Viral Vaccine For Avian Species (e.g., Poultry Or Other Birds, Etc.) Patents (Class 424/816)
  • Patent number: 8865178
    Abstract: The present invention is related to the field of wound healing or tissue regeneration due to disease (i.e., for example, cardiovascular diseases, osetoarthritic diseases, or diabetes). In particular, the present invention provides compositions and methods comprising molecules with linked ?-gal epitopes for induction of recruitment of macrophages localized within or surrounding damaged tissue. The recruited macrophages recruit stem cells and promote the repair and regeneration of the treated injured tissue. In some embodiments, the present invention provides treatments for tissue repair in normal subjects and in subjects having impaired healing capabilities, such as diabetic and aged subjects. In some embodiments, the present invention provides treatments for injured tissues such as brain, peripheral nerve, heart muscle, skeletal muscle, cartilage, bone, gastrointestinal tract and dysfunctional endocrine tissues.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: October 21, 2014
    Assignee: University of Massachusetts
    Inventor: Uri Galili
  • Patent number: 8440198
    Abstract: The present invention is related to the field of wound healing or tissue regeneration due to disease (i.e., for example, cardiovascular diseases, osetoarthritic diseases, or diabetes). In particular, the present invention provides compositions and methods comprising molecules with linked ?-gal epitopes for induction of an inflammatory response localized within or surrounding damaged tissue. In some embodiments, the present invention provides treatments for tissue repair in normal subjects and in subjects having impaired healing capabilities, such as diabetic and aged subjects.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: May 14, 2013
    Assignee: University of Massachusetts
    Inventor: Uri Galili
  • Patent number: 8329192
    Abstract: The present invention provides isolated metal regulated polypeptides obtainable from a Campylobacter spp., and compositions including the polypeptides. The present invention also includes methods for using the compositions disclosed herein, including methods for treating in infection in a subject, for treating a condition caused by a Campylobacter spp., and for decreasing colonization of an animal.
    Type: Grant
    Filed: September 20, 2004
    Date of Patent: December 11, 2012
    Assignee: Epitopix LLC
    Inventors: Darren E. Straub, Daryll A. Emery
  • Patent number: 7749979
    Abstract: A CpG DNA adjuvant in avian vaccines is disclosed, which includes an immunostimulatory oligodeoxynucleotide (ODN) having a sequence of SEQ ID NO: 2. The CpG DNA adjuvant in avian vaccines is advantageous to carry out large-scale production, specifically enhance avian innate and adaptive immune responses, and the CpG DNA adjuvant is hardly to be digested by DNase due to its particular structures.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: July 6, 2010
    Assignee: National Pingtung University of Science and Technology
    Inventors: Hso-Chi Chaung, Li-Hsiang Hung, Yi-Yang Lien
  • Patent number: 7153511
    Abstract: The present invention provides an avian recombinant herpesvirus modified by the presence of the cDNA encoding, the VP2 of the Delaware Variant E strain of IBDV, a subtype of IBDV serotype 1 strains. The present invention further provides an avian recombinant herpesvirus comprised of the VP2 gene of which the backbone virus is a Marek's disease vaccine strain, such as herpesvirus of turkeys. A poultry vaccine including the avian herpes recombinant virus described in the present invention can induce in chickens protective immunity against a variety of different subtypes of IBDV.
    Type: Grant
    Filed: April 27, 2004
    Date of Patent: December 26, 2006
    Assignee: Zeon Corporation
    Inventors: Takanori Sato, Yoshinari Tsuzaki, Motoyuki Esaki, Kristi M. Dorsey
  • Patent number: 7090854
    Abstract: The present invention provides a new antigenic type of chicken anaemia viruses (CAV). The CAV according to this invention is isolatable from turkeys in the field and its virulence for chickens is significantly reduced. This property makes these viruses particularly suited for preparing a live vaccine for protecting poultry against disease conditions resulting from CAV infection.
    Type: Grant
    Filed: February 3, 2004
    Date of Patent: August 15, 2006
    Assignee: Akzo Nobel N.V.
    Inventors: Carla Christina Schrier, Henricus Johannes Maria Jagt
  • Patent number: 6764684
    Abstract: The present invention provides an avian recombinant herpesvirus modified by the presence of the cDNA encoding the VP2 of the Delaware Variant E strain of IBDV, a subtype of IBDV serotype 1 strains. The present invention further provides an avian recombinant herpesvirus comprised of the VP2 gene, of which the backbone virus is a Marek's disease vaccine strain, such as herpesvirus of turkeys. A poultry vaccine including the avian herpes recombinant virus described in the present invention can induce in chickens protective immunity against a variety of different subtypes of IBDV.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: July 20, 2004
    Assignee: Zeon Corporation
    Inventors: Shuji Saitoh, Takashi Okuda, Mayumi Kubomura, Kristi M. Moore
  • Patent number: 6723324
    Abstract: The present invention provides a new antigenic type of chicken anaemia viruses (CAV). The CAV according to this invention is isolatable from turkeys in the field and its virulence for chickens is significantly reduced. This property makes these viruses particularly suited for preparing a live vaccine for protecting poultry against disease conditions resulting from CAV infection.
    Type: Grant
    Filed: February 27, 2001
    Date of Patent: April 20, 2004
    Assignee: Akzo Nobel NV
    Inventors: Carla Christina Schrier, Henricus Johannes Maria Jagt
  • Publication number: 20020192234
    Abstract: An immunogenic preparation or vaccine against avian pneumovirosis, comprising an antigen of the avian pneumovirus strain C990427, in a vehicle or excipient which is acceptable from the veterinary point of view and, optionally, an adjuvant.
    Type: Application
    Filed: May 24, 2002
    Publication date: December 19, 2002
    Inventor: Sylvain Gabriel Goutebroze
  • Patent number: 6479056
    Abstract: A salmonella live vaccine produced from at least one attenuated immunologic live vaccine strain, characterized in that the vaccine strain has an envelope marker which results in an increased sensitivity of the vaccine strain toward a specific therapeutically effective antibiotic and has at least one chromosomal antibiotic resistance mutation for the attenuation.
    Type: Grant
    Filed: October 11, 2000
    Date of Patent: November 12, 2002
    Assignee: Lohman Animal Health GmbH & Co. KG
    Inventors: Klaus Linde, Jörg Beer, Bärbel Pless
  • Patent number: 6458363
    Abstract: The present invention is directed to a method to prepare an inactivated w/o emulsion adjuvated vaccine, wherein an aqueous solution comprising one or more inactivated angigens is mixed under mild conditions with a ready-made w/o emulsion. Preferably the vaccine is prepared just prior to vaccination. The aqueous solution and w/o emulsion are stirred or shaken by mechanical means or by hand. The present invention also relates to a kit of parts for use in a method according to the invention.
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: October 1, 2002
    Assignee: Akzo Nobel N.V.
    Inventors: Carla Christina Schrier, Eric Onno Rijke
  • Publication number: 20020081316
    Abstract: The present invention provides a novel avian herpesvirus (NAHV) vector and recombinant vaccines made therefrom that are useful to immunize avian species against Marek's disease, infectious laryngotracheitis and Newcastle disease. Methods of immunizing an avian species against Marek's disease, infectious laryngotracheitis and Newcastle disease are also provided.
    Type: Application
    Filed: June 14, 2001
    Publication date: June 27, 2002
    Inventors: Mark D. Cochran, Stephanie M. Cook, Martha A. Wild
  • Patent number: 6361775
    Abstract: The invention encompasses methods and compositions for inducing an immune response in an anti-Gal synthesizing animal including viral and tumor antigens manipulated to express &agr;-galactosyl epitopes.
    Type: Grant
    Filed: October 15, 1998
    Date of Patent: March 26, 2002
    Assignees: Medical College of Pennsylvania, Hahnemann University
    Inventors: Uri Galili, Patricia M. Repik
  • Patent number: 6312696
    Abstract: The present invention discloses a DNA molecule that encodes a polypeptide that has the amino acid sequence described in SEQ ID No. 2 or an amino acid sequence that is at least 80% homologous with said amino acid sequence, a recombinant containing said DNA molecule, and a vaccine having for its active ingredient said recombinant.
    Type: Grant
    Filed: February 19, 1999
    Date of Patent: November 6, 2001
    Assignee: Nippon Zeon Co., LTD
    Inventors: Yoshinari Tsuzaki, Takashi Okuda
  • Patent number: 6306400
    Abstract: The avian recombinant live vaccine comprises, as vector, an ILTV virus comprising and expressing at least one heterologous nucleotide sequence, this nucleotide sequence being inserted into the insertion locus formed by the intergenic region situated between the stop codons of the ORF D and ORF E of ILTV and which, in a specific ILTV strain, is defined between nucleotides 3873 and 4260 in SEQ ID No:1. The heterologous nucleotide sequence may be under the control of a strong eukaryotic promoter, such as the CMV-IE promoter, and may be derived from the Newcastle disease virus, Marek's disease virus, the infectious bursal disease virus, the infectious bronchitis virus, the chicken anaemia virus and the chicken pneumovirosis virus. Multivalent vaccine formula comprising at least two live vaccines according to the invention. ILTV virus thus recombined.
    Type: Grant
    Filed: July 28, 1999
    Date of Patent: October 23, 2001
    Assignee: Merial
    Inventors: Michel Bublot, Eliane Laplace, Jean-Christophe Audonnet
  • Patent number: 6270770
    Abstract: The present invention for the first time discloses a health problem in broilers at about 3-5 weeks, resulting in significant production losses, and demonstrates that these production losses can be prevented by a live attenuated CAA vaccine for mucosal administration.
    Type: Grant
    Filed: October 24, 1997
    Date of Patent: August 7, 2001
    Assignee: Akzo Nobel N.V.
    Inventors: Carla Christina Schrier, Pieter Matthijs Van Dijk
  • Patent number: 6241991
    Abstract: The invention relates to a new aviadenovirus which was isolated from a pigeon. The aviadenovirus according to the present invention comprises group-I specific antigen and cannot be neutralized by antiserum against any of the FAV serotypes 1-12. The present invention also relates to an antibody or antiserum immunoreactive with a fibre of the new aviadenovirus, a fibre thereof as well as a vaccin against PiAV related diseases comprising a chemically or physically inactivated virus an attenuated virus, a fibre or fragment thereof, a host cell transformed with a nucleic acid sequence encoding an amino acid sequence comprising an immunogenic determent or a functional variant thereof of a fibre of the aviadenovirus according to the present invention, together with a pharmaceutical carrier.
    Type: Grant
    Filed: February 25, 1999
    Date of Patent: June 5, 2001
    Assignee: Akzo Nobel N.V.
    Inventors: Guntram Paul, Michael Bernhard Hess
  • Patent number: 6231868
    Abstract: A system for the generation of live, nonpathogenic Birnavirus such as infectious bursal disease virus (IBDV), a segmented double-stranded (ds)RNA virus of the Birnavirdae family, using synthetic transcripts derived from cloned DNA has been developed. Independent full-length cDNA clones were constructed which contained the coding and non-coding regions of RNA segments A and B of IBDV, respectively. Segment A was modified to prevent the expression of NS protein. Synthetic RNAs of both segments were produced by in vitro transcription of linearized plasmids with T7 RNA polymerase. Transfection of Vero cells with combined plus-sense transcripts of both segments generated infectious virus as early as 36 hours post-transfection. The development of a system for producing NS protein deficient IBDV will greatly facilitate studies of immunosuppression, and aid in the development of live attenuated vaccines for IBDV.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: May 15, 2001
    Assignee: University of Maryland-Biotechnology Institute
    Inventors: Vikram N. Vakharia, Kun Yao
  • Patent number: 6153199
    Abstract: The living recombinant avian vaccine comprises, as a vector, an ILTV virus comprising and expressing at least one heterologous nucleotide sequence, this nucleotide sequence being inserted in the insertion locus defined between the nucleotides 1624 and 3606 at the SEQ ID NO: 5. The vaccine may in particular comprise a sequence coding for an antigen of an avian pathogenic agent selected among the group consisting of the Newcastle disease virus (NDV), the infections bursal virus (IBDV), the Marek disease virus (MDV), the infectious bronchitis virus (IBV), the chicken anaemia virus (CAV), thee chicken pneumovirosis virus, preferably under the control of a strong eukariotic promoter. A multivalent vaccine formula is also disclosed.
    Type: Grant
    Filed: December 23, 1998
    Date of Patent: November 28, 2000
    Assignee: Merial
    Inventors: Jean-Christophe Audonnet, Michel Bublot, Michel Riviere
  • Patent number: 6129920
    Abstract: The present invention is concerned with Infectious bursitis virus (IBDV) vaccines containing IBDV antigen material which is derived from a mammalian cell line infected with IBDV.
    Type: Grant
    Filed: September 12, 1996
    Date of Patent: October 10, 2000
    Assignee: Akzo Nobel
    Inventors: Piet Van Der Marel, Pieter Gerardus Mooren
  • Patent number: 6086892
    Abstract: This invention relates to a novel infectious bronchitis virus (IBV) serotype and to attenuated IBV strains derived therefrom, and also to live or inactivated vaccines made using such IB virus. This invention also relates to a method for protecting poultry against IBV using these vaccines.
    Type: Grant
    Filed: March 26, 1998
    Date of Patent: July 11, 2000
    Assignee: Akzo Nobel N.V.
    Inventor: Jane Kathleen Alexandra Cook
  • Patent number: 6048535
    Abstract: A multivalent poultry vaccine is provided having two or more live biological agents or microbial components. Each live biological agent or microbial component is effective in preventing or treating an avian disease, and the multivalent vaccine is safe and effective for immunizing poultry in ovo. Methods are also provided for vaccinating poultry by administering such a multivalent vaccine in ovo.
    Type: Grant
    Filed: June 12, 1997
    Date of Patent: April 11, 2000
    Assignee: Regents of the University of Minnesota
    Inventor: Jagdev M. Sharma
  • Patent number: 6019985
    Abstract: Methods are provided for improved immunization against coccidiosis and other bacterial, viral, or parasitic diseases in poultry. One method includes administering a solution of Propionibacterium acnes suspended in normal saline to a chick at age day one, following hatching. An anticoccidial vaccine and/or other vaccine is then administered to the chick such as by oral administration. Alternatively the method includes the steps of aseptically injecting Propionibacterium acnes in ovo at about day 18 in development, followed by post-hatching vaccination with an anticoccidial vaccine and/or other vaccine. Alternatively, either method can be utilized without the subsequent vaccination step for stimulating non-specific cell-mediated immune responses in poultry.
    Type: Grant
    Filed: February 27, 1998
    Date of Patent: February 1, 2000
    Assignee: Munova Corporation
    Inventors: Jenaay M. Brown, Larry R. McDougald
  • Patent number: 6013261
    Abstract: A recombinant herpes virus is provided which efficiently expresses an exogenous protein of interest in an inoculated animal host to thereby endow the host with excellent immunization. A recombinant herpes virus which incorporates an exogenous gene expression cassette in which a herpes virus-derived gB gene (a gene homologous to herpes simplex virus gB gene) promoter is used as a promoter for expression of an exogenous gene.
    Type: Grant
    Filed: January 30, 1997
    Date of Patent: January 11, 2000
    Assignee: Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
    Inventors: Kengo Sonoda, Masashi Sakaguchi, Kazuo Matsuo, Fukusaburo Hamada
  • Patent number: 6001348
    Abstract: The present invention provides NAD-independent Mycoplasma synoviae of strain MS1. The invention also refers to microbiological cultures comprising Mycoplasma synoviae of this strain. Next to this, the invention refers to live vaccines derived from these strains, for the protection of poultry against Mycoplasma synoviae infection. Furthermore, the invention provides methods for the preparation of such vaccines. Also, the use of NAD-independent Mycoplasma synoviae strains for the preparation of live vaccines for the protection of poultry against Mycoplasma synoviae infection is disclosed.
    Type: Grant
    Filed: December 5, 1997
    Date of Patent: December 14, 1999
    Assignee: Akzo Nobel N.V.
    Inventor: Maarten Hendrik Witvliet
  • Patent number: 5993822
    Abstract: The present invention provides a vaccine which is protective against avian polyomavirus infection in a bird which is classified as being a member of the Psittaciformes order which comprises an immunogenic amount of a modified live avian polyomavirus in a pharmaceutically acceptable carrier. Methods are also provided for preventing avian polyomavirus infection in a bird, or in several different species of birds, classified as being a member of the Psittaciformes order, comprising administering a vaccine comprising an immunogenic amount of a modified live avian polyomavirus and a pharmaceutically acceptable carrier. A preferred embodiment provides a modified live avian polyomavirus vaccine for prevention of wild-type infection in a Budgerigar, lovebird or Cockatiel.
    Type: Grant
    Filed: June 4, 1997
    Date of Patent: November 30, 1999
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Branson W. Ritchie, Phil D. Lukert, Denise Pesti
  • Patent number: 5965139
    Abstract: Novel sequences in the genome of a wild type isolate of chicken infectious anemia virus are described, The amino acid sequence of a polypeptide, VP1, encoded by a novel sequence is also disclosed. Additionally, disclosed are the unexpected properties of the isolate which are related to novel amino acids positioned in the amino acid sequence of this isolate's VP1, as compared to the sequence of VP1 found in cell culture-adapted strains; and use of the novel sequences and their respective polypeptides in strategies to control chicken infectious anemia such as by vaccination.
    Type: Grant
    Filed: April 16, 1998
    Date of Patent: October 12, 1999
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Karel A. Schat, Christiane Soine, Benjamin Lucio, Randy Renshaw
  • Patent number: 5958424
    Abstract: Recombinant genetic information (DNA or RNA), comprising a Chicken Anemia Virus (CAV)-specific nucleotide sequence and the use thereof for diagnostics, vaccination or protein production. Recombinant CAV protein and the use thereof for diagnostics, vaccination or production of CAV-specific antibodies. The use of CAV-specific antibodies thus obtained.
    Type: Grant
    Filed: August 13, 1997
    Date of Patent: September 28, 1999
    Assignee: Leadd BV
    Inventors: Mathews H.M. Noteborn, Gerden F. De Boer
  • Patent number: 5916879
    Abstract: The present invention describes a reliably protective avian vaccine that contains a DNA transcription unit comprising a nucleic acid that encodes a viral protein. This effective and reliable avian vaccine significantly improves upon that which heretofore has been disclosed. The present invention demonstrates that the reliable efficacy found for DNA influenza vaccines, formerly observed in experimental inbred mice, can now be obtained for outbred avian species as well. Methods of use and specific DNA constructs are disclosed.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: June 29, 1999
    Assignee: St. Jude Children's Research Hospital
    Inventor: Robert Webster
  • Patent number: 5914113
    Abstract: The present invention is concerned with the preparation of improved inactivated vaccines, in particular of inactivated poultry vaccines. The immunogenicity of the inactivated immunogens in such vaccines is enhanced in case live CAV are administered in a combination vaccine with these inactivated immnogens.
    Type: Grant
    Filed: September 26, 1997
    Date of Patent: June 22, 1999
    Assignee: Akzo Nobel, N.V.
    Inventor: Carla Christina Schrier
  • Patent number: 5888518
    Abstract: A method for preventing and treating parasitic infections in animals by administering a lysine analog, such as EACA, to the animals on a continuous basis. In the preferred embodiment, the method of the present invention is directed to preventing and treating coccidial infections in poultry by adding EACA to the daily diet of a poultry flock. EACA may also be administered in ovo before hatching. The administration of EACA enhances the natural immune response of the poultry to the invading coccidial organisms and enables the poultry to combat the parasites without the need for antibiotics. Another aspect of the present invention involves preventing parasitic diseases in humans and animals by prophylactically administering a serine protease inhibitor, such as EACA, as an adjuvant in conjunction with a conventional vaccine effective against the target parasite.
    Type: Grant
    Filed: October 6, 1995
    Date of Patent: March 30, 1999
    Inventors: Guy R. Beretich, Sr., Louis D. Beretich
  • Patent number: 5879675
    Abstract: The invention encompasses methods and compositions for inducing an immune response in an anti-Gal synthesizing animal including viral and tumor antigens manipulated to express .alpha.-galactosyl epitopes.
    Type: Grant
    Filed: September 11, 1996
    Date of Patent: March 9, 1999
    Assignee: Medical College of Pennsylvania and Hahnemann University
    Inventors: Uri Galili, Patricia M. Repik
  • Patent number: 5871744
    Abstract: A system for the generation of live Birnavirus such as infectious bursal disease virus (IBDV), a segmented double-stranded (ds)RNA virus of the Birnavirdae family, using synthetic transcripts derived from cloned DNA has been developed. Independent full-length cDNA clones were constructed which contained the entire coding and non-coding regions of RNA segments A and B of IBDV, respectively. Synthetic RNAs of both segments were produced by in vitro transcription of linearized plasmids with T7 RNA polymerase. Transfection of Vero cells with combined plus-sense transcripts of both segments generated infectious virus as early as 36 hours post-transfection. The development of a reverse genetics system for dsRNA viruses will greatly facilitate studies of the regulation of viral gene expression pathogenesis, and design of a new generation of live and inactivated vaccines.
    Type: Grant
    Filed: September 5, 1996
    Date of Patent: February 16, 1999
    Assignee: University of Maryland-Biotechnology Inst.
    Inventors: Vikram N. Vakharia, Egbert Mundt
  • Patent number: 5858368
    Abstract: A method of preparing a recombinant influenza vaccine using DNA technology is provided. The resulting vaccine is a multivalent, preferably trivalent, influenza vaccine based on a mixture of recombinant hemagglutinin antigens cloned from influenza viruses having epidemic potential. The recombinant hemagglutinin antigens are full length, uncleaved (HAO), glycoproteins produced from baculovirus expression vectors in cultured insect cells and purified under non-denaturing conditions. The recombinant vaccine can be developed from primary sources of influenza, for example, nasal secretions from infected individuals, rather than from virus adapted to and cultured in chicken eggs. The process for cloning influenza hemagglutinin genes from influenza A and B viruses uses specially designed oligonucleotide probes and PCR. In the preferred embodiment, the cloned HA genes are then modified by deletion of the natural hydrophobic signal peptide sequences and replacing them with a new baculovirus signal peptide.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: January 12, 1999
    Assignee: Protein Sciences Corporation
    Inventors: Gale E. Smith, Franklin Volvovitz, Bethanie E. Wilkinson, Andrei I. Voznesensky, Craig S. Hackett
  • Patent number: 5853733
    Abstract: The present invention provides a recombinant herpesvirus of turkeys designated S-HVT-050 (ATCC Accession No. VR 2400). A vaccine is provided which comprises an effective immunizing amount of S-HVT-050 and a suitable carrier. A method of immunizing a fowl against disease caused by Marek's disease virus and Newcastle disease virus is also provided which comprises administering to the fowl an effective immunizing dose of the vaccine of the present invention.
    Type: Grant
    Filed: June 13, 1996
    Date of Patent: December 29, 1998
    Assignee: Syntro Corporation
    Inventors: Mark D. Cochran, Richard D. Macdonald
  • Patent number: 5804195
    Abstract: Invention relates to a vaccine for the prevention of Infectious Bursal Disease in poultry comprising an effective immunizing amount of a live attenuated intermediately-pathogenic IBD virus belonging to the strain deposited at the ECACC under No. V92052301 (MB), an effective immunizing amount of a live attenuated intermediately-pathogenic IBD virus belonging to the strain deposited at the ECACC under No. V92100106 (MB-2), or an effective immunizing amount of a live attenuated intermediately-pathogenic IBD virus belonging to the strain deposited at the ECACC under No. V92102209 (MB-1).
    Type: Grant
    Filed: November 30, 1993
    Date of Patent: September 8, 1998
    Assignee: ABIC Ltd.
    Inventor: Bezalel Gutter
  • Patent number: 5762939
    Abstract: A method of preparing a recombinant influenza vaccine using DNA technology is provided. The resulting vaccine is a trivalent influenza vaccine based on a mixture of recombinant hemagglutinin antigens cloned from influenza viruses having epidemic potential. The recombinant hemagglutinin antigens are full length, uncleaved (HA0), glycoproteins produced from baculovirus expression vectors in cultured insect cells and purified under non-denaturing conditions. The process for cloning influenza hemagglutinin genes from influenza A and B viruses uses specially designed oligonucleotide probes and PCR. The cloned HA genes are then modified by deletion of the natural hydrophobic signal peptide sequences and replacing them with a new baculovirus signal peptide. A general approach for the efficient extraction and purification of recombinant HA protein produced in insect cells is also disclosed which can be adapted for the purification of rHA proteins from A sub-types and B type influenza viruses.
    Type: Grant
    Filed: September 13, 1993
    Date of Patent: June 9, 1998
    Assignee: MG-PMC, LLC
    Inventors: Gale Eugene Smith, Franklin Volvovitz, Bethanie Eident Wilkinson, Craig Stanway Hackett
  • Patent number: 5750113
    Abstract: This invention relates to a novel infectious bronchitis virus (IBV) serotype and to attenuated IBV strains derived therefrom, and also to live or inactivated vaccines made using such IB virus.
    Type: Grant
    Filed: December 14, 1995
    Date of Patent: May 12, 1998
    Assignee: Akzo Nobel N.V.
    Inventor: Jane Kathleen Alexandra Cook
  • Patent number: 5733556
    Abstract: The present invention provides a combination vaccine for use in the protection of poultry against ND comprising an expression system, such as a virus vector, expressing a NDV immunogenic protein, and a live NDV vaccine strain. It is demonstrated that such a combination vaccine affords good local and systemic protection.
    Type: Grant
    Filed: October 15, 1996
    Date of Patent: March 31, 1998
    Assignee: Akzo Nobel N.V.
    Inventors: Carla Christina Schrier, Heinrich Dieter Lutticken
  • Patent number: 5728569
    Abstract: The present invention provides a live and inactivated Chicken Anaemia Agent vaccine capable of evoking an immune response in a vaccinated chicken. The CAA virus of the vaccine is attenuated by serial passages in embryonated eggs.
    Type: Grant
    Filed: September 2, 1994
    Date of Patent: March 17, 1998
    Assignee: Akzo Nobel N.V.
    Inventor: Carla Christina Schrier
  • Patent number: 5693530
    Abstract: A novel nucleotide sequence in the genome of Marek's disease virus (MDV) containing an open reading frame, whose expression is associated with lytic infection and tumor cell development in MDV-infected cells, is described. Also described is the use of this novel sequence for molecular diagnostics of serotype 1 MDV; and to generate a recombinant MDV by inserting one or more endogenous or exogenous genes, operably linked to a control element for expression, into a region of the MDV genome comprising the novel nucleotide sequence, wherein the insertion interrupts expression of the open reading frame.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 2, 1997
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Karel A. Schat, Kazuhiko Ohashi, Priscilla H. O'Connell
  • Patent number: 5686077
    Abstract: The present invention provides a live and inactivated Chicken Anaemia Agent vaccine capable of evoking an immune response in a vaccinated chicken. The CAA virus of the vaccine is attenuated by serial passages in embryonated eggs.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: November 11, 1997
    Assignee: Akzo Nobel N.V.
    Inventor: Carla Christina Schrier
  • Patent number: 5676952
    Abstract: Herpesviruses naturally deficient in gD, that is to say not expressing their gD gene in vitro or not possessing this gene, are transformed to express gD in vitro. This transformation by genetic recombination can consist in replacement of the natural promoter by another one or insertion of an expression cassette containing gD and a promoter. The invention also relates to these viruses incorporating a gene coding for an antigen of interest, to the vaccines obtained and to the methods of culture thus improved. The invention relates in particular to avian herpesviruses, especially MDV, and the VZV virus.
    Type: Grant
    Filed: April 19, 1995
    Date of Patent: October 14, 1997
    Assignee: Rhone Merieux, societe anonyme
    Inventors: Jean-Christophe Francis Audonnet, Raphael Jean Darteil, Michel Albert Emile Riviere, Vladimir Zelnik, Louis Joseph Norman Ross
  • Patent number: 5602022
    Abstract: A method of producing infectious bursal disease virus comprising culturing infectious bursal disease virus in a mammalian cell line for two to ten days.
    Type: Grant
    Filed: November 20, 1992
    Date of Patent: February 11, 1997
    Assignee: Akzo Nobel, N.V.
    Inventors: Piet Van Der Marel, Pieter G. Mooren
  • Patent number: 5565202
    Abstract: A vaccine for Marek's disease using mutant strains of a serotype 2 field isolate, designated 471B/1, is disclosed. The mutant viruses, which are produced by serial passage of 471B/1 in cell culture, not only retain effective immunizing ability against Marek's disease virus, but which also exhibit reduced enhancement of lymphoid leukosis in comparison to non-passaged 471B/1 and conventional serotype 2 vaccines. These viruses or immunogenic components thereof can be formulated into monovalent and polyvalent vaccines.
    Type: Grant
    Filed: August 12, 1994
    Date of Patent: October 15, 1996
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventor: Richard L. Witter
  • Patent number: 5523088
    Abstract: The present invention provides a vaccine which is protective against avian polyomavirus infection in a bird which is classified as being a member of the Psittaciformes order which comprises an immunogenic amount of an inactivated avian polyomavirus in a pharmaceutically acceptable carrier. Also provided is an adjuvant suitable for use in a bird which is classified as being a member of the Psittaciformes order. Further provided is a composition which produces an anamnestic response against avian polyomavirus infection in a sensitized bird which is classified as being a member of the Psittaciformes order, which comprises an anamnestic response inducing amount of a recombinant protein (e.g., VP1 capsid protein) of avian polyomavirus in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: January 13, 1994
    Date of Patent: June 4, 1996
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Branson W. Ritchie, Frank D. Niagro, Kenneth S. Latimer
  • Patent number: 5518724
    Abstract: A new virus not neutralized or bound by monoclonal antibodies which are group neutralizing to all IBDV vaccines of current art, and capable of inducing infectious bursal disease in poultry is identified, in essentially pure form. A test kit, and assay for the presence of the virus is disclosed, together with the vaccine incorporating the virus. A monoclonal antibody Mab 50, which neutralizes the virus, form the basis of an alternative vaccine.
    Type: Grant
    Filed: September 15, 1992
    Date of Patent: May 21, 1996
    Assignee: University of Maryland
    Inventors: David B. Snyder, deceased, Vikram Vakharia
  • Patent number: 5470734
    Abstract: The present invention is concerned with a recombinant Herpesvirus of Turkeys (HVT), containing a heterologous gene incorporated into an insertion region of the genome of HVT. The invention also relates to a vector vaccine comprising such a recombinant HVT which expresses a heterologous antigenic polypeptide and induces an adequate immune response on infection of an appropriate host animal.
    Type: Grant
    Filed: February 16, 1993
    Date of Patent: November 28, 1995
    Assignee: Akzo Nobel N.V.
    Inventors: Paulus J. A. Sondermeijer, Johannes A. J. Claessens, Albert P. A. Mockett
  • Patent number: 5443982
    Abstract: This invention involves a chemically transformed chicken hepatocyte derived cell line which is capable of efficiently supporting replication of infectious laryngotracheitis virus (ILTV) and methods for cultivating ILTV using this hepatocellular carcinoma cell line. The virus harvested from these continuous cell culture methods can be used as a vaccine against ILTV infection.
    Type: Grant
    Filed: July 13, 1993
    Date of Patent: August 22, 1995
    Assignee: Solvay Animal Health, Inc.
    Inventors: Ellan Welniak, Gary R. Petersen
  • Patent number: 5443831
    Abstract: An isolated nucleic acid molecule encoding the gB glycoprotein of Infectious Laryngotracheitis Virus is disclosed. Also disclosed is incorporation of the gB gene into recombinant avipox virus for a vaccine used to immunize fowl.
    Type: Grant
    Filed: November 19, 1993
    Date of Patent: August 22, 1995
    Assignee: University of Delaware
    Inventors: Calvin L. Keeler, David J. Poulsen