Microscope Patents (Class 359/368)
  • Patent number: 11921273
    Abstract: Provided are a pulse compressor and a two-photon excited fluorescence microscope. The microscope includes a light source which generates a laser beam having a pulse, a pulse compressor which compresses the pulse of the laser beam, an objective lens which provides the laser beam to a specimen, and image sensors which receive the laser beam and obtain images of the specimen. The pulse compressor may include a grating plate, a corner cube provided on one side of the grating plate, and a retroreflector provided on the other side of the grating plate.
    Type: Grant
    Filed: August 30, 2021
    Date of Patent: March 5, 2024
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Sang Kyun Lee, Dong Hoon Song, Hong-Seok Seo, Chul Huh
  • Patent number: 11921275
    Abstract: The present invention relates to an illumination filter system (2) for medical imaging, in particular multispectral fluorescence imaging, as performed e.g. in a microscope (1) or endoscope, such as a surgical microscope, in particular a surgical multispectral fluorescence microscope, comprising a first optical filter (35). The present invention also relates to an observation system (3) for medical imaging, in particular multispectral fluorescence imaging, as performed e.g. in a microscope (1) or endoscope, in particular a multispectral fluorescence microscope, comprising a beam splitter (21) adapted to split a light image (13) into a first light portion (16, 17) along a first light path (18) and a second light portion (20) along a second light path (19).
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: March 5, 2024
    Assignee: Leica Instruments (Singapore) Pte. Ltd.
    Inventors: Manfred Kuster, George Themelis
  • Patent number: 11911109
    Abstract: Systems and methods for imaging an eye are disclosed. The systems and methods may include at least one plenoptic camera. The systems and methods may include an illumination source with a plurality of lights.
    Type: Grant
    Filed: August 25, 2022
    Date of Patent: February 27, 2024
    Assignee: Dr. John Berestka
    Inventor: John Berestka
  • Patent number: 11883125
    Abstract: Provided is a microscope drape capable of further facilitating an attachment operation thereof to a surgical microscope. A microscope drape comprises: a lens cap attached to and detached from a housing of an objective lens of a surgical microscope; a protective lens protecting the objective lens; and a drape main body covering the surgical microscope. The lens cap is formed such that a portion in a circumferential direction of a cylinder is opened, and has an arc-shaped cross section perpendicular to an optical axis of the objective lens. The microscope drape includes: a protective lens holder that is a cylinder whose outside diameter is larger in size than an inside diameter of the lens cap in a natural state and holds the protective lens; and a joint that pivotably supports the protective lens holder with respect to the lens cap around a pivot axis perpendicular to the optical axis.
    Type: Grant
    Filed: May 23, 2022
    Date of Patent: January 30, 2024
    Assignee: MEILLEUR CO., LTD
    Inventor: Tsurashi Yamane
  • Patent number: 11879730
    Abstract: A laser interferometer includes a light source that emits first laser light, an optical modulator that includes a vibrator and modulates the first laser light by using the vibrator to generate second laser light including a modulated signal, a photodetector that receives interference light between third laser light including a sample signal generated by reflecting the first laser light on an object and the second laser light to output a light reception signal, and an optical path length variable section that changes an optical path length of an optical path through which the third laser light propagates.
    Type: Grant
    Filed: August 24, 2021
    Date of Patent: January 23, 2024
    Assignee: SEIKO EPSON CORPORATION
    Inventor: Jun Kitagawa
  • Patent number: 11877888
    Abstract: Systems and methods for providing guidance to an operator of an ultrasound device that comprises an ultrasound probe housing that contains a plurality of probes. In embodiments, images of inside a body of a patient generated in accordance with reflected ultrasonic waves from the probes are received, the images are processed to identify a needle that has been inserted into the body of the patient, and a notification to the operator is generated based on one or more of a distance or direction of the needle relative to a location of an anatomical part also identified by processing of the images, a distance or direction of the needle relative to an internal target body location also identified by processing of the images, or a distance or direction of the needle relative to a desired path of the needle also identified by processing of the images.
    Type: Grant
    Filed: February 3, 2023
    Date of Patent: January 23, 2024
    Assignee: DANDELION TECHNOLOGIES LLC
    Inventors: Paul Adams, Christopher Vetter, Michael Andrew Holtman
  • Patent number: 11841490
    Abstract: An arrangement for light sheet microscopy contains an illumination objective for illuminating a sample located on a slide in a medium with a light sheet, a detection objective, a separation layer system, a first adaptive optical detection correction element, and a further adaptive optical detection correction element and/or a first adaptive optical illumination correction element, and optionally, a further adaptive optical illumination correction element. The arrangement contains an adjustment device for the controlled movement of the first detection correction element and of the further detection correction element and/or of the first illumination correction element and of the further illumination correction element; and a control unit, to generate control commands and to actuate the adjustment devices by means of the control commands such that aberrations are reduced. Corresponding objectives and a corresponding method for reducing aberrations can be used.
    Type: Grant
    Filed: September 1, 2021
    Date of Patent: December 12, 2023
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Marco Pretorius, Lars-Christian Wittig
  • Patent number: 11838675
    Abstract: A depth imaging system in a vehicle includes a lens that includes a polarization-coded aperture. The polarization-coded aperture includes a perpendicular polarization portion to pass incident light entering the perpendicular polarization portion of the polarization-coded aperture as perpendicularly polarized light. The polarization-coded aperture also includes a parallel polarization portion to pass the incident light entering the parallel polarization portion of the polarization-coded aperture as parallel polarized light. An image sensor provides a perpendicularly polarized image based on the perpendicularly polarized light and a parallel polarized image based on the parallel polarized light. A controller processes the perpendicularly polarized image and the parallel polarized image to identify one or more objects in a field of view of the depth imaging system and to determine a range to each of the one or more objects.
    Type: Grant
    Filed: February 23, 2021
    Date of Patent: December 5, 2023
    Assignee: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventor: Emanuel Mordechai
  • Patent number: 11819274
    Abstract: A retina viewing system and method of using the same includes an ophthalmic microscope, a disposable lens attachment, and an electronic control unit (ECU). The microscope has an optical head and a set of internal focusing lenses, the latter providing the microscope with a variable working distance or focal length. The disposable lens attachment includes a resilient body with a proximal end connected to the optical head and a distal end connected to a high-power/high-diopter distal lens. The ECU executes instructions for viewing a retina or other intraocular anatomy of a patient eye. Execution of the instructions causes the ECU to automatically adjust the variable working distance or focal length of the microscope when viewing an image of the retina through the distal lens.
    Type: Grant
    Filed: December 9, 2020
    Date of Patent: November 21, 2023
    Assignee: Alcon Inc.
    Inventor: Ashok Burton Tripathi
  • Patent number: 11822066
    Abstract: A sample observation device (1) includes: an emission optical system (3) for emitting planar light (L2) onto a sample (S); a scanning unit (4) for scanning the sample (S) with respect to an emission face (R) of the planar light (L2); an imaging optical system (5) having an observation axis (P2) inclined with respect to the emission face (R) and for forming an image from observation light (L3) generated in the sample (S) in accordance with the emission of the planar light (L2); an image acquiring unit (6) for acquiring a plurality of partial image data corresponding to a part of an optical image according to the observation light (L3) formed as an image by the imaging optical system (5); and an image generating unit (8) for generating observation image data of the sample S based on the plurality of partial image data generated by the image acquiring unit (6).
    Type: Grant
    Filed: May 24, 2022
    Date of Patent: November 21, 2023
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Satoshi Yamamoto, Masanori Matsubara, Norikazu Sugiyama
  • Patent number: 11808932
    Abstract: A module for a microscope stand comprises a control device with at least one computer hardware component being configured to control the microscope stand. The module further comprises a locating device configured to interact with another locating device formed in a housing of the microscope stand for mounting the module at a predetermined installation site within the housing.
    Type: Grant
    Filed: February 22, 2021
    Date of Patent: November 7, 2023
    Assignee: Leica Instruments (Singapore) Pte. Ltd.
    Inventors: Patrick Szabo, Leander Gaechter
  • Patent number: 11803043
    Abstract: Apparatuses, systems, and methods for dynamically shaped focal surface with a scanning microscope. A microscope (e.g., a scanning confocal microscope) may use a scanning element to scan an illumination beam to generate a focal region. The scanning element may include multiple degrees of freedom, such as rotation and translation along orthogonal axes. For example, if the illumination beam is a line focus, rotation along a first axis and translation along a second orthogonal axis may sweep the line focus across a focal surface which is substantially flat and normal to the second axis. In some embodiments, the microscope may be a dual-axis handheld microscope, where a single objective in a handheld housing is used to both direct the scanned illumination beam and receive the collected light.
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: October 31, 2023
    Assignee: University of Washington
    Inventors: Jonathan T. C. Liu, Lingpeng Wei, Chengbo Yin
  • Patent number: 11796784
    Abstract: A surgical microscope system having a head unit microscope assembly and a foot control assembly in operative communication with the head unit microscope assembly. The head unit microscope assembly being configured to selectively couple to a floor stand assembly such that the that the head unit microscope assembly can be positioned in a desired operative location by the user. The head unit microscope assembly including one or more of: a mounting adaptor, an XY directional stage, a tilt drive, a focus drive; a microscope subassembly, and/or an illumination system.
    Type: Grant
    Filed: November 11, 2022
    Date of Patent: October 24, 2023
    Inventors: Robert T. Hewlett, Jonathan M. Butler
  • Patent number: 11770514
    Abstract: An optical observation instrument according to the invention, in particular a surgical microscope or exoscope, comprises an optics unit with an objective arrangement and at least one electronic image recorder, wherein the optics unit has a first stereo channel with a first beam path and a second stereo channel with a second beam path for recording a stereo image of an object field with the at least one electronic image recorder and wherein the first and the second beam path extend through the objective arrangement. Further, the observation instrument comprises a retaining apparatus which comprises a retaining bracket, which engages over the optics unit, wherein the retaining bracket comprises an operating device with a number of operating elements for controlling a retaining arm, to which the retaining apparatus is connectable.
    Type: Grant
    Filed: January 11, 2021
    Date of Patent: September 26, 2023
    Assignee: KARL STORZ SE & Co. KG
    Inventors: Sebastian Barth, Markus Blocherer, Christoph Busch, Manuel Ebert, Jonas Forster, Andreas Heni, Benedikt Köhler, Robert Lange, Laura Steck, Annika Witte, Laura Ziegler, Walter Vogel, Kay Behrendt
  • Patent number: 11761881
    Abstract: A system for microscopic examination of a sample has a microscope and an incubation environment conditioning unit connected to the microscope. The microscope has a microscope housing enclosing an illumination optics, a microscope stage and an imaging optics, an integrated sample chamber located within the microscope housing and formed by a separated housing section within the microscope housing. The housing section has a microscope interface for connecting the incubation environment conditioning unit to the sample chamber and/or to a stage top chamber for placing within the sample chamber and for receiving the sample. The system provides a first and a second incubation modes. In the first incubation mode the sample chamber is incubated by supply of a first incubation atmosphere by the incubation environment conditioning unit. In the second incubation mode the stage top chamber is incubated by supply of a second incubation atmosphere by the incubation environment conditioning unit.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: September 19, 2023
    Assignee: LEICA MICROSYSTEMS CMS GMBH
    Inventor: Stefan Christ
  • Patent number: 11747604
    Abstract: A method for scanning a sample includes generating at least two illumination points in order to form a point pattern, wherein the point pattern has a settable number of illumination points. At least one freely selectable parameter for defining the point pattern is preset or is set. At least one predefined region of the sample is scanned by moving the point pattern defined by the freely selectable parameter along a first direction such that scan lines assigned to the illumination points of the point pattern are generated, and along a second direction such that further scan lines are generated in each case following the scan lines. The movement of the point pattern in the second direction is carried out in scan steps of identical size or at a constant speed. The illumination points of the point pattern are arranged on a line along the second direction.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: September 5, 2023
    Assignee: LEICA MICROSYSTEMS CMS GMBH
    Inventors: Lars Friedrich, Holger Birk
  • Patent number: 11734936
    Abstract: A digital microscope system comprises an imaging device configured to generate digital image data representing a target region of an object, the target region being determined by a changeable setting of the imaging device; and a controller configured to generate monitor image data corresponding to the digital image data generated in accordance with the setting, the monitor image data being configured to be displayed as a monitor image; wherein the controller is further configured to change the setting in response to a user input; and wherein the controller is further configured to compensate for a delay in updating the monitor image data in accordance with the changed setting by storing the digital image data generated in accordance with the unchanged setting in response to the user input and generating simulation monitor image data by performing digital image processing on the stored digital image data taking into account the changed setting, the simulation monitor image data being configured to be displayed
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: August 22, 2023
    Assignee: Leica Instruments (Singapore) Pte. Ltd.
    Inventor: Marc Honegger
  • Patent number: 11719929
    Abstract: Disclosed are optical trains for imaging systems. More particularly described are imaging systems configured to limit optical aberrations. Also disclosed are methods of limiting optical aberrations in imaging systems.
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: August 8, 2023
    Assignee: RareCyte, Inc.
    Inventors: Jeremy Ryan Cooper, David Stewart
  • Patent number: 11714269
    Abstract: Apparatus and method for capturing an image having a detection beam path for guiding detection radiation from a sample to a detector having a plurality of detector elements. The detector has no more than ten and, preferably, four or five detector elements; and an evaluation unit, which is configured to carry out an evaluation in accordance with the Airyscan method on the image data captured by means of the detector and which generates a high-resolution image.
