Abstract: A computerized electro-mechanical drug delivery device configured to deliver at least one dose of two or more medicaments. The device comprises a control unit. An electro-mechanical drive unit is operably coupled to the control unit and a primary reservoir for a first medicament and a secondary reservoir for a fluid agent, e.g. a second medicament. An operator interface is in communication with the control unit. A single dispense assembly is configured for fluid communication with the primary and the secondary reservoir. Activation of the operator panel sets a first dose from the primary reservoir and based on the first dose and a therapeutic dose profile, the control unit is configured to determine a dose or range of the fluid agent. Alternatively, the control unit determines or calculates a dose or range of a third medicament. Further, a dispense interface for use with a drug delivery device is disclosed.

Abstract: Systems and methods for producing nitric oxide (NO) to be used in medical applications are provided. In some embodiments, systems and methods are provided for a NO generator that is capable of generating a desired concentration of NO to be provided to a respiratory system for inhalation by a patient.

Abstract: A method of determining a duration of safe apnoea. Information is obtained relating to a respiratory indicator, and a duration of safe apnoea is determined from the obtained information. A respiratory therapy system has one or more patient interfaces. A processor is configured to determine a duration of safe apnoea based on obtained information relating to a respiratory indicator.

Abstract: Disclosed is a device for respiration with at least one pressurized gas source for respiratory gas and a sensor unit for determination of respiratory gas pressure and/or flow rate and/or volume and a control unit. The control unit records an individual breathing pattern of a patient and from this forms an individual pressure profile for the patient which is provided by the pressurized gas source.

Abstract: Methods and system for treating obstructive sleep apnea and snoring are disclosed. The system generally comprises a mask for delivering pressurized air to patient's breathing orifice, a sensing mechanism for continuously assessing the state of patient's breathing and a pressure generator for generating the pressurized air in the mask. The pressurized air is applied to the breathing orifice only during selected portions of the breathing cycle, when such pressure might be required to prevent occlusion of the airway or to restore patency of the airway after such occlusion occurs.

Abstract: The present disclosure delineates both active as well as passive respiratory filtration systems. The respiratory filtration systems are configured to be worn by a user, providing the user protection from the ambient environment, possibly containing microorganisms, pathogens, particulate matter, and the like. The respiratory filtration system is also designed to protect others by filtering the exhalation air released into the environment by the user. The disclosed respiratory filtration system(s) includes one or more hygienic materials. The hygienic materials are carefully selected and disposed at predetermined locations within the respiratory filtration system, so to optimize user to the observer(s) communications, especially the oronasal cover. Optimized communications include the transmission of distortion-free speech and/or unobstructed view of the user's oronasal area, especially the mouth.

Abstract: This invention provides ventilators that provide superior air-oxygen mixing and gas delivery. The ventilators that supply a gas mixture to the lungs of a subject. The gas mixture comprises a first gas (e.g. oxygen) and a second gas (e.g. ambient air). The ventilators comprise a first gas inlet, a second gas inlet, flow modulator of the first gas, a flow modulator of the second gas, a junction configured to mix the first gas and the second gas, a patient interface configured to deliver the gas mixture to a subject, a pressure sensor, a plurality of flow sensors comprising at least a first flow sensor and a second flow sensor, and at least one controller configured for obtaining data from the pressure sensor and flow sensors and controlling the flow modulators to provide a gas mixture having a target pressure and a target oxygen content.

Abstract: The present disclosure generally relates to systems and methods for delivery of therapeutic gas to patients, using techniques to compensate for disruptions in breathing gas flow measurement, such as when breathing gas flow measurement is unavailable or unreliable. Such techniques include using historical breathing gas flow rate data, such as moving average flow rates, moving median flow rates and/or flow waveforms. At least some of these techniques can be used to ensure that interruption in therapeutic gas delivery is minimized or eliminated.

Abstract: Systems and methods provide respiratory therapy to a subject through a pressurized flow of breathable gas. Timing and other characteristics of pressure and flow levels provided during inhalations and exhalations are adjusted in order to increase the volumetric rate of expulsion of CO2.

