Abstract: A self-emulsifying composition contains: 70 to 90% by weight of at least one compound selected from the group consisting of ?3 polyunsaturated fatty acids and their pharmaceutically acceptable salts and esters; 0.5 to 6% by weight of water; 1 to 29% by weight of a polyoxyethylene sorbitan fatty acid ester as an emulsifier (optionally including a polyoxyl castor oil, and not including lecithin); and lecithin in an amount of 3 to 40 parts by weight in relation to 100 parts by weight of ?3 polyunsaturated fatty acids and the like. The self-emulsifying composition is excellent in self-emulsifying property, composition dispersibility, emulsion stability, and absorbability, is free from ethanol and polyhydric alcohols or only has such an alcohol added thereto at a reduced concentration, and is useful for foods and pharmaceuticals.

Abstract: A liquid crystal emulsification method that can reduce formulation restriction and adjust the size of a dispersed phase with small variation in size of the dispersed phase, and a liquid crystal emulsion are provided. The liquid crystal emulsification method includes: adding a moisture content and/or an oil content at a predetermined ratio to a surfactant having an HLB falling within a predetermined range; and setting a temperature during formation of a dispersion or an emulsion to a predetermined temperature, to adjust a lamellar liquid crystal having a regular molecular arrangement in which the oil content and/or the moisture content are alternately arranged in a bilayer membrane formed from the surfactant.

Abstract: A solid particle, a preparation method therefor, and a pharmaceutical composition. The solid particle comprises a porous solid particle and a non-aqueous liquid formula. The non-aqueous liquid formula comprises 0.10-4.00 wt % of a hydrophobic active pharmaceutical agent, 28.00-99.90 wt % of a hydrophobic solubilizