Skin Burn Or Open Wound Treatment Patents (Class 424/78.06)
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Patent number: 11872245Abstract: According to the present invention there is provided a polymer comprising at least one antiseptic/analgesic/anti-inflammatory monomeric unit in conjunction with at least three further monomeric units, said three further monomeric units eliciting properties selected from the group consisting of: temperature activation, water solubility, mechanical strength, protein/polysaccharide bonding capacity, and combinations thereof. In particular, disclosed herein is a polymer, wherein the water-soluble monomeric unit is a hydrophilic ethylene glycol (OEGMA) moiety; the mechanical strength-conferring monomeric unit is polylactide-co-2-hydroxy-ethyl-methyl acrylate (PLA/HEMA); the protein-reactive monomeric unit is an N-acryloxysuccinimide (NAS) moiety; and the thermosetting monomeric unit is an N-isopropyl acrylamide (NIPAAm) moiety. The anti-septic/analgesic/anti-inflammatory monomeric unit comprises a methacrylic ester derivative of salicylic acid (5-HMA or 4-HMA, or a combination thereof).Type: GrantFiled: December 21, 2021Date of Patent: January 16, 2024Assignee: TRIMPH IP PTY LIMITEDInventors: Ali Fathi, Fariba Dehghani
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Patent number: 11851514Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.Type: GrantFiled: August 27, 2021Date of Patent: December 26, 2023Assignee: Life Technologies ASInventors: Geir Fonnum, Nils Pontus Lundberg, Muhammed Talha Gokmen, Synne Larsen, Wilhelm Glomm, Heidi Johnsen, Ruth Schmid, Lars Kilaas
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Patent number: 11185546Abstract: Methods and kits for improving tear production are described, along with topical pharmaceutical compositions. In certain instances, the composition comprises pentoxifylline and a pharmaceutically acceptable carrier. The compositions also may further comprise another active agent, such as an anti-bacterial agent, antiviral agent, antifungal agent, or immunosuppressant agent, and combinations thereof.Type: GrantFiled: May 11, 2020Date of Patent: November 30, 2021Assignee: Harrow IP, LLCInventors: John Scott Karolchyk, John P. Saharek
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Patent number: 11130833Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.Type: GrantFiled: October 8, 2020Date of Patent: September 28, 2021Assignee: LIFE TECHNOLOGIES ASInventors: Geir Fonnum, Nils Pontus Lundberg, Muhammed Talha Gokmen, Synne Larsen, Wilhelm Glomm, Heidi Johnsen, Ruth Schmid, Lars Kilaas
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Patent number: 10836854Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.Type: GrantFiled: July 19, 2016Date of Patent: November 17, 2020Assignees: SINTEF, LIFE TECHNOLOGIES ASInventors: Geir Fonnum, Nils Pontus Lundberg, Muhammed Talha Gokmen, Synne Larsen, Wilhelm Glomm, Heidi Johnsen, Ruth Schmid, Lars Kilaas
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Patent number: 10758472Abstract: Oral care compositions comprising: (a) a peroxide complex comprising a peroxide component and an N-vinyl heterocyclic polymer (e.g., poly-N-vinyl polylactam, or poly-N-vinyl-polyimide); (b) a whitening agent (e.g., hydrogen peroxide); and (c) an orally acceptable carrier. In one embodiment, the carrier comprises a film forming material. Methods are also provided for making an oral care composition comprising: (a) mixing a whitening agent, silicone adhesive and carrier fluid to form a homogenous mixture; (b) adding a peroxide complex to said homogenous mixture, wherein said complex comprises hydrogen peroxide and an N-vinyl heterocyclic polymer; and (c) mixing under vacuum.Type: GrantFiled: February 20, 2018Date of Patent: September 1, 2020Assignee: Colgate-Palmolive CompanyInventors: Lynette Zaidel, Guisheng Pan, Suman Chopra, Prakasarao Mandadi, Michael Prencipe
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Patent number: 10596205Abstract: Dental, vaginal and anal cream composed of exclusively natural active principles containing glycerides and Vitamin A and D, easily retained and preserved when in contact with the inflamed mucosa due to its adhesive mucosal base.Type: GrantFiled: December 5, 2018Date of Patent: March 24, 2020Assignee: REV PHARMA Corp.Inventor: Efrain Ramon Vasquez
