Molecular Oxygen Patents (Class 436/136)
  • Patent number: 11170986
    Abstract: The disclosure relates to an apparatus, method and process for detecting rare earth elements. The system includes an LED powered by a first power source and a focusing lens in optical communication with the LED. A shortpass filter is in optical communication with the focusing lens; and a fiber bifurcated cable in optical communication with the shortpass filter. The system includes a probe tip in optical communication with the fiber bifurcated cable and a sample; a first aspheric lens in optical communication with the fiber bifurcated cable. A longpass filter is in optical communication with the first aspheric lens and a second aspheric lens in optical communication with the longpass filter. The system includes a spectrometer connected to a power source, where the spectrometer is in optical communication with the second aspheric lens.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: November 9, 2021
    Assignee: U.S. Department of Energy
    Inventors: John C Ahern, Paul R Ohodnicki, Jr., John P Baltrus, Jacob Lorenzi Poole
  • Patent number: 10802007
    Abstract: To provide: a composition for oxygen detection, which has excellent oxygen detection characteristic (ability), and which is safer than conventional compositions for oxygen detection, thereby being able to be sealed in packages containing food, pharmaceutical products or the like without anxiety; and an oxygen detector onto which this composition for oxygen detection is applied or printed. This composition for oxygen detection contains a redox dye, a food dye, a reducing sugar, an edible reduction promoter and an edible humectant in the composition, and enables quick detection of the presence or absence of oxygen by means of color change. Since this composition for oxygen detection is composed only of food, a pharmaceutical product and edible components allowed to be used for the food or pharmaceutical product, this composition for oxygen detection is safe to the human body.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: October 13, 2020
    Assignee: TOKIWA SANGYO CO., LTD.
    Inventors: Tatsuo Yamazaki, Hiroshi Kase, Naoto Abe
  • Patent number: 10424846
    Abstract: Antenna devices, antenna systems and methods of their fabrication are disclosed. One such antenna device includes a semiconductor chip and a chip package. The semiconductor chip includes at least one antenna that is integrated into a dielectric layer of the semiconductor chip and is configured to transmit electromagnetic waves. In addition, the chip package includes at least one ground plane, where the semiconductor chip is mounted on the chip package such that the ground plane(s) is disposed at a predetermined distance from the antenna to implement a reflection of at least a portion of the electromagnetic waves.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: September 24, 2019
    Assignee: International Business Machines Corporation
    Inventors: Duixian Liu, Arun S. Natarajan, Jean-Olivier Plouchart, Scott K. Reynolds
  • Patent number: 10134853
    Abstract: A method of manufacturing a semiconductor device includes irradiating the semiconductor body with particles through a first side of the semiconductor body, removing at least a part of impurities from an irradiated part of the semiconductor body by out-diffusion during thermal treatment in a temperature range between 450° C. to 1200° C., and forming a first load terminal structure at the first side of the semiconductor body.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: November 20, 2018
    Assignee: Infineon Technologies AG
    Inventor: Hans-Joachim Schulze
  • Patent number: 9425063
    Abstract: A method of reducing an impurity concentration in a semiconductor body includes irradiating the semiconductor body with particles through a first side of the semiconductor body. The method further includes removing at least a part of impurities from an irradiated part of the semiconductor body by out-diffusion during thermal treatment in a temperature range between 450° C. to 1200° C.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: August 23, 2016
    Assignee: Infineon Technologies AG
    Inventor: Hans-Joachim Schulze
  • Patent number: 9080976
    Abstract: A measuring device measures singlet oxygen luminescence which is excited by one or more photosensitizers. The measuring device contains a photosensitive detector, an excitation source, and a control and evaluating unit that is coupled to the photosensitive detector and the excitation source. The excitation source is configured to radiate excitation light into a measurement volume from a plurality of emission positions in order to excite the photosensitizer or photosensitizers. The excitation source preferably contains light-emitting diodes as lighting devices, the light of which is used directly as an excitation light in order to excite the photosensitizers.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: July 14, 2015
    Assignee: Humbolt-Universitaet zu Berlin
    Inventors: Steffen Hackbarth, Jan Schlothauer
  • Patent number: 8987001
    Abstract: The present invention relates to an oxygen indicator in which the presence or absence of oxygen is made visible by a color change, and to the use of such oxygen indicator for monitoring parenteral and enteral dosage forms.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: March 24, 2015
    Assignee: B. Braun Melsungen AG
    Inventors: Volker Krueger, Rolf Beck
  • Publication number: 20140329332
    Abstract: Device (10) for rapid detection of biological oxygen consumption and method of classifying biological samples (e.g., positive and negative samples) (5) by detecting biological oxygen consumption. Each well (29) on a multi-well plate (20, 30) is hermetically sealed from the surrounding environment and other wells after deposit of a biological sample within the well by a cover plate (30) and an adherent gasket (40) sandwiched between the plates.
