Of Inorganic Phosphorus Compound In Body Fluid Patents (Class 436/105)
  • Publication number: 20150093771
    Abstract: An analytical device for analysis of chemical or biological samples, a method of using such a device, based on rotation of the device, integrated sample dosing and optical detection, and a system comprising such a device are disclosed. The analytical device comprises a device body having a liquid processing unit. The liquid processing unit comprises a mixing chamber for mixing a sample with a reagent, a sample dosing chamber for delivering a defined volume of the sample to the mixing chamber, and a reagent channel for delivering the reagent to be mixed with the sample, wherein the mixing chamber also serves as a detection chamber.
    Type: Application
    Filed: December 2, 2014
    Publication date: April 2, 2015
    Inventors: Patrick Griss, Rainer Jaeggi, Goran Savatic, Vuk Siljegovic
  • Patent number: 8859291
    Abstract: The invention provides methods for isolating a target molecule from a sample. In an embodiment, the method involves contacting a sample with a capture agent, the agent comprising a siderophore and a transition metal cation, under conditions wherein the agent is capable of binding a target molecule to form a target molecule-capture agent complex, wherein the target molecule is selected from the group consisting of a phosphorylated molecule, a nitrotyrosine-containing molecule and a sulfated molecule, and separating the target molecule-capture agent complex from the sample, thereby isolating the target molecule from the sample. Also provided are methods for determining the presence of a target molecule in a sample, that involve contacting a sample with a capture agent, the agent comprising a siderophore and a transition metal cation.
    Type: Grant
    Filed: June 9, 2005
    Date of Patent: October 14, 2014
    Assignee: PerkinElmer LAS, Inc.
    Inventors: Roger Bossé, Wayne F. Patton, Philippe Roby
  • Patent number: 8822225
    Abstract: A method of identifying a patient who is non-compliant with prescribed diet and/or phosphate binder regimen calculates a phosphorus-protein ratio (PPR) by calculating the patient's protein intake, measuring the patient's serum phosphorus concentration, and estimating the amount of phosphorus removed by the patient's kidneys from measured residual urea clearance. The PPR is the ratio between the total amount of phosphorus removed from the patient and the patient's protein intake. The method enables identifying a patient that is non-compliant with prescribed diet and/or phosphate binder regimen if the PPR is outside of an acceptable range.
    Type: Grant
    Filed: October 1, 2010
    Date of Patent: September 2, 2014
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Frank A. Gotch, Amanda K. Stennett, Norma J. Ofsthun
  • Patent number: 8751167
    Abstract: A method and apparatus is provided for concentration determination of at least one component in an acid catalyst for hydrocarbon conversion containing an unknown concentration of an acid, an acid-soluble-oil (ASO), and water. An instrument configured for measuring a property of the acid catalyst, has responsivities to concentrations of one of the acid, ASO, and water, substantially independent of the concentrations of the others of the acid catalyst, ASO, and water. A temperature detector is configured to generate temperature data for the acid catalyst. A processor is configured to capture data generated by the temperature detector and the instrument, and to use the data in combination with a model to determine a temperature compensated concentration of the one of the acid, the ASO, and the water. Optionally, one or more other instruments configured for measuring other properties of the liquid mixture may also be used.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: June 10, 2014
    Assignee: Invensys Systems, Inc.
    Inventor: W. Marcus Trygstad
  • Publication number: 20130244263
    Abstract: The invention is directed to a method of identifying a patient undergoing periodic hemodialysis treatments at increased risk for death that includes determining at least one of the patient's clinical or biochemical parameters, consisting of serum bicarbonate concentration level, serum potassium concentration level, serum calcium concentration level, hemoglobin concentration level, serum phosphorus concentration level, neutrophil to lymphocyte ratio, equilibrated normalized protein catabolic rate (enPCR), equilibrated fractional clearance of total body water by dialysis and residual kidney function (eKdrt/V), EPO resistance index, transferrin saturation index, serum ferritin concentration level, serum creatinine concentration level, platelet count, Aspartat-Aminotransferase level, and Alanin-Aminotransferase level at periodic hemodialysis treatments, and identifying a patient as having an increased risk for death if the patient has a significant change in the rate of change of at least one of the patient's cli
    Type: Application
    Filed: December 1, 2011
    Publication date: September 19, 2013
    Inventors: Peter Kotanko, Stephan Thijssen, Len Usvyat, Nathan W. Levin
  • Patent number: 8455227
    Abstract: This invention provides methods for to the use of the difference in phosphodiester (PDE)/phosphomonoester (PME) ratio in biological fluids, as an analytical criterion to image both the presence and degree of viral infection in-vivo.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: June 4, 2013
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Tomasz Rozmyslowicz, Krzysztof Wroblewski, Glen N. Gaulton
  • Patent number: 8445289
    Abstract: A method and apparatus is provided for determining concentration of components in a liquid hydrocarbon mixture including hydrocarbons and water flowing through an alkylation process. A fluid flow path conveys the liquid continuously from the alkylation process through a first instrument configured for measuring a property of the liquid mixture, and having responsivities to concentration of the components, which are independent of the concentration of the water. A temperature detector generates temperature data for the liquid, and a second instrument measures another property of the liquid mixture. The instruments have mutually distinct responsivities to concentrations of the components.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: May 21, 2013
    Assignee: Invensys Systems, Inc.
    Inventors: W. Marcus Trygstad, Bruce Keen, Russell Jackson
  • Patent number: 8211706
    Abstract: A method and apparatus is provided for determining concentration of components in a liquid hydrocarbon mixture including hydrocarbons and water flowing through an alkylation process. A fluid flow path conveys the liquid continuously from the alkylation process through a first instrument configured for measuring a property of the liquid mixture, and having responsivities to concentration of the components, which are independent of the concentration of the water. A temperature detector generates temperature data for the liquid, and a second instrument measures another property of the liquid mixture. The instruments have mutually distinct responsivities to concentrations of the components.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: July 3, 2012
    Assignee: Invensys Systems, Inc.
    Inventors: W. Marcus Trygstad, Russell Jackson, Bruce A. Keen
  • Patent number: 8168437
    Abstract: The disclosure provides a method for quantitatively determining risedronate in a urine sample by adding an internal standard to the urine sample, applying the urine sample to a polymeric water-wettable reverse-phased sorbent preconditioned with methanol, washing the sorbent with TEA in water and formic acid in methanol, eluting risedronate with a mixture of methanol and water containing EDTA under vacuum, evaporating the eluted solution and reconstituting with a mixture of methanol and NH4OH buffer and analyzing the sample with a LC-MS/MS system.
    Type: Grant
    Filed: September 4, 2009
    Date of Patent: May 1, 2012
    Assignee: Sanofi-Aventis U.S. LLC
    Inventors: Liduo Shen, Yongyi Luo
  • Patent number: 7972863
    Abstract: A method and apparatus is provided for determining concentration of components in a liquid hydrocarbon mixture including hydrocarbons and water flowing through an alkylation process. A fluid flow path conveys the liquid continuously from the alkylation process through a first instrument configured for measuring a property of the liquid mixture, and having responsivities to concentration of the components, which are independent of the concentration of the water. A temperature detector generates temperature data for the liquid, and a second instrument measures another property of the liquid mixture. The instruments have mutually distinct responsivities to concentrations of the components.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: July 5, 2011
    Assignee: Invensys Systems, Inc.
    Inventors: W. Marcus Trygstad, Russell Jackson, Bruce A. Keen
  • Patent number: 6667291
    Abstract: The present invention relates, in part, to newly developed assay for diagnosing cancers, particularly endometrial and mammary, endometriosis and endometrial fibroids along with methods for identifying therapeutic agents that modulate endometrial steroid binding protein II activity for the treatment of the above disorders.
    Type: Grant
    Filed: November 3, 1999
    Date of Patent: December 23, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Carl J Schmidt, Xin-Min Wang
  • Patent number: 6521615
    Abstract: This invention provides a method of treating an animal with pyrophosphate gout or osteoarthritis comprising administering an effective amount of a calcium antagonist, thereby reducing calcium pyrophosphate crystal deposition in the animal.
