipe can pass into the aperture, through the combustible material reservoir and into the passageway that communicates with the mouthpiece receiver and a second connector element coupled to the first connector element, with both connector elements structured to transmit an electric current from the battery to a laser diode or induction coil heat source located within the combustible material reservoir.

Abstract: An electronic pipe includes a first pipe section having an electronic module and a first connector element that communicates with the electronic module. A second pipe section is structured to be removeably attachable to the first pipe section, the second pipe section including a combustible material reservoir having a passageway that communicates with a mouthpiece receiver, with an aperture located on a surface of the second pipe section, the aperture communicating with the combustible material reservoir so that a fluid exterior to the electronic pipe can pass into the aperture, through the combustible material reservoir and into the passageway that communicates with the mouthpiece receiver and a second connector element structured to removeably couple to the first connector element, with both connector elements structured to transmit an electric current from the battery to a heating element located within the combustible material reservoir.

Abstract: A signaling apparatus for an anesthesia machine, the signaling apparatus comprising an user input sub-module for receiving input information from an user, an available gas sub-module for signaling types of currently available gases according to information of the user input sub-module, and an available gas outlet sub-module for signaling currently available gas outlets according to information of the user input sub-module.

Abstract: An autoinjector having a body (1010; 2010) receiving a reservoir, a piston, a needle, an actuating 5 sleeve (1011;2011) having a contact end to contact the body of the user and displaceable relative to the body between projected positions, in which the actuating sleeve at least partially projects out of the body receiving a reservoir, and an actuation position, in which the actuating sleeve is axially displaced towards the interior of the body receiving a reservoir. The actuating sleeve is in a first projected position prior to actuation of the autoinjector and in a second projected position after actuation of the autoinjector. The actuating sleeve or the body receives a reservoir having a flexible tab adapted to deform laterally relative to the actuating sleeve and/or relative to the body receiving a reservoir when the actuating sleeve is displaced from its first projected position towards its actuation position then from its return actuation position towards its second projected position.

Abstract: A device for dispensing individual doses of powder from respective pockets of a disc-shaped carrier by outwardly rupturing a lidding foil by means of pressure on an opposite side surface, the device providing individual respective deaggregation flow paths for each pocket, split airstreams allowing improved entrainment of powder, a cam mechanism for outwardly rupturing the pockets, an indexing mechanism linked to the cam mechanism and a dose counter.

Abstract: Processes and devices for delivering a fluid by chemical reaction are disclosed. A chemical reaction is initiated in a reaction chamber to produce a gas, and the gas acts upon a piston to deliver the fluid. Preferred devices typically include an upper chamber, a lower chamber, a fluid chamber, a piston between the lower chamber and the fluid chamber, and a barrier between the upper chamber and the lower chamber. When the barrier is broken, reagents in the upper chamber and the lower chamber are mixed together to generate the gas.

Abstract: A method and system for optimizing the dispensing of aerosol medicaments by “pulsing” a total dose volume as a series of shorter, low volume bursts is described. Aerosol performance when metering at a low volume e.g. <10 ?L is enhanced by an increase in the fine particle fraction, particularly when pulsing a dose to achieve a high total dose volume. By utilising a solenoid valve, the system can deliver a medicament in a single low volume pulse; or in multiple low volume pulses. Performance can be tailored to obtain a preferred fine particle dose and fraction. By manipulating the solenoid valve timings, a single formulation with a concentration X may be used to provide a range of doses. A minimum interval between pulses to achieve separate “non-interacting” plumes which allow keeping total inhalation time comparable to a conventional single dose MDI actuation is also described.

Abstract: A medical apparatus is provided with a housing; a mixer including a gas reservoir; a water unit for flowing water to the mixer; a gas unit for flowing gas to the gas reservoir; a gas output for flowing gas from the gas reservoir to the mixer so that gas is mixed with water to form a first mixture, a line for carrying the first mixture; a valve disposed downstream of the line; Venturi tubes disposed downstream of the valve; medication units for containing liquid medication, each medication unit being in fluid communication with the corresponding Venturi tube; a mixing device disposed downstream of the Venturi tubes to atomize the liquid medication and the first mixture to form a second mixture; a control panel electrically connected to the gas reservoir, the mixer, the valve, the medication units, and the mixing device respectively; and an outlet.

Abstract: Systems and methods are provided for humidifying ventilation gas. Systems and methods may include a nasal interface apparatus for receiving ventilation gas from gas delivery tubing and for humidifying ventilation gas. The nasal interface apparatus may have one or more channels within the nasal interface to deliver gas from a gas delivery circuit to a patient's nose; one or more structures in fluid communication with the one or more channels to direct ventilation gas to the patient's nose; and a hygroscopic material within the nasal interface in the flow path of the ventilation gas.

Abstract: The present invention prevents liquid droplets from colliding with each other and prevents changes in the liquid droplet size, and prevents degeneration of medicinal solutions from occurring in the center portion where the flow rate of the airflow is maximum inside the airflow path. Inside an inhalation flow path of a flow path mouthpiece unit having a mouthpiece at one end, a cylindrical structure is disposed, and the cross-section of the inhalation flow path is made ring-shaped. The surface of the structure is provided with medicine ejection portions, and the medicinal liquids are supplied from a reservoir provided inside the structure. Even when the medicine ejection portions are simultaneously driven, this structure prevents the liquid droplets from colliding with each other to change the liquid droplet size and the like.

Abstract: A device (1) for delivering mist to the human face is capable of targeting different kinds of mist to different zones of the human face. To this end, the device (1) comprises different nozzle sets, wherein each of the different nozzle sets serves for letting out a different kind of mist, and wherein each of the different nozzle sets is positioned in a zone (7, 10) of the device (1) corresponding to a zone of the human face to be treated by means of the mist delivered by the nozzle set concerned during operation of the device (1). By having an appropriate number and positioning of the nozzles (2, 3, 4, 5), facial zones can be treated separately, wherein it is possible to realize optimal skin treatment per facial zone.

Abstract: Dispensing apparatus for delivering metered doses of product from a pressurized dispensing container, having a housing for receiving, in use, the pressurized dispensing container, and an outlet through which, in use, metered doses of product from the pressurized dispensing container can be dispensed. The housing has an aperture via which the pressurized dispensing container can be inserted into the housing. The dispensing apparatus is at least partially enclosed by a shrink wrapped film, the shrink wrapped film including an opening which is: (a) at least partly aligned with the aperture of the housing; and (b) dimensioned so as to allow, in use, said pressurized dispensing container to pass through the opening in order to be inserted into the housing via the aperture.

Abstract: The present invention is directed to devices, systems, and methods for monitoring inhaled drug usage to predict when an acute attack or exacerbation of a disease, such as a respiratory disease, is imminent. Instrumented inhalers that use modular designs with standard components are disclosed, as are systems for monitoring the instrumented inhalers. Also disclosed are methods for determining whether or not a patient's inhaled drug usage pattern indicates that an acute attack or disease exacerbation is imminent, and notifying appropriate medical personnel of any usage patterns indicative of an attack or disease exacerbation. If such an attack or exacerbation is imminent, additional therapeutic agents may be dispensed to the patient or other interventions made.

Abstract: Pharmaceutically engineered aerosols (e.g. submicrometer and nano-particles and droplets) containing a hygroscopic growth excipient or agent are employed to improve the delivery of respiratory aerosols to the lung. Inclusion of the hygroscopic agent results in near zero depositional loss in the nose-mouth-throat regions and near 100% deposition of the aerosol in the lung. Targeting of the aerosol to specific lung depths is also possible. In addition, methods and apparatuses for delivering aerosols to the lung are provided. The aerosol is delivered to one nostril of a patient while a relatively high humidity gaseous carrier is delivered to the other nostril, resulting in post-nasopharyngeal growth of the aerosol to a size that promotes deposition in the lung.

