Bacterial Vaccine For Fish Patents (Class 424/827)
  • Patent number: 8993252
    Abstract: The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccharide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provides methods of making and methods of using such compositions.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: March 31, 2015
    Assignee: Epitopix, LLC
    Inventors: Daryll A. Emery, Darren E. Straub
  • Patent number: 8414947
    Abstract: The present invention is directed to a pharmaceutical preparation for oral application for treatment of fish, in particular for vaccination of fish of the salmon family and other fish having a comparable digestive system against bacterial and/or viral infections, in particular against VHS and IHN. The invention is also directed to a method for producing the preparation.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: April 9, 2013
    Assignee: Riemser Arzneimittel AG
    Inventors: Malte Adelmann, Dieter Fichtner, Bodo Lange, Werner Weitschies
  • Patent number: 8318152
    Abstract: An exemplary embodiment providing one or more improvements includes probiotic compositions comprising probiotic microorganisms with dried vegetable, fruit, cereal, or herb powder. Feeding human or animals either having biological or environmental changes with probiotic compositions has a positive effect in relieving the changes. Positive effects has been demonstrated in humans, dogs, and fish.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: November 27, 2012
    Assignee: Imagilin Technology, LLC
    Inventor: Jhy-Jhu Lin
  • Patent number: 7674892
    Abstract: The hsp70 gene from an Arthrobacter species has been isolated and sequenced. The encoded protein is believed to be highly immunogenic, especially in fish, and also has utility as a non-specific adjuvant, and as an adjuvanting carrier for heterologous antigens.
    Type: Grant
    Filed: July 14, 2003
    Date of Patent: March 9, 2010
    Assignee: Novartis AG
    Inventors: Steven Gareth Griffiths, Rachael Jane Ritchie, Nathalie C. Simard
  • Patent number: 7138124
    Abstract: The present invention provides compositions including at least two siderophore receptor polypeptides and at least two porins from a gram negative microbe, and preferably, lipopolysaccharide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provides methods of makino and methods of using such compositions.
    Type: Grant
    Filed: June 3, 2003
    Date of Patent: November 21, 2006
    Assignee: Epitopix, LLC
    Inventors: Daryll A. Emery, Darren E. Straub, Donavan E. Zammert, Gayla K. Kallevig
  • Patent number: 6379677
    Abstract: Safe and effective mono and polyvalent vaccines against Streptococcus iniae may be prepared from formalin-killed cells and concentrated extracellular products of Streptococcus iniae which include one or more of deposited strains NRRL B-30238 and NRRL B-30242. Intraperitoneal and intramuscular vaccination of tilapia show acquisition of effective immunity against homologous and heterologous isolates of S. iniae.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: April 30, 2002
    Assignee: The United States of America as represented by the Secretary of the Department of Agriculture
    Inventors: Phillip H. Klesius, Craig A. Shoemaker, Joyce J. Evans
  • Patent number: 6350454
    Abstract: Live-attenuated vaccines against Edwardsiella ictaluri or against Pasteurella piscicida are disclosed. Both vaccines are incapable of reversion to virulence, because both are made by deletion mutations in the aroA gene, the purA gene, or both. These vaccines may be used not only to vaccinate fish against Edwardsiella ictaluri or Pasteurela piscicida, but also to serve as vectors to present antigens from other pathogens to the fish, thereby serving as vaccines against other pathogens as well, with no risk of infection by reversion to the virulent form of the pathogen in which the antigen occurs naturally.
    Type: Grant
    Filed: October 8, 1999
    Date of Patent: February 26, 2002
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventor: Ronald L. Thune
  • Patent number: 6153202
    Abstract: Methods for the safe and effective live in ovo vaccination of eyed eggs of catfish against enteric septicemia of catfish (ESC) were created through the use of rifampicin resistant native E. ictaluri isolates; these including rifampicin-resistant strain ATCC 202058 of Edwardsiella ictaluri originally isolated from the walking catfish Clarius batrachus from Thailand. Single immersion exposure of eyed eggs of catfish stimulated strong acquired immunity against many isolates of E. ictaluri without the need for booster immunization.
    Type: Grant
    Filed: August 6, 1999
    Date of Patent: November 28, 2000
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Phillip H. Klesius, Craig A. Shoemaker, Joyce J. Evans
  • Patent number: 6019981
    Abstract: Safe and effective live vaccines against enteric septicemia of catfish (ESC) were created through the induction of rifampicin resistance in native E. ictaluri isolates; these including rifampicin-resistant strain (RE-33) of Edwardsiella ictaluri originally isolated from the walking catfish Clarius batrachus from Thailand. Single immersion exposure of catfish fry stimulated strong acquired immunity against many isolates of E. ictaluri without the need for booster immunization.