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Patent number: 10426803Abstract: A composition and method for treating Epidermolisis bullosa (EB), comprising: applying to skin or mucosal surfaces of a patient in need of treatment for EB a dressing gauze or bandage without prior cleaning of said skin or mucosal surfaces, wherein distributed on said dressing is an effective amount of a composition containing beeswax; an oleaginous base, vitamins and a pharmaceutically acceptable excipient; then removing said dressing at least twice per day without damaging the patient's skin or mucosal surfaces due to removal of the dressing.Type: GrantFiled: June 18, 2018Date of Patent: October 1, 2019Assignee: REV PHARMA CORPInventor: Efrain Ramon Vasquez
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Patent number: 10278870Abstract: A system for treating a tissue site includes a reduced-pressure source to apply reduced pressure, a manifold in fluid communication with the pressure source to provide reduced pressure to the tissue site, and a drape for adhering to the tissue site to cover the tissue site and the manifold. The drape includes an adhesive layer for sealing the drape to the tissue site to create a sealed space having the manifold therein, and a non-adhesive layer formed from a portion of the adhesive layer. A method for manufacturing a medical drape includes providing a sheet of adhesive material and treating a side of the sheet of adhesive material to form a non-adhesive layer and an adhesive layer. The method laminates a release liner adjacent the adhesive layer.Type: GrantFiled: December 22, 2016Date of Patent: May 7, 2019Assignee: KCI Licensing, Inc.Inventors: Timothy Mark Robinson, Christopher Brian Locke
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Patent number: 10159593Abstract: A medical bandaging product that includes a flexible medical material including an elongate fabric, a reactive system, and microspheres. In certain aspects, a component of the reactive system is homogeneously impregnated into or coated throughout the flexible medical material without being encapsulated in the microspheres such that the reactive system remains stable and non-activated in the absence of an activating agent, and hardens upon activation by exposure to the activating agent to form a rigid, self-supporting structure. In this aspect, the microspheres are homogeneously impregnated into or coated throughout the flexible medical material, the microspheres encapsulate an activating agent and are configured to release the activating agent to form the rigid, self-supporting structure.Type: GrantFiled: May 23, 2014Date of Patent: December 25, 2018Assignee: BSN MEDICAL, INC.Inventor: John C. Evans
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Patent number: 9757492Abstract: The present invention relates to a process for producing a hydroxy amino polymer comprising the steps: a) Reaction of an H functional starter compound bearing at least one Zerewitinoff active H atom with an unsaturated, cyclical carboxylic acid anhydride and at least one alkylene oxide compound for obtaining a prepolymer bearing hydroxyl groups, b) Addition of a primary amine and/or of ammonia to the double bond(s) of the prepolymer bearing hydroxyl groups obtained according to step a) for obtaining the hydroxy amino polymer, wherein the ratio of added amino groups to hydroxyl groups in a hydroxy amino polymer is at least 0.6. Furthermore, the invention relates to a hydroxy amino polymer, which can be achieved according to this process as well as a polyurea/polyurethane system, which contains such a hydroxy amino polymer.Type: GrantFiled: January 10, 2017Date of Patent: September 12, 2017Assignee: Adhesys Medical GmbHInventors: Heike Heckroth, Christoph Eggert, Jörg Hofmann, Klaus Lorenz, Edward Browne, Hartmut Nefzger
