Abstract: A composition includes Commiphora mukul extract, Camellia sinensis extract, and Trigonella foenum-graecum extract. The composition may further include Allium sativum extract, Zingiber officinale extract, and Cinnamomum verum extract. The composition may include Commiphora mukul extract at about 24%-36% by weight of the total composition, the Allium sativum extract at about 20%-30% by weight of the total composition, the Camellia sinensis extract at about 12%-18% by weight of the total composition, the Trigonella foenum-graecum extract at about 12%-18% by weight of the total composition, the Zingiber officinale extract at about 8%-12% by weight of the total composition, and the Cinnamomum verum extract at about 4%-6% by weight of the total composition. The disclosure further provides methods of treating hyperlipidemia using the disclosed compositions.

Abstract: This invention relates to a method of treating Attention-Deficit Hyperactivity Disorder by orally administering to a subject a composition containing a Radix Polygalae (Polygala tenuifolia Willd) extract (such as PDC-1421). A solid dosage form of the composition can be prepared into the gelatin capsule. The oral administration of the composition in healthy volunteers was safe and well-tolerated for the daily dose from 380 mg to 3800 mg. The composition can be administered chronically over at least 25 days; the daily dose is administered once per day, twice per day, or three times per day, wherein each dose is 380-760 mg of the botanical extract.

Abstract: The present invention relates to an organoleptically improved dietary fiber composition comprising Trigonella foenum-graecum (fenugreek) seeds in the form of flakes with improved palatability, and method(s) of preparing the said composition. More particularly, invention relates to nutrient rich de-bitterised and de-fatted fenugreek dietary fiber and administering the same in a subject to bring satiety, feeling of fullness, appetite suppression, less desire to consume food, which may further lead to reduction or management of weight. The present invention can be used for the development of functional food, dietary plan and as a nutritional supplement. The present invention also relates to methods of managing various conditions such as, but not limited to, management of weight, appetite scores, glucose homeostasis, body mass index and serum insulin levels or any combinations thereof using the said composition.

Abstract: The present invention relates generally to methods of use and compositions useful for moisturizing skin and/or lightening or whitening skin. The composition includes a combination of Angelica acutiloba root extract and a Salicornia herbacea extract.

Abstract: The present invention relates generally to methods of use and compositions useful for moisturizing skin and/or lightening or whitening skin. The composition includes a combination of Angelica acutiloba root extract and a Salicornia herbacea extract.

Abstract: The present disclosure provides methods for treating or preventing Huntington's disease (HD) in a subject in need thereof, comprising administering a therapeutic agent that activates mTORC 1 function and/or increases Ras Homolog Enriched in Striatum (Rhes) level in the subject's brain as compared to the function or level in the subject prior to treatment, and methods for modulating mHTT-associated metabolic phenotypes and/or reversal of striatal atrophy by administering a therapeutic agent that activates mTORC1 function and/or increases Ras Homolog Enriched in Striatum (Rhes) level in the subject's brain as compared to the function or level in the subject prior to treatment.

Abstract: A nutritional supplement provides Vitamin E; sophora flavescens extract; zinc; and at least two ingredients selected from the group consisting of hemp grapeseed extract, hemp curcumin, hemp boswellia, hemp black pepper, hemp magnolia, hemp ginger, hemp oregano leaf, hemp orange peel, hemp methyl sulfano methane (MSM), hemp poplar, hemp chia, hemp meadow sweet, hemp clove powder, hemp cinnamon, and hemp basil (excluding hay basil and hay basil extract). The supplement can be used to reduce joint inflammation, reduce stiffness, reduce lameness, improve flexion, and improve amount of movement and mobility by supporting joint health.

Abstract: A cleansing composition comprising an aqueous solution of an anionic polymer, a nonionic polymer and a system of surfactants. Solutions as described herein comprise two distinct aqueous phases having different compositions and density. Further methods of use are also disclosed.

Abstract: The invention relates to a particular cosmetic active substance that is constituted through bioconversion by Lactobacillus arizonensis of its original substrate, Simmondisia chinens. The invention also relates to a preparation method, to compositions comprising same, and to uses thereof for cosmetic applications.

