Solid Candy Type Patents (Class 514/948)
  • Patent number: 6936244
    Abstract: A composition for treatment of bacterial infections of the eye is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme. The carrier for delivering at least one lytic enzyme to the eye may be but is not limited to the use of an isotonic solution.
    Type: Grant
    Filed: May 14, 2002
    Date of Patent: August 30, 2005
    Assignees: New Horizons Diagnostics Corp, Rockefeller University
    Inventors: Vincent Fiochetti, Lawrence Loomie
  • Patent number: 6562372
    Abstract: A tocotrienol-containing powder prepared by a process wherein an oil containing a tocotrienol is treated with a lecithin, a cellulose and an emulsifying agent in water to form an emulsion, a powder substance is mixed with the formed emulsion to form a suspension and then the formed suspension is spray-dried. The powder containing tocotrienol, which has excellent storage stability and free flowability, can be used in preparing a tablet which comprises the powder compressed into a tablet form.
    Type: Grant
    Filed: April 5, 2000
    Date of Patent: May 13, 2003
    Assignee: Fuji Chemical Industry Co., Ltd.
    Inventors: Shinichiro Yokoi, Nobukazu Tanaka, Yoshiharu Horita, Terumasa Hosokawa, Takeshi Shishido, Heiji Ikushima
  • Patent number: 6461634
    Abstract: A food, or ready-to-drink beverage, delivery system for increasing the production and release of human growth hormone (HGH) for anti-aging effects and/or to improve a condition of HGH deficiency. A food bar, powder, other food forms, or ready-to-drink beverage that contains the full range and optimal dosages of vitamins, minerals, non-prescription hormonal and herbal supplements most desired by individuals who regularly take such supplements from numerous bottles or other packages. HGH stimulation and the above-described supplementation may be delivered for oral ingestion separately or together in the same aliquot, said aliquot providing a pleasant-tasting and convenient snack or mini-meal in addition to the specific HGH stimulation and supplementation. L-glutamine, glycine and melatonin are sufficient to boost HGH up to age 60, and it is preferred to add L-arginine and L-lysine for individuals of age 60 and older.
    Type: Grant
    Filed: August 17, 2000
    Date of Patent: October 8, 2002
    Inventor: Edward Marshall
  • Patent number: 6455069
    Abstract: The present invention relates to a mixture of a starch and at least one other excipient for tabletting wherein the starch is free-flowing compressible processed starch powder suitable for use both as a binder and as a disintegrant in tablets. The free-flowing starch powder improves the characteristics and the properties of the tablets when mixed with one or more different excipients. The present invention also discloses a method for obtaining tablets comprising the free-flowing compressible processed starch together with at least one excipient and the tablets obtained by such a method.
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: September 24, 2002
    Assignee: Cerestar Holding B.V.
    Inventors: Jacques Loïc Marie Michaud, Liesbeth Maria Fernande Meeus
  • Patent number: 6432444
    Abstract: A bandage for treating a bacterial infection of skin is disclosed wherein the bandage contains a composition produced by the method of obtaining an effective amount of at least one lytic enzyme genetically coded for by a specific bacteriophage specific for a bacteria infecting the skin, wherein the bacteria to be treated is selected from the group consisting of Staphylococcus, Pseudomonas, Streptococcus, and combinations thereof. This lytic enzyme is specific for and has the ability to digest a cell wall of one of the bacteria and is coded for by the same bacteriophage capable of infecting the bacteria being digested. The enzyme produced is mixed with a topical carrier.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: August 13, 2002
    Assignee: New Horizons Diagnostics Corp
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 6399089
    Abstract: Compositions and methods for balancing body weight by inhibiting re-uptake of serotonin, regulating metabolism, potentiating insulin, and inhibiting lipogenesis, in a mammal. The compositions comprise chromium, fat-free cocoa powder, Hypericum perforatum extract, Garcinia cambogia extract, Ginkgo biloba extract, Panax ginseng extract, and quercetin.
    Type: Grant
    Filed: May 15, 2000
    Date of Patent: June 4, 2002
    Inventors: Inna Yegorova, David Jiang
  • Patent number: 6399098
    Abstract: The present invention discloses a method for treating baterial dental caries caused by Streptococcus mutans, comprising administering a composition comprising an effective amount of at least one lytic enzyme produced by a bacteriophage specific for Streptococcus mutans, with the lytic enzyme having the ability to exclusively digest a cell wall of the Streptococcus mutans infecting all or part of a mouth or teeth, and a toothpaste for delivering the enzyme to the mouth and teeth.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: June 4, 2002
    Assignee: New Horizons Diagnostics Corp
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 6365209
    Abstract: A novel encapsulated product is provided and includes: at least one active ingredient; at least one compressible material; and at least one tableting material; wherein the encapsulated product is in the form of a caplet having a diameter of from about 1 millimeter to about 7 millimeters and a length from about 1 millimeter to about 7 millimeters. A method for preparing the encapsulated product is also provided. The encapsulated product may be incorporated into a food item, a soft confectionery product, a hard confectionery product, a jelly gum confectionery product, and a dry beverage or chewing gum product.
    Type: Grant
    Filed: February 7, 2001
    Date of Patent: April 2, 2002
    Assignee: Capricorn Pharma, Inc.
    Inventor: Subraman Rao Cherukuri
  • Patent number: 6335012
    Abstract: The present invention discloses a method for treating dental caries, comprising administering a composition comprising an effective amount of at least one lytic enzyme produced by a bacteriophage specific for said bacteria, the lytic enzyme having the ability to digest a cell wall of the bacteria infecting all or part of a mouth or teeth, and a carrier for delivering the enzyme to the mouth and teeth.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: January 1, 2002
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 6326002
    Abstract: The present invention discloses a method for treating Streptococcal infections of the upper respiratory tract, comprising administering an effective amount of a lysin enzyme produced by group C Streptococcal bacteria infected with a C1 bacteriophage specific for the bacteria to a mouth, throat, or nasal passage of a mammal, the method providing a concentration of from about 100 to 500,000 active enzyme units per milliliter of fluid in the environment of said nasal or oral passages.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: December 4, 2001
    Assignee: New Horizons Diagnostics Corporation
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 6238661
    Abstract: Compositions and methods for the prophylactic and therapeutic treatment of bacterial infections are disclosed which comprise administering to an individual an effective amount of a composition comprising an effective amount of lytic enzyme and a carrier for delivering the lytic enzyme. This method and composition can be used for the treatment of upper respiratory infections, skin infections, wounds, burns, vaginal infections, eye infections, intestinal disorders and dental problems.
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: May 29, 2001
    Assignee: New Horizons Diagnostics Corp.
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 6210686
    Abstract: Yeast-derived fiber has been demonstrated, as described herein, to effectively improve the serum lipid profile in humans, when provided as a dietary supplement, without some of the disadvantages known to accompany dietary supplementation with oat fiber or psyllium fiber. Described herein are dietary supplements comprising yeast fiber, e.g., &bgr;-glucan or glucomannan, and further comprising folic acid or a salt thereof, vitamin B6, vitamin B12, and vitamin E. The dietary supplements of the invention can further comprise fats, carbohydrates and proteins, for example, and other ingredients added to formulate a food product. Such food products can be in the form, for example, of solid or semi-solid foods, such as food bars, pudding, or spreads. By including folate and vitamin B6, the dietary supplement provides a second benefit of suppressing the level of homocysteine in the blood.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: April 3, 2001
    Assignee: Beth Israel Deaconess Medical Center
    Inventors: Stacey J. Bell, R. Armour Forse, Bruce R. Bistrian
  • Patent number: 6056955
    Abstract: The present invention discloses a method and composition for the topical treatment of streptococcal infections by the use of a lysin enzyme blended with a carrier suitable for topical application to dermal tissues. The method for the treatment of dermatological streptococcal infections comprises administering a composition comprising effective amount of a therapeutic agent, with the therapeutic agent comprising a lysin enzyme produced by group C streptococcal bacteria infected with a C1 bacteriophage. The therapeutic agent can be in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: September 14, 1999
    Date of Patent: May 2, 2000
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 6056954
    Abstract: A method for the prophylactic and therapeutic treatment of bacterial infections is disclosed which comprises the treatment of an individual with an effective amount of a lytic enzyme composition specific for the infecting bacteria, with the lytic enzyme comprising an effective amount of lytic enzyme, wherein the lytic enzyme is in an environment having a pH which allows for activity of said lytic enzyme; and a carrier for delivering said lytic enzyme. This method, and composition can be used for the treatment of upper respiratory infections, skin infections, wounds, and burns, vaginal infections, eye infections, intestinal disorders and dental problems.
