With Fluorescence Or Luminescence Patents (Class 436/172)
  • Patent number: 11933731
    Abstract: The present disclosure relates to using Surface-Enhanced Raman Spectroscopy (SERS) for detecting analytes in samples. Uses can include, for example, detection of tetrahydrocannabinol (THC) using SERS, as well as apparatuses and systems to implement such detection methods.
    Type: Grant
    Filed: May 12, 2021
    Date of Patent: March 19, 2024
    Assignee: Hound Labs, Inc.
    Inventors: Jeffrey A. Stoll, Samartha G. Anekal, Karan Mohan
  • Patent number: 11739261
    Abstract: A fluorescent compound for acid detection is strongly emissive in the solid state and can aggregate in the presence of an acid. As such, a fluorescent intensity emitted from the compound can be enhanced from an original intensity level in the presence of an acid. The fluorescent compound can emit an enhanced fluorescent intensity in the presence of an ultra-low acid concentration, for example, a concentration of at least about 10?20 M.
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: August 29, 2023
    Assignee: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Benzhong Tang, Xin Cai, Jianguo Wang
  • Patent number: 11707240
    Abstract: An inverse visualization of a time-resolved angiographic image data set of a vascular system of a patient that was recorded by a medical imager during the flow of a contrast medium through the vascular system is provided. The time-resolved angiographic image data set of the vascular system has a temporal sequence of frames of the vascular system corresponding to the contrast medium filling process. A data set from bolus arrival times for each pixel or voxel is determined. The bolus arrival time corresponds to the time in the temporal sequence at which a predetermined contrast enhancement due to the contrast medium filling first occurs. A data set of temporally inverted bolus arrival times with respect to the contrast medium filling is determined for each pixel or voxel, resulting in a temporally inverted sequence of frames with respect to the contrast medium filling. The time-resolved angiographic image data set in the temporally inverted sequence is visualized.
    Type: Grant
    Filed: January 19, 2021
    Date of Patent: July 25, 2023
    Assignee: Siemens Healthcare GmbH
    Inventors: Markus Kowarschik, Sebastian Schafer
  • Patent number: 11685741
    Abstract: The present disclosure relates to compounds of Formula I, II, or III and compositions of the same, which are reversible off-on or ratiometric fluorescent iron sensors and are useful in live-cell imaging of labile iron ions and their quantification in subcellular compartments, as well as treatment of diseases associated with iron dyshomoestasis.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: June 27, 2023
    Assignee: University of Massachusetts
    Inventor: Maolin Guo
  • Patent number: 11635385
    Abstract: A method for fast extracting an organic pollutant in a complex system is disclosed, which includes following steps. A surface-enhanced Raman scattering (SERS) spectrum of an organic pollutant is divided to obtain P wavelength sub-intervals with overlapping regions. The P wavelength sub-intervals are screened to obtain ? wavelength sub-intervals. The ? wavelength sub-intervals are screened to obtain a required wavelength sub-interval. The required wavelength sub-interval is screened to obtain a required wavelength subset. A method and a system for fast detecting an organic pollutant in a complex system are also disclosed.
    Type: Grant
    Filed: October 20, 2021
    Date of Patent: April 25, 2023
    Assignees: JiMei University, Jiangsu University
    Inventors: Quansheng Chen, Huanhuan Li, Qin Ouyang, Jiaji Zhu, Yi Xu, Tianhui Jiao, Haihui Pan
  • Patent number: 11549860
    Abstract: A method and a system for interrogating an optical fiber includes a probe signal that has a first frequency comb at a first repetition rate (?f) injected into the optical fiber. A backscattering signal that includes the probe signal convolved with an impulse response of the optical fiber in reflection which is sensitive to at least one parameter being measured from the optical fiber is gathered. The backscattering signal is beaten with a local oscillator signal to generate a beating signal, the local oscillator signal including a second frequency comb at a second repetition rate that is offset from the first repetition rate (?f+?f) and being mutually coherent with the first frequency comb. The resulting beating signal is analysed to thereby determine the at least one parameter being measured from the optical fiber.
    Type: Grant
    Filed: May 20, 2021
    Date of Patent: January 10, 2023
    Assignee: ARAGON PHOTONICS LABS S.L.U.
