Bacterial Vaccine For Fish Patents (Class 424/827)
-
Patent number: 8993252Abstract: The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccharide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provides methods of making and methods of using such compositions.Type: GrantFiled: March 21, 2013Date of Patent: March 31, 2015Assignee: Epitopix, LLCInventors: Daryll A. Emery, Darren E. Straub
-
Patent number: 8414947Abstract: The present invention is directed to a pharmaceutical preparation for oral application for treatment of fish, in particular for vaccination of fish of the salmon family and other fish having a comparable digestive system against bacterial and/or viral infections, in particular against VHS and IHN. The invention is also directed to a method for producing the preparation.Type: GrantFiled: December 13, 2005Date of Patent: April 9, 2013Assignee: Riemser Arzneimittel AGInventors: Malte Adelmann, Dieter Fichtner, Bodo Lange, Werner Weitschies
-
Patent number: 8318152Abstract: An exemplary embodiment providing one or more improvements includes probiotic compositions comprising probiotic microorganisms with dried vegetable, fruit, cereal, or herb powder. Feeding human or animals either having biological or environmental changes with probiotic compositions has a positive effect in relieving the changes. Positive effects has been demonstrated in humans, dogs, and fish.Type: GrantFiled: April 16, 2009Date of Patent: November 27, 2012Assignee: Imagilin Technology, LLCInventor: Jhy-Jhu Lin
-
Patent number: 7674892Abstract: The hsp70 gene from an Arthrobacter species has been isolated and sequenced. The encoded protein is believed to be highly immunogenic, especially in fish, and also has utility as a non-specific adjuvant, and as an adjuvanting carrier for heterologous antigens.Type: GrantFiled: July 14, 2003Date of Patent: March 9, 2010Assignee: Novartis AGInventors: Steven Gareth Griffiths, Rachael Jane Ritchie, Nathalie C. Simard
-
Patent number: 7138124Abstract: The present invention provides compositions including at least two siderophore receptor polypeptides and at least two porins from a gram negative microbe, and preferably, lipopolysaccharide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provides methods of makino and methods of using such compositions.Type: GrantFiled: June 3, 2003Date of Patent: November 21, 2006Assignee: Epitopix, LLCInventors: Daryll A. Emery, Darren E. Straub, Donavan E. Zammert, Gayla K. Kallevig
-
Patent number: 6379677Abstract: Safe and effective mono and polyvalent vaccines against Streptococcus iniae may be prepared from formalin-killed cells and concentrated extracellular products of Streptococcus iniae which include one or more of deposited strains NRRL B-30238 and NRRL B-30242. Intraperitoneal and intramuscular vaccination of tilapia show acquisition of effective immunity against homologous and heterologous isolates of S. iniae.Type: GrantFiled: February 25, 2000Date of Patent: April 30, 2002Assignee: The United States of America as represented by the Secretary of the Department of AgricultureInventors: Phillip H. Klesius, Craig A. Shoemaker, Joyce J. Evans
-
Patent number: 6350454Abstract: Live-attenuated vaccines against Edwardsiella ictaluri or against Pasteurella piscicida are disclosed. Both vaccines are incapable of reversion to virulence, because both are made by deletion mutations in the aroA gene, the purA gene, or both. These vaccines may be used not only to vaccinate fish against Edwardsiella ictaluri or Pasteurela piscicida, but also to serve as vectors to present antigens from other pathogens to the fish, thereby serving as vaccines against other pathogens as well, with no risk of infection by reversion to the virulent form of the pathogen in which the antigen occurs naturally.Type: GrantFiled: October 8, 1999Date of Patent: February 26, 2002Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventor: Ronald L. Thune
-
Patent number: 6153202Abstract: Methods for the safe and effective live in ovo vaccination of eyed eggs of catfish against enteric septicemia of catfish (ESC) were created through the use of rifampicin resistant native E. ictaluri isolates; these including rifampicin-resistant strain ATCC 202058 of Edwardsiella ictaluri originally isolated from the walking catfish Clarius batrachus from Thailand. Single immersion exposure of eyed eggs of catfish stimulated strong acquired immunity against many isolates of E. ictaluri without the need for booster immunization.Type: GrantFiled: August 6, 1999Date of Patent: November 28, 2000Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Phillip H. Klesius, Craig A. Shoemaker, Joyce J. Evans
-
Patent number: 6019981Abstract: Safe and effective live vaccines against enteric septicemia of catfish (ESC) were created through the induction of rifampicin resistance in native E. ictaluri isolates; these including rifampicin-resistant strain (RE-33) of Edwardsiella ictaluri originally isolated from the walking catfish Clarius batrachus from Thailand. Single immersion exposure of catfish fry stimulated strong acquired immunity against many isolates of E. ictaluri without the need for booster immunization.Type: GrantFiled: March 6, 1998Date of Patent: February 1, 2000Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Phillip H. Klesius, Craig A. Shoemaker