    Type: Application
    Filed: November 22, 2011
    Publication date: November 6, 2014
    Applicant: LUXCEL BIOSCIENCES LTD.
    Inventors: Dmitri Boris Papkovsky, James Nial Hynes
  • Patent number: 8852950
    Abstract: A method for determining an NOx concentration in a measurement gas is provided, where a measurement value for the NOx concentration is determined from the sensor signal of a gas sensor and a measurement value for the concentration of a second component in the measurement gas is determined. A corrected value for the NOx in the measurement gas is determined from the measurement values, and the measurement value and the corrected measurement value for the NOx concentration are displayed and/or output.
    Type: Grant
    Filed: September 3, 2008
    Date of Patent: October 7, 2014
    Assignee: Testo AG
    Inventors: Knut Hoyer, Andreas Kaufmann, Reinhold Munch, Thomas Springmann
  • Publication number: 20140287514
    Abstract: The present invention includes a sensing device and method detecting the presence of a chemical analyte, comprising: a surface; a continuous or discontinuous terbium(III)-triphenylphosphine oxide coordination polymer layer deposited on the surface, wherein the polymer layer is porous; and a luminescence detector, wherein one or more analytes that interact with the polymer layer luminesce at distinct wavelengths unique to each analyte.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 25, 2014
    Inventors: Simon M. Humphrey, Bradley J. Holliday
  • Publication number: 20140273043
    Abstract: The present disclosure relates to an optical fluorescence sensor comprising a probe for sensing glucose, an intra-reference probe, and a matrix. The present disclosure also relates to an optical fluorescence dual sensor comprising a probe for sensing glucose, a probe for sensing oxygen, an intra-reference probe, and a matrix. The present disclosure additionally relates to methods of preparing these sensors and methods of using them.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Inventors: Yanqing Tian, Liqiang Zhang, Fengyu Su, Deirdre Meldrum, Sean Buizer
  • Patent number: 8828728
    Abstract: An aquatic environment monitoring system and method that includes correction for adverse conditions in the monitoring system involving the development of confidence levels for certain conditions in the monitoring system using stored information related to the aquatic environment and/or the monitoring system. Corrections to adverse conditions may be made by the environment monitoring system automatically by the monitoring system and manually via communications to a user of the system.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: September 9, 2014
    Assignee: Step Ahead Innovations, Inc.
    Inventor: James E. Clark
  • Patent number: 8790930
    Abstract: A chemical indicator having a particulate inorganic substrate, and at least one reactive dye or ink coated on and/or impregnated within the particulate inorganic substrate. Coating and/or impregnating at least one reactive dye or ink on or within a particulate inorganic substrate improves the storage stability and/or thermal stability of the at least one reactive dye or ink, which typically includes relatively unstable compounds. This allows the present indicators to be incorporated into thermoplastic polymer materials and processed conventionally while maintaining the efficacy and stability of the new indicators. The indicators provide simple, reliable, and cost effective detection means for detecting analytes such as ammonia, carbon dioxide, and oxygen, and may find use in applications such as food packaging and medical applications.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: July 29, 2014
    Assignee: University of Strathclyde
    Inventors: Andrew Mills, Pauline Grosshans, Graham Skinner
  • Patent number: 8778085
    Abstract: A dissolved nitrogen concentration monitoring method is used for monitoring a dissolved nitrogen concentration of a cleaning liquid when an ultrasonic wave is irradiated onto the cleaning liquid in which a substrate is dipped. The method includes measuring an amount of increase of a dissolved oxygen concentration of the cleaning liquid resulting from an oxygen molecule generated from a water molecule as a result of a radical reaction caused by ultrasonic wave irradiation. A dissolved nitrogen concentration of the cleaning liquid is calculated from the measured amount of increase of dissolved oxygen concentration based on a predetermined relationship between a dissolved nitrogen concentration and an amount of increase of dissolved oxygen concentration.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: July 15, 2014
    Assignee: Siltronic AG
    Inventors: Teruo Haibara, Etsuko Kubo, Yoshihiro Mori, Masashi Uchibe
  • Patent number: 8751188
    Abstract: A photoluminescent temperature sensing device and method utilizing a semi-conductor optical device adapted to operate as both a light-emitting device and a light detection device. The optical device emits a pulse of incident light, producing photoluminescent light that is received at the optical device. Signal information associated with a temperature-dependent characteristic of the photoluminescent light is created and temperature information if obtained from the signal information.
