Bacterial Vaccine For Avian Species (e.g., Poultry Or Other Birds, Etc.) Patents (Class 424/826)
  • Patent number: 8999374
    Abstract: The present invention is to provide a ?-1,4-mannobiose-containing composition which can inhibit colonization of salmonella in animal body and effectively excrete salmonella outside the body and the method for producing thereof, a feed additive containing the ?-1,4-mannobiose-containing composition, and a feed blended with the ?-1,4-mannobiose-containing composition.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: April 7, 2015
    Assignee: Fuji Oil Co., Ltd.
    Inventors: Toshimichi Morikoshi, Futoshi Yokomizo
  • Patent number: 8993252
    Abstract: The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccharide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provides methods of making and methods of using such compositions.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: March 31, 2015
    Assignee: Epitopix, LLC
    Inventors: Daryll A. Emery, Darren E. Straub
  • Patent number: 8173139
    Abstract: Populations of Salmonella in animals may be substantially reduced by treatment with a vaccine composition which has been produced by exposing whole, intact cells of a Salmonella species to irradiation with an electron beam under conditions effective to kill the cells. The electron beam irradiated cells of Salmonella are effective for stimulating protective immune responses in the animals against the Salmonella. Induction of these immune responses significantly reduces or eliminates the colonization of the animal by the Salmonella, and consequently reduces or eliminates the shedding of Salmonella in the feces of the animals.
    Type: Grant
    Filed: September 10, 2009
    Date of Patent: May 8, 2012
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventors: Jackson L. McReynolds, Suresh Pillai, Palmy Rose Rajan Jesudhasan, Martha Lucia Cepeda Hernandez
  • Patent number: 7749979
    Abstract: A CpG DNA adjuvant in avian vaccines is disclosed, which includes an immunostimulatory oligodeoxynucleotide (ODN) having a sequence of SEQ ID NO: 2. The CpG DNA adjuvant in avian vaccines is advantageous to carry out large-scale production, specifically enhance avian innate and adaptive immune responses, and the CpG DNA adjuvant is hardly to be digested by DNase due to its particular structures.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: July 6, 2010
    Assignee: National Pingtung University of Science and Technology
    Inventors: Hso-Chi Chaung, Li-Hsiang Hung, Yi-Yang Lien
  • Patent number: 7744868
    Abstract: One embodiment of the present invention is directed to the use of a novel competitive exclusion bacterial composition to prevent or reduce Salmonella or Campylobacter colonization in poultry.
    Type: Grant
    Filed: November 22, 2004
    Date of Patent: June 29, 2010
    Assignee: University of Georgia Research Foundation
    Inventors: Michael P. Doyle, Guodong Zhang, Li Ma
  • Patent number: 7138124
    Abstract: The present invention provides compositions including at least two siderophore receptor polypeptides and at least two porins from a gram negative microbe, and preferably, lipopolysaccharide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provides methods of makino and methods of using such compositions.
    Type: Grant
    Filed: June 3, 2003
    Date of Patent: November 21, 2006
    Assignee: Epitopix, LLC
    Inventors: Daryll A. Emery, Darren E. Straub, Donavan E. Zammert, Gayla K. Kallevig
  • Patent number: 6936263
    Abstract: The present invention relates to the use of the major OprI lipoprotein of Pseudomonas aeruginosa to elicit a Type-1 immune response towards a heterologous antigen. The invention relates specifically to the use of OprI—antigen fusion proteins to elicit the Type-1 response. More particularly, the present invention is directed to pharmaceutical formulations comprising OprI and/or OprI fusion proteins, optionally together with a suitable excipient, to stimulate the Th1 dependent, cellular immune response.
    Type: Grant
    Filed: August 16, 2002
    Date of Patent: August 30, 2005
    Assignee: Vlaams Interuniversitair Instituut voor Biotechnologie VZW
    Inventors: Hilde Revets, Pierre Cornelis, Patrick De Baetselier
  • Patent number: 6790446
    Abstract: The present invention relates to vaccines comprising antiserum raised against a flagellaless Campylobacter strain for the prevention of Campylobacter colonization in animals. The invention also relates to antigenic Campylobacter proteins visible in a Western blot of Campylobacter jejuni protein after incubation of said Western blot with antibodies against a flagellaless mutant of Campylobacter jejuni and not visible after incubation of said blot with antibodies against wild type Campylobacter jejuni, and to their use in vaccines and the manufacturing thereof. The invention further relates to vaccines comprising such proteins and antibodies against such proteins. The invention further relates to the use of such Campylobacter proteins and to antiserum and antibodies raised against Campylobacter antigens for the preparation of vaccines. Finally, the invention relates to methods for the preparation of such vaccines.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: September 14, 2004
    Assignee: Akzo Nobel, NV
    Inventors: Antonius Arnoldus Christiaan Jacobs, Johannes Franciscus van den Bosch, Petrus Johannes Maria Nuijten
  • Patent number: 6713073
    Abstract: A method of vaccinating poultry by spraying the poultry with an effective amount of a live avirulent derivative of an enteropathogenic enterobacteria is disclosed.
    Type: Grant
    Filed: July 24, 1998
    Date of Patent: March 30, 2004
    Assignee: Megan Health, Inc.
    Inventor: Sandra M. Aehle
  • Patent number: 6585980
    Abstract: Purified and isolated nucleic acid molecules are provided which encode a FlaC flagellin protein of a strain of Campylobacter, particularly C. jejuni, or a fragment or an analog of the FlaC flagellin protein. The nucleic acid molecules may be used to produce proteins free of contaminants derived from bacteria normally containing the FlaA or FlaB proteins for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecules, proteins encoded thereby and antibodies raised against the proteins, may be used in the diagnosis of infection.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: July 1, 2003
    Assignee: The University of Toronto
    Inventors: Voon Loong Chan, Helena Louie
  • Patent number: 6432412
    Abstract: The invention provides a vaccine for immunizing poultry and other animals against infection by a gram-negative bacteria, and a method of immunizing an animal using the vaccine. The vaccine may contain purified siderophore receptor proteins derived from a single strain or species of gram-negative bacteria or other organism, which are cross-reactive with siderophores produced by two or more strains, species or genera of gram-negative bacteria. The invention further provides a process for isolating and purifying the siderophore receptor proteins, and for preparing a vaccine containing the proteins. Also provided is a method for diagnosing gram-negative sepsis.
    Type: Grant
    Filed: July 26, 1999
    Date of Patent: August 13, 2002
    Assignee: Willmar Poultry Company, Inc.
    Inventors: Daryll A. Emery, Darren E. Straub, Richard Huisinga, Beth A. Carlson
  • Patent number: 6231871
    Abstract: The present invention relates generally to modified microorganisms suitable for use as live in ovo vaccines for avian species. The live in ovo vaccines of the present invention are useful for inducing immunity before or immediately after hatching against a virulent form of the modified microorganism or a microorganism immunologically related to the modified microorganism or a virulent organism or virus carrying an antigenic determinant expressed by the modified microorganism in the live vaccine. The subject live in ovo vaccines are particularly efficacious in enhancing the survival rate of newly-hatched poultry birds.
    Type: Grant
    Filed: May 6, 1996
    Date of Patent: May 15, 2001
    Assignee: American Cyanamid Company
    Inventor: Peter John Coloe
  • Patent number: 6027736
    Abstract: The invention provides a vaccine for immunizing poultry and other animals against infection by a gram-negative bacteria, and a method of immunizing an animal using the vaccine. The vaccine may contain purified siderophore receptor proteins derived from a single strain or species of gram-negative bacteria or other organism, which are cross-reactive with siderophores produced by two or more strains, species or genera of gram-negative bacteria. The invention further provides a process for isolating and purifying the siderophore receptor proteins, and for preparing a vaccine containing the proteins. Also provided is a method for diagnosing gram-negative sepsis.
    Type: Grant
    Filed: July 30, 1997
    Date of Patent: February 22, 2000
    Assignee: Willmar Poultry Country, Inc.
    Inventors: Daryll A. Emery, Darren E. Straub, Richard Huisinga, Beth A. Carlson
  • Patent number: 6019985
    Abstract: Methods are provided for improved immunization against coccidiosis and other bacterial, viral, or parasitic diseases in poultry. One method includes administering a solution of Propionibacterium acnes suspended in normal saline to a chick at age day one, following hatching. An anticoccidial vaccine and/or other vaccine is then administered to the chick such as by oral administration. Alternatively the method includes the steps of aseptically injecting Propionibacterium acnes in ovo at about day 18 in development, followed by post-hatching vaccination with an anticoccidial vaccine and/or other vaccine. Alternatively, either method can be utilized without the subsequent vaccination step for stimulating non-specific cell-mediated immune responses in poultry.
    Type: Grant
    Filed: February 27, 1998
    Date of Patent: February 1, 2000
    Assignee: Munova Corporation
    Inventors: Jenaay M. Brown, Larry R. McDougald
  • Patent number: 6019984
    Abstract: Novel bacterial preparations containing one or more isolated and purified strain of a microorganism which produces one or more RTX toxins, and which strain has at least one RTX toxin which is substantially cell-associated. Methods of preparing the bacterial preparations and their use as vaccines and to produce antibodies for passive immunization are described.
    Type: Grant
    Filed: December 23, 1996
    Date of Patent: February 1, 2000
    Assignee: University of Guelph
    Inventors: Janet MacInnes, Paul Ricciatti, Bonnie Mallard, Soren Rosendal, deceased
  • Patent number: 6001348
    Abstract: The present invention provides NAD-independent Mycoplasma synoviae of strain MS1. The invention also refers to microbiological cultures comprising Mycoplasma synoviae of this strain. Next to this, the invention refers to live vaccines derived from these strains, for the protection of poultry against Mycoplasma synoviae infection. Furthermore, the invention provides methods for the preparation of such vaccines. Also, the use of NAD-independent Mycoplasma synoviae strains for the preparation of live vaccines for the protection of poultry against Mycoplasma synoviae infection is disclosed.
    Type: Grant
    Filed: December 5, 1997
    Date of Patent: December 14, 1999
    Assignee: Akzo Nobel N.V.
    Inventor: Maarten Hendrik Witvliet
  • Patent number: 5980907
    Abstract: Attenuated microorganism for use in immunoprophylaxis in which the attenuation is brought about by the presence of a mutation in the DNA sequence of the microorganism which encodes, or which regulates the expression of DNA encoding a protein that is produced in response to environmental stress, the microorganism optionally being capable of expressing DNA encoding a heterologous antigen.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 9, 1999
    Assignee: Glaxo Wellcome Inc.
    Inventors: Gordan Dougan, Ian George Charles, Carlos Estenio Hormaeche, Kevin Stuart Johnson, Steven Neville Chatfield
  • Patent number: 5955090
    Abstract: The present invention relates to a hybrid protein comprising the Pseudomonas aeruginosa outer membrane protein I (OprI) which is fused with its amino terminal end to the carboxy-terminal end of a carboxy-terminal portion of the Pseudomonas aeruginosa outer membrane protein F (OprF), as well as to monoclonal or polyclonal antibodies against this hybrid protein. Both, the hybrid protein and the antibodies directed to the hybrid protein confer protection against an infection by Pseudomonas aeruginosa to laboratory animals or man.
    Type: Grant
    Filed: December 14, 1995
    Date of Patent: September 21, 1999
    Assignee: Chiron Behring GmbH & Co.
    Inventors: Bernhard Knapp, Klaus-Dieter Hungerer, Michael Broker, Bernd-Ulrich von Specht, Horst Domdey
  • Patent number: 5925361
    Abstract: The present invention relates to a novel bacterial respiratory poultry disease and the identification of the causative agent. A vaccine derived from this agent was effective in preventing the disease in chickens challenged with the virulent field strains.
    Type: Grant
    Filed: November 1, 1996
    Date of Patent: July 20, 1999
    Assignee: Akzo Nobel, N.V.
    Inventors: Paul Karel Storm, Paul Cornelius Maria van Empel
  • Patent number: 5888518
    Abstract: A method for preventing and treating parasitic infections in animals by administering a lysine analog, such as EACA, to the animals on a continuous basis. In the preferred embodiment, the method of the present invention is directed to preventing and treating coccidial infections in poultry by adding EACA to the daily diet of a poultry flock. EACA may also be administered in ovo before hatching. The administration of EACA enhances the natural immune response of the poultry to the invading coccidial organisms and enables the poultry to combat the parasites without the need for antibiotics. Another aspect of the present invention involves preventing parasitic diseases in humans and animals by prophylactically administering a serine protease inhibitor, such as EACA, as an adjuvant in conjunction with a conventional vaccine effective against the target parasite.