Abstract: The invention relates to a soybean seed extract, method for producing the same and uses of the extract of soybean seeds in promoting wound healing, promoting neuron cell proliferation and/or treating brain diseases and/or neurodegenerative diseases, treating breast cancer, reducing side effects of interfering with DNA and/or RNA replication drugs and/or enhancing pharmaceutical effects of interfering with DNA and/or RNA replication drugs.

Abstract: A method of reducing the appearance of fine lines or wrinkles or increasing skin elasticity or skin firmness is disclosed. The method can include topically applying to the fine line or wrinkle or to sagging or loose skin an effective amount of a topical composition comprising a combination of vegetable amino acids from navy bean, Myrciaria dubia fruit extract, Peucedanum graveolens extract, and tetrahexyldecyl ascorbate. The combination can reduce the appearance of the fine line or wrinkle, increases skin elasticity, or increases skin firmness.

Abstract: Methods for treating excess pigmentation, including treatment of post inflammatory hyperpigmentation (PIH), are disclosed. The disclosed methods comprise administration of a composition comprising bakuchiol substantially free of furanocoumarins to a mammal. Compositions comprising bakuchiol and methods for their preparation are also disclosed.

Abstract: The present invention relates to a method for activating tumor-infiltrating lymphocytes (TILs) in a subject in need, particularly by administering to the subject a fermented composition generated via fermentation of symbiotic microbiota in a medium.

Abstract: A herbal composition with significant potent therapeutic effects for treating neurodegenerative diseases by targeting both amyloid-? (A?) and tau-associated neurofibrillary tangles (NFTs) is provided.

Abstract: A nutritional supplement provides Vitamin E; Sophora Flavescens extract; zinc; and at least two ingredients selected from the group consisting of hemp grapeseed extract, hemp curcumin, hemp boswellia, hemp black pepper, hemp magnolia, hemp ginger, hemp oregano leaf, hemp orange peel, hemp methyl sulfano methane (MSM), hemp poplar, hemp chia, hemp meadow sweet, hemp clove powder, hemp cinnamon, and hemp basil (excluding hay basil and hay basil extract). The supplement can be used to reduce joint inflammation, reduce stiffness, reduce lameness, improve flexion, and improve amount of movement and mobility by supporting joint health.

Abstract: Compositions intended for application onto human skin damaged by oxidative stress can include (1) a mixture of at least: (a) a leaf extract of Aristotelia chilensis; (b) a leaf extract of Buddleja globosa; (c) a leaf extract of Ugni molinae; (d) optionally, a bark/seed extract of Entada phaseoloides; (e) optionally, a blend of Pfaffia paniculata, Ptychopetalum olacoides, and Lilium candidum extracts; and (f) at least one humectant; (2) an emulsifier; and (3) a dermatologically acceptable carrier, wherein (a)-(f) are employed in amounts sufficient to synergistically neutralize existing free radicals present in the skin, while proactively priming the skin by repairing and/or protecting its Stratum corneum without unduly impairing the Stratum corneum's acid mantle, and wherein the composition is natural, free of a skin-sensitizing amount of an essential oil, and has a pH ranging from about 4.5 to about 5.5.

Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating, preventing or treating postmenopausal or climacteric symptoms, which include but are not limited to bone loss, bone remodeling, hot flushes and vaginal atrophy. The present invention also provides methods for modulating, preventing or treating postmenopausal or climacteric symptoms using the compositions disclosed herein.

Abstract: The disclosure relates to a method for alleviating cancer pain and/or treating cancer skin inflammation in a subject in need of such treatment; the soybean seed extract composition comprises a soybean seed extract and a soybean seed vapor fraction.

Abstract: Methods for treating excess pigmentation, including treatment of post inflammatory hyperpigmentation (PIH), are disclosed. The disclosed methods comprise administration of a composition comprising bakuchiol substantially free of furanocoumarins to a mammal. Compositions comprising bakuchiol and methods for their preparation are also disclosed.