Abstract: In a preferred embodiment, systems and methods for delivering oxygen to a passenger of an aircraft via an oxygen mask having one or more sensors involve analyzing blood oxygen saturation measurements from the sensor(s) to determine a current oxygen saturation level, determining the current oxygen saturation level is insufficient, and adjusting an oxygen flow rate to the mask to compensate for the current blood oxygen saturation level.

Abstract: A wearable device for comprehensive bio-monitoring of physiologic metrics to determine metabolic, pulmonary and cardiac function and oxygen saturation measurements from breathing mask apparatuses. The device non-invasively monitors the physiologic profile of the subject, and is capable of detecting physiologic changes, predicting onset of symptoms, and alerting the wearer or another person or system. In some embodiments, the device comprises both a wearable sensor suite and a portable gas composition and flow analysis system. In preferred embodiments, it comprises a miniaturized non-invasive sensor suite for detecting physiologic changes to detect dangerous breathing or other health conditions. The acquired physiologic profile is used to generate alarms or warnings based on detectable physiological changes, to adjust gas delivery to the subject, alter mission profiles, or to transfer control of the craft or other duties away from a debilitated subject.

Abstract: A method for detecting faulty operation of a gas blower driven by an electronically commutated DC motor. The DC motor of the gas blower is controlled by an integrated electronic motor control circuit. The electrical current draw, required in operation to reach a predetermined blower speed of the gas blower, is measured. It is measured as a measured variable via the electronic motor control circuit. The electronic motor control circuit performs a plausibility check of the measured electrical current draw. The measured value of the electrical current draw, at a predetermined blower speed, is compared to a current draw reference value characteristic stored in the electronic motor control circuit. Thus, a warning and/or an error code is issued by the electronic motor control circuit. The warning is based on deviation of the measured value of the electrical current draw beyond a tolerance range around the reference characteristic.

Abstract: An anesthetic vaporizer system includes a reservoir containing anesthetic agent, an agent level sensor measuring an agent level of the anesthetic agent in the reservoir, a display, and a controller. The controller is configured to receive agent level measurements from the agent level sensor over a time period, and determine the anesthetic agent is being added to the reservoir from an agent source based on the agent level measurements over the time period. A filling status is determined based on the agent level measurements and a filling status indicator is displayed based on the determined filling status.

Abstract: A photothermal absorbance detection apparatus comprises a flow cell comprising a first temperature responsive device on an input side, a second temperature responsive device on an output side, and a detection region between the first temperature responsive device and the second temperature responsive device; and a light-emitting device positioned proximate to the detection region and configured to transmit electromagnetic radiation towards the detection region; wherein the first temperature responsive device and the second temperature responsive device together measure a change in temperature of a fluid passing through the detection region.

Abstract: The disclosure provides a way to supplement the tidal volume delivered to the patient by a leaking re-breather when the delivered volume becomes less than that set by the ventilator (in either pressure-regulated or volume modes). This may be accomplished with a shunt—a gas conduit joining the non-patient side of the re-breather to the patient side. A low-resistance, plenum or a draw-over vaporizer may also be incorporated into the gas pathway. Such a device may include a housing with a movable partition separating an actuating side from a patient side. The housing includes a ventilator orifice for pneumatic communication between a ventilator and the actuating side and a patient orifice for pneumatic communication between the patient side and a patient. A shunt defines a bypass flow path from the actuating side and to the patient side when the moveable partition is at a maximal displacement towards the patient side.

Abstract: Provided herein is a method for automatically controlling inspired oxygen delivery, including: receiving signals representing a plurality of input oxygen saturation (SpO2) values for a patient; generating control values based on the input SpO2 values and a target SpO2 value; and generating output inspired oxygen concentration (FiO2) values based on the control values and reference inspired oxygen concentration (rFiO2) values; wherein the control values include: immediate control values, generated based on the input SpO2 values, the target SpO2 value, and an immediate gain coefficient; accumulation control values, generated based on the input SpO2 values, the target SpO2 value, and an accumulation gain coefficient; and predictive control values, generated based on the input SpO2 values, the target SpO2 value, and a predictive gain coefficient; wherein the immediate gain coefficient is determined based on the rFiO2 value; and wherein a non-linear compensation weighting is applied to the accumulation control val

Abstract: A temporary power distribution device for receiving and distributing electrical power from an external power supply on a temporary basis. The temporary power distribution devices can include a plurality of electrical outlets and/or electrical communication outlets and may include additional safety features for the loss of power and/or the notification of an emergency condition. The temporary power distribution device may be portable and is meant to be portable even during use.

Abstract: A device for use as part of a breathing assistance system for providing gases to a user. The device may include a fan, an enclosure for receiving a humidification chamber or both. A user interface of the device can indicate the operating mode of the device, whether a peripheral device is connected and whether a gases conduit is correctly connected to the outlet of the device. A controller in the device may hide or block options from the display of the user interface and may also initiate a power save mode when the device is powered by a battery.

Abstract: A respirator assembly comprising a face mask fitting snugly over the mouth and nose, allowing little to no air leakage; at least two flexible connecting tubes coming out of the upper front part of the mask, an inspiratory line and an expiratory line, wherein the inspiratory line is connected to a one-way valve which allows air to flow in for inspiration and closes during expiration, and the expiratory line is connected to a one-way valve which allows the air to flow out during expiration and closes during inspiration; connected to a sanitizing chamber, wherein each sanitizing chamber comprises a means of emitting ultraviolet light and a power source, wherein the sanitizing chambers have ports to the exterior which are covered by material formed of or equivalent to surgical masks.

Abstract: A method and apparatus to identify the source of oxygen delivery failure to a patient. The apparatus includes a pressure sensor to detect a patient's breathing pressure and ambient pressure, an oxygen flow analyzer to measure oxygen flow to the patient, and a processor to analyze the breathing pressure values, ambient pressure value, and oxygen flow rate values. When the oxygen flow rate value is greater than a predetermined threshold value, the processor is programmed to compare the breathing pressure values to the ambient pressure value and output an apnea alarm or an oxygen delivery device displacement alarm.

Abstract: An endotracheal tube alarm apparatus includes an inner cannula having an outer mating surface, the outer mating surface having a seated first electrical conductor, and a ventilator tube having an inner mating surface slidably coupled to the outer mating surface of the inner cannula, the inner mating surface having seated second and third electrical conductors extending circumferentially about the inner mating surface and each in complementary opposition to the first electrical conductor so that the third electrical conductor is in electrical communication with the second electrical conductor through the first electrical conductor.

Abstract: An anesthesia system has a unit for measuring oxygen concentration delivered to a patient, a unit for sending an alarm to an operator if the measured oxygen concentration is below a first threshold value, and a unit for automatically increasing a setting of oxygen in a fresh gas setting, so that the oxygen concentration delivered to a patient is increased, if the measured oxygen concentration is below a second threshold value. The system allows for increased safety or a lowered fresh gas flow with a maintained safety level.

Abstract: A system and method for delivering oxygen to a passenger of an aircraft including a a supply of oxygen, an oral-nasal mask, a controller for adjusting a flow of oxygen from the supply of oxygen to the oral-nasal mask, and a sensor for determining a user's blood oxygen saturation level, wherein the controller adjusts the flow of oxygen based on the sensor's determination of the user's blood oxygen saturation level.

Abstract: A system, apparatus and methods are provided for supplying gases to a user. The supply includes a sub-therapeutic mode and a pressure support mode for delivering therapy to a user. A flow diversion device or valve switches from a first mode corresponding with the sub-therapeutic mode of the system to a second mode corresponding with the pressure support mode of the system. In the first mode, the valve opens a larger flow path between the interior of the user interface and ambient air than in the second mode.

Abstract: This disclosure describes systems and methods for providing an optimized proportional assist breath type during ventilation of a patient. The disclosure describes a novel breath type that delivers a target airway pressure calculated based on a desired patient effort range to a triggering patient.

Abstract: A controller for controlling a breathing apparatus that comprises a plurality of oxygen sensors, each for sensing an oxygen content of a gas in the breathing apparatus, the controller being configured to control the operation of the breathing apparatus based on the output of one or more of the oxygen sensors and additional information relating to the operation of the breathing apparatus. Also a breathing apparatus comprising the controller and the plurality of oxygen sensors.