    Type: Grant
    Filed: October 6, 1995
    Date of Patent: March 30, 1999
    Inventors: Guy R. Beretich, Sr., Louis D. Beretich
  • Patent number: 5871744
    Abstract: A system for the generation of live Birnavirus such as infectious bursal disease virus (IBDV), a segmented double-stranded (ds)RNA virus of the Birnavirdae family, using synthetic transcripts derived from cloned DNA has been developed. Independent full-length cDNA clones were constructed which contained the entire coding and non-coding regions of RNA segments A and B of IBDV, respectively. Synthetic RNAs of both segments were produced by in vitro transcription of linearized plasmids with T7 RNA polymerase. Transfection of Vero cells with combined plus-sense transcripts of both segments generated infectious virus as early as 36 hours post-transfection. The development of a reverse genetics system for dsRNA viruses will greatly facilitate studies of the regulation of viral gene expression pathogenesis, and design of a new generation of live and inactivated vaccines.
    Type: Grant
    Filed: September 5, 1996
    Date of Patent: February 16, 1999
    Assignee: University of Maryland-Biotechnology Inst.
    Inventors: Vikram N. Vakharia, Egbert Mundt
  • Patent number: 5830479
    Abstract: The invention provides a vaccine for immunizing poultry and other animals against infection by a gram-negative bacteria, and a method of immunizing an animal using the vaccine. The vaccine may contain purified siderophore receptor proteins derived from a single strain or species of gram-negative bacteria or other organism, which are cross-reactive with siderophores produced by two or more strains, species or genera of gram-negative bacteria. The invention further provides a process for isolating and purifying the siderophore receptor proteins, and for preparing a vaccine containing the proteins. Also provided is a method for diagnosing gram-negative sepsis.
    Type: Grant
    Filed: February 8, 1995
    Date of Patent: November 3, 1998
    Assignee: Willmar Poultry Company, Inc.
    Inventors: Daryll A. Emery, Darren E. Straub, Richard Huisinga, Beth A. Carlson
  • Patent number: 5792452
    Abstract: A live Salmonella vaccine having an increased stability is disclosed. Further, immunization methods of a host such as chickens against Salmonella diseases are carried out by the use of the vaccine. The vaccine may be administered orally or parenterally and includes one or more of the live vaccines disclosed herein. The live vaccine is produced from one or more live vaccine strains with metabolic drift attenuation via an increased generation time. The vaccine is an immunogenic, stable and single or multiple marker live vaccine strain with or without envelope mutation; and the live vaccine is a suppressor mutant of an original live vaccine strain still having the attenuation marker(s) of the original live vaccine strain but a shortened generation time and having macrolide tolerance.
    Type: Grant
    Filed: October 3, 1994
    Date of Patent: August 11, 1998
    Inventor: Klaus Linde
  • Patent number: 5641491
    Abstract: New methods and compositions suitable for the vaccination of poultry against pathogenic Escherichia coli are presented. The invention uses the clonal structure of bacterial populations in order to successfully vaccinate aginst such poultry pathogens by selecting out closely related non-pathogenic organisms. Live E. coli strain 364 is used to effect immunization.
    Type: Grant
    Filed: June 15, 1993
    Date of Patent: June 24, 1997
    Assignee: The Penn State Research Foundation
    Inventors: Richard A. Wilson, Thomas Whittam, Vivek Kapur
  • Patent number: 5576003
    Abstract: The present invention relates to a novel bacterial respiratory poultry disease and the identification of the causative agent Ornithobacterium rhinotracheale. A vaccine derived from this agent was effective in preventing the disease in chickens challenged with the virulent field strains.
    Type: Grant
    Filed: June 9, 1994
    Date of Patent: November 19, 1996
    Assignee: Akzo Nobel N.V.
    Inventors: Paul K. Storm, Paul C. M. van Empel
  • Patent number: 5527529
    Abstract: The present invention discloses a novel approach to attenuating bacteria and for their use as live vaccines. The vaccines can be used in human and animal medicine.In particular, there is disclosed a method of attenuating a bacteria by mutating a gene concerned with the regulation of one or more genes concerned with expression of outer membrane proteins, particularly porin proteins.
    Type: Grant
    Filed: April 10, 1995
    Date of Patent: June 18, 1996
    Assignees: The Wellcome Foundation Limited, The Royal Society, The Lister Institute of Preventive Medicine, The University Court of The University of Dundee
    Inventors: Gordan Dougan, Steven N. Chatfield, Christopher F. Higgins, Charles J. Dorman