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Patent number: 9487558Abstract: Peptides having four to six amino acid residues are disclosed that possess biological activity. These peptides constitute short fragments of the peptide HB-107 (MPKEKVFLKIEKMGRNIRN) (SEQ ID NO: 10), which itself is a fragment of the antimicrobial protein cecropin B, and exhibit cell stimulatory and migratory properties. The inventive peptides comprise four to six contiguous amino acid residues located between position 11 and 16 of HB107 (MPKEKVFLKIEKMGRNIRN) (SEQ ID NO: 10), namely EKMGRN (SEQ ID NO: 1). The disclosed peptides comprise a useful agent for the medical treatment of injury to the skin, such as from diabetic ulcers. The peptides also are effective in preventing and reversing skin surface damage resulting from various environmental insults. Importantly, the therapeutic effects of the peptides manifest at concentrations equal to or greater than those of peptide HB-107 (SEQ ID NO: 10), and thus represent a less expensive, more versatile means for developing effective therapies.Type: GrantFiled: January 21, 2014Date of Patent: November 8, 2016Assignee: HELIX BIOMEDIX INC.Inventors: Lijuan Zhang, Robin Carmichael
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Patent number: 9457062Abstract: The present invention relates to methods for modulating Toll-like receptor signalling in a subject, or in at least one cell, tissue or organ thereof, methods for treating or preventing a disease or condition in a subject, methods for modulating the production and/or secretion of one or more immunomodulators in a subject, or at least one cell, tissue or organ thereof, wherein said methods involve the administration of chaperonin 10, and wherein the chaperonin 10 associates with a Toll-like receptor in an activation cluster. Also contemplated are associated compositions and uses thereof.Type: GrantFiled: July 11, 2006Date of Patent: October 4, 2016Assignee: CBIO LIMITEDInventors: Barbara J. Johnson, Caroline A. Dobbin, Dean J. Naylor, Linda A. Ward, Inge E. A. Flesch, Christopher B. Howard
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Patent number: 9457123Abstract: An adhesive hydrogel dressing as well as methods of applying the dressing to a patient. The dressing generally comprises an adhesive hydrogel pad, a backing layer, and an adhesive layer on the backing layer facing the hydrogel pad. The adhesive layer and backing layer form a perimeter around the hydrogel pad and hold the hydrogel pad in place on an application surface. A release element is in contact with at least a portion of the edge of the hydrogel pad proximate the area that the hydrogel pad and release liner separate during liner removal.Type: GrantFiled: September 23, 2009Date of Patent: October 4, 2016Assignee: 3M INNOVATIVE PROPERTIES COMPANYInventors: David R. Holm, Scott A. Burton, Robert A. Asmus, Richard L. Jacobson
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Patent number: 9415002Abstract: A polysilicone base for medical and cosmetic compositions includes a dimethicone fluid, a volatile cyclosiloxane, a silicone elastomer, and nanoparticulate silica. The polysilicone base may also include one or more therapeutic agents for reducing the formation and appearance of scar tissue at the site of a wound. The polysilicone base is spreadable, but does not run off of the wound site. The polysilicone base is phase-stable, in that it does not separate into phases.Type: GrantFiled: December 22, 2015Date of Patent: August 16, 2016Assignee: Englewood Lab, LLCInventors: Julio Lamberty, Yi-Chun Lin
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Patent number: 9254133Abstract: Cyanoacrylate adhesive compositions comprise a mixture of two cyanoacrylate monomers, including 2-octyl cyanoacrylate and n-butyl cyanoacrylate. The monomers are stabilized and sterilized by irradiation, and do not substantially increase in viscosity after sterilization or after two years of shelf storage. These compositions have anti-microbial properties, and may be used to close wounds as well as secure catheters inserted into the body in place.Type: GrantFiled: February 18, 2014Date of Patent: February 9, 2016Assignee: Adhezion Biomedical, LLCInventors: Sheng Zhang, Rafael Ruiz, Sr.