-
Patent number: 6019984Abstract: Novel bacterial preparations containing one or more isolated and purified strain of a microorganism which produces one or more RTX toxins, and which strain has at least one RTX toxin which is substantially cell-associated. Methods of preparing the bacterial preparations and their use as vaccines and to produce antibodies for passive immunization are described.Type: GrantFiled: December 23, 1996Date of Patent: February 1, 2000Assignee: University of GuelphInventors: Janet MacInnes, Paul Ricciatti, Bonnie Mallard, Soren Rosendal, deceased
-
Patent number: 6010705Abstract: Live-attenuated vaccines against Edwardsiella ictaluri or against Pasteurella piscicida are disclosed. Both vaccines are incapable of reversion to virulence, because both are made by deletion mutations in the aroA gene, the purA gene, or both. These vaccines may be used not only to vaccinate fish against Edwardsiella ictaluri or Pasteurella piscicida, but also to serve as vectors to present antigens from other pathogens to the fish, thereby serving as vaccines against other pathogens as well, with no risk of infection by reversion to the virulent form of the pathogen in which the antigen occurs naturally.Type: GrantFiled: April 11, 1997Date of Patent: January 4, 2000Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Ronald L. Thune, Richard K. Cooper
-
Patent number: 5976538Abstract: According to the present invention the adjuvants comprise an emulsion containing at least one synthetic hydrophobic lipopolysaccharide, which can either or not be provided with anionic groups, while maintaining the overall hydrophobicity, an interface-forming constituent (such as an oil) and optionally an aqueous solute. In particular the adjuvant and vaccines prepared with it contain a lipopolysaccharide which had an HLB value of less then 9, more favorably less than 4.Type: GrantFiled: November 15, 1996Date of Patent: November 2, 1999Assignee: American Cyanamid CompanyInventors: Lucas A.T. Hilgers, Peter-Paul L.I. Platenburg
-
Patent number: 5871751Abstract: A vaccine and method for treating fish susceptible to infection by Renibacterium salmoninarum is described. The vaccine comprises killed microorganisms that lack intact cell-surface-associated protein p57. The vaccine can be used in combination with additional materials, such as, without limitation, adjuvants, plasticizers, pharmaceutical excipients, antigens other than the cells lacking intact cell-surface-associated protein p57, diluents, carriers, binders, lubricants, glidants, aesthetic compounds, such as flavoring and coloring agents, and combinations thereof. The vaccine may be enteric-coated for oral delivery. The enteric coating generally comprises a polymer coating that is impervious to dissolution and/or degradation in the stomach, but is dissolved upon passing to the higher pH environments of the intestine. A preferred embodiment of the vaccine is made using spherical sugar microspheres.Type: GrantFiled: October 12, 1994Date of Patent: February 16, 1999Assignee: The State of Oregon Acting By and Through the State Board of Higher Education on Behalf of Oregon State UniversityInventors: John Mark Christensen, Steve Kaattari, Jon D. Piganelli, Gregory Wiens, Jia Ai Zhang
-
Patent number: 5804199Abstract: The invention relates to a vaccine comprising an antigenic substance and a mixture of two adjuvants wherein one adjuvant is oil-based whereas the other adjuvant is water-based.Type: GrantFiled: July 22, 1996Date of Patent: September 8, 1998Assignee: Akzo Nobel N. V.Inventors: Per Martin Aasjord, Audun Helge Nerland, Dag Harald Knappskog
-
Patent number: 5616329Abstract: A method is described for preparing an antigenic product which incorporates exposing an aerosol of a microbial suspension to temperatures at which substantially only the heat stable components of the microbial suspension which retain their immunogenic properties remain. More specifically, the aerosol is exposed to an elevated temperature which denatures all labile components and removes the liquid portion of the aerosol by evaporation.Type: GrantFiled: July 5, 1994Date of Patent: April 1, 1997Assignee: Microtek Research and Development Ltd.Inventors: Stephen G. Newman, William W. Kay
-
Patent number: 5525353Abstract: This invention relates broadly to a novel ambient-temperature process for making aquatic animal feed including fish and crustaceans and to the aquatic animal feed so produced.Type: GrantFiled: April 22, 1994Date of Patent: June 11, 1996Assignee: Aquacenter, Inc.Inventor: James R. Fajt
-
Patent number: 5498414Abstract: Novel attenuated strains of Aeromonas salmonicida are disclosed that are effective as live effective vaccines against furunculosis in fish. These vaccines may be administered by the immersion of fish in a solution of the vaccine. Methods of producing these strains and other strains having the identifying characteristics of these strains are also disclosed.Type: GrantFiled: October 5, 1992Date of Patent: March 12, 1996Assignee: University of VictoriaInventors: Julian C. Thornton, William W. Kay