Abstract: A capnography system (100, 400), comprising: a controller (110, 410) configured to obtain a sample gas flow from a physical interface (107) for a patient (101); determine a change in a characteristic of the sample gas flow during a sampling time interval; determine whether the change in the characteristic of the sample gas flow during the sampling time interval is equal to or greater than a corresponding threshold value; determine that supplemental oxygen is provided when it is determined that the change in the characteristic of the sample gas flow is equal to or greater than the threshold value; and determine that supplemental oxygen is not provided when it is determined that the change in the characteristic of the sample gas flow is less than the threshold value.

Abstract: Systems and methods for detecting extubation of an endotracheal tube (ETT) are described. Extubation of the ETT can be identified by comparing to a threshold, a difference between a determined first volume of breathing gas during a first inspiratory period to a determined second volume of breathing gas during a second inspiratory period. If the difference exceeds the threshold, an alarm can be activated indicating extubation. Extubation detection may also be based on a difference between inspiratory pressures during separate inspiratory periods. Partial extubation and full extubation may also be discerned. Further, extubation of an ETT may be detected without the use of an exhalation flow sensor.

Abstract: A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways includes a frame member, a cushion assembly provided to the frame member, and an anterior wall member repeatedly engageable with and disengageable from the cushion assembly. The frame member includes connectors operatively attachable to a positioning and stabilizing structure. The cushion assembly includes a seal-forming structure and a void defined by an anterior surface of the cushion assembly. The anterior wall member has a predetermined surface area to seal the void of the cushion assembly and form a gas chamber when the anterior wall member and the cushion assembly are engaged. The void of the cushion assembly is sized such that the patient's nose and/or mouth is substantially exposed when the anterior wall member is disengaged from the cushion assembly thereby improving breathing comfort of the patient.

Abstract: A manual patient ventilation system includes a breathing bag manually compressed by a clinician to ventilate a patient via a patient interface device, a gas supply system supplying fresh gas to the breathing bag at a fresh gas flow rate, a pressure sensor measuring a patient airway pressure (PAW) throughout a compression and release cycle of the breathing bag by the clinician, a fresh gas controller comprising a processor, and a manual ventilation control module executable on the processor by the fresh gas controller. The manual ventilation control module includes instructions executable to receive the Paw measurements and determine a fresh gas flow rate based thereon. The gas supply system is then controlled to supply the fresh gas flow rate into the breathing circuit.

Abstract: A channel assembly is disclosed, which may comprise a microfluidic channel. Methods of manufacture are also disclosed as are detectors and detector components which may comprise such a channel assembly. An example is a detection apparatus comprising: a detector for detecting a substance of interest; and a pneumatic system comprising a microfluidic channel assembly comprising a first microfluidic channel for dispensing vapour to the detector, wherein the first microfluidic channel comprises a groove in a surface of a polymer body and a wall of the first channel is provided by a film bonded to the surface of the body over the groove.

Abstract: An apparatus including a tubular channel having a pathway extending between a proximal end and a distal end of the tubular channel. The proximal end is configured to connect directly or indirectly to an end tidal CO2 monitor. The distal end has an opening. The apparatus further includes a detection member including a chamber disposed in fluid communication with the pathway of the tubular channel such that gas entering the tubular channel via the opening on the distal end passes into the chamber. A detection element is disposed within the chamber and includes a component that is sensitive to one or more systemic biomarkers such that, upon exposure to a predetermined concentration level of the one or more systemic biomarkers contained in the gas, a state of the detection element experiences a permanent alteration and the detection member indicates that the predetermined concentration level of the one or more systemic biomarkers is present in the gas.

Abstract: A modularized respiratory treatment apparatus provides various respiratory pressure treatments. The apparatus may be formed by discrete connectable modules such as a flow generator module, alarm module and/or humidifier module. Each module may include its own external casing or housing to independently retain or enclose the respective components that serve the function of the module. Different modules may be adapted with different components and functionalities and may be readily coupled using standardized gas and electrical connection configurations that have flow and communication paths that extend through the modules. When coupled, operation of the respiratory treatment apparatus may be controlled by detection of different modules, such as the alarm module that generates visual and/or audible alarms based on detected conditions, so as to selectively enable or disable different respiratory treatments.