Abstract: The present application relates to a pharmaceutical composition/formulation for improving or preventing progression of chronic kidney disease (CKD) caused due to inflammation and/or Klotho under expression. More particularly, the invention relates to a composition/formulation comprising a synergistic combination of Palmitoylethanolamide (PEA), Cholecalciferol and one or more natural ingredients. The invention also provides various formulations and methods of preparing the same.

Abstract: An anxiolytic composition includes a synergistic combination of an L-theanine and a whey protein composition.

Abstract: Disclosed is a novel composition effective to improve lactation and milk production in an animal. In some embodiments the composition comprises a fiber-depleted fraction derived from fenugreek in combination with additives that synergistically improve the effective of the composition. Additives that enhance the effect of the fenugreek fraction can include apple cider vinegar, fennel seed powder, saw palmetto berry extract, kelp powder, and methylsulfonylmethane.

Abstract: Combined therapy of cancer using an immune check point modulators (e.g., an immune checkpoint inhibitor) and a fermented product, which may be prepared using symbiotic microbiota.

Abstract: A use of isomaltulose in the preparation of a vaginal composition, wherein the amount of isomaltulose used is 0.05-20% (w/w). A vaginal composition contains 0.05-20% (w/w) of isomaltulose. The composition may be a health product, health care product, cleaning product, skin care product, deodorant, cosmetic, or disinfectant composition or a pharmaceutical composition. A non-therapeutic vaginal care method, a non-therapeutic vaginal cleaning method, a method for improving vaginal acidity, a method for promoting growth of Lactobacillus in the vagina, and a method for preventing and treating vaginal dysbacteriosis, especially bacterial vaginal diseases, these methods being implemented by administering the composition to women's vagina.

Abstract: Phosphatidic acid is administered orally to increase muscle mass and strength in exercising mammals. Phosphatidic acid is administered orally to aging, bedridden or cachectic patients to improve nitrogen balance. The preferred form of phosphatidic acid for administration is phosphatidic acid-enriched lecithin. Creatine is co-administered orally to increase the muscle-building and strength effect. Other suggested additives include nutritional and herbal supplements, micronutrients and hormones.

Abstract: The present invention relates to the field of carrier and delivery systems for active molecular compounds. In particular, the present invention provides aqueous dispersions for delivery of active molecular compounds.

Abstract: A method for at least one of adjusting the biological clock, improving sleep quality, and facilitating sleep is provided, wherein the method comprises administering to the subject an effective amount of a Momordica charantia extract, wherein the extract is obtained by extracting a fruit of Momordica charantia with water.

Abstract: The present invention provides a pharmaceutical composition or a cosmetic product which can accelerate production of ceramide in cells. The ceramide production-accelerating agent contains a plant selected from the group consisting of Radix Heraclei Scabridi, Rhizoma Dioscoreae, Radix Rehmanniae, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Radix Et Rhizoma Rhei, Pseudobulbus Bletillae, Radix Polygoni Multiflori, Radix Platycodi, and Herba Leonuri, or an extract thereof as an active ingredient. Further, the present invention provides a moisturizing agent containing a plant selected from the group consisting of Herba Leonuri and Rhizoma Dioscoreae, or an extract thereof as an active ingredient.

Abstract: The present invention relates generally to methods of use and compositions useful for treating, preventing, and or reducing the appearance of stretch marks. The composition includes a combination of vegetable amino acids, Myrciaria dubia fruit extract, Peucedanum graveolens extract, and tetrahexyldecyl ascorbate.

Abstract: Novel insecticidal proteins isolated from Bacillus thuringiensis that are active against lepidopteran insect pests are disclosed. The DNA encoding the insecticidal proteins can be used to transform various prokaryotic and eukaryotic organisms to express the insecticidal proteins. These recombinant organisms can be used to control lepidopteran insects in various environments.

Abstract: A novel soybean variety, designated 5PWYL70 is provided. Also provided are the seeds of soybean variety 5PWYL70, cells from soybean variety 5PWYL70, plants of soybean 5PWYL70, and plant parts of soybean variety 5PWYL70. Methods provided include producing a soybean plant by crossing soybean variety 5PWYL70 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety 5PWYL70, methods for producing other soybean varieties or plant parts derived from soybean variety 5PWYL70, and methods of characterizing soybean variety 5PWYL70. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety 5PWYL70 are further provided.