    Type: Grant
    Filed: January 4, 2001
    Date of Patent: February 18, 2003
    Assignee: The Regents of the University of California
    Inventor: J. Edwin Seegmiller
  • Patent number: 6025202
    Abstract: A biosensor based on complexes between biomolecule receptors and colloidal Au nanoparticles, and more specifically, colloid layers of receptor/Au complexes that can be used to detect biomolecule analytes through measuring of binding-induced changes in electrical resistance or surface plasmon resonance. Also disclosed is a method for detecting and analysing carrier-borne chemical compounds with Raman spectroscopy using an improved SERS substrate. Further disclosed is an improved method for detecting compounds in solvents using capillary electrophoresis in conjunction with Raman spectroscopy.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: February 15, 2000
    Assignee: The Penn State Research Foundation
    Inventor: Michael J. Natan
  • Patent number: 5994141
    Abstract: Methods for diagnosing and screening for ovarian carcinomas in a subject are provided The methods employ the steps of preparing a plasma sample from a blood specimen from the subject, and assaying for the presence of lysophosphatidic acid in the plasma sample. The presence of lysophosphatidic acid in the plasma sample is indicative of ovarian carcinoma in the subject. In a preferred embodiment the plasma sample is prepared under conditions which minimize the release of lysophosphatidic acid from platelets in the blood specimen into the plasma.
    Type: Grant
    Filed: August 25, 1998
    Date of Patent: November 30, 1999
    Assignee: The Cleveland Clinic Foundation
    Inventors: Yan Xu, Graham Casey, Douglas C. Gaudette, Bruce J. Holub, Gordon B. Mills
  • Patent number: 5858797
    Abstract: A unitized, one step test reagent composition, device and method is presented for the determination of phosphorus in various test sample fluids such as soil extracts. The invention is a modification of the Murphy and Riley methodology which utilizes a molybdate salt and a reducing agent to generate "molybdenum blue" in the presence of phosphate. In addition to the molybdate salt, the test reagent composition includes a chromogenic reducing agent which contributes to the color development and a solid buffer. The composition is preferably incorporated into a matrix such as paper for ease of handling.
    Type: Grant
    Filed: June 5, 1997
    Date of Patent: January 12, 1999
    Assignee: Environmental Test Systems, Inc.
    Inventors: Yuriy Vladimirovich Evtodienko, Michael Allen Van Lente
  • Patent number: 5824555
    Abstract: The present invention provides a new method for detecting the presence of gynecological carcinomas in a patient. The method, which comprises detecting the presence of lysophosphatidic acid in a plasma sample of the patient, is useful for detecting ovarian carcinoma, cervical carcinoma, endometrial carcinoma, and peritoneal carcinoma. In a preferred embodiment the method comprises: providing a blood specimen from the patient, obtaining a plasma sample for the blood specimen under conditions which minimize the release of lysophosphatidic acid from the platelets in the blood specimen into the plasma, extracting lipids from the plasma, and detecting the presence of lysophosphatidic acid in the lipid extract. A new method for extracting lysophosphatidic acid from a biological fluid is also provided.
    Type: Grant
    Filed: May 30, 1996
    Date of Patent: October 20, 1998
    Assignee: The Cleveland Clinic Foundation
    Inventors: Yan Xu, Graham Casey
  • Patent number: 5817454
    Abstract: A portable apparatus for detecting the presence of at least one methylxanthine chemical species such as caffeine or theophylline in a beverage comprises a first portion comprising an effective concentration of phosphodiesterase enzyme, a second portion comprising cyclic AMP, and means for indicating inhibition of degradation of the cyclic AMP by the phosphodiesterase due to the presence of the methylxanthine species. A method for determining the presence of at least one methylxanthine chemical species in a beverage comprises contacting at least one test portion of the beverage with effective concentrations of at least one phosphodiesterase enzyme and cyclic AMP, and further contacting the test portion with means for indicating the inhibition of the degradation of the cyclic AMP by the phosphodiesterase due to the presence of the methylxanthine species.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 6, 1998
    Assignee: Coffee Chek, Inc.
    Inventors: Stuart Harris, David Levin
  • Patent number: 5756631
    Abstract: Viscous, liquid hexafluoroisopropanol-siloxane polymers having the basic structure: ##STR1## wherein R.sub.1 is a monovalent hydrocarbon radical selected from the group consisting of C.sub.1 -C.sub.6 alkyl groups; cyclohexyl groups and phenyl groups;R.sub.2 is ##STR2## wherein m=1 to 4; and n is an integer greater than 1, are useful for rapid, reversible vapor sorption, especially for hydrogen bond accepting vapors.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: May 26, 1998
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventor: Jay W. Grate
  • Patent number: 5707875
    Abstract: Using a mixed sample of a plurality of phosphoric acid compounds different in chemical structure as a sample for measurement, a .sup.31 P nuclear magnetic resonance signal obtained through polarization transfer between .sup.17 O and .sup.31 P is observed and signals obtained without polarization transfer are eliminated, whereby .sup.31 P nuclear magnetic resonance signal spectrum of an .sup.17 O-labeled phosphoric acid is selectively observed. For this purpose, a double resonance NMR detector capable of exciting .sup.17 O and .sup.31 P at the same time is connected to an NMR spectrometer, and using a pulse train which permits observation of a .sup.31 P nuclear magnetic resonance signal obtained through polarization transfer between .sup.17 O and .sup.31 P, a .sup.31 P nuclear magnetic resonance signal from the .sup.17 O-labeled phosphoric acid is observed, and signals for .sup.17 O-unlabeled .sup.31 P are eliminated.
    Type: Grant
    Filed: August 10, 1995
    Date of Patent: January 13, 1998
    Assignee: Hitachi, Ltd.
    Inventors: Mitsuru Tamura, Yoshinori Harada, Norio Shimizu, Kenji Yasuda
  • Patent number: 5702954
    Abstract: An apparatus to detect and measure the amount of phosphorus in phosphorus-containing compounds comprises a burning chamber with a housing having an integral combustion chamber. A flammable reducing agent such as hydrogen is introduced into the combustion chamber along with a sample containing phosphorus admixed with air or oxygen. At least a portion of any phosphorus in the sample will be converted into phosphorus monoxide (PO) by the combustion. The resulting phosphorus monoxide is immediately drawn into a low-pressure, ambient temperature reaction chamber and reacted with ozone to convert the phosphorus monoxide to chemiluminescent phosphorus dioxide. A light-measuring device then measures the intensity of the light released from the chemiluminescent phosphorus dioxide.
    Type: Grant
    Filed: September 29, 1995
    Date of Patent: December 30, 1997
    Assignee: Colorado Seminary
    Inventors: Donald H. Stedman, Patti A. Meeks
  • Patent number: 5270216
    Abstract: A process for measurement of low levels of phosphonates in brine waters wherein the phosphonate samples are acidified with hydrochloric acid promptly upon removal from an oil or gas well to prevent phosphonate precipitation or adsorption. The hydrochloric acid acidified phosphonate is digested in the presence of an oxidizing agent at elevated temperature and pressure for sufficient time to oxidize substantially all of the phosphonate to orthophosphate. The phosphorous containing compound is extracted with an organic extractant, preferably selected from the group consisting of methyl iso-butyl ketone/cyclohexane mixture and ethyl acetate, followed by color development for absorption spectrophotometry.
    Type: Grant
    Filed: February 13, 1992
    Date of Patent: December 14, 1993
    Assignee: Gas Research Institute
    Inventors: Amy T. Kan, Kuruvila Varughese, John E. Oddo, Mason B. Tomson
  • Patent number: 5225349
    Abstract: Inositol phosphates and/or derivatives thereof are analytically separated, whereby a quaternary amine is mixed with an aqueous solution containing one or more inositol phosphates and/or derivatives thereof. The aqueous solution obtained is fed to an analytical column containing a solid non-polar phase and the different constituents thereof are detected.
    Type: Grant
    Filed: February 19, 1992
    Date of Patent: July 6, 1993
    Assignee: Perstorp AB
    Inventors: Hubertus Irth, Ruth Kornfeldt, Lars Persson
  • Patent number: 5166074
    Abstract: A method of detecting the initial concentration of a water-treatment chemical present in a diluted aqueous system, by (1) incorporating into the aqueous system, a mixture including a known amount of the active ingredient and a known amount of an ultra-violet sensitive compound having the formula (I): ##STR1## wherein halogen is chlorine or bromine; X is ##STR2## and a and b, independently are 0 or 1; M is hydrogen or an alkaline metal ion; and (2) detecting the concentration of the compound of formula I, by exposing to ultra-violet light a sample of the aqueous system so treated.
    Type: Grant
    Filed: November 7, 1990
    Date of Patent: November 24, 1992
    Inventors: Adrian M. Vessey, David S. Ryder
  • Patent number: 4826773
    Abstract: A reagent for determining quantitatively the amount of phosphorous in bodily fluids which comprises a surface active agent, a strong acid, ammonium molybdate, a heavy metal chelating compound, and anti-oxidant, and deionized water is described. A method of using such a reagent is also described.
    Type: Grant
    Filed: July 18, 1988
    Date of Patent: May 2, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard A. Kaufman, Henry J. Rosenfeld, Denise Zaunczkowski
  • Patent number: 4743561
    Abstract: An improved method and reagents are disclosed for determining a ligand in an assay solution containing the ligand, a reagent system and a luminescent compounds, wherein the intensity of the light emitted by the assay solution is related to the change in the transmittive properties of the assay solution produced by the interaction of the ligand to be determined and a reagent system capable of producing a change in the transmittive properties of the assay solution in the presence of the ligand.
    Type: Grant
    Filed: March 5, 1985
    Date of Patent: May 10, 1988
    Assignee: Abbott Laboratories
    Inventor: Mark R. Shaffar
  • Patent number: 4731331
    Abstract: A reagent of the type comprising an acid, a molybdate salt, a non-ionic surfactant, and polyvinylpyrrolidone (PVP). The reagent is characterized in that it further comprises an enhancing amount of at least one sugar alcohol. Also, a method for assaying inorganic phosphorus of the type which comprises mixing a sample of biological fluid with a reagent and measuring the absorbance of the resulting solution. The method is characterized in that the above reagent is employed therein. The method can further be characterized in that the measurement can be made via a rate technique.
    Type: Grant
    Filed: July 17, 1984
    Date of Patent: March 15, 1988
    Assignee: Beckman Instruments, Inc.
    Inventors: Frank R. Shu, James H. Francis
  • Patent number: 4599316
    Abstract: An improved photometric method for the determination of inorganic phosphate in fluids is disclosed.The method makes use of two reagents, an acid reagent and an ammonium molybdate reagent. Utilizing these reagents, the method comprises the following steps:(a) forming a first mixture consisting of a sample fluid and acid reagent;(b) measuring the light absorbance of said first mixture;(c) forming a second mixture consisting of said first mixture and ammonium molybdate reagent;(d) measuring the light absorbance of said second mixture;(e) calculating the difference in light absorbance (.DELTA.A sample) between the light absorbances measured for said first and second mixtures; and,(f) determining the concentration of inorganic phosphate in said sample fluid by comparing the difference in light absorbance (.DELTA.A sample) for said sample fluid to the difference in light absorbance (.DELTA.A standard) for a standard fluid having a known concentration of inorganic phosphate, .DELTA.
    Type: Grant
    Filed: December 2, 1983
    Date of Patent: July 8, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Benjamin A. Hahn, Richard A. Kaufman, Alexander F. Wesolowski
  • Patent number: 4447544
    Abstract: An aqueous reagent for determining inorganic phosphate in a protein-containing liquid biological sample comprises a molybdate salt, an acid capable of reacting with the molybdate salt to form molybdic acid for complexation with phosphate to form phosphomolybdate complexes, a ferric salt in an amount sufficient to inhibit turbidity in the sample, and a nonionic surfactant reagent in an amount sufficient to further inhibit turbidity in the sample, the molybdate salt and the acid being present in amounts sufficient to form an amount of molybdic acid sufficient to produce a detectible color change when complexed with phosphate in the sample.
    Type: Grant
    Filed: July 22, 1982
    Date of Patent: May 8, 1984
    Assignee: Instrumentation Laboratory Inc.
    Inventors: Bruce P. Neri, Stanley M. Liffmann