    Type: Grant
    Filed: September 14, 1999
    Date of Patent: May 2, 2000
    Assignee: New Horizons Diagnostics Corp
    Inventors: Vincent A. Fischetti, Lawrence Loomis
  • Patent number: 6017528
    Abstract: The present invention relates to compositions containing Group C streptococcal phage associated lysin enzyme for the prophylactic and therapeutic treatment of Streptococcal infections, including the infection commonly known as strep throat. Methods for therapeutically and prophylactically treating such infections also are described.
    Type: Grant
    Filed: February 25, 1999
    Date of Patent: January 25, 2000
    Assignee: New Horizons Diagnostics
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 6017548
    Abstract: An oil-in-water emulsion for treating the skin comprising from about 2 to about 10 weight percent of a cationic emulsifier such as dimethyl distearyl ammonium halide, a substantially nonionizable humectant such as glycerine and a weakly acidic material having a disassociation constant of about I to 6. The amount of weakly acidic material is such that the pH of the finished emulsion is about 2.5 to 4.5. also disclosed is a method of preparing the emulsion.
    Type: Grant
    Filed: January 27, 1997
    Date of Patent: January 25, 2000
    Assignee: The Andrew Jergens Company
    Inventors: Howard Epstein, Matthew S. Jonasse
  • Patent number: 6010719
    Abstract: Freeze-dried disintegrating tablets, said tablets containing at least a therapeutic agent, a matrix forming agent and a binding agent, in which the tablets contain more than 20% by weight of a matrix forming agent selected from the group consisting of maltodextrins having a DE value between 12 and 40, isomalt and mixtures thereof, the weight ratio between said matrix forming agent and the binding agent being comprised between 2:1 and 50:1.
    Type: Grant
    Filed: September 16, 1997
    Date of Patent: January 4, 2000
    Assignee: Universiteit Gent
    Inventors: Jean Paul Remon, Sam Corveleyn
  • Patent number: 5997862
    Abstract: The present invention relates to an oral delivery system containing a group c streptococcal phage associated lysin enzyme for the prophylactic and therapeutic treatment of Streptococcal A throat infections, commonly known as strep throat.
    Type: Grant
    Filed: October 31, 1997
    Date of Patent: December 7, 1999
    Assignee: New Horizons Diagnostics Corporation
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 5980936
    Abstract: Multiple emulsions comprising a discontinuous emulsified phase incorporating a highly polar liquid, a second component selected from the group consisting of fluorocarbons and hydrocarbons and a continuous hydrophobic phase are disclosed. In preferred embodiments, the hydrophobic phase may comprise a fluorocarbon or hydrocarbon. Additionally, the stable multiple emulsions of the present invention may further incorporate a bioactive agent and are particularly suitable for drug delivery including pulmonary drug delivery.
    Type: Grant
    Filed: August 7, 1997
    Date of Patent: November 9, 1999
    Assignee: Alliance Pharmaceutical Corp.
    Inventors: Marie-Pierre Krafft, Jean G. Riess, Leila Zarif
  • Patent number: 5928664
    Abstract: The present invention provides consumable, gummy delivery systems and methods of making the same. The gummy delivery systems include an active ingredient admixed with a glycerylated gelatin matrix prepared by heating an aqueous solution of gelatin and glycerin to a temperature and for a time sufficient to remove some of the moisture content of the initial aqueous solution. The active ingredient can be delivered from a shearform matrix carrier.
    Type: Grant
    Filed: February 11, 1998
    Date of Patent: July 27, 1999
    Assignee: Fuisz Technologies Ltd.
    Inventors: Robert K. Yang, T. Victor Oh
  • Patent number: 5902797
    Abstract: A nutritional supplement comprising approximately from about 5 to about 25 grams carbohydrate; approximately from about 1 to about 25 grams protein; and approximately from about 1 to about 10 grams fat, for use in treating low appetite that may result in weight loss, is described.
    Type: Grant
    Filed: November 10, 1997
    Date of Patent: May 11, 1999
    Assignees: Beth Israel Deaconess Medical Center, Medical Foods, Inc.
    Inventors: Stacey J. Bell, R. Armour Forse, Bruce R. Bistrian, Robert C. Jones
  • Patent number: 5895644
    Abstract: The present invention contemplates a translucent, preferably clear, anhydrous gel composition (for example a solid stick, soft solid, cream as well as any form commonly referred to as a gel), especially an antiperspirant stick composition, comprising: (a) dibenzylidene sorbitol; (b) a selected derivatized guar, especially an hydroxy C.sub.3 -C.sub.4 alkyl guar having a level of hydroxyalkylation of 0.4-1.5 molar substitution ("MS"); and (c) a solvent selected so that is will not react with the DBS itself or, if an acid catalyst is present, will not react in the presence of DBS with an acid catalyst such as an antiperspirant active salt.
    Type: Grant
    Filed: November 20, 1997
    Date of Patent: April 20, 1999
    Assignee: Colgate-Palmolive Company
    Inventors: Joseph Albanese, Tom Schamper
  • Patent number: 5866163
    Abstract: The present invention is a method of preparing rapidly dissolving comestible units such as tablets. The present invention also includes an apparatus for making the comestible units and the units themselves. The product prepared in accordance with the present invention can include active ingredients and is capable of dissolving in the mouth of the consumer within several seconds. The unit dosage forms prepared in accordance with the present invention are particularly useful as antacids and as a delivery vehicle for biologically active ingredients, especially those which are ideally combined with antacid ingredients in order to ameliorate the effects of antacid environment.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: February 2, 1999
    Assignee: Fuisz Technologies Ltd.
    Inventors: Garry L. Myers, Gerald E. Battist, Richard C. Fuisz
  • Patent number: 5855908
    Abstract: Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering lipophilic and nonlipophilic drugs in a dose-to-effect manner such that sufficient drug is administered to produce precisely a desired effect. The invention also relates to manufacturing techniques that enable therapeutic agents to be incorporated into nondissolvable drug containment matrixes which are capable of releasing the drug within a patient's mouth. An appliance or holder is preferably attached to the drug containment matrix. Employing the present invention the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods.
    Type: Grant
    Filed: November 15, 1994
    Date of Patent: January 5, 1999
    Assignee: University of Utah Research Foundation
    Inventors: Theodore H. Stanley, Brian Hague
  • Patent number: 5785989
    Abstract: Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering lipophilic and nonlipophilic drugs in a dose-to-effect manner such that sufficient drug is administered to produce precisely a desired effect. The invention also relates to a manufacturing technique that enables a therapeutic agent or drug to be incorporated into a flavored dissolvable matrix. An appliance or holder is preferably attached to the dissolvable matrix. Employing the present invention the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods.
    Type: Grant
    Filed: March 19, 1997
    Date of Patent: July 28, 1998
    Assignee: University Utah Research Foundation
    Inventors: Theodore H. Stanley, Brian Hague
  • Patent number: 5783207
    Abstract: The present invention relates to a selectively removable nicotine-containing dosage form for use in the transmucosal delivery of nicotine to a patient. More specifically, the present invention is directed to a nicotine-containing dosage-form comprising an attached holder member which may be used to manipulate the dosage form within the mouth of the patient as part of an effective smoking cessation program or in situations where smoking is undesirable or not permitted. Nicotine is released from a dosage form and absorbed through the intra-oral mucosal surfaces as the nicotine-containing matrix releases nicotine within the user's mouth. The user may selectively insert and remove the dosage form as desired to control the release of nicotine. In addition, the user may manipulate the dosage form by use of the holder means in such a manner to meet the user's psychological need or desire for ritualistic oral stimulation similar to cigarette smoking.