    Type: Grant
    Filed: March 4, 2021
    Date of Patent: August 1, 2023
    Assignee: CARL ZEISS MICROSCOPY GMBH
    Inventors: Oliver Holub, Mirko Liedtke, Stanislav Kalinin, Dieter Huhse
  • Patent number: 11714270
    Abstract: A laser scanning system for capturing an image of a specimen is described herein. The laser scanning system includes a light source configured to emit a light beam for illuminating the specimen, a scanning unit including a plurality of reflectors for scanning the light beam along first and second axes, and a data acquisition unit configured to control acquisition of the image. The laser scanning system can include a control circuit configured to receive a reference clock signal for the first reflector and generate a synchronization clock signal based on the reference clock signal. The laser scanning system can include a synchronization controller configured to control the scanning unit and the data acquisition unit. The synchronization controller can be configured to receive the synchronization clock signal, receive a plurality of imaging parameters, and generate a plurality of control signals based on the synchronization clock signal and the imaging parameters.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: August 1, 2023
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Adela Ben-Yakar, Ki Hyun Kim, Evan Hegarty, Sertan Kutal Gokce, Sudip Mondal
  • Patent number: 11709350
    Abstract: A sample observation device includes: an emission optical system that emits planar light to a sample on an XZ plane; a scanning unit that scans the sample in a Y-axis direction so as to pass through an emission surface of the planar light; an imaging optical system that has an observation axis inclined with respect to the emission surface and forms an image of observation light generated in the sample; an image acquisition unit that acquires a plurality of pieces of XZ image data corresponding to an optical image of the observation light; and an image generation unit 8 that generates XY image data based on the plurality of pieces of XZ image data. The image generation unit extracts an analysis region of the plurality of pieces of XZ image data acquired in the Y-axis direction, integrates brightness values of at least the analysis region in a Z-axis direction to generate X image data, and combines the X image data in the Y-axis direction to generate the XY image data.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: July 25, 2023
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventor: Satoshi Yamamoto
  • Patent number: 11703672
    Abstract: A microscopic transmitted light contrasting method includes illuminating a sample through asymmetrical first and second illumination pupils and imaging the sample through asymmetrical first and second detection pupil in order to generate, respectively, first and second partial images. The first illumination pupil and the first detection pupil, as well as the second illumination pupil and the second detection pupil, are arranged pivoted in relation to one another and partially overlapping in projection on a plane perpendicular to an optical axis in such a way that first and third regions of an angular space are in a bright field and second and fourth regions of the angular space are in a dark field, and the first and second partial images each have a bright and a dark field component. An image of the sample is generated from the first and second partial images.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: July 18, 2023
    Assignee: LEICA MICROSYSTEMS CMS GMBH
    Inventor: Christian Schumann
  • Patent number: 11686931
    Abstract: A three-dimensional viewing includes a pair of digital image sensors in communication with a pair of digital displays and controlled by a pair of processors to render three-dimensional images of samples on the displays.
    Type: Grant
    Filed: April 1, 2021
    Date of Patent: June 27, 2023
    Assignee: World Precision Instruments
    Inventors: Clifford Bredenberg, Cory Boyes, Chris Hatcher
  • Patent number: 11681132
    Abstract: An embodiment of a phase mask includes a light blocking layer disposed on a substrate, where the light blocking layer has a number of optically transmissive regions each configured as a first pattern. The first pattern includes two segments that have different phase configurations from each other, and the light blocking layer includes at least three angular orientations of the first pattern.
    Type: Grant
    Filed: February 16, 2021
    Date of Patent: June 20, 2023
    Assignee: Thermo Electron Scientific Instruments LLC
    Inventor: Michael Georgiadis
  • Patent number: 11662575
    Abstract: An example head-mounted display device includes a light projector and an eyepiece. The eyepiece includes a light guiding layer and a first focusing optical element. The first focusing optical element includes a first region having a first optical power, and a second region having a second optical power different from the first optical power. The light guiding layer is configured to: i) receive light from the light projector, ii) direct at least a first portion of the light to a user's eye through the first region to present a first virtual image to the user at a first focal distance, and iii) direct at least a second portion of the light to the user's eye through the second region to present a second virtual image to the user at a second focal distance.
    Type: Grant
    Filed: January 31, 2022
    Date of Patent: May 30, 2023
    Assignee: Magic Leap, Inc.
    Inventors: Eric C. Browy, Derek Michael Geiger
  • Patent number: 11662565
    Abstract: A microscope system 1 includes an eyepiece 104, an objective 102 that guides light from a sample to the eyepiece 104, and a tube lens 103 that is disposed on a light path between the eyepiece 104 and the objective 102 and forms an optical image of the sample on the basis of light therefrom. The microscope system 1 further includes a projection apparatus 133 that projects first and second projection images onto an image plane on which the optical image is formed, in a manner such that the first and second projection images are capable of being distinguished from each other. The first projection image is based on an analysis result provided by a computer for the digital image data of the sample. The second projection image is based on an input operation performed by a user and includes at least input information provided by the user.
    Type: Grant
    Filed: March 9, 2021
    Date of Patent: May 30, 2023
    Assignee: EVIDENT CORPORATION
    Inventors: Akifumi Kabeya, Tetsuya Shirota, Tatsuo Nakata
  • Patent number: 11635609
    Abstract: A microscope includes a control system connected to an illumination system and an imaging system. The control system is configured to: detect an image affecting change in microscope settings and/or in a location of the sample, the image affecting change resulting in an alteration of the sample image; cause the imaging system to deliver a live image stream of live images of the sample in a first imaging mode, or to deliver a still image stream of still image(s) of the sample in a second imaging mode, and to switch from the first imaging mode into the second imaging mode when no image affecting change is detected, using one of the last live images of the first imaging mode for at least a part of the still image stream in the second imaging mode; and reduce an illumination intensity of the illumination system during the second imaging mode.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: April 25, 2023
    Assignee: LEICA MICROSYSTEMS CMS GMBH
    Inventors: Florian Timmesfeld, Oliver Keul, Volker Schacht
  • Patent number: 11635607
    Abstract: A method of microscopy comprises collecting an emission light; symmetrically dispersing the collected emission light into a first order (“1st”) light and a negative first order (“?1st”) light using a grating; wherein the 1st light comprises spectral information and the ?1st light comprises spectral information; capturing the 1st light and the ?1st light using a camera, localizing the one or more light-emitting materials using localization information determined from both the first spectral image and the second spectral image; and determining spectral information from the one or more light-emitting materials using the first spectral image and/or the second spectral image; wherein the steps of localizing and obtaining are performed simultaneously. A spectrometer for a microscope comprises a dual-wedge prism (“DWP”) for receiving and spectrally dispersing a light beam, wherein the DWP comprises a first dispersive optical device and a second dispersive optical device adhered to each other.
    Type: Grant
    Filed: May 18, 2021
    Date of Patent: April 25, 2023
    Assignee: Northwestern University
    Inventors: Ki-Hee Song, Cheng Sun, Hao F. Zhang
  • Patent number: 11619586
    Abstract: A system, including an optical imaging assembly configured to image a sample at an object plane to an image plane; an image sensor arranged at the image plane and configured to capture images of the sample for a field of view of the system; a light source configured to emit light having a wavelength, ?; a spatial light modulator (SLM) arranged to receive the light emitted from the light source and to provide a spatially modulated light pattern; one or more optical elements arranged to receive the spatially modulated light pattern from the SLM and to direct the spatially modulated light pattern to the image plane; and an electronic controller in communication with the image sensor and the spatial light modulator, the electronic controller being programmed to identify one or more targets in the field of view of the optical imaging assembly and to control the spatial light modulator to selectively direct light from the light source to the one or more targets identified by the electronic controller.
    Type: Grant
    Filed: July 8, 2021
    Date of Patent: April 4, 2023
    Assignee: X Development LLC
    Inventors: Benoit Schillings, Anupama Thubagere Jagadeesh
  • Patent number: 11612350
    Abstract: Methods and apparatuses are disclosed for modifying images of skin so as to reduce or enhance the appearance of component pigments, such as melanin and hemoglobin. A diffuse reflectance image of skin, such as a cross-polarized contact dermoscopy image, which conveys information regarding subsurface features of the skin, is processed so as to extract pigment distribution information, which is then used to correct the diffuse reflectance image, such as by reducing the appearance of melanin to allow better visualization of hemoglobin-related structures, such as vasculature. Alternatively, the diffuse reflectance image can be corrected so as to reduce the appearance of hemoglobin to allow better visualization of melanin-related structures.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: March 28, 2023
    Assignee: Canfield Scientific, Incorporated
    Inventor: Sachin V. Patwardhan
  • Patent number: 11611722
    Abstract: A microscope system is provided with a microscope that acquires images at least at a first magnification and a second magnification higher than the first magnification, and a processor. The processor is configured to specify a type of a container in which a specimen is placed, and when starting observation of the specimen placed in the container at the second magnification, the processor is configured to specify a map region corresponding to a map image constructed by stitching together a plurality of second images acquired by the microscope at a higher magnification than the first magnification by performing object detection according to the type of the container on a first image that includes the container acquired by the microscope at the first magnification, and cause a display unit to display the first image and a range of the map region on the first image.
    Type: Grant
    Filed: May 19, 2021
    Date of Patent: March 21, 2023
    Assignee: Evident Corporation
    Inventors: Keita Kojima, Motohiro Shibata, Takehiko Hayashi, Keigo Mori
  • Patent number: 11609416
    Abstract: Disclosed herein are systems for imaging of samples using an array of micro optical elements and methods of their use. In some embodiments, an optical chip comprising an array of micro optical elements moves relative to an imaging window and a detector in order to scan over a sample to produce an image. A focal plane can reside within a sample or on its surface during imaging. Detecting optics are used to detect back-emitted light collected by an array of micro optical elements that is generated by an illumination beam impinging on a sample. In some embodiments, an imaging system has a large field of view and a large optical chip such that an entire surface of a sample can be imaged quickly. In some embodiments, a sample is accessible by a user during imaging due to the sample being exposed while disposed on or over an imaging window.
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: March 21, 2023
    Assignee: SamanTree Medical SA
    Inventors: Etienne Shaffer, Bastien Rachet, Aurèle Timothée Horisberger, Jonathan Abel Pirolet, Diego Joss, Andrey Naumenko, Frédéric Schmitt
  • Patent number: 11604343
    Abstract: The invention relates to a plenoptic ocular device intended to be coupled in an ocular port of an optical instrument configured to generate a real image of a sample on a focal plane situated in a region close to said ocular port, said plenoptic ocular device being configured to capture said real image, generate a set of elemental images and send them to recording means with spatial discretisation which in turn comprises communication means configured to transmit the set of elemental images to external image processing means.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: March 14, 2023
    Assignee: Universitat De Valencia
    Inventors: Manuel Martinez Corral, Genaro Saavedra Tortosa, Gabriele Scrofani, Angel Tolosa Ruiz, Jorge Garcia Sucerquia
  • Patent number: 11598944
    Abstract: A light sheet microscope includes an object slide, and optical illumination and detection systems. The optical illumination system includes an illumination objective configured to illuminate a first object plane that is oblique relative to a slide plane with a light sheet. The optical detection system includes a detection objective and an image sensor device. The image sensor device is configured to define a first image plane which is orthogonal to an optical axis of the detection objective and to define a second image plane which is tilted relative to the first image plane. The detection objective is configured to image a focal plane onto the first image plane and to image a second object plane of the object onto the second image plane, the focal plane being coincident with the first object plane, and the second object plane being parallel to or coincident with the slide plane.
    Type: Grant
    Filed: April 28, 2021
    Date of Patent: March 7, 2023
    Assignee: LEICA MICROSYSTEMS CMS GMBH
    Inventor: Florian Fahrbach
  • Patent number: 11595575
    Abstract: An imaging device may code light, passing through an imaging optical lens arranged in a multi-lens array (MLA), and may transmit the light to a sensing element, and the sensing element may restore an image based on sensed information.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: February 28, 2023
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Yang Ho Cho, Deokyoung Kang, Geonwoo Kim, Dong Kyung Nam
  • Patent number: 11592653
    Abstract: An auto-focusing system is disclosed. The system includes an illumination source. The system includes an aperture. The system includes a projection mask. The system includes a detector assembly. The system includes a relay system, the relay system being configured to optically couple illumination transmitted through the projection mask to an imaging system. The relay system also being configured to project one or more patterns from the projection mask onto a specimen and transmit an image of the projection mask from the specimen to the detector assembly. The system includes a controller including one or more processors configured to execute a set of program instructions. The program instructions being configured to cause the one or more processors to: receive one or more images of the projection mask from the detector assembly and determine quality of the one or more images of the projection mask.
    Type: Grant
    Filed: March 31, 2020
    Date of Patent: February 28, 2023
    Assignee: KLA Corporation
    Inventors: Xiumei Liu, Kai Cao, Richard Wallingford, Matthew Giusti, Brooke Bruguier
  • Patent number: 11592658
    Abstract: The present invention relates in general to microscopy systems. In particular, the present invention relates to microscopes rendering digital images of samples, with the capability to digitally control the focus of the microscope system, and the software used to control the operation of the digital microscope system. Further, the present invention relates to a microscope structure that allows for compact and multi-functional use of a microscope, providing for light shielding and control with samples that require specific light wavelength characteristics, such as fluorescence, for detection and imaging. The microscope is adjustable, with a structure that can move along range(s) of motion and degree(s) of freedom to allow for ease of access to samples, shielding of samples, and manipulation of a display apparatus.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: February 28, 2023
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Frank Hsiung, Kelly Kroeger, Robert Archer, Veronika Kortisova, Teresa Rubio, Amber Iraeta
  • Patent number: 11536953
    Abstract: A confocal microscope device for scanning a two-dimensional array of illumination beams over a target surface and scanning a corresponding two-dimensional array of emission beams stimulated by the array of illumination beams on to a sensor of an imaging device. The device comprises first scanning optics operable to scan the array of illumination beams over the target surface along a first axis and scan the array of emission beams over the sensor along the first axis.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: December 27, 2022
    Assignee: VisiTech International Limited
    Inventors: Steven Coleman, Andrew Roberts, Jafer Sheblee
  • Patent number: 11531220
    Abstract: Disclosed is a defect inspection device for determining anomaly of an inspection object. The defect inspection device may include: a lighting system which includes a light source for transmitting light onto the inspection object; and a dynamic diffuser located between the light source and the inspection object and capable of controlling a diffusivity of light transmitted onto the inspection object; and one or more processors for controlling the dynamic diffuser based on characteristics of the inspection object.
    Type: Grant
    Filed: April 9, 2021
    Date of Patent: December 20, 2022
    Assignee: COGNEX CORPORATION
    Inventors: Kiyoung Song, Hunmin Cho, Jonggyu Im
  • Patent number: 11525989
    Abstract: The invention relates to an optical assembly for scanning excitation radiation and/or manipulation radiation in a laser scanning microscope.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: December 13, 2022
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Tiemo Anhut, Matthias Wald, Daniel Schwedt, Tobias Kaufhold, Beate Böhme
  • Patent number: 11519833
    Abstract: Auto sampler rack mounts and fluid vials that can be used with them are described. In some configurations, the rack mount can be configured to spin each fluid vial rotationally to assist in mixing or stirring of fluid in the vial and/or to maintain fluid homogeneity. If desired, the fluid vial may include one or more internal features to assist in the mixing or stirring.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: December 6, 2022
    Assignee: PERKINELMER HEALTH SCIENCES CANADA, INC.
    Inventor: Hamid Badiei
  • Patent number: 11513332
    Abstract: Provided is a microscope apparatus including: a microscope section configured to perform magnified observation of a subject's eye while obtaining a red reflex caused by irradiating a fundus of the subject's eye with illuminating light; a holding section configured to hold the microscope section; and a tilting section configured to tilt an illumination optical axis which is an optical axis of an illumination optical system, and an observation optical axis which is an optical axis of an observation optical system in the microscope section, around a tilt reference point in an interior of the subject's eye as a base point, while maintaining a substantially coaxial state between the illumination optical axis and the observation optical axis.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: November 29, 2022
    Assignee: SONY OLYMPUS MEDICAL SOLUTIONS INC.
    Inventors: Tomonori Ishikawa, Noboru Shibuya, Yoshia Hoshino, Takashi Fukaya, Masaaki Ueda
  • Patent number: 11513327
    Abstract: Upstream a microscope objective lens, a polarization direction of a light beam is tilted with a first electro-optical deflector between a first polarization direction with which the light beam is deflected by a first polarization beam splitter by a first angle and a second polarization direction with which it is deflected by a second angle. With a second electro-optical deflector, the polarization direction of the light beam is tilted between a third polarization direction with which the light beam is deflected by a second polarization beam splitter by a third angle and a fourth polarization direction with which it is deflected by a fourth angle. By rotating the polarization direction of the light beam by means of the first and second electro-optical deflectors in a coordinated way the light beam is tilted about a fixed point in a pupil of the objective lens.
    Type: Grant
    Filed: June 9, 2020
    Date of Patent: November 29, 2022
    Assignee: DEUTSCHES KREBSFORSCHUNGSZENTRUM
    Inventors: Johann Engelhardt, Jonas Marquard
  • Patent number: 11506879
    Abstract: The invention provides an optical super-resolution microscopic imaging system comprising a dichroic beamsplitter for annular parallel light to transmit through; a focusing lens used for converging the annular parallel light transmitted through the dichroic beamsplitter; a confocal pinhole for the annular parallel light after being converged to pass through to filter the annular parallel light; a varifocal lens system for collimating the annular parallel light passing through the confocal pinhole into excited annular parallel light; and a detector for receiving and processing fluorescence emitted by the excited sample, the fluorescence emitted by the excited sample being returned by the same way, and the dichroic beamsplitter separating the fluorescence emitted by the sample from an annular parallel light path and turning the fluorescence to the detector to obtain a super-resolution image of the sample.
    Type: Grant
    Filed: September 1, 2020
    Date of Patent: November 22, 2022
    Assignee: Beijing Century Sunny Technology Co., Ltd.
    Inventors: Bo Lai, Jiguang Wang
  • Patent number: 11500186
    Abstract: A microscope objective is disclosed comprising; a lens; a housing; a lens holder that is arranged to couple the lens to the housing; a first conductor and a second conductor, the first conductor and the second conductor extending along a sidewall of the housing, the first conductor and the second conductor being arranged to form at least one loop that is that is disposed about at least a portion of a perimeter of a field of view of the lens.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: November 15, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Dirk R. Englund, Hyeongrak Choi, Michael P. Walsh
  • Patent number: 11487093
    Abstract: The disclosure relates to a method for scanning microscopy wherein a specimen is scanned simultaneously with a plurality of illumination spots of an excitation light. The light emitted by one specimen location irradiated with one illumination spot is detected independently of the light emitted by another specimen location illuminated with another illumination spot. A microscopic image of the specimen can be compiled from the emitted light detected for the different specimen locations. The method provides that the intensities of the different illumination spots are set independently of one another, and in that the illumination spots are guided over the specimen one after another in a scan line. The disclosure additionally relates to a scanning microscope.
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: November 1, 2022
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Helge Eggert, Michael Hilbert
  • Patent number: 11482021
    Abstract: A microscope for adaptive sensing may comprise an illumination assembly, an image capture device configured to collect light from a sample illuminated by the assembly, and a processor. The processor may be configured to execute instructions which cause the microscope to capture, using the image capture device, an initial image set of the sample, identify, in response to the initial image set, an attribute of the sample, determine, in response to identifying the attribute, a three-dimensional (3D) process for sensing the sample, and generate, using the determined 3D process, an output image set comprising more than one focal plane. Various other methods, systems, and computer-readable media are also disclosed.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: October 25, 2022
    Assignee: SCOPIO LABS LTD.
    Inventors: Ben Leshem, Eran Small, Itai Hayut, Erez Na'Aman, Eyal Ben-Bassat
  • Patent number: 11474335
    Abstract: A microscope objective for imaging a specimen using a microscope, the microscope objective being designed as an air objective for microscopy without an immersion medium or as an oil immersion objective for microscopy with an oil-based immersion medium or as a water immersion objective for microscopy with a water-based immersion medium. The front lens of the microscope objective is provided with a coating which repels an immersion medium and is lipophobic and hydrophobic if the objective is an air objective, only lipophobic if the objective is a water immersion objective, and only hydrophobic if the objective is an oil immersion objective.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: October 18, 2022
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Thomas Ohrt, Michael Goegler, Thorsten Kues
  • Patent number: 11467388
    Abstract: An objective optical system (43) includes: a reflection surface (RS1) which reflects light traveling toward a sample (SP); a reflection surface (RS2) which reflects light reflected by the reflection surface (RS1) toward the sample (SP); and a transmission portion (TS) which is disposed on an optical path of light reflected by the reflection surface (RS2), which has a liquid contact surface coming into contact with liquid (WT) interposed between the liquid contact surface and the sample (SP), and of which the liquid contact surface is formed to be substantially orthogonal to the optical path of light reflected by the reflection surface (RS2).
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: October 11, 2022
    Assignee: YOKOGAWA ELECTRIC CORPORATION
    Inventor: Hiroyuki Sangu
  • Patent number: 11460682
    Abstract: An observation device includes: an illumination optical system configured to emit illumination light to above a sample from below; and an objective optical system configured to acquire an image of transmitted light below the sample in a path different from a path for the illumination optical system, the transmitted light resulting from the illumination light that has been emitted from the illumination optical system, that has been reflected above the sample, and that has passed through the sample. The objective optical system includes, in the vicinity of a pupil plane, a pupil modulation element that partially decreases transmittance and that modulates the phase of light, and the illumination optical system includes a light source, and an illumination-region restricting section configured to restrict light from the light source to a particular emission region.
    Type: Grant
    Filed: November 20, 2019
    Date of Patent: October 4, 2022
    Assignee: EVIDENT CORPORATION
    Inventor: Tadashi Hirata