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Patent number: 9090670Abstract: The current invention relates to the use of a peptide comprising an amino acid sequence in the preparation of a medicament for the regeneration of tissue, preferably for the treatment of a wound. Further the invention relates to compositions comprising such peptides, and use of said peptides in both medical and nonmedical (cosmetic) applications.Type: GrantFiled: March 14, 2013Date of Patent: July 28, 2015Assignee: Rapid Pathogen Screening, Inc.Inventors: Johannes Gerhardus Maria Bolscher, Arie van Nieuw Amerongen, Engelmundus Cornelis Ignatius Veerman, Menno Johannes Oudhoff, Willem van't Hof, Kamran Nazmi, Petronella Adriana Maria van den Keijbus
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Publication number: 20150139933Abstract: A method for the polymerization of ?-lipoic acid and ?-lipoic acid derivatives includes preparing an ?-lipoic formulation, exposing the ?-lipoic formulation to an aqueous phase and a gaseous phase at a gas/water interface, and allowing the ?-lipoic formulation to polymerize at the gas/water interface to form a poly(?-lipoic acid) polymer. The ?-lipoic formulation can be an ?-lipoic solution of an ?-lipoic solute and an organic solvent miscible with water, and can also be an ?-lipoic acid or oligomer or polymer thereof in liquid (typically melt) form.Type: ApplicationFiled: November 21, 2014Publication date: May 21, 2015Inventors: Judit E. Puskas, Emily Q. Rosenthal-Kim
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Patent number: 9033959Abstract: A skin graft applicator with a handle member and a roller member is described for use in applying a skin graft to a patient. The skin graft applicator has a manipulator pad for positioning the skin graft, and a roller member for forcing air and fluid from underneath the skin graft ensuring the proper bond between graft and tissue.Type: GrantFiled: February 18, 2011Date of Patent: May 19, 2015Assignee: Mercy Health System, Inc.Inventor: Bharat Shah
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Patent number: 9005662Abstract: An article comprising a polyelectrolyte complex comprising an interpenetrating network of at least one predominantly positively charged polyelectrolyte polymer and at least one predominantly negatively charged polyelectrolyte polymer, the polyelectrolyte complex further comprising a plurality of closed-shell pores, the plurality of pores having at least one average transverse dimension between about 100 nanometer and about 1000 micrometers.Type: GrantFiled: August 19, 2010Date of Patent: April 14, 2015Assignee: The Florida State University Research Foundation, Inc.Inventor: Joseph B. Schlenoff
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Publication number: 20150096912Abstract: A solid wound dressing material comprising: at least about 5 wt % collagen; from about 6 wt % to about 9 wt % polyvinylpyrrolidone triiodide (PVP-I); and from 0 wt % to about 20 wt % water; wherein the weight percentages are based on the dry weight of the composition. Also provided are methods of making such materials, and wound dressings comprising such materials. In another aspect the invention provides a solid wound dressing material comprising: at least about 5 wt % collagen; from about 10 wt % to about 90 wt % Cadexomer iodine; and from 0 wt % to about 20 wt % water, wherein the weight percentages are based on the dry weight of the composition. Also provided are wound dressings comprising the materials.Type: ApplicationFiled: May 1, 2013Publication date: April 9, 2015Applicant: Systagenix Wound Management (US), Inc.Inventor: Lorna McInroy
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Publication number: 20150096503Abstract: A method of treating a hoof of an ungulate animal. The method comprises coating one or both of (i) at least a portion of a bottom surface of the hoof or (ii) at least a portion of a block surface with a curable polymer and allowing the polymer to cure for a period of time. The polymer is cured within 60 seconds or less of the coating and the cured polymer has a Shore D hardness of about 10 to about 50. The curable polymer is provided as a two component system. The first component is a reaction product of (a) comprises 4-4?-diphenylmethane-diisocyanate, castor oil, isocyanatopropyltriethoxysilane, and glycidoxypropyltrimethoxysilane, and wherein (b) comprises dicyclohexylmethane-4,4-diisocyanate, polyether polyol, 4,4?-diphenylmethane-diisocyanate (MDI), and triethoxy(3-isocyanatopropyle)silane. The second component comprises polyoxypropylene oxide ether polyol, diol (2000 MW), polyxoypropylene oxide ether polyol, triol (450 MW), tetrahydroxypropylethylendiamine, metaxylenediamine, and organobismuth catalyst.Type: ApplicationFiled: October 4, 2013Publication date: April 9, 2015Applicant: Vettec, Inc.Inventors: Frank Dugan, Frank Rovelli, Paul Wittrock
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Patent number: 8999314Abstract: Disclosed herein are methods and compositions of treating a subject suffering from a wound. In exemplary examples, the method involves elevating MCPIP levels in a subject in need. Elevating MCPIP levels may involve direct administration (e.g. delivery of protein) or indirect administration (e.g. delivery vehicle capable of increasing expression of MCPIP).Type: GrantFiled: April 21, 2014Date of Patent: April 7, 2015Assignee: University of Central Florida Research Foundation, Inc.Inventors: Pappachan E. Kolattukudy, Jianli Niu
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Patent number: 8999297Abstract: A generally non-acidic hemostatic agent, having a relatively neutral pH comprising a magnesium compound, such as a magnesium chloride, a magnesium sulfate and/or a magnesium acetate based compound. The resultant agent is generally less caustic than previous agents, when using a similar amount of active material.Type: GrantFiled: July 13, 2009Date of Patent: April 7, 2015Assignee: Inter-Med, Inc.Inventors: Gary J. Pond, John Baeten
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Patent number: 8987339Abstract: Provided herein are pre-formulations forming a biocompatible hydrogel polymer comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the biocompatible hydrogel polymer covers a wound in a mammal and adheres to the surrounding skin tissue. In other embodiments, the hydrogel polymer is delivered into a joint space to treat joint disease or navicular disease.Type: GrantFiled: March 14, 2014Date of Patent: March 24, 2015Assignee: Medicus Biosciences LLCInventors: Syed H. Askari, Yeon S. Choi
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Patent number: 8979726Abstract: A composition and method of arresting the flow of blood from a bleeding wound. The composition preferably includes an anhydrous salt ferrate compound preferably combined with an effective amount of an insoluble cation exchange material and an effective amount of anhydrous Magnetite mixed uniformly together. Povidone iodine may be added for enhanced antimicrobial properties. In the method, a quantity of the composition is magnetically attached to a surface of a magnet, after which the powderous mixture is applied to the wound by pressing the surface covered with the powderous compound against the wound for a time sufficient to clot the blood to arrest substantial further blood flow from the wound.Type: GrantFiled: February 6, 2013Date of Patent: March 17, 2015Assignee: Biolife, L.L.C.Inventors: John Hen, Talmadge Kelly Keene, Mark Travi
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Publication number: 20150071869Abstract: A monomeric adhesive composition includes a stabilized polymerizable monomer, such as a 1,1-disubstituted monomer, including a cyanoacrylate, and a wound healing agent, wherein the wound healing agent is 5,5-disubstitutedhydantoin, including phenytoin; and a method for making said composition.Type: ApplicationFiled: November 17, 2014Publication date: March 12, 2015Inventors: Sheng Zhang, Rafael Ruiz, SR.
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Publication number: 20150064129Abstract: The invention discloses a composition comprising hyaluronic acid with a high molecular weight and povidone-iodine in low amount that has advantageous efficacy in enhancing wound healing and maintains high stability. Also disclosed is a method of using the composition of the invention in healing wounds.Type: ApplicationFiled: September 4, 2013Publication date: March 5, 2015Applicant: TAIWAN BIOTECH CO., LTD.Inventors: LiChin Lin, YuKao Cheng, YuHua Chen, ShuFang Chiang
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Patent number: 8968710Abstract: A topical anesthetic is provided containing about 3 wt % to 10 wt % tetracaine in a vehicle suitable for administration to the skin or mucosa. The vehicle for transporting the tetracaine includes a water soluble mucoadhesive or a combination of mucoadhesives such as a high molecular weight poly(ethylene oxide) homopolymer and a cellulose polymer. The vehicle also includes propylene glycol. The tetracaine is ground into a powder and is suspended in a plasticized hydrocarbon gel which completes the vehicle.Type: GrantFiled: January 6, 2014Date of Patent: March 3, 2015Inventors: Alan J. Wickenhauser, Stephen E. Peipert