Abstract: The invention provides a process for the separation of pea protein. The process begins with an aqueous extract or solution of pea protein, which is passed through at least one expanded bed absorption (EBA) process. The EBA process comprises contacting the aqueous extract or solution of pea protein with at least one adsorbent resin, said adsorbent resin comprising at least one ligand (L1 or L2), having particular chemical structures. Proteins of interest are isolated by eluting them from said adsorbent resin. The invention also provides various protein compositions obtainable via the method of the invention.

Abstract: Methods for treating excess pigmentation, including treatment of post inflammatory hyperpigmentation (PIH), are disclosed. The disclosed methods comprise administration of a composition comprising bakuchiol substantially free of furanocoumarins to a mammal. Compositions comprising bakuchiol and methods for their preparation are also disclosed.

Abstract: Disclosed is a topical skin composition. The composition can include 50 to 75% by weight of water, 2 to 7% by weight of caprylic/capric triglyceride, 2 to 7% by weight of Butyrospermum parkii (shea) butter, 2 to 7% by weight of Helianthus annuus (sunflower) seed oil, 1 to 5% by weight of cetyl alcohol, 1 to 5% by weight of glyceryl stearate, and 0.1 to 2% by weight of beeswax.

Abstract: The present disclosure provides polymorphic forms of sodium benzoate with a X-ray diffraction pattern comprising characteristic peaks at a reflection angle 2? of approximately 5.9, 30.2, and 31.2 degrees; or a X-ray diffraction pattern comprising characteristic peaks at a reflection angle 2? of approximately 3.7, 5.9, and 26.6 degrees. Also provided herein are methods of preparing the polymorphic forms of sodium benzoate and uses thereof in treating and/or reducing the risk for a neuropsychiatric disorder (e.g., schizophrenia, psychotic disorders, depressive disorders, or Alzheimer's disease).

Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating, preventing or treating postmenopausal or climacteric symptoms, which include but are not limited to bone loss, bone remodeling, hot flushes and vaginal atrophy. The present invention also provides methods for modulating, preventing or treating postmenopausal or climacteric symptoms using the compositions disclosed herein.

Abstract: An excipient from Trigonella foenum-graceum seeds and a process for preparation thereof is disclosed. The excipient obtained from Trigonella foenum-graceum seeds, comprising insoluble and soluble dietary fibers can be used in various pharmaceutical or cosmetic compositions and food, nutritional or dietary preparations.

Abstract: The present invention relates to the field of carrier and delivery systems for active molecular compounds. In particular, the present invention provides aqueous dispersions for delivery of active molecular compounds.

Abstract: The invention provides a beverage composition comprising hydrolyzed collagen and vitamin C, or a derivative thereof, which is particularly suitable for improving skin hydration and skin condition. Additional active ingredients may include methyl sulphonyl methane, a vitamin selected from the vitamin B complex, L-lysine, omega-3 and omega-6 fatty acids. The beverage composition is such that it promotes higher absorption and bioavailability of skin-nourishing ingredients. The beverage composition can improve the moisture content of the skin and can prevent fine lines and wrinkles.

Abstract: The present invention provides methods, systems and devices for drug-drug interaction and adverse event analysis. Chemical structures for one or more pairs of drugs are obtained from at least one of a user and a database. A chemical fingerprint is generated for each drug of the one or more pairs of drugs based on the chemical structure of the drug. Drug-drug interaction prediction is performed for each pair of drugs based on the chemical fingerprints. Adverse event prediction is performed based on the predicted drug-drug interaction for the one or more pairs of drugs.

Abstract: The present invention provides compounds and compositions for the amelioration of arthritis and joint injuries by inducing mesenchymal stem cells into chondrocytes.

Abstract: The invention is a method of enhancing female libido by administering an effective amount of a fenugreek extract, for example fenugreek seed extract, to a female in need of enhanced libido. The female can be a human female.