Abstract: A CPAP compliance notification apparatus for use with a CPAP device having a flow generator, a CPAP hose, and a CPAP mask, the CPAP compliance notification apparatus, including a patient occupancy mat, an air pressure sensor, an air pressure tube, a compliance notification controller unit, a housing, a user interface, a programmable logic controller together with a patient to control parameters of the CPAP compliance notification apparatus in implementing a compliant CPAP treatment to the patient.

Abstract: An active exhalation valve for use with a ventilator to control flow of patient exhaled gases. The valve includes a patient circuit connection port, a patient connection port, an exhaled gas port, a pilot pressure port, and a valve seat. The valve further has a movable poppet with inner and outer bellows members and a bellows poppet face. An activation pressure applied to the pilot pressure port extends the bellows members to move the poppet face into engagement with the valve seat and restrict flow of patient exhaled gases to the exhaled gas port, and the reduction of the activation pressure allows the bellows members to move the poppet face away from the valve seat and out of engagement with the valve seat to permit flow of patient exhaled gases to the exhaled gas port, thereby controlling the flow of patient exhaled gases from the valve.

Abstract: The electrical connections of a chamber or enclosure for a water tub can be protected through the use of spill element sensors. The spill element sensors can help to disable the delivery of power to the heater of a water tub in the event that the electrical connections become wet.

Abstract: A smart mask includes a main mask body including a first opening end and a second opening end. A diameter of the first opening end is smaller than a diameter of the second opening end. The mask further includes a front mask body arranged at the first opening end and fixing straps arranged at the second opening end. The front mask body includes a filter configured to absorb pollutants in air entering the front mask body and a sensor configured to record a wearing time of the smart mask.

Abstract: A wearable device for comprehensive bio-monitoring of physiologic metrics to determine metabolic, pulmonary and cardiac function and oxygen saturation measurements from breathing mask apparatuses. The device non-invasively monitors the physiologic profile of the subject, and is capable of detecting physiologic changes, predicting onset of symptoms, and alerting the wearer or another person or system. In some embodiments, the device comprises both a wearable sensor suite and a portable gas composition and flow analysis system. In preferred embodiments, it comprises a miniaturized non-invasive sensor suite for detecting physiologic changes to detect dangerous breathing or other health conditions. The acquired physiologic profile is used to generate alarms or warnings based on detectable physiological changes, to adjust gas delivery to the subject, alter mission profiles, or to transfer control of the craft or other duties away from a debilitated subject.

Abstract: A connection assembly for a respiratory therapy system, comprising: an outlet assembly, said outlet assembly including an outlet housing and a swivelling disc located on said outlet housing, said outlet housing and said swivelling disc defining, at least in part, a recess; an outlet connector located at an end of a tube portion, said outlet connector including an electrical connector; and a cable having a first end to connect to the electrical connector and a second end to connect to at least one electrical component of the respiratory therapy system, said cable having a slack portion, wherein said outlet connector and said swivelling disc are rotatable in unison between a first position and a second position, and wherein the slack portion of the cable extends from the recess and wraps around the swivelling disc as the swivelling disc is rotated from the first position to the second position.

Abstract: The present disclosure generally relates to systems and methods for delivery of therapeutic gas to patients, using techniques to compensate for disruptions in breathing gas flow measurement, such as when breathing gas flow measurement is unavailable or unreliable. Such techniques include using historical breathing gas flow rate data, such as moving average flow rates, moving median flow rates and/or flow waveforms. At least some of these techniques can be used to ensure that interruption in therapeutic gas delivery is minimized or eliminated.

Abstract: The present invention relates to a multiple connector device for respiratory circuits with alarm due to disconnection, which comprises a main body which is hollow inside, which is in the form of a cross having four arms which are: an upper vertical tubular arm inside of which is housed a driving element which projects into the interior of the lower vertical arm; a lower vertical arm preferably of a square form, which is partially hollow in the interior thereof for the purpose of housing a segment of the driving element and a control element; a right lateral arm; and a left lateral arm which is a mirror image of the right lateral arm, wherein the driving element is in the form of an arrow that effects an axial movement along the upper vertical arm and the lower vertical arm of the main body and the control element is an electronic board that includes all of the electronic components for operating the multiple connector device and which together with the arrangement of the driving element enable the proper func

Abstract: Provided is a gas storing mask which, with a simple configuration, allows a reduction in feeling of discomfort given to a patient. An oxygen delivering mask (1a) includes a first sheet (2) and a second sheet (3), oxygen supplied from outside the oxygen delivering mask (1a) being stored in a gas storing part (4) formed between the first sheet (2) and the second sheet (3).