    Type: Grant
    Filed: March 6, 1998
    Date of Patent: February 1, 2000
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Phillip H. Klesius, Craig A. Shoemaker
  • Patent number: 6019984
    Abstract: Novel bacterial preparations containing one or more isolated and purified strain of a microorganism which produces one or more RTX toxins, and which strain has at least one RTX toxin which is substantially cell-associated. Methods of preparing the bacterial preparations and their use as vaccines and to produce antibodies for passive immunization are described.
    Type: Grant
    Filed: December 23, 1996
    Date of Patent: February 1, 2000
    Assignee: University of Guelph
    Inventors: Janet MacInnes, Paul Ricciatti, Bonnie Mallard, Soren Rosendal, deceased
  • Patent number: 6010705
    Abstract: Live-attenuated vaccines against Edwardsiella ictaluri or against Pasteurella piscicida are disclosed. Both vaccines are incapable of reversion to virulence, because both are made by deletion mutations in the aroA gene, the purA gene, or both. These vaccines may be used not only to vaccinate fish against Edwardsiella ictaluri or Pasteurella piscicida, but also to serve as vectors to present antigens from other pathogens to the fish, thereby serving as vaccines against other pathogens as well, with no risk of infection by reversion to the virulent form of the pathogen in which the antigen occurs naturally.
    Type: Grant
    Filed: April 11, 1997
    Date of Patent: January 4, 2000
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Ronald L. Thune, Richard K. Cooper
  • Patent number: 5976538
    Abstract: According to the present invention the adjuvants comprise an emulsion containing at least one synthetic hydrophobic lipopolysaccharide, which can either or not be provided with anionic groups, while maintaining the overall hydrophobicity, an interface-forming constituent (such as an oil) and optionally an aqueous solute. In particular the adjuvant and vaccines prepared with it contain a lipopolysaccharide which had an HLB value of less then 9, more favorably less than 4.
    Type: Grant
    Filed: November 15, 1996
    Date of Patent: November 2, 1999
    Assignee: American Cyanamid Company
    Inventors: Lucas A.T. Hilgers, Peter-Paul L.I. Platenburg
  • Patent number: 5871751
    Abstract: A vaccine and method for treating fish susceptible to infection by Renibacterium salmoninarum is described. The vaccine comprises killed microorganisms that lack intact cell-surface-associated protein p57. The vaccine can be used in combination with additional materials, such as, without limitation, adjuvants, plasticizers, pharmaceutical excipients, antigens other than the cells lacking intact cell-surface-associated protein p57, diluents, carriers, binders, lubricants, glidants, aesthetic compounds, such as flavoring and coloring agents, and combinations thereof. The vaccine may be enteric-coated for oral delivery. The enteric coating generally comprises a polymer coating that is impervious to dissolution and/or degradation in the stomach, but is dissolved upon passing to the higher pH environments of the intestine. A preferred embodiment of the vaccine is made using spherical sugar microspheres.
    Type: Grant
    Filed: October 12, 1994
    Date of Patent: February 16, 1999
    Assignee: The State of Oregon Acting By and Through the State Board of Higher Education on Behalf of Oregon State University
    Inventors: John Mark Christensen, Steve Kaattari, Jon D. Piganelli, Gregory Wiens, Jia Ai Zhang
  • Patent number: 5804199
    Abstract: The invention relates to a vaccine comprising an antigenic substance and a mixture of two adjuvants wherein one adjuvant is oil-based whereas the other adjuvant is water-based.
    Type: Grant
    Filed: July 22, 1996
    Date of Patent: September 8, 1998
    Assignee: Akzo Nobel N. V.
    Inventors: Per Martin Aasjord, Audun Helge Nerland, Dag Harald Knappskog
  • Patent number: 5616329
    Abstract: A method is described for preparing an antigenic product which incorporates exposing an aerosol of a microbial suspension to temperatures at which substantially only the heat stable components of the microbial suspension which retain their immunogenic properties remain. More specifically, the aerosol is exposed to an elevated temperature which denatures all labile components and removes the liquid portion of the aerosol by evaporation.
    Type: Grant
    Filed: July 5, 1994
    Date of Patent: April 1, 1997
    Assignee: Microtek Research and Development Ltd.
    Inventors: Stephen G. Newman, William W. Kay
  • Patent number: 5525353
    Abstract: This invention relates broadly to a novel ambient-temperature process for making aquatic animal feed including fish and crustaceans and to the aquatic animal feed so produced.
    Type: Grant
    Filed: April 22, 1994
    Date of Patent: June 11, 1996
    Assignee: Aquacenter, Inc.
    Inventor: James R. Fajt
  • Patent number: 5498414
    Abstract: Novel attenuated strains of Aeromonas salmonicida are disclosed that are effective as live effective vaccines against furunculosis in fish. These vaccines may be administered by the immersion of fish in a solution of the vaccine. Methods of producing these strains and other strains having the identifying characteristics of these strains are also disclosed.
    Type: Grant
    Filed: October 5, 1992
    Date of Patent: March 12, 1996
    Assignee: University of Victoria
    Inventors: Julian C. Thornton, William W. Kay