    Inventors: Hugo Fidalgo Martins, Miguel Soriano Amat, María del Rosario Fernández Ruiz, Sonia Martín López, Miguel González Herráez, Javier Preciado Garbayo, Asier Villafranca Velasco
  • Patent number: 11543350
    Abstract: A calibration target for calibrating an optoelectronic device for analyzing biomolecules by detecting fluorescence signals from a sample includes a substrate and a solid fluorescent layer that is disposed on the substrate and capable of being excited by laser light. The fluorescent layer has an optically inactive matrix having embedded therein a carbon-based component that is excitable to light emission.
    Type: Grant
    Filed: June 2, 2021
    Date of Patent: January 3, 2023
    Assignee: IMT MASKEN UND TEILUNGEN AG
    Inventor: Goetz Thorwarth
  • Patent number: 11530352
    Abstract: Provided herein are processes for preparing fluorescent 1-cyano-2-substituted isoindole compounds or N-substituted phthalazinium compounds, comprising reacting an aromatic dialdehyde or aromatic aldehyde-ketone compound with a material that contains primary amino or hydrazine groups, and assaying methods involving the processes thereof.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: December 20, 2022
    Assignee: Illumina, Inc.
    Inventors: Ali Asadi, Jian-Sen Li
  • Patent number: 11505530
    Abstract: Disclosed are a 1,8-naphthalimide derivative, a preparation method therefor and a use thereof. The 1,8-naphthalimide derivative is easy to prepare, and is an enhanced Cu2+ fluorescent probe, which can detect Cu2+ by two wavelengths and be applied to almost-all-water systems. According to atitration experiments and blank experiments at 392 nm and 754 nm, the detection limit of the 1,8-naphthalimide derivative of the present invention for Cu2+ is 2.6368×10?7 mol/L and 2.0156×10?7 mol/L, respectively, indicating that same can perform quantitative detection for Cu2+ with a high selectivity and a high sensitivity by using two wavelengths. In addition, a pH colorimetric switch based on 1,8-naphthalimide can rapidly and reversibly respond to a pH by means of three ways: a maximum absorption wavelength, absorbance and color change. Same has a narrow switching pH range, a good selectivity and a high sensitivity, can be used in almost-all-water systems.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: November 22, 2022
    Assignee: SOOCHOW UNIVERSITY
    Inventors: Dongmei Xu, Yufen Chen
  • Patent number: 11473152
    Abstract: The present invention relates to barcodes coated with metal nanoshells and to methods of making the metal nanoshell-coated barcodes. The metal nanoshell-coated barcodes of the present invention have applications in detection systems, including multiplex detection systems.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: October 18, 2022
    Inventors: Warren Che War Chan, Leo Y. T. Chou, Kun Chen
  • Patent number: 11447606
    Abstract: Disclosed herein is a porous polymeric material having a repeating unit according to Formula (I) or (IV), wherein each of A and E has a ? conjugated system and each of X and G contain a flexible tetraphenylethylene (TPE) group. Also disclosed herein are fluorescent chemical sensors or biosensors or environmental monitoring assays or nanosheets or composite materials that include the polymer, and a method of detecting a volatile organic chemical or a metal ion in solution phase.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: September 20, 2022
    Assignee: National University of Singapore
    Inventors: Dan Zhao, Jinqiao Dong
  • Patent number: 11434532
    Abstract: Disclosed herein are methods and systems for detection and discrimination of optical signals from a densely packed substrate. There have broad applications for biomolecule detection near or below the diffraction limit of optical systems, including in improving the efficiency and accuracy or polynucleotide sequencing applications.
    Type: Grant
    Filed: May 21, 2021
    Date of Patent: September 6, 2022
    Assignee: APTON BIOSYSTEMS, INC.