Abstract: A video feed of one or more pupils of a patient can be received and processed to determine a raw measure of pupil size of the one or more pupils over time. Based on this raw measure, at least one of a) a depth of anesthesia for the patient, b) an index of cognitive activity for the patient, and c) a degree of perfusion of an anesthetic being administered to the patient to one or both hemispheres of a brain of the patient can be determined such that one or more actions can be caused to be performed. Related systems, methods, and article of manufacture are described.

Abstract: Method and system are disclosed for determining conditions of components that are removably coupled to articles of personal protection equipment (PPE) by tracking the components against predetermined criteria.

Abstract: A breathing apparatus according to embodiments of the invention includes a facemask portion sized to cover a lower portion of a wearer's face. The facemask portion includes a flow chamber. The flow chamber includes a first opening disposed near a first end of the flow chamber, a second opening disposed near a second end of the flow chamber, and a serpentine passage disposed between the first opening and the second opening. At least one light emitting diode configured to emit light having a peak wavelength in the ultraviolet range is disposed in the serpentine passage. The at least one light emitting diode is disposed off center relative to a centerline oriented along a direction of air flow through the serpentine passage.

Abstract: An infusion pump assembly includes a reservoir assembly configured to contain an infusible fluid. A motor assembly is configured to act upon the reservoir assembly and dispense at least a portion of the infusible fluid contained within the reservoir assembly. Processing logic is configured to control the motor assembly. The processing logic includes a primary microprocessor configured to execute one or more primary applications written in a first computer language; and a safety microprocessor configured to execute one or more safety applications written in a second computer language.

Abstract: A patient interface for delivery of a supply of pressurized air or breathable gas to an entrance of a patient's airways includes a frame member, a cushion assembly provided to the frame member, and an anterior wall member repeatedly engageable with and disengageable from the cushion assembly. The frame member includes connectors operatively attachable to a positioning and stabilizing structure. The cushion assembly includes a seal-forming structure and a void defined by an anterior surface of the cushion assembly. The anterior wall member has a predetermined surface area to seal the void of the cushion assembly and form a gas chamber when the anterior wall member and the cushion assembly are engaged. The void of the cushion assembly is sized such that the patient's nose and/or mouth is substantially exposed when the anterior wall member is disengaged from the cushion assembly thereby improving breathing comfort of the patient.

Abstract: According to an embodiment of the present invention, a ventilation monitoring device comprises at least one processor and at least one memory including computer program code. The at least one memory and the computer program code is configured with the at least one processor to cause the ventilation monitoring device to determine whether an intubated subject's tracheal tube is properly placed by receiving an indication of a subject's breath from at least one sensor.

Abstract: A coupling for use in a system (2) for communicating a flow of gas from a pressure generating device (4) to an airway of a patient includes a first portion (16, 16?, 16?) adapted to be coupled in fluid communication with the pressure generating device and a second portion (10) selectively coupled to the first portion. The second portion is adapted to be coupled in fluid communication with the airway of the patient. At least one of the first portion and the second portion includes an illuminated portion (18, 20), the illuminated portion being adapted to be visible to a patient when the first and second portions are uncoupled and adapted to be not visible to a user when the first and second portions are coupled. The illuminated portion assists a user in locating and recoupling the first and second portions of the coupling in a darkened room.

Abstract: A filter assembly for a breathing apparatus, such as a powered air purifying respirator. The filter assembly includes a frame for receiving and retaining a filter element, a cover connected to the frame and dimensioned to cover the aperture, a filter element, and an indicator for indicating when the filter element is retained in the filter frame and the cover is arranged across the aperture. A powered breathing apparatus including the filter assembly is also disclosed.