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Publication number: 20140377211Abstract: An in situ film-forming sprayable methyl acetate-based solution of at least one absorbable, low-crystallinity, segmented copolymer contains at least one bioactive agent, which exhibits antimicrobial, anti-inflammatory, antiviral, anesthetic, hemostatic, and/or antineoplastic activity. The absorbable polymers can be a polyaxial copolyester, polyether-ester and polyether-ester urethane and the bioactive solution thereof can be applied onto animal and human skin or accessible body cavities to prevent or treat one or more disorder susceptible to the bioactive agent therein.Type: ApplicationFiled: September 9, 2014Publication date: December 25, 2014Applicant: POLY-MED, INC.Inventors: Shalaby W. Shalaby, Joel T. Corbett, Jason Olbrich
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Patent number: 8916143Abstract: The present disclosure provides injectable synthetic and biodegradable polymeric biomaterials that effectively prevent seroma, a common postoperative complication following ablative and reconstructive surgeries. Provided biomaterials include physically crosslinked hydrogels that are thixotropic, display rapid chain relaxation, are easily extruded through narrow gauge needles, biodegrade into inert products, are well tolerated by soft tissues, and effectively prevent seroma in a radical breast mastectomy animal model.Type: GrantFiled: November 3, 2009Date of Patent: December 23, 2014Assignee: Cornell UniversityInventors: David Putnam, Peter Zaweneh, Jason Spector
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Publication number: 20140370075Abstract: Reinforced, laminated, impregnated, and materials with composite properties as cross linked polyvinyl alcohol hydrogel structures in bulk or cellular matrix forms that can take essentially any physical shape, or can have essentially any size, degree of porosity and surface texture. They have a wide range of physical properties, unusual and unique combinations of physical properties and unique responses to stress fields, which allows for their use in many end use applications.Type: ApplicationFiled: August 21, 2014Publication date: December 18, 2014Inventor: Nedeljko Vladimira Gvozdic
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Publication number: 20140369952Abstract: A medical adhesive with good biodegradable performance capable of undergoing crosslinking copolymerization, comprising a mono-alpha-cyanoacrylate and a bis-alpha-cyanoacrylic acid diol ester monomer molecule. The olefinic bonds in the mono-alpha-cyanoacrylate structure are polymerized in the presence of infinitesimal anions to form a solid 3D high polymer; the 3D high polymer is provided with degradation sites on the web-like backbone chain, with clear degradation path and absorbable degradation products. The medical adhesive can be used for wound adhesive, large area wound hemostasia, and visceral and soft tissue wound closure.Type: ApplicationFiled: October 31, 2012Publication date: December 18, 2014Inventors: Keliang Liu, Liang Xu, Qingsong Zhang, Dazhen Cai, Qingbin Meng
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Publication number: 20140348774Abstract: The present inventions relate to a number of fields including wound healing, a waterless antibacterial disinfectant, a surgical scrub, insect repellant, and methods of treating traumatic injuries, particularly those on the battlefield where there is a need to stabilize the patient and prevent infection.Type: ApplicationFiled: June 9, 2014Publication date: November 27, 2014Applicant: Aurora Pharmaceutical, LLCInventors: Michael Strobel, Gene Komer
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Publication number: 20140348775Abstract: [Problems] The objective is to provide a new low-toxic drug for external use for intractable diseases, such as erosion, decubitus, and skin ulcer, that prevents cicatrization and reduces iodine accumulation on wound surfaces with sufficiently promoting healing. [Means for solving problem] Preparation of a wound treatment drug for external use containing oily bases and iodine but substantially no white soft sugar, which is a characteristic of the drug of this invention. The invented drug prevents infection through the wound surface due to a sufficient bactericidal effect of iodine, and promotes wound healing, prevents cicatrization and reduces iodine accumulation on the wound surface by maintenance of appropriate moisture in the wound surface due to a moisturizing effect of oily bases.Type: ApplicationFiled: August 8, 2014Publication date: November 27, 2014Inventors: Hitoshi MIZUTANI, Yoshiaki MIYAMOTO, Atsushi NISHIKAWA
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Patent number: 8894986Abstract: A monomeric adhesive composition includes a stabilized polymerizable monomer, such as a 1,1-disubstituted monomer, including a cyanoacrylate, and a wound healing agent, wherein the wound healing agent is 5,5-disubstitutedhydantoin, including phenytoin; and a method for making said composition.Type: GrantFiled: August 9, 2011Date of Patent: November 25, 2014Assignee: Adhezion Biomedical, LLCInventors: Sheng Zhang, Rafael Ruiz, Sr.