Abstract: A fluid dispenser device comprising: a reservoir (1) of fluid to be dispensed; a dispenser member (2), such as a pump or a valve, mounted on said reservoir (1); and a body (3) that is suitable for receiving said reservoir (1), said body (3) being provided with a dispenser orifice and an opening (310) through which said reservoir (1) can be inserted into the body (3), said reservoir (1) being displaceable in said body (3) between a rest position and a dispensing position, said reservoir (1) being removable from said body (3); said reservoir (1) and said body (3) including respective ID means (10, 11) that make it possible to associate said reservoir (1) with said body (3).

Abstract: Containers for incrementally dispensing pressurized contents are described. The containers comprise a vessel suited to contain pressurized contents, a port integral with the vessel and through which pressurized contents contained in the vessel can be released from the vessel, preferably incrementally in approximately equal amounts, and a measuring device disposed in or otherwise associated with the vessel such that the quantity or amount of contents in the vessel can be measured or assessed. The measuring device senses ambient conditions in the vessel and, directly or with other components, indicates, for example, the amount of pressurized contents remaining in the vessel and displaying it to an observer. Devices for incrementally dispensing pressurized contents from such containers are also described.

Abstract: A conventional respiratory nebulizer has an emergency medication dose storage system delivering the stored medication dose directly to the nebulizing chamber with a single impulse of manual force to a simple mechanical delivery system, thereby making the nebulizer useable in two steps: (a) opening the medication capsule with a simple opening action; and (b) inhaling the nebulized medication. The nebulizer can be operated without disassembling the nebulizer housing so as to expose the nebulizing chamber and without manually opening the liquid medication container and, without spillage and without manual pouring of the liquid medication directly into the nebulizing chamber, and without reassembling the nebulizer housing before positioning the inhaler mouthpiece in the mouth so as to inhale the nebulized medication. The delivery system includes a pressure burstable seal at one end of the capsule, which is burst by the application of force against the opposite end of the capsule.

Abstract: A conventional respiratory nebulizer has an emergency medication dose storage system delivering the stored medication dose directly to the nebulizing chamber with a single impulse of manual force to a simple mechanical delivery system, thereby making the nebulizer useable in two steps: (a) opening the medication capsule with a simple opening action; and (b) inhaling the nebulized medication. The nebulizer can be operated without disassembling the nebulizer housing so as to expose the nebulizing chamber and without manually opening the liquid medication container and, without spillage and without manual pouring of the liquid medication directly into the nebulizing chamber, and without reassembling the nebulizer housing before positioning the inhaler mouthpiece in the mouth so as to inhale the nebulized medication. The delivery system includes a pressure burstable seal at one end of the capsule, which is burst by the application of force against the opposite end of the capsule.

Abstract: A spray or injection device that includes a casing or a pusher that includes at least one tab radially moveable between a first radial position, in which the tab does not impede the movement of the pusher with respect to the casing, and a second radial position in which the tab opposes movement of the pusher. The pusher or the casing, respectively, includes at least one ramp-shaped projection configured to bring the tab into the second radial position and then allow it to return to the first radial position. The pusher or the casing further includes at least one stop between the pusher and casing to delineate the end of a first stroke corresponding to a first dose of medicament, and the beginning of a second stroke corresponding to a second dose of medicament.

Abstract: Containers for incrementally dispensing pressurized contents are described. The containers comprise a vessel suited to contain pressurized contents, a port integral with the vessel and through which pressurized contents contained in the vessel can be released from the vessel, preferably incrementally in approximately equal amounts, and a measuring device disposed in the vessel. The measuring device senses ambient conditions in the vessel and, directly or with other components, indicates, for example, the amount of pressurized contents remaining in the vessel and displaying it to an observer; methods for comparing the amount of contents actually released from the vessel compared to a theoretical constant; and methods for time logging (alone or in conjunction with the logging of other data) the actuation of the dispensing valve for comparison to a prescribed method. Devices (including metered dose inhalers) for incrementally dispensing pressurized contents from such containers are also described.