    Type: Grant
    Filed: February 4, 1997
    Date of Patent: July 21, 1998
    Assignee: University of Utah Research Foundation
    Inventors: Theodore H. Stanley, Brian Hague
  • Patent number: 5512290
    Abstract: A powder-form composition of 2-acetyl-1-pyrroline incorporated with a support of maltodextrin and/or cyclodextrin. The composition is prepared by hydrolyzing a 2-(1-alkoxyethenyl)-1-pyrroline with an acid to obtain a reaction medium, adding an equimolar amount of a base to the reaction medium to obtain a neutralized reaction medium containing 2-acetyl-1-pyrroline, combining maltodextrin and/or cyclodextrin with the neutralized reaction medium to obtain a support solution and freeze-drying the support solution to obtain the composition.
    Type: Grant
    Filed: December 27, 1994
    Date of Patent: April 30, 1996
    Assignee: Nestec S.A.
    Inventors: Philippe Duby, Tuong Huynh-Ba
  • Patent number: 5468500
    Abstract: A natural tasting soursop flavoring composition prepared by combining methyl butanoate, methyl 2-butenoate, butanoic acid, methyl hexanoate, methyl 2-hexenoate, hexanoic acid and linalool.
    Type: Grant
    Filed: October 29, 1993
    Date of Patent: November 21, 1995
    Assignee: University of Puerto Rico
    Inventors: Manuel Rodriguez-Flores, Sonia Rivera-Gonzalez
  • Patent number: 5409905
    Abstract: Present invention is a non-toxic, flavor stable, pleasant tasting composition releasing Zn.sup.2+ from compositions containing a highly ionizable zinc compound other than zinc gluconate that reduces the duration of common colds in humans. The composition is used in the oral cavity of a human suffering from a common cold. The composition comprises highly ionizable zinc compounds and a pharmaceutically acceptable carrier such as fructose, dextrose or sucrose with various additions. Compositions are unique in that they are non-toxic, pleasant tasting and do not have an offensive aftertaste, yet deliver zinc ions into oral tissues which may be used to treat common colds, reduce the duration of common colds or cure common colds in humans in need of such treatment. Compositions are non-toxic, thermally, chemically and flavor stable. The compositions may be prepared in the form of compressed tablets, lozenges, powders, liquids or chewing gums.
    Type: Grant
    Filed: March 21, 1994
    Date of Patent: April 25, 1995
    Inventor: George A. Eby, III
  • Patent number: 5370864
    Abstract: The present invention relates to oral compositions in the form of microcapsules which reduce oral bacteria and provide long lasting breath protection.
    Type: Grant
    Filed: June 29, 1993
    Date of Patent: December 6, 1994
    Assignee: The Procter & Gamble Company
    Inventors: Liezl G. Peterson, Lowell A. Sanker, James G. Upson
  • Patent number: 5330760
    Abstract: A solid effervescent antacid formulation comprising as primary ingredients from about 35 to about 53 percent by weight of calcium carbonate, from about 0 to about 14 percent by weight of magnesium carbonate, from about 3.5 to about 7 percent by weight of a bicarbonate salt, from about 3.5 to about 7 percent by weight of malic acid and from about 21 to about 35 percent by weight of a bulking agent.
    Type: Grant
    Filed: August 27, 1992
    Date of Patent: July 19, 1994
    Assignee: Sterling Winthrop Inc.
    Inventor: William C. Walton
  • Patent number: 5300305
    Abstract: Microcapsules providing breath protection are described and claimed as well as methods of their use.
    Type: Grant
    Filed: February 12, 1993
    Date of Patent: April 5, 1994
    Assignee: The Procter & Gamble Company
    Inventors: Judith H. Stapler, Mary A. Hunter
  • Patent number: 5286496
    Abstract: The present invention relates to oral compositions in the form of microcapsules which reduce oral bacteria and provide long lasting breath protection.
    Type: Grant
    Filed: January 11, 1993
    Date of Patent: February 15, 1994
    Assignee: The Procter & Gamble Company
    Inventors: Judith H. Stapler, Mary Ann Hunter
  • Patent number: 5286748
    Abstract: Compositions and a general method are described to shorten the duration of common colds by administration of medicaments to and into the oral tissues, rather than to the nose, or by injection or by oral administration. Compositions for oral absorption by a human contain medicinal agents including antiviral agents, antirhinoviral agents, interferon, interferon inducers, T-cell lymphocyte mitogens and other agents desirable or theoretically useful in shortening the duration of common colds. All compositions include medicaments contained in a consumable, sweet pharmaceutical carrier, prepared in the form of a pleasant tasting lozenge, powder, liquid or chewable composition. All compositions are for delivery of medicinal agent to the oral and oral pharyngeal mucosa of a human with said composition being absent the normal offensive aftertaste of medicinal agent, and being intended for use in shortening the duration of common colds.
    Type: Grant
    Filed: November 27, 1991
    Date of Patent: February 15, 1994
    Inventor: George A. Eby, III
  • Patent number: 5286489
    Abstract: This disclosure relates to drug-polymer matrix compositions comprising an active ingredient having an amine or amido group and a pharmaceutically acceptable copolymer having a plurality of carboxylic acid and ester groups wherein the matrix dissociates in a media having a pH of less than 4, thereby releasing the active ingredient into the media.
    Type: Grant
    Filed: March 16, 1993
    Date of Patent: February 15, 1994
    Assignee: The Procter & Gamble Company
    Inventors: Josef H. Tsau, Nalinkant C. Damani
  • Patent number: 5273753
    Abstract: A functional food which comprises a glucosyltransferase and/or a fructosyltransferase each having a water-soluble polysaccharide production ability, and a base therefor.
    Type: Grant
    Filed: July 19, 1991
    Date of Patent: December 28, 1993
    Assignee: Kabushiki Kaisha Advance
    Inventors: Kazuoki Ishihara, Masao Takahashi
  • Patent number: 5272166
    Abstract: The present invention relates to methods and corresponding agents for lowering plasma Lp(a) levels by the administration of agents that reduce Lp(a) and selectively separate therefrom the apo(a) component and/or prevent Lp(a) formation. Suitable agents include sulfhydryl reducers, such as N-acetylcysteine. The present method and agents may be administered alone or in conjunction with other therapy for the lowering of LDL cholesterol.
    Type: Grant
    Filed: March 2, 1992
    Date of Patent: December 21, 1993
    Assignee: The Rockefeller University
    Inventors: Jan L. Breslow, Dov Gavish
  • Patent number: 5230897
    Abstract: Pharmaceutical compositions and transdermal patches comprised of pentamidine and a penetration enhancing amount of a terpene selected from the group consisting of menthol, carvone, carveol, dihydrocarveol, dihydrocarvone, neomenthol, isopulegol, terpene-4-ol, menthone, pulegol, camphor, geraniol, .alpha.-terpineol, citral, linalol, carvacrol, thymol and anethole are disclosed for delivery of a therapeutically effective amount of pentamidine or its pharmaceutically acceptable salts.
    Type: Grant
    Filed: October 31, 1991
    Date of Patent: July 27, 1993
    Assignee: G. D. Searle & Co.
    Inventors: Martin J. Griffin, Tugrul T. Kararli, Stanley C. Penzotti, Jr., Rachelle M. Rydzik, Cynthia M. Schmidt
  • Patent number: 5215756
    Abstract: A method is disclosed for preparing pharmaceutical and other matrix systems that comprises solidifying a matrix composition dissolved or dispersed in a first solvent and subsequently contacting the solidified matrix with a second solvent that is substantially miscible with the first solvent at a temperature lower than the solidification point of the first solvent, the matrix components being substantially insoluble in the second solvent, whereby the first solvent is substantially removed resulting in a usable matrix.
    Type: Grant
    Filed: November 6, 1990
    Date of Patent: June 1, 1993
    Inventors: Dilip J. Gole, R. Saul Levinson, James Carbone, J. Desmond Davies
  • Patent number: 5134162
    Abstract: A process for lowering the blood cholesterol of hyperlipidemic patients by oral ingestion of pyruvate and a confection (cereal bar, fruit bar, candy) containing pyruvate as the ingestion medium.
    Type: Grant
    Filed: December 24, 1990
    Date of Patent: July 28, 1992
    Assignee: The Montefiore Hospital Association of Western Pennsylvania
    Inventor: Ronald T. Stanko
  • Patent number: 5132114
    Abstract: Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering drugs in a dose-to-effect manner such that sufficient drug is administered to produce precisely a desired effect. The invention also relates to a manufacturing technique that enables a therapeutic agent or drug to be incorporated into a flavored confectionary base and to compress or otherwise attach the solid confectionary mixture onto an appliance or holder.Employing the present invention the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods. The present invention achieves these advantages by incorporating the drug into a compressed powder "candy" matrix.
    Type: Grant
    Filed: September 5, 1989
    Date of Patent: July 21, 1992
    Assignee: University of Utah Research Foundation
    Inventors: Theodore H. Stanley, Brian Hague
  • Patent number: 5102664
    Abstract: The application discloses a good-tasting and palatable gritty drug formulation, wherein the grittiness is associated as a part of a pleasurable organoleptic sensation, which contains a gritty and optionally bad-tasting or odoriferous drug and a seedy fibrous fruit, and optionally an aqueous medium and a gelling agent, and preferably also a sweetener and a flavoring agent, wherein the gritty drug is representatively an antihypercholesterolemic drug, especially a bile acid sequestrant, and particularly cholestyramine, a method for the preparation thereof, and a method of converting a gritty drug into a more readily-acceptable formulation which assists with patient compliance.
    Type: Grant
    Filed: July 19, 1989
    Date of Patent: April 7, 1992
    Inventor: Charles E. Day
  • Patent number: 5000946
    Abstract: The invention relates to sunscreen compositions comprising an effective component at least one compound of formula I ##STR1## wherein R.sup.1 is selected from alkyl, alkenyl, alkynyl substituted alkyl, substituted alkenyl, phenyl, substituted phenyl, substituted benzyl, cycloalkyl, cycloalkenyl, substituted cycloalkyl, substituted cycloalkenyl and polymeric groups;R.sup.2 is selected from hydrogen, alkyl and alkoxy; and wherein R.sup.1 and R.sup.2 may form a carbocyclic ring which may be substituted;R.sup.3 is selected from alkyl, sustituted alkyl, alkenyl, substituted alkenyl, alkynyl, phenyl, benzoyl, substituted phenyl, substituted benzyl, substituted benzoyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, alkanyoyl, substituted alkanoyl, polymeric groups, the group OROROR.sup.9 wherein R is a bivalent hydrocarbon radical and R.sup.9 is alkyl, alkenyl, phenyl benzyl, substituted phenyl, substituted benzyl;R.sup.4 is alkyl or alkoxy; n is an integer from 0 to 4; andR.sup.
    Type: Grant
    Filed: May 26, 1988
    Date of Patent: March 19, 1991
    Inventors: Graham Bird, Neil Fitzmaurice, Walter C. Dunlap, Bruce E. Chalker, Wickramasinghe M. Bandaranayake
  • Patent number: 4971798
    Abstract: Disclosed is a hard confection containing Palatinit (hydrogenated isomaltulose) and a medicinally active ingredient. Such a formulation has been found to dissolve more slowly than similar formulations based on sugar rendering them suitable for dispensing the active ingredient over an extended period of time.
    Type: Grant
    Filed: November 30, 1989
    Date of Patent: November 20, 1990
    Assignee: Miles Inc.
    Inventors: Kenneth A. Coia, Michael J. Lynch
  • Patent number: 4950689
    Abstract: An ingestible gel confectionary delivery system which includes a pectin gel component in an amount sufficient to form a gel confectionary unit, and an edible insoluble solid in an amount sufficient to strengthen the internal pectin gel network and to bind internal moisture sufficiently to enhance mold removal capabilities. Preferably the delivery system also includes a further active ingredient such as a drug, medicament, or nutritional supplement. The product and method of the present invention also includes a composition in which the gel delivery system can be molded directly in the receptacle which is used to dispense the confectionary unit to the consumer. This significantly enhances the manufacture of product prepared in accordance with the invention.
    Type: Grant
    Filed: March 31, 1987
    Date of Patent: August 21, 1990
    Inventors: Robert K. Yang, James J. Shaw, James E. Bagan, Amy J. Becker, Shan-Shan Sheu
  • Patent number: 4937076
    Abstract: A chewable aspirin and buffering material tablet and method for producing same is disclosed herein. In a single dosage form the aspirin and buffering materials are integrally dispersed and bound in a fatty material of chocolate, synthetic chocolate or hydrogenated tallow. The tablet is for gastrointestinal applications and is especially adopted for use with animals, particularly dogs, and can be molded into a variety of shapes including that of a miniature dog bone.
    Type: Grant
    Filed: October 31, 1986
    Date of Patent: June 26, 1990
    Assignee: Combe Incorporated
    Inventor: Herbert Lapidus
  • Patent number: 4917894
    Abstract: An oral anesthetic composition comprising an anesthetically effective amount of a compound of formula (I) ##STR1## wherein R is alkyl of 2 to 8 carbon atoms or a pharmaceutically acceptable salt thereof and an anesthetically effective amount of a rapid-onset anesthetic selected from the group consisting of benzyl alcohol, phenol, phenolate sodium, hexylresorcinol, menthol, salicyl alcohol and benzocaine in combination with a pharmaceutically acceptable carrier, said carrier being in orally administrable form.
    Type: Grant
    Filed: June 29, 1988
    Date of Patent: April 17, 1990
    Assignee: Beecham Inc.
    Inventors: Joseph A. Matthias, Kim L. Bildstein
  • Patent number: 4894233
    Abstract: A drug delivery system comprising a core material comprising a drug, and a hydrophobic matrix coating the core. The coating delays hydration of the drug and masks the taste of the drug. The coating comprises an emulsifier, an edible fatty acid or wax and a glyceride. The delivery system can be incorporated into various food products, pharmaceutical preparations and proprietary products.
    Type: Grant
    Filed: July 26, 1988
    Date of Patent: January 16, 1990
    Inventors: Shri C. Sharma, James J. Shaw, Robert K. Yang
  • Patent number: 4889711
    Abstract: A novel composition for antiperspirant aerosol comprises an antiperspirant substance, a silicone-treated clay mineral and an oil substance.When the composition is sprayed over the skin, sweat can readily evaporate immediately after spraying and even after perspiration. Thus, the composition ensures a very good feel in use.
    Type: Grant
    Filed: August 8, 1988
    Date of Patent: December 26, 1989
    Assignee: Kao Corporation
    Inventors: Masanobu Kai, Etsuko Chiku
  • Patent number: 4886783
    Abstract: This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said systemic agent an effective amount of a membrane penetration enhancer having the structural formula ##STR1## wherein each X, Y and Z may represent oxygen, sulfur or two hydrogen atoms, provided however that, when Z represents two hydrogen atoms, both X and Y represent oxygen or sulfur and when Z represents oxygen or sulfur at least one of X and Y must represent oxygen or sulfur; m is 2-6; R' is H or a lower alkyl group having 1-4 carbon atoms; n is 0-16 and R is --CH.sub.3, ##STR2## wherein R" is H or halogen.
    Type: Grant
    Filed: August 17, 1988
    Date of Patent: December 12, 1989
    Assignee: Nelson Research & Development Co.
    Inventors: Gevork Minaskanian, James V. Peck