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Patent number: 8895542Abstract: Disclosed is a medicinal cream that includes flisidic acid which is made in situ under an oxygen-free environment using sodium fusidate. The fusidic acid is made by dissolving the sodium fusidate in a co-solvent under inert gas purging and under vacuum, and converting the sodium fusidate to fusidic acid in situ by adding an acid under stirring, The disclosed medicinal cream also includes a biopolymer and a cream base comprising at least one of each of a primary and secondary emulsifier, a waxy material, and water.Type: GrantFiled: April 12, 2010Date of Patent: November 25, 2014Inventors: Vanangamudi Subramaniam Sulur, Madhavan Srinivasan, Neelakandan Narayanan Chulliel, Haridas Sankar, Kuppusamy Senthilkumar
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Publication number: 20140341836Abstract: Methods are provided for making freeze dried hydrogel and structures therefrom that may be introduced into a patient's body for medical applications. Precursor components are combined to initiate crosslinking. The combined precursor components are placed in a chilled tray, and allowed to crosslink to a desired level of complete crosslinking before and/or after being placed onto the tray. The partially crosslinked hydrogel is frozen and freeze dried. After freeze drying, the hydrogel is conditioned to substantially complete crosslinking, and formed into one or more structures, e.g., plugs, hemostatic, or other medical devices. For example, the hydrogel may be cut, machined, rolled, folded, compressed, and/or cored into that may be loaded into delivery devices that may be introduced into a body to implant or otherwise deliver the structures into the body, e.g., to seal a puncture or other passage through tissue.Type: ApplicationFiled: July 9, 2014Publication date: November 20, 2014Inventors: Amarpreet S. Sawhney, Steven L. Bennett, Suresh S. Pai, Scott R. Sershen, Fred H. Co
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Publication number: 20140341837Abstract: A composition and method useful in promoting hemostasis, absorbing ooze, and being antimicrobial with respect to an open wound. The composition broadly includes an antimicrobial agent, preferably povidone iodine, preferably a ferrate compound, and a cation ion exchange resin. This composition will destroy a biofilm which has formed over the open wound in providing a soluble iron compound, a cation chelation compound, and an active antimicrobial compound effective against planktonic microorganisms and biofilms. The antimicrobial agent is locked or sealed within the scab formed over the wound to maintain long-term positioning and anti-dilution of the antimicrobial over the wound.Type: ApplicationFiled: July 30, 2014Publication date: November 20, 2014Inventors: Talmadge Kelley Keene, John Hen
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Publication number: 20140341838Abstract: Biocompatible adhesive materials, such as for use with biological tissues and/or medical implants, are provided, as well as methods and kits for making and using the biocompatible adhesive materials. The biocompatible adhesive materials include a dendrimer component and a polymer component, and may be tailored for specific tissue types and conditions.Type: ApplicationFiled: July 30, 2014Publication date: November 20, 2014Inventors: Natalie Artzi, Elazer R. Edelman, Nuria Oliva Jorge, Maria Carcole Solanes
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Patent number: 8889114Abstract: The present invention refers to the use of growth factors, which are effective on mesothelial cell proliferation, used in a sterilized carboxymethylchitosan pharmaceutical composition employed to reduce postoperative adhesions severity. The present invention also provides a method to inhibit postoperative adhesions severity.Type: GrantFiled: March 19, 2009Date of Patent: November 18, 2014Assignees: Fundacao Sao Francisco XavierInventors: Jackson Brandão Lopes, Luis Alberto Oliveira Dallan
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Publication number: 20140328776Abstract: Compositions, kits and methods of preparing a biocompatible film for cosmetic or medical uses are disclosed. The compositions or kits contain polyvinyl acetal (PVA), siloxane and a solvent. The siloxane can have a hydrophilic group. Once the solvent content is reduced, for instance, by evaporation, the mixture of PVA and siloxane is solidified, forming a film. The compositions and kits, optionally, further include one or more of an antimicrobial agent, a pigment, an anti-inflammatory agent, an anesthetic agent or a hemostatic agent. Such a film can be used, for example, in the form of an antimicrobial sealant, a liquid bandage, body paints, scar camouflage, water-proof sun block, makeup sealer, or antimicrobial wipe or spray.Type: ApplicationFiled: July 16, 2014Publication date: November 6, 2014Inventor: SHAOSHENG DONG