Abstract: A spray or injection device that includes a casing or a pusher that includes at least one tab radially moveable between a first radial position, in which the tab does not impede the movement of the pusher with respect to the casing, and a second radial position in which the tab opposes movement of the pusher. The pusher or the casing, respectively, includes at least one ramp-shaped projection configured to bring the tab into the second radial position and then allow it to return to the first radial position. The pusher or the casing further includes at least one stop between the pusher and casing to delineate the end of a first stroke corresponding to a first dose of medicament, and the beginning of a second stroke corresponding to a second dose of medicament.

Abstract: An ejection apparatus for ejecting droplets of liquid includes a loading portion, a reader, and a judging unit. The loading portion detachably loads therein a liquid cartridge container for containing liquid, and a liquid ejection cartridge having an ejecting portion for ejecting liquid separately, or as a combined kit. The reader reads information attached to at least one of the liquid cartridge container and the liquid ejection cartridge. The judging unit judges, based on the information read by the reader, whether each of the liquid cartridge container and the liquid ejection cartridge loaded in the loading portion is appropriate, or whether a combination of the liquid cartridge container and the liquid ejection cartridge is a predetermined combination. The ejection apparatus allows a user to relatively readily and accurately carry out ejection of appropriate liquid by an appropriate ejection unit.

Abstract: An improved nebulizer places a venturi in close proximity to or inside a patient's oral cavity. One or more medicine feed lines feeds the medicine to a location proximate to a venturi. A plurality of medicines may be administered simultaneously to the patient, with preferably each medicine vial being shape-keyed to a medicine receiver of corresponding shape. The medicine vial or vials may contain a standard unit dose of medication. A portable gas canister can be utilized to supply air pressure to the venturi when a press open release closed type valve is actuated.

Abstract: A spray or injection device that includes a casing or a pusher that includes at least one tab configured to move radially between a first radial position in which the tab does not impede the movement of the pusher with respect to the casing, and a second radial position in which the tab opposes movement of the pusher. The tab includes an opening. The pusher or the casing, respectively, includes at least one ramp-shaped projection configured to bring the tab into the second radial position then to penetrate the opening thereby allowing the tab to return to the first radial position. The pusher or the casing, respectively, further includes at least one stop region against which the tab abuts when the tab is brought into the second radial position by the projection. The stop region occurring just before the projection being opposite the opening.

Abstract: Disclosed is an absorbent article including a temperature change member for providing a cooling effect. The temperature change member includes a matrix of fibers and temperature change material intermixed within the matrix of fibers. The temperature change material includes erythritol.

Abstract: A liquid ejection device, includes: a plurality of storing parts for storing liquids; a plurality of liquid-feeding parts connected to the respective storing parts; a ejection part for ejecting a liquid; a plurality of flow paths connected to the plurality of liquid-feeding parts, respectively; and a connection part for joining the plurality of flow paths and connecting them as a single flow path to the ejection part. The plurality of liquid-feeding parts are actuated to mix the liquids from the plurality of storing parts in the single flow path joined at the connection part and feed a mixture of the liquids to the ejection part to eject the mixture from the ejection part. According to the ejection device of the present invention, the ejection amount or the mixing ratio can be easily changed in a comparatively precise manner.

Abstract: An inhalation device configured to programmably emit small droplets of multiple components in which quantities of the multiple components can vary with each successive activation of the inhalation device.