    Inventors: Bryan P. Staker, Niandong Liu, Manohar R. Furtado, Rixun Fang, Norman Burns, Windsor Owens
  • Patent number: 11402376
    Abstract: In one embodiment, the present invention includes a system for detecting a target analyte which includes a microfluidic device having least one microfluidic channel with a binding surface positioned in the microfluidic channel with further include a first electrode and a second electrode. The system may further include a detector and a voltage supply. Also included is a method to detect a target analyte using a described microfluidics device, introducing solution with a target analyte to a binding surface, and binding the target analyte to the binding surface by applying an electrical potential between the first and second electrodes during at least a portion of the binding step, which enhances the rate of binding of the target analyte molecules to the binding molecules. The method then includes the steps of detecting a reporter molecule which corresponds to the amount of the bound target analyte molecules, which correlates with the amount of target analyte in the original sample.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: August 2, 2022
    Assignee: UNIVERSITY OF WYOMING
    Inventors: Debashis Dutta, Michael Taylor, Ravichander Rao Peesara
  • Patent number: 11402330
    Abstract: A method for measuring optical signal detector performance that includes directing light emitted from an optical signal detector onto a first non-fluorescent surface portion in a first detection zone of the optical signal detector. A first characteristic of light detected by a first sensor of the first optical signal detector is measured while the first non-fluorescent surface portion is in the first detection zone of the optical signal detector. Light emitted from the optical signal detector is directed into a first void in the first detection zone of the optical signal detector. A second characteristic of light detected by the first sensor of the optical signal detector is measured while the first void is in the first detection zone of the optical signal detector. And an operational performance status of the optical signal detector is determined based on at least one of the first characteristic and the second characteristic.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: August 2, 2022
    Assignee: GEN-PROBE INCORPORATED
    Inventors: David Opalsky, Srajan Raghuwanshi, James Bui
  • Patent number: 11375927
    Abstract: An analyte monitoring system may include an analyte sensor and a transceiver. The analyte sensor may include: a sensor housing, an analyte indicator on at least a portion of the sensor housing, a protective material on at least a portion of the analyte indicator, and a light source in the sensor housing and configured to emit excitation light to analyte indicator. The transceiver may be configured to receive the sensor measurements conveyed by the analyte sensor, infer information about a condition of the environment surrounding the analyte sensor, and calculate an analyte level using at least one or more of the sensor measurements and the inferred information about the condition of the environment surrounding the sensor. The protective material may have a thickness that is thin enough to allow at least some of the excitation light to pass through the protective material and into the environment surrounding the analyte sensor.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: July 5, 2022
    Assignee: Senseonics, Incorporated
    Inventors: Andrew DeHennis, Xiaoxiao Chen
  • Patent number: 11370922
    Abstract: Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I), including stereoisomers, salts and tautomers thereof, wherein R1, R2, R3, L1, L2, L3, L4, L5, M, m and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: June 28, 2022
    Assignee: Sony Corporation
    Inventors: Tracy Matray, Sharat Singh, Michael VanBrunt
  • Patent number: 11313800
    Abstract: A method for the detection and quantification, in a complex aqueous fluid, of additives and water-soluble polymers used in the enhanced recovery of oil and shale gas.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: April 26, 2022
    Assignees: TOTAL SA, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Mattéo Martini, Olivier Tillement, Arthur Marais, Christian Hurtevent, Stéphane Jouenne
  • Patent number: 11279716
    Abstract: The present specification relates to a cyclic compound containing nitrogen, and a color conversion film, a backlight unit, and a display apparatus, including the same.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: March 22, 2022
    Assignee: LG CHEM, LTD.
    Inventors: Hye Mi Oh, Dong Mok Shin
  • Patent number: 11230663
    Abstract: The present disclosure relates to luminescent including photon up-conversion nanoparticles. These nanoparticles include a polymeric organic matrix, at least one light emitter distributed within this matrix, a stabilizing agent, and at least one metal particle enclosed within the matrix, wherein the metal particles are plasmonic nanoparticles. The present disclosure further relates to methods of manufacture and to uses of such nanoparticles.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: January 25, 2022
    Assignee: Sony Corporation
    Inventors: Tzenka Miteva, Anthony Roberts, Michaela Mai, Markus Obermaier, Gabriele Nelles, Vitor Deichmann, Vladimir Yakutkin, Jan Rother
  • Patent number: 11169368
    Abstract: Embodiments of the present invention provide a method and system for processing microscopy images to enable localisation analysis of high density raw data, and thereby achieve higher spatial resolution than would otherwise be the case. This is achieved by exploiting temporal redundancies in the image data resulting from close-to emitters that would otherwise be resolved as a single emitter were they to emit or fluoresce at the same time, but which, by virtue of emitting or fluorescing at slightly different (yet potentially overlapping) times, can be subject to temporal filtering by different filters of different temporal bandwidth to resolve the two emitters. Effectively, the different temporal filters have different time constants which work together to effectively highlight the different emission or fluorescence times of the two emitters, to thereby allow the two close-to emitters to be separately resolved.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: November 9, 2021
    Assignee: King's College London
    Inventors: Richard Marsh, Susan Cox
  • Patent number: 11169057
    Abstract: A particle dispersion method for dispersing particles (500) fixed on the inner surface of a container (12) into a liquid. The particle dispersion method includes a discharge step of discharging a liquid into the container (12). The container (12) has a cylindrical main body part (310), and an inclined part (311) having an inner diameter that decreases from the main body part (310) side to the bottom part side and having a constant angle relative to the central axis of the container. In the discharge step, the liquid is discharged from above the inclined part (311) toward the inclined part (311) on the side opposite the particles (500) fixed to the inner surface of the container (12) across the central axis (300) of the container (12).
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: November 9, 2021
    Assignee: Sysmex Corporation
    Inventors: Hiroaki Tobimatsu, Toshimi Sato
  • Patent number: 11079319
    Abstract: A porous mirror (1) for detection of an analyte (96) in a fluid (99) by optical probing, comprising a translucent slab (2) with a front side (3), and a backside (4) facing away from the front side (3), wherein the front side (3) is adapted for being contacted with a fluid (99), and a reflective layer (5) at the front side (3) of the translucent slab (2), the reflective layer (5) being adapted to reflect light reaching the reflective layer from the backside (4) of the translucent slab (2), wherein the translucent slab (2) comprises pores (6), wherein the pores (6) are dead end pores (6) extending from respective openings (7) at the front side (3) into the translucent slab (2), through the reflective layer (5), wherein a cross-sectional dimension of the openings (7) of the pores (6) is dimensioned so as to prevent larger particles or debris, if any included the fluid, from entering the pores (6), while allowing the analyte (96) in the fluid (99) to enter the pores (6) via diffusion.
    Type: Grant
    Filed: April 21, 2020
    Date of Patent: August 3, 2021
    Assignee: RADIOMETER MEDICAL APS
    Inventor: Thomas Kjaer
  • Patent number: 11009458
    Abstract: Optical reference devices for calibrating or monitoring the performance of an optical measurement device, such as a fluorometer, are made from thermoplastics from the polyaryletherketone (PAEK) family of semi-crystalline thermoplastics, including polyether ether ketone (PEEK). The reference device may be made as a master reference device having a known emission output—as determined by a standard optical measurement device—that is used to calibrate other optical measurement devices against the standard. The reference device may be made in the shape of a receptacle vial so that the reference device can be placed in the receptacle holding structure of an instrument in which the optical measurement device is installed and used to calibrate or monitor the optical measurement device within the instrument. The reference device may be part of the probe of a pipettor or pick and place mechanism or it may be a cap that can be secured to the end of such a probe.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: May 18, 2021
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Norbert D. Hagen, David Opalsky, George T. Walker, Byron J. Knight
  • Patent number: 10866194
    Abstract: A process for detecting oil or lubricant contamination in the production of an article by adding a Stokes-shifting taggant to an oil or lubricant of a machine utilized to produce the article or a component thereof, irradiating the articles produced with a first wavelength of radiation, and monitoring the articles for emission of radiation at a second wavelength. The taggant can be in the form of a composition containing a Stokes-shifting taggant, which absorbs radiation at a first wavelength and emits radiation at a second wavelength, different from said first wavelength, dissolved or dispersed in an oil or lubricant.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: December 15, 2020
    Assignee: Altria Client Services LLC
    Inventor: William James Faenza
  • Patent number: 10829687
    Abstract: A composite particle that includes: a fluorescent semiconductor core/shell nanoparticle (preferably, nanocrystal); and a stabilizing additive of the formula (I), wherein R1 is a hydrocarbyl group, including aryl, alkaryl, alkyl or aralkyl, preferably at least one of R1 is aryl or alkaryl, more preferably at least two are aryl or alkaryl; R2 is R1 when a is one and a C1-C10 divalent alkylene when a is 2; Z is P, As or Sb.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: November 10, 2020
    Assignee: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Michael C. Palazzotto, Saswata Chakraborty, Wayne S. Mahoney, Guy D. Joly, Karissa L. Eckert
  • Patent number: 10782239
    Abstract: Embodiments of the present disclosure pertain to methods of monitoring an environment for the presence of a solvent by: (i) exposing the environment to a luminescent compound, where the relative luminescence emission intensity of the luminescent compound changes upon interaction with the solvent; and (ii) monitoring a change in the relative luminescence emission intensity of the luminescent compound, where the absence of the change indicates the absence of the solvent from the environment, and where the presence of the change indicates the presence of the solvent in the environment. The luminescent compounds include a phosphorous atom with one or more carboxyl groups, where the carboxyl groups are coordinated with one or more metallic ions (e.g., lanthanide ions and yttrium ions). The present disclosure also pertains to sensors for monitoring an environment for the presence of a solvent, where the sensors include one or more of the aforementioned luminescent compounds.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: September 22, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventor: Simon M. Humphrey
  • Patent number: 10739263
    Abstract: A system including an optical signal detector and a controller operatively coupled to the optical signal detector and configured to determine an operational performance status of the optical signal detector. The optical signal detector includes a detection channel having a light source and a sensor, where the detection channel is configured to emit and focus light generated by the light source at a detection zone and to receive and focus light on the sensor. The optical performance status of the optical signal detector is based on a measured characteristic of light focused on the sensor while a non-fluorescent surface is in the detection zone and/or a measured characteristic of light focused on the sensor while a void is in the detection zone.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: August 11, 2020
    Assignee: GEN-PROBE INCORPORATED
    Inventors: David Opalsky, Srajan Raghuwanshi, James Bui
  • Patent number: 10677788
    Abstract: One aspect relates to a method of calibrating event data. The method includes obtaining, via an electronic device including a processor, event data for an assay including a reagent. The reagent is associated with one of a plurality of manufacturing lots of the reagent. The method includes receiving one or more calibration factors for the reagent based on an identifier associated with the one of the plurality of manufacturing lots. The method further includes generating calibrated event data based on an application of the one or more calibration factors to the event data.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: June 9, 2020
    Assignee: Becton, Dickinson and Company
    Inventors: Ramez Emile Necola Shehada, Oliver Crespo-Diaz, Paul Limb
  • Patent number: 10663395
    Abstract: A porous mirror (1) for detection of an analyte (96) in a fluid (99) by optical probing, comprising a translucent slab (2) with a front side (3), and a backside (4) facing away from the front side (3), wherein the front side (3) is adapted for being contacted with a fluid (99), and a reflective layer (5) at the front side (3) of the translucent slab (2), the reflective layer (5) being adapted to reflect light reaching the reflective layer from the backside (4) of the translucent slab (2), wherein the translucent slab (2) comprises pores (6), wherein the pores (6) are dead end pores (6) extending from respective openings (7) at the front side (3) into the translucent slab (2), through the reflective layer (5), wherein a cross-sectional dimension of the openings (7) of the pores (6) is dimensioned so as to prevent larger particles or debris, if any included the fluid, from entering the pores (6), while allowing the analyte (96) in the fluid (99) to enter the pores (6) via diffusion.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: May 26, 2020
    Assignee: RADIOMETER MEDICAL APS
    Inventor: Thomas Kjaer
  • Patent number: 10620124
    Abstract: In a multi-color CARS microscope, it has been difficult to accurately bring optical axes of pump light and Stokes light into correspondence and to stably acquire a spectral signal. Accordingly, in an optical analysis device, CARS light is generated from, a sample by using a residual component of the pump light introduced to an optical waveguide and the Stokes light generated in an optical waveguide.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: April 14, 2020
    Assignee: HITACHI, LTD.
    Inventor: Hideharu Mikami
  • Patent number: 10563142
    Abstract: A method of correcting measurements of a chemical sensor used in an industrial facility. The method involves correcting for errors known to occur in the steady state and the dynamic state for specifically recognized situations. This method allows for correcting errors that occur due to deadtime, false zero measurements, and non-linear disturbances. The method combines automated measurement techniques and human know how to progressively learn and refine the accuracy of the corrections.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: February 18, 2020
    Assignee: ECOLAB USA INC.
    Inventors: Jin Wang, Nigel P. Hilton, Glenn L. Scattergood, Sam Ferguson
  • Patent number: 10527614
    Abstract: The present disclosure provides methods and kits for detecting analytes using avidin-biotin assays.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: January 7, 2020
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: David Peretz
  • Patent number: 10501787
    Abstract: This invention relates to a PCR fluorescence reference standard and to a method for manufacturing a PCR fluorescence reference standard. The PCR fluorescence reference standard comprises a fluorophore suspended in a thermoplastic polymer matrix. The PCR fluorescence reference standard of the invention has a greater shelf life than fluorophores dissolved in a solution and can advantageously be used to validate a fluorescence signal obtained in a thermal cycler.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: December 10, 2019
    Assignee: Starna Scientific Limited
    Inventors: Keith Hulme, Nathan Hulme, John Hammond
  • Patent number: 10495619
    Abstract: A device for determining at least one condition parameter relating to a concentration or a partial pressure of an analyte in a gaseous medium, the device including at least one light source configured to emit light; at least one light receiver configured to detect the light; at least one optical sensor unit, and at least one temperature measuring device configured to measure a temperature of the optical sensor unit at least indirectly, wherein at least the light source, the light receiver and the temperature measuring device are arranged within a housing and at least the sensor unit is arranged outside of the housing, wherein at least one optical property of the sensor unit is a function of the condition parameter of the analyte, wherein light rays emitted by the sensor unit due to the sensor unit being irradiated by the light source are detectable by the light receiver.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: December 3, 2019
    Assignee: Pyro Science GmbH
    Inventors: Roland Thar, Jan Fischer
  • Patent number: 10466234
    Abstract: A method of producing a labeled antibody, including the steps of: a) allowing silica nanoparticles containing a functional molecule and having a thiol group on a surface thereof, and a linker molecule containing a maleimido group and an amino group, to coexist in a solvent to form a thioether bond between the thiol group and the maleimido group, thereby obtaining functional molecule-containing silica nanoparticles on which the linker molecule is bonded; and b) allowing the functional molecule-containing silica nanoparticles on which the linker molecule is bonded, carbodiimide and an antibody to coexist in an aqueous solvent to form an amide bond between the amino group of the linker molecule and a carboxyl group of the antibody.
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: November 5, 2019
    Assignee: FURUKAWA ELECTRIC CO., LTD.
    Inventors: Nobumitsu Yamanaka, Hideki Aizawa, Michio Ohkubo, Kazutomi Miyoshi
  • Patent number: 10466177
    Abstract: A sample comprising a first substance and a second substance is modified by breaking down molecular bonds of the second substance of the sample to form a modified sample having altered surface enhanced luminescence (SEL) characteristics to reduce overlapping of SEL characteristics of the first substance in the second substance. Surface enhanced luminescence data resulting from excitation of the modified sample is collected. Characteristics of the first substance based upon the collected surface enhanced luminescence data are identified.
    Type: Grant
    Filed: February 28, 2016
    Date of Patent: November 5, 2019
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Ning Ge, Viktor Shkolnikov, Anita Rogacs, Paul J. Benning
  • Patent number: 10444158
    Abstract: Systems, methods, and software that measure a plurality of error values each related to a different condition of an aquatic environment monitoring system including a degradation in a chemical indicator due to photo-aging, a degradation in a chemical indicator due to water-aging, a physical contamination of a chemical indicator, an illumination imbalance related to an optical reader, a degradation of a light source of an optical reader, a contamination in water between an optical reader and a chemical indicator, a displacement due to friction between a chemical indicator apparatus and a monitoring unit, an error intrinsic in a chemical indicator, and an error in distance between a chemical indicator and an optical reader. The plurality of error values are used to determine a confidence level that is compared to a threshold value associated with the monitoring system. A correction instruction is generated for correcting one or more of the conditions.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: October 15, 2019
    Assignee: Step Ahead Innovations, Inc.
    Inventor: James E. Clark
  • Patent number: 10434186
    Abstract: The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: October 8, 2019
    Assignee: LUMIPHORE, INC.
    Inventors: Nathaniel G. Butlin, Darren Magda, Jide Xu
  • Patent number: 10364249
    Abstract: The present invention relates to a new class of substituted aza-triangulenium fluorescent dyes having a hydroxy group attached to an aryl as quenching group. The new substituted aza-triangulenium fluorescent dyes may be attached to a linker, conjugated to carrier molecule such as e.g. a protein, a nucleic acid, a lipid, or a saccharide, or deposited or immobilized on solid support materials. The substituted aza-triangulenium fluorescent dyes are useful for various purposes, including use in sensors for monitoring or determining the concentration of analytes, such as H+(pH), Na+, K+, Ca2+, O2, CO2, H2O2, ionic strength, redox potentials, metal ions, and metabolites.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: July 30, 2019
    Assignee: Kobenhavns Universitet
    Inventors: Bo V. Laursen, Martin Rosenberg, Thomas Just Sorensen
  • Patent number: 10330688
    Abstract: This invention provides methods and biomarkers for diagnosing autism by identifying cellular metabolites differentially produced in autistic patient samples versus non-autistic controls. Methods for identifying a unique profile of metabolites present or secreted in brain tissue, cerebrospinal fluid, plasma, or biofluids of autistic samples are described herein. The individual metabolites or a pattern of secreted metabolites provides metabolic signatures of autism, which can be used to provide a diagnosis thereof.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: June 25, 2019
    Assignees: Wisconsin Alumni Research Foundation, Stemina Biomarker Discovery, Inc.
    Inventors: Gabriela Gebrin Cezar, Alan M. Smith
  • Patent number: 10249831
    Abstract: The present invention relates to electronic devices containing special cyclic lactams, more particularly organic electroluminescent devices, and to special cyclic lactams for use in electronic devices, more particularly in organic electroluminescent devices.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: April 2, 2019
    Assignee: Merck Patent GmbH
    Inventors: Philipp Stoessel, Amir Hossain Parham, Christof Pflumm, Anja Jatsch, Thomas Eberle, Jonas Valentin Kroeber
  • Patent number: 10132808
    Abstract: A method uses flow cytometry to prepare surface enhanced Raman scattering (SERS) substrates for obtaining SERS spectra of bacteria. The method involves using a flow cytometer to sort bacterial cells into populations of bacterial cells based upon their biophysical characteristics. The cells may then be washed with a borate buffer to remove any chemical species that degrade the SERS response. A colloid-coated bacteria suspension is then created by mixing one of the populations of bacterial cells with SERS-active colloidal particles. The colloid-coated bacteria suspension is incubated until the SERS-active colloidal particles partition through the capsule and bind to the cell wall for each bacterial cell in the colloid-coated bacteria suspension. The colloid-coated bacteria suspension is then disposed onto a filter and a SERS spectra of the colloid-coated bacteria suspension is obtained using a Raman spectrometer.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: November 20, 2018
    Assignee: The United States of America as represented by Secretary of the Navy
    Inventors: Pamela A. Boss, Kara C. Sorensen, Robert D. George, Anna Y. Obraztsova, Jonathon K. Oiler
  • Patent number: 10054546
    Abstract: A system and method for detecting an analyte includes a waveguide configured to receive a narrow-band laser signal; and a sorbent material covering an analyte detection region of the waveguide, wherein the sorbent material is configured to sorb the analyte and bring the analyte to an evanescent field of the waveguide, and wherein Raman scattering is produced by an interaction of the evanescent field and the analyte sorbed in the sorbent material along the analyte detection region of the waveguide, and the waveguide is further configured to collect the Raman scattering along the analyte detection region of the waveguide, wherein the collected Raman scattering indicates a type of the analyte.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: August 21, 2018
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Todd H. Stievater, Jacob B. Khurgin, Dmitry A. Kozak, Scott A. Holmstrom, R. Andrew McGill
  • Patent number: 10054552
    Abstract: An example method of inspecting a part includes applying a penetrant dye to the part, the penetrant dye exhibiting a fluorescent color when subjected to light from a lighting device. A portion of the part is illuminated with light from the lighting device. An image of the portion of the part is automatically recorded with a camera while the portion is illuminated. An uncertainty metric for the image is automatically determined that is indicative of a likelihood that pixels in the image having the fluorescent color represent damage to the part. At least one of the part, lighting device, and camera are automatically adjusted based on the uncertainty metric being within a predefined range. The automatic recording, determining, and adjusting steps are iteratively repeated until the uncertainty metric is greater than the predefined range, or a predefined number of iterations have been performed for the portion of the part.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: August 21, 2018
    Assignee: UNITED TECHNOLOGIES CORPORATION
    Inventors: Sergio S. Frutuoso, Alan Matthew Finn, Gene B. Donskoy
  • Patent number: 9943487
    Abstract: One aspect of the invention is a polymer material comprising a capsule coated with PDA. In certain embodiments, the capsule encapsulates a functional agent. The encapsulated functional agent may be an indicating agent, healing agent, protecting agent, pharmaceutical drug, food additive, or a combination thereof.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: April 17, 2018
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Scott R. White, Nancy R. Sottos, Sen Kang, Marta B. Baginska
  • Patent number: 9945848
    Abstract: One aspect relates to a method of calibrating event data. The method includes obtaining, via an electronic device including a processor, event data for an assay including a reagent. The reagent is associated with one of a plurality of manufacturing lots of the reagent. The method includes receiving one or more calibration factors for the reagent based on an identifier associated with the one of the plurality of manufacturing lots. The method further includes generating calibrated event data based on an application of the one or more calibration factors to the event data.
    Type: Grant
    Filed: February 5, 2015
    Date of Patent: April 17, 2018
    Assignee: Becton, Dickinson and Company
    Inventors: Ramez Emile Necola Shehada, Oliver Crespo-Diaz, Paul Limb
  • Patent number: 9804331
    Abstract: A robust sensor, suitable for dipping into fluid wells, includes (a) a stem; (b) a whispering gallery mode (“WGM”) resonator mechanically supported by the stem; and (c) feed and pickup optical fibers optically coupled with the WGM resonator and mechanically coupled with the stem, thereby defining a stem-resonator-fiber assembly, wherein a portion of the stem-resonator-fiber assembly including the WGM resonator can fit within an imaginary cylinder having a diameter of 7 mm (or 2 mm, or even 1 mm). Such a whispering gallery mode (“WGM”) dip sensor, including (1) a stem, (2) a WGM resonator, and (3) feed and pickup optical fibers, may be made by (a) fabricating the WGM resonator and the stem from an optical fiber; (b) fabricating tapers on the feed and pickup fibers; (c) positioning tapers of the feed and pickup fibers relative to the WGM resonator such that an optical coupling between the tapers and the WGM resonator is established; and (d) mechanically coupling the stem with the feed and pickup fibers.
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: October 31, 2017
    Assignee: NEW YORK UNIVERSITY
    Inventors: Monica Agarwal, Natalie Huiyi Luo, Iwao Teraoka
  • Patent number: 9772485
    Abstract: A method for light-microscopy imaging of a sample structure (2, 34) is described, having the following steps: preparing the sample structure (2, 34) with markers that are transferrable into a state imageable by light microscopy, generating a sequence of individual-image data sets by sequential imaging of the sample structure (2, 34), in such a way that for each image, only a subset of the totality of the markers is in each case transferred into the state imageable by light microscopy, the markers of the respective subset having an average spacing from one another which is greater than the resolution limit of light-microscopy imaging which determines the extent of a light distribution representing one of the respectively imaged markers, generating at least two data blocks in which multiple successive individual-image data sets are respectively combined, superposing the individual-image data sets contained in the respective data block to yield a superposed-image data set, identifying an image offset between
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: September 26, 2017
    Assignee: Leica Microsystems CMS GmbH
    Inventors: Marcus Dyba, Volker Seyfried
  • Patent number: 9739770
    Abstract: Systems and methods are provided for detecting one or more particles such as individual unlabeled molecules or single nanoparticles. In examples described herein, optical energy is introduced into a microtoroid or other microcavity to generate an evanescent field. The microcavity has a functionalized outer surface that has been functionalized with a chemically or biologically active substance such as an antibody, antigen or protein. An indication of a particle bound to the functionalized outer surface of the microcavity is then detected based on a reactive interaction between the particle and the evanescent field while using frequency locking, balanced detection and various filtering techniques. The frequency locking, balanced detection and filtering techniques reduce the signal-to-noise ratio (SNR) of the detection system so that single nanoparticles (e.g. 2.5 nanometers (nm) in radius) and individual molecules (e.g. 15.5 kilo-Dalton (kDa) in size) can be detected in aqueous solution in some examples.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: August 22, 2017
    Inventor: Tsu-Te Judith Su
  • Patent number: 9733252
    Abstract: Methods and systems for plasmonically enhanced bionanoantennas for tagging, tracking, and locating targets of interest at long distances in both day and nighttime conditions. The nanoantennas are used to tag a target of interest and emit a wavelength to impart a unique biometric signature. The nanoantennas are detectable by selectively harvesting and plasmonically enhancing incident light in the visible region, then upconverting that energy through an activated phosphor.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: August 15, 2017
    Assignee: SRC, INC.
    Inventor: Adam J. Lowe