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Patent number: 8877169Abstract: A method of preparing hydrogel structure, wherein the hydrogel structure comprises: (a) a one way penetrating polyurethane film layer, (b) a hydrophobic pressure sensitive adhesive layer, (c) a multi-directional elastic meltblown nonwoven, (d) an interpenetrating polymer network, and (e) a hydrophilic hydrogel; and the method comprises: (i) coating the hydrogel in a form of solution on the meltblown non-woven to form a product 1, (ii) UV curing the product 1 in step (i), forming a composite comprising a hydrogel layer on the top, an interpenetrating polymer network in the middle, and a meltblown non-woven layer on the bottom, wherein the interpenetrating polymer network is a mixture of the hydrogel and the meltblown non-woven, (iii) providing polyurethane film layer coated with pressure sensitive adhesive layer, and (iv) laminating part of exposed fibers of meltblown non-woven with the pressure sensitive adhesive layer, forming a hydrogel structure.Type: GrantFiled: May 2, 2012Date of Patent: November 4, 2014Assignee: Compose Element LimitedInventor: Tsu-Tai Lin
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Patent number: 8865655Abstract: A compound of the general Structure (VII) or (VIII) including isoteres and pharmaceutically acceptable salts thereof, wherein R1, R2 (where X=—CONR6—), R3 and R7 are the same or different and each represents an amino-acid side chain moiety; R2 (where X=—CHZ—), R4 and R6 are the same or different and each represents hydrogen, C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl; K represents a linear or branched chain of carbon atoms and containing 1-10 atoms; L represents a moiety capable of chelating zinc in the active site of a histone deacetylase (HDAC) or of conversion to such a moiety in vivo (by hydrolysis or reduction, for example); M is a linear or branched chain of carbon or other atoms and containing 1-10 atoms, and capable of undergoing in vivo cleavage to give Structure (VII); and Z is a heteroatom bonded to the macrocycle by a single or double bond, and any other group bonded to Z is H or a protecting group.Type: GrantFiled: November 22, 2007Date of Patent: October 21, 2014Assignee: Karus Therapeutics LimitedInventors: Arasu Ganesan, Graham Keith Packham, Alexander Richard Liam Cecil
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Publication number: 20140308331Abstract: This invention relates to compositions and applications for an interpolymer network delivery system containing iodine.Type: ApplicationFiled: August 12, 2012Publication date: October 16, 2014Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Joachim B. Kohn, Carmine P. Iovine, Niraj Ramachandran
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Patent number: 8859618Abstract: This invention is a composition comprising a cyclic siloxane, a silicone occlusive fluid, a silicone occlusive gel, and a silicone resin powder. The composition is useful for wound healing.Type: GrantFiled: September 19, 2013Date of Patent: October 14, 2014Assignee: Valeant Pharmaceuticals InternationalInventors: Irwin Palefsky, Ni'Kita Wilson
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Patent number: 8840873Abstract: A method of treating burns, preferably second and third degree burns, by administration of an oxidative reduction potential (ORP) water solution that is stable for at least twenty-four hours is provided.Type: GrantFiled: March 23, 2006Date of Patent: September 23, 2014Assignee: Oculus Innovative Sciences, Inc.Inventor: Hojabr Alimi
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Publication number: 20140271491Abstract: The present invention relates to a long-lasting medical product for protecting or treating a lesion in the gastrointestinal tract. The medical product includes a protective covering, wherein the medical product upon application at and about the site of the lesion adheres to the gastrointestinal tissue and is capable of remaining at and about the site of the lesion for a time sufficient to allow the lesion to heal or be treated.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: COOK MEDICAL TECHNOLOGIES LLCInventors: Shaun D. Gittard, John Crowder Sigmon, JR., Vihar C. Surti
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Publication number: 20140271528Abstract: Provided herein are pre-formulations forming a biocompatible hydrogel polymer comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the biocompatible hydrogel polymer covers a wound in a mammal and adheres to the surrounding skin tissue. In other embodiments, the hydrogel polymer is delivered into a joint space to treat joint disease or navicular disease.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: Medicus Biosciences LLCInventors: Syed H. ASKARI, Yeon S. CHOI, Paul YuJen WAN
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Publication number: 20140248231Abstract: Provided herein are in vivo gelling ophthalmic pre-formulations forming a biocompatible retinal patch comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the retinal patch at least partially adheres to the site of a retinal tear. Also provided herein are methods of treating retinal detachment by delivering an in vivo gelling ophthalmic pre-formulation to the site of a retinal tear in human eye, wherein the in vivo gelling ophthalmic pre-formulation forms a retinal patch.Type: ApplicationFiled: May 8, 2014Publication date: September 4, 2014Applicant: Medicus Biosciences LLCInventors: Syed H. ASKARI, Yeon S. CHOI