Abstract: The concentration of xenon, in a medical gas mixture of xenon as an active component with a known composition of oxygen and, optionally, nitrogen and/or helium recirculating through a medical device (103) in which carbon dioxide is introduced into the mixture, is monitored by removal (135, 133) of carbon dioxide downstream of the medical device (103) and subsequently passing the carbon dioxide-free gas through an ultrasonic gas analyser (143) upstream of the medical device. The gas analyzer determines the xenon concentration by measuring the time delay between transmission of an ultrahigh frequency ultrasonic pulse of at least 100 kHz axially through the sample chamber from a location at one end thereof and reflection of said pulse axially from the other end of the sample chamber back to said location. An analyser of novel construction is disclosed.

Abstract: A metered dose inhaler for use with a removable pressurized aerosol canister, or reservoir, having a display for indicating to a user the state of the canister. A memory device on the canister or a housing which houses the canister stores information indicative of doses dispensed from, or remaining in, the canister. That information is processed to provide and display information representative of the state of the canister.

Abstract: A medicine ejection apparatus ejecting a plurality of medicines contained in a plurality of reservoirs includes a medicine identification section that identifies the medicines. A decision section is also provided to decide an ejection order in which the medicines are ejected, according to the combination of the identified medicines. In a medicine ejection section, the medicines are ejected in the ejection order decided by the decision section.

Abstract: A fluid dispenser device having a body (1), a fluid reservoir (3) containing two half-doses, a dispensing mechanism that dispenses a half-dose of fluid upon actuation, and an energy accumulation mechanism (50, 51, 55) that accumulates energy in the hand of the user and released suddenly so that each of the half-doses is dispensed in full. The dispensing mechanism includes a dispensing member (8) mounted to slide in the reservoir (3) for dispensing the fluid, an actuating element (5) mounted to move between a rest position and an actuating position and on which the user exerts an actuating force to move the dispensing member (8) inside said reservoir (3). The actuating element is mounted to move in a direction substantially transverse to the direction in which the dispensing member (8) moves, and a dose-splitting mechanism (7, 12) dispenses a half-dose of fluid each time the dispensing mechanism is actuated.

Abstract: A method for crystallizing a substance, especially an inhalable medicament, comprising the following steps: (a) dissolving said substance in a solvent, to produce a solution of said substance, (b) producing a segmented stream which consists of alternating segments of said solution of the substance and of a transport medium, (c) introducing said segmented stream into the first end of a retention stretch, which retention stretch has a first end and a second end, so that said segmented stream passes from said first end to said second end of said retention stretch, and exists from the second end of the retention stretch, (d) cooling the retention stretch, to thereby bring about crystallization of the substance in the segments of solution, in the segmented stream, as said segmented stream passes through the retention stretch, and (e) separating the crystals of material from the segmented stream as it exits from the second end of the retention stretch.

Abstract: Bioactive agents are topically administered or delivered to a mucous membrane by a jet dispenser using inkjet technology, such as that used in printing. The dispenser propels precise volumes of droplets or powder for administration to a subject, such as being inhaled through the mouth or nose. A controller in the dispenser may control delivery of multiple different drugs, timing of drug administration, or change drug regimens in response to a changing medical condition of a patient, such as those monitored by a sensor in communication with the controller, for example to prevent an overdose. Administration methods are also provided, along with replacement kits.

Abstract: An organizational treatment device and method for the treatment of obstructive pulmonary disease comprising both controller and rescue medications such that the need for rescue medication and consequent need for controller medication can be more certainly determined than at present.

Abstract: A method for crystallizing a substance, especially an inhalable medicament, comprising the following steps: (a) dissolving said substance in a solvent, to produce a solution of said substance, (b) producing a segmented stream which consists of alternating segments of said solution of the substance and of a transport medium, (c) introducing said segmented stream into the first end of a retention stretch, which retention stretch has a first end and a second end, so that said segmented stream passes from said first end to said second end of said retention stretch, and exits from the second end of the retention stretch, (d) cooling the retention stretch, to thereby bring about crystallization of the substance in the segments of solution, in the segmented stream, as said segmented stream passes through the retention stretch, and (e) separating the crystals of material from the segmented stream as it exits from the second end of the retention stretch.