Abstract: Disclosed is a composition in the form of an oil-in-water emulsion, including: 5-55 wt % of an oil phase; 0.025-3.75 wt % of at least one cross-linked anionic polyelectrolyte resulting from the polymerization of partially or completely salified 2-methyl 2-[(1-oxo 2-propenyl) amino] 1-propanesulfonic acid, with at least one neutral monomer selected from acrylamide, (2-hydroxy ethyl) acrylate, and N,N-dialkyl arylamides. Each alkyl group includes 1-4 carbon atoms, and at least one monomer, where R is an alkyl radical including 8-20 carbon atoms and n is a number no smaller than one and no larger than twenty, in the presence of a cross-linking agent; 0.025-3.75 wt % of a galactomannan having a degree of substitution of approximately 1/3; 37.5-94.95 wt % of a cosmetically acceptable aqueous phase, the aqueous phase including 1-25 wt % of a salt, the weight ratio between the galactomannan and the cross-linked anionic polyelectrolyte being 1:3 to 3:1.

Abstract: Provided are: a production method for salt-free miso, in which steamed soy beans and koji are pressurized, heated, and fermented; salt-free miso obtained by said production method; and a hepatic function improvement agent and a hypertension improvement agent that contain said salt-free miso as an effective component thereof.

Abstract: A wound dressing makes use of polysaccharides, including the formation of a range of variable viscosity mixtures that use a solid polysaccharide such as medical grade cane sugar and a liquid polysaccharide such as honey, both of which have inherent beneficial properties for wound healing. The mixture is applied to an absorbent surface that is designed to absorb the mixed polysaccharide only partially.

Abstract: The invention provides drug compositions with synergistic effects, which includes alcohol-soluble and water-insoluble liquorices extracts and at least one kind of anti-tumor or glucose-and-lipid-lowering drug/eatable substance, and can be used to treat tumor or lower blood glucose and lipid. Besides, the invention also provides pharmaceutical preparation, pharmaceutical application, therapeutic and preparation methods, etc. related to this drug compositon.

Abstract: The present invention concerns the antidiabetic-activity of compounds type A, namely of 8-?-D-glucosylgenistein, which is not toxic to eukaryotic cells and has demonstrated to produce complete normalization of fasting hyperglycaemia, to reduce excessive postprandial glucose excursion, to increase glucose-induced insulin secretion and insulin sensitivity. An alternative synthesis for this molecular entity and its binding ability to ?-amyloid oligomers is also included in the present invention, which also comprises Genista tenera ethyl acetate extract for use as antihyperglycaemic, agent i.e. for lowering blood glucose levels in mammals that are pre-diabetic or have type 2 or type 1 diabetes. The inhibitory activity of ?-glucosidase by Genista tenera ethyl acetate and butanol extracts and that of glucose-6-phosphatase by these two extracts and the diethyl ether plant extract is also part of the present invention.

Abstract: In a new supplemental combination and method of treatment, the herbs Vitex agnus-castus (chasteberry), green tea, and arginine treat premenstrual syndrome, premenstrual tension, as an alternative to conventional women's hormone replacement therapy, and to offset the problems related to sub-optimal hormone balance or decline resulting from age, genetics, stress, or environmental influences. Furthermore, the combination may be enhanced with a phytoestrogen and/or a progesterone-receptor enhancing agent.

Abstract: The present invention relates to the field of carrier and delivery systems for active molecular compounds. In particular, the present invention provides aqueous dispersions for delivery of active molecular compounds.

Abstract: Disclosed herein are an anti-obesity agent from natural products based on angiogenesis inhibitory actions, and an angiogenesis inhibitor or a composition for inhibiting obesity, containing at least one selected from the group consisting of Psoraleae Semen extract, Siegesbeckiae Herba extract, and Corni Fructus extract. Because the Psoraleae Semen extract, Siegesbeckiae Herba extract, and Corni Fructus extract of the present invention exhibit angiogenesis inhibitory effects and obesity inhibitory effects, they may be usefully used as an agent for prevention and treatment of angiogenesis-related diseases or obesity.