    Type: Grant
    Filed: April 18, 2011
    Date of Patent: June 10, 2014
    Assignee: Powell Canada, Inc.
    Inventor: Roy Belak
  • Patent number: 8748192
    Abstract: The present invention relates to an optical fluorescence dual sensor comprising a probe for sensing pH, a probe for sensing oxygen, an intra-reference probe and a matrix. The present invention also relates to methods of preparing an optical fluorescence dual sensor and methods of using them.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: June 10, 2014
    Assignee: Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of Arizona State University
    Inventors: Yanqing Tian, Weiwen Zhang, Deirdre Meldrum, Hongguang Lu, Yuguang Jin, Mark Holl
  • Publication number: 20140154811
    Abstract: Technologies are generally described for gas filtration and detection devices. Example devices may include a graphene membrane and a sensing device. The graphene membrane may be perforated with a plurality of discrete pores having a size-selective to enable one or more molecules to pass through the pores. A sensing device may be attached to a supporting permeable substrate and coupled with the graphene membrane. A fluid mixture including two or more molecules may be exposed to the graphene membrane. Molecules having a smaller diameter than the discrete pores may be directed through the graphene pores, and may be detected by the sensing device. Molecules having a larger size than the discrete pores may be prevented from crossing the graphene membrane. The sensing device may be configured to identify a presence of a selected molecule within the mixture without interference from contaminating factors.
    Type: Application
    Filed: November 30, 2012
    Publication date: June 5, 2014
    Inventors: Angele Sjong, Kraig Anderson, Gary L. Duerksen, Seth Adrian Miller
  • Patent number: 8703500
    Abstract: A chemical sensor can include a nanofiber mass of p-type nanofibers having a HOMO level greater than ?5.0 eV. Additionally, the chemical sensor can include oxygen in contact with the p-type nanofibers. Further, the chemical sensor can include a pair of electrodes in electrical contact across the nanofiber mass, where the p-type nanofibers conduct an electric current that decreases upon contact with an amine compound.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: April 22, 2014
    Assignee: University of Utah Research Foundation
    Inventors: Ling Zang, Yanke Che
  • Publication number: 20140093971
    Abstract: A system for determining concentration of oxygen in a chemical mixture is presented. The system includes a first sensing device configured to measure the concentration of oxygen in the chemical mixture and generate a first output signal, where the first output signal is indicative if the concentration of oxygen in the chemical mixture and a type of the chemical mixture. Furthermore, the system includes a second sensing device configured to measure the concentration of oxygen in the chemical mixture and generate a second output signal. In addition, the system includes a processing unit operatively coupled to the first sensing device and the second sensing device and configured to determine the concentration of oxygen in the chemical mixture based on the first output signal, the second output signal, or both the first output signal and the second output signal based on a type of the chemical mixture.
    Type: Application
    Filed: September 28, 2012
    Publication date: April 3, 2014
    Applicant: GENERAL ELECTRIC COMPANY
    Inventor: Daniel George Norton
  • Publication number: 20140065271
    Abstract: Oxygen sensors and their uses are disclosed, and more particularly to oxygen sensors for use in product packaging for storing an article in a packaging envelope under modified atmosphere conditions wherein the oxygen sensors comprise solid oxo-hydroxy metal ion materials, optionally modified with one or more ligands and/or optionally having polymeric structures. The sensors may be present in a hydrated, oxygen permeable matrix, for example formed from a material, such as gelatine. The sensors are useful in many technical fields, and find particular application in the field of food packaging as they are safely disposable (e.g. are environmentally friendly), cheap to manufacture, and provide detectable changes in the presence of oxygen that are easy to read.
    Type: Application
    Filed: January 25, 2012
    Publication date: March 6, 2014
    Applicant: Medical Research Council
    Inventors: Jonathan Joseph Powell, Nuno Jorge Rodrigues Faria, Carlos Andre Passos Bastos
  • Patent number: 8663996
    Abstract: A system for measuring the oxygen concentration of a gas includes a catalytic reactor, first and second temperature sensors and a control unit. The catalytic reactor includes a combustion catalyst that supports the catalytic combustion of hydrocarbon fuel vapor in a gas stream. The first temperature sensor is located upstream of the catalytic reactor for sensing an upstream temperature of the gas stream, and the second temperature sensor is located downstream of the catalytic reactor for sensing a downstream temperature of the gas stream. The control unit compares the upstream temperature and the downstream temperature to determine the oxygen concentration of the gas stream.
    Type: Grant
    Filed: April 26, 2010
    Date of Patent: March 4, 2014
    Assignee: Hamilton Sundstrand Corporation
    Inventor: William Beeson
  • Patent number: 8658429
    Abstract: A photoluminescent oxygen probe including a tack with a layer of a pressure-sensitive adhesive and an oxygen-sensitive photoluminescent element on the underside of the head. The probe is effective for sensing oxygen concentration within an enclosed space by puncturing the container defining the enclosed space the with the probe's shank and adhering the underside of the probe's head to the container so as to sealingly surround the puncture, thereby placing the oxygen-sensitive photoluminescent dye on the underside of the probe's head into sensible communication with the enclosed space through the puncture hole.
    Type: Grant
    Filed: August 6, 2012
    Date of Patent: February 25, 2014
    Assignee: Mocon, Inc.
    Inventors: Daniel W. Mayer, John Eastman
  • Publication number: 20140045272
    Abstract: A measuring device measures singlet oxygen luminescence which is excited by one or more photosensitizers. The measuring device contains a photosensitive detector, an excitation source, and a control and evaluating unit that is coupled to the photosensitive detector and the excitation source. The excitation source is configured to radiate excitation light into a measurement volume from a plurality of emission positions in order to excite the photosensitizer or photosensitizers. The excitation source preferably contains light-emitting diodes as lighting devices, the light of which is used directly as an excitation light in order to excite the photosensitizers.
    Type: Application
    Filed: April 12, 2012
    Publication date: February 13, 2014
    Applicant: HUMBOLDT-UNIVERSITAET ZU BERLIN
    Inventors: Steffen Hackbarth, Jan Schlothauer
  • Patent number: 8647876
    Abstract: An oxygen permeability measuring apparatus for measuring an oxygen permeation rate of oxygen barrier film in a dark room is provided. A container is charged with inert gas, and sealed hermetically by use of the oxygen barrier film at least partially. A chemiluminescent compound is contained in the container, for emitting light by oxidation with the oxygen. A photon detector detects photons emitted by the chemiluminescent compound so as to determine an amount of the oxygen permeated through the oxygen barrier film. Preferably, the container includes a container body. An opening is formed in the container body, and closed hermetically by the oxygen barrier film attached thereto. The photon detector is disposed inside or outside the container. The oxygen permeation rate is equal to or less than 10?2 cc/m2·day·atm. The chemiluminescent compound includes tetrakis(dimethylamino)ethylene.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: February 11, 2014
    Assignee: Fujifilm Corporation
    Inventors: Tomoyuki Shimoda, Yoshio Inagaki, Kimiaki Miyamoto
  • Patent number: 8642350
    Abstract: A sensor material of the type comprising a long-decay photoluminescent, protonable dye embedded in a suitable polymeric matrix, is used for generating a specific optical response to two different analytes present in a sample, thus allowing selective determination of the two analytes in the sample. Also described is a method for the simultaneous sensing of a first and second analyte in a sample. The method comprises the steps of irradiating a sensor material of the type comprising a long-decay photoluminescent protonable dye embedded in a suitable polymeric matrix with light of one or two wavelengths, determining photoluminescence intensity and lifetime signals originating from the sensor, and correlating the photoluminescence intensity signal with a concentration of the first analyte and the photoluminescence lifetime signal(s) with the concentration of the second analyte.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: February 4, 2014
    Assignee: University College Cork, National University of Ireland, Cork
    Inventor: Dmitri Papkovsky
  • Publication number: 20130224874
    Abstract: Oxygen levels in biological tissue or systems can be measured by the phosphorescence quenching method using phosphorescent porphyrin probes, also referred to as a dendritic oxygen probes, with controllable quenching parameters and defined biodistributions. Provided are a “next generation” of oxygen sensors with substantially improved phosphorescence emission for better imaging capabilities, ease of use, increasing the quantum efficiency (phosphorescence intensity) and extending their range of applicability including constructing a class of oxygen sensors for making measurements in organic media. In addition, provided are methods for synthesizing new porphyrin constructs in which the porphyrin is made less flexible and more planar, changing with decrease internal quenching, and thereby increasing the phosphorescence emission used for oxygen sensing.
    Type: Application
    Filed: February 27, 2013
    Publication date: August 29, 2013
    Inventors: Sergei A. Vinogradov, David F. Wilson
  • Patent number: 8501100
    Abstract: An oxygen sensor includes a metalloporphyrin for detecting oxygen levels. The oxygen sensors may also include a light source and a detector. The sensors are configured to measure changes in spectra in response to the redox reaction. They can detect a variety of samples for presence and changes in oxygen concentration in both solution and gaseous form.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: August 6, 2013
    Assignee: Empire Technology Development LLC
    Inventor: Toshimi Fukui
  • Publication number: 20130177995
    Abstract: An oxygen sensor includes an epitaxial oxide thin film double perovskite oxygen sensor formed on a single crystal oxide substrate. The thin film includes a lanthanide element, barium, cobalt, and oxygen.
    Type: Application
    Filed: December 4, 2012
    Publication date: July 11, 2013
    Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: Board Of Regents Of The University Of Texas System
  • Publication number: 20130102024
    Abstract: The present invention relates to an optical fluorescence dual sensor comprising a probe for sensing pH, a probe for sensing oxygen, an intra-reference probe and a matrix. The present invention also relates to methods of preparing an optical fluorescence dual sensor and methods of using them.
    Type: Application
    Filed: October 24, 2012
    Publication date: April 25, 2013
    Applicants: Arizona State
    Inventor: Arizona Board of Regents, a body corporate of the
  • Patent number: 8415166
    Abstract: The present invention provides a device for the detection of a peroxide-based explosive, in particular, triacetone triperoxide (TATP), which is based on a molecular controlled semiconductor resistor (MOCSER) and composed of at least one insulating or semi-insulating layer, at least one conducting semiconductor layer, two conducting pads and a layer of multifunctional organic molecules capable of adsorbing molecules of the peroxide-based explosive. The invention further provides an array of semiconductor devices for the selective detection of a peroxide-based explosive, as well as a method for the selective detection of vapors of a peroxide-based explosive in a gaseous mixture using this array.
    Type: Grant
    Filed: May 12, 2009
    Date of Patent: April 9, 2013
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Ron Naaman, Eyal Capua, Roberto Cao
  • Patent number: 8415167
    Abstract: It is an object of the present invention to provide: an oxygen indicator aqueous solution for an oxygen detector that has high heat resistance, can be stored at room temperature, and can maintain an excellent ability to detect oxygen, regardless of the atmospheric temperature; an oxygen detector; and a method for manufacturing an oxygen detector. In order to achieve this object, there is provided an oxygen indicator aqueous solution for an oxygen detector that is an aqueous solution comprising reducing saccharides, a basic substance, and a redox dye reduced by the reducing saccharides, the aqueous solution comprising, as the reducing saccharides, a monosaccharide as a first component and a reducing trisaccharide as a second component. In addition, there is provided a manufacturing method preferred for the manufacturing of the oxygen detector.
    Type: Grant
    Filed: October 19, 2010
    Date of Patent: April 9, 2013
    Assignee: Powdertech Co., Ltd.
    Inventors: Ryuichi Kodama, Mitsuyuki Sato
  • Publication number: 20130029374
    Abstract: A method, and a measuring point for performing the method, for measuring at least one physical and/or chemical, process variable of a medium contained in a single use container. A single use sensor is connected with the single use container. The single use sensor with the single use container is sterilized by radiation, especially beta or gamma radiation. An electronics unit is connected with the single use sensor, and the electronics unit is connected with at least one superordinated system via at least one interface. The electronics unit and/or the single use sensor are/is supplied with energy, and measurement data of the single use sensor are registered. The measurement data are processed by the electronics unit and/or the superordinated system, data, including measurement data, are transmitted to the superordinated system and/or received from the superordinated system, and, after termination of one or more measuring cycles, the electronics unit is released from the single use sensor.
    Type: Application
    Filed: July 24, 2012
    Publication date: January 31, 2013
    Applicant: Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG
    Inventors: Andreas Eberheim, Christian Fanselow
  • Publication number: 20130005046
    Abstract: A method of contemporaneously monitoring changes in analyte concentration in a plurality of samples using a single monitoring device, wherein monitoring can be commenced and continued on independent timelines for each sample.
    Type: Application
    Filed: June 30, 2011
    Publication date: January 3, 2013
    Inventors: Daniel W. Mayer, Timothy A. Ascheman
  • Patent number: 8337757
    Abstract: A method is provided for controlling the operating temperature of a catalytic reactor using a closed-loop system that provides for varying the reactor input and other operating parameters in order to maintain the operating temperature of the reactor at or near the initial setpoint temperature for operation of the reactor. In one example, maximum and minimum operating temperatures with a catalytic partial oxidation reactor are controlled, as well as maintaining control over the corresponding minimum required ratio of oxygen atoms to carbon atoms, such that the operating temperature within the reactor is maintained below the material limits but above threshold temperatures for coking.
    Type: Grant
    Filed: February 9, 2009
    Date of Patent: December 25, 2012
    Assignee: Precision Combustion, Inc.
    Inventors: Subir Roychoudhury, Joel M. Desjardins, David Spence, Richard Mastanduno, Dennis E. Walsh, William C. Pfefferle
  • Patent number: 8323978
    Abstract: A calibration device and method of using the device to calibrate an analytical instrument capable of reading a photoluminescent oxygen probe. The device includes at least (a) a first mass of an oxygen sensitive photoluminescent dye retained within a hermetically sealed space so as to isolate the dye from environmental oxygen, and in fluid communication with an activated metal-air battery whereby any oxygen permeating into the hermetically sealed space is quickly consumed by the battery, and (b) a second mass of an oxygen sensitive photoluminescent dye in fluid communication with an environmental concentration of oxygen.
    Type: Grant
    Filed: May 20, 2011
    Date of Patent: December 4, 2012
    Assignee: Mocon, Inc.
    Inventors: Timothy A. Ascheman, Daniel W. Mayer
  • Publication number: 20120295364
    Abstract: A self-contained, remotely interrogatable, autonomously positionable, pressure probe and methods of manufacturing and using. The probe (10) includes (i) a hermetically sealed, flexible, gas impermeable sachet (50) capable of equilibriating to a surrounding pressure, (ii) an optically-active, target-analyte partial pressure sensitive material (20) within the sachet, and (iii) a gaseous headspace (58) within the sachet containing a known concentration of the target-analyte (A).
    Type: Application
    Filed: January 27, 2010
    Publication date: November 22, 2012
    Inventors: Dmitri Boris Papkovsky, Richard Fernandes
  • Patent number: 8304252
    Abstract: The present invention is directed to a regio-and stereoselective bioconversion of selected aliphatic dinitriles into corresponding cyanocarboxylic acids. More particularly, the present invention provides methods for the conversion of 2-isobutyl-succinonitrile into (S)-3 cyano-5-methylhexanoic acid, which is a useful intermediate in the synthesis of (S)-3(aminomethyl)-5-methylhexanoic acid (pregabalin). Pregabalin can be used for treating certain cerebral diseases, for example, in the treatment and prevention of seizure disorders, pain, and psychotic disorders.
    Type: Grant
    Filed: April 20, 2010
    Date of Patent: November 6, 2012
    Assignee: Pfizer Inc.
    Inventors: Michael P. Burns, Justin K. Weaver, John Wing Wong
  • Publication number: 20120276647
    Abstract: A chemical indicator comprises a particulate inorganic substrate, and at least one reactive dye or ink coated on and/or impregnated within the particulate inorganic substrate. Coating and/or impregnating at least one reactive dye or ink on or within a particulate inorganic substrate improves the storage stability and/or thermal stability of the at least one reactive dye or ink, which typically comprises relatively unstable compounds. This allows the present indicators to be incorporated into thermoplastic polymer materials and processed conventionally while maintaining the efficacy and stability of the new indicators. The indicators provide simple, reliable, and cost effective detection means for detecting analytes such as ammonia, carbon dioxide, and oxygen, and may find use in applications such as food packaging and medical applications.
    Type: Application
    Filed: October 14, 2010
    Publication date: November 1, 2012
    Applicant: UNIVERSITY OF STRATHCLYDE
    Inventors: Andrew Mills, Pauline Grosshans, Graham Skinner
  • Patent number: 8273033
    Abstract: A mainstream gas monitoring system and method that includes a mainstream airway adapter, and a gas sensing assembly associated with the mainstream airway adapter to measure an analyte of a gas flow through the adapter. A gas sensing portion outputs a signal indicative of the analyte in a gas flow in the mainstream airway adapter. A processing portion receives the signal from the gas sensing portion and determines an amount of the analyte in the gas flow based on the signal from the gas sensing portion. The gas sensing portion is subject to temperature variations associated with variations in flow rate and direction of respiratory gases. Methods are described that utilize the measurement of instantaneous respiratory flow rate combined with estimates of gas temperature and composition to estimate the sensor cooling effects from which a flow based time varying compensation factor is derived.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: September 25, 2012
    Assignee: RIC Investments, LLC
    Inventors: Joesph A. Orr, Paul B. Gunneson, Anthony T. Pierry
  • Patent number: 8257978
    Abstract: Provided are novel technical means for obtaining useful knowledge in practical application of antioxidation action of dissolved hydrogen and in practical application of active oxygen scavenging action in water. Based on the temporal profile of the difference between the dissolved oxygen amount measured with forcibly dissolving hydrogen and the dissolved oxygen amount measured with blowing any other gas than hydrogen, the reaction between dissolved hydrogen and dissolved oxygen is quantitatively evaluated. Based on the temporal profile of the difference between the dissolved oxygen amount measured with making a photosensitizing dye contained in water and with forcibly dissolving hydrogen therein, and the dissolved oxygen amount measured without making a photosensitizing dye contained in water and with forcibly dissolving hydrogen therein, the reaction between dissolved hydrogen and dissolved oxygen is quantitatively evaluated.
    Type: Grant
    Filed: March 4, 2009
    Date of Patent: September 4, 2012
    Assignees: Eureka-Lab Inc., Seiji Katayama
    Inventors: Seiji Katayama, Yumiko Katayama
  • Patent number: 8241911
    Abstract: A calibration card and method of using the card to calibrate an analytical instrument capable of reading a photoluminescent oxygen probe. The card includes at least (a) a first mass of an oxygen sensitive photoluminescent dye retained within a hermetically sealed space so as to isolate the dye from environmental oxygen, and in fluid communication with an activated metal-air battery whereby any oxygen permeating into the hermetically sealed space is quickly consumed by the battery, and (b) a second mass of an oxygen sensitive photoluminescent dye in fluid communication with the environment whereby the second mass of photoluminescent dye is exposed to an environmental concentration of oxygen.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: August 14, 2012
    Assignee: Mocon, Inc.
    Inventors: Timothy A. Ascheman, Daniel W. Mayer, Stephen D. Tuomela
  • Patent number: 8222041
    Abstract: A high electron mobility transistor (HEMT) capable of performing as a CO2 or O2 sensor is disclosed, hi one implementation, a polymer solar cell can be connected to the HEMT for use in an infrared detection system. In a second implementation, a selective recognition layer can be provided on a gate region of the HEMT. For carbon dioxide sensing, the selective recognition layer can be, in one example, PEI/starch. For oxygen sensing, the selective recognition layer can be, in one example, indium zinc oxide (IZO). In one application, the HEMTs can be used for the detection of carbon dioxide and oxygen in exhaled breath or blood.
    Type: Grant
    Filed: May 8, 2009
    Date of Patent: July 17, 2012
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Fan Ren, Stephen John Pearton
  • Patent number: 8219247
    Abstract: A method of operating a furnace having process tubes and multiple burners where it is desired to conform the temperatures of the process tubes to selected target temperature criterion. The present method provides a systematic and quantitative approach to determine how to adjust burner flow rates to result in desired tube wall temperatures, for example to minimize the temperature deviation between tube wall temperatures at a predetermined elevation in the furnace.
    Type: Grant
    Filed: November 19, 2009
    Date of Patent: July 10, 2012
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Ali Esmaili, William Robert Licht, Xianming Jimmy Li, Oliver J. Smith, IV
  • Publication number: 20120094390
    Abstract: Binding an analyte can cause a change in fluorescence emission of a sensor. The change in fluorescence can be related to the amount of analyte present. The sensor can include a semiconductor nanocrystal linked to a fluorescent moiety. Upon excitation, the fluorescent moiety can transfer energy to the semiconductor nanocrystal, or vice versa.
    Type: Application
    Filed: December 19, 2011
    Publication date: April 19, 2012
    Inventors: Preston T. Snee, Rebecca C. Somers, Daniel G. Nocera, Moungi G. Bawendi
  • Patent number: 8114673
    Abstract: This invention relates to an irreversible indicator for detecting oxidizing agents, or in particular an oxygen indicator, comprising at least one redox-sensitive dyestuff, at least one semiconductor material and at least one electron donor. This indicator is activated by exposure to light of about 200-400 nm. The invention also relates to UV light detector.
    Type: Grant
    Filed: September 2, 2002
    Date of Patent: February 14, 2012
    Assignee: University of Strathclyde
    Inventors: Andrew Mills, Soo-Keun Lee
  • Patent number: 8093055
    Abstract: A calibration tool for use in combination with a photoluminescent oxygen-sensitive working probe and an analytical instrument capable of reading the working probe. The calibration tool is effective for achieving two-point calibration of the analytical instrument, and includes at least first and second solid state compositions having different sensitivities to oxygen. The first composition is an oxygen-sensitive photoluminescent dye that is the same as that in the working probe, embedded within an oxygen-permeable carrier matrix that is the same as that in the working probe. The second composition is an oxygen-sensitive photoluminescent dye that is the same as that in the first composition, embedded within a carrier matrix that is different from that in the first composition. The oxygen sensitivity of the second composition is less than the oxygen sensitivity of the first composition.
    Type: Grant
    Filed: December 8, 2009
    Date of Patent: January 10, 2012
    Assignees: Mocon, Inc., Luxcel Biosciences, Ltd.
    Inventors: Daniel W. Mayer, Dmitri Boris Papkovsky
  • Publication number: 20110275985
    Abstract: Disclosed are magnetic nanosensors or transducers that permit measurement of a physical parameter in an analyte via magnetic reasonance measurements, in particular of non-agglomerative assays. More particularly, in certain embodiments, the invention relates to designs of nanoparticle reagents and responsive polymer coated magnetic nanoparticles. Additionally provided are methods of use of nanoparticle reagents and responsive polymer coated magnetic nanoparticles for the detection of a stimulus or an analyte with NMR detectors.
    Type: Application
    Filed: July 2, 2009
    Publication date: November 10, 2011
    Applicant: T2 Biosystems, Inc.
    Inventors: Thomas Jay Lowery, JR., James J. Koziarz, Douglas A. Levinson, David A. Berry, Tuan A. Elstrom, Sonia Kumar, Mark John Audeh
  • Patent number: 8048677
    Abstract: The invention relates to a sensor board comprising a plate-like body comprising a body material and having two surfaces substantially parallel to each other, and at least one optical sensor and at least one non-optical sensor, the sensors being positioned at the same surface of the body, wherein the body includes a first area having a thickness D1 of the body material and a second area having a thickness D2 of the body material, where D1>D2>0, the at least one optical sensor being positioned at the second area.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: November 1, 2011
    Assignee: Radiometer Medical ApS
    Inventor: Michael Svendsmark Hansen
  • Publication number: 20110236986
    Abstract: A sensor material of the type comprising a long-decay photoluminescent, protonable dye embedded in a suitable polymeric matrix, is used for generating a specific optical response to two different analytes present in a sample, thus allowing selective determination of the two analytes in the sample. Also described is a method for the simultaneous sensing of a first and second analyte in a sample. The method comprises the steps of irradiating a sensor material of the type comprising a long-decay photoluminescent protonable dye embedded in a suitable polymeric matrix with light of one or two wavelengths, determining photoluminescence intensity and lifetime signals originating from the sensor, and correlating the photoluminescence intensity signal with a concentration of the first analyte and the photoluminescence lifetime signal(s) with the concentration of the second analyte.
    Type: Application
    Filed: March 29, 2011
    Publication date: September 29, 2011
    Applicant: UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK
    Inventor: Dmitri Papkovsky
  • Publication number: 20110223678
    Abstract: A calibration device and method of using the device to calibrate an analytical instrument capable of reading a photoluminescent oxygen probe. The device includes at least (a) a first mass of an oxygen sensitive photoluminescent dye retained within a hermetically sealed space so as to isolate the dye from environmental oxygen, and in fluid communication with an activated metal-air battery whereby any oxygen permeating into the hermetically sealed space is quickly consumed by the battery, and (b) a second mass of an oxygen sensitive photoluminescent dye in fluid communication with an environmental concentration of oxygen.
    Type: Application
    Filed: May 20, 2011
    Publication date: September 15, 2011
    Inventors: Timothy A. Ascheman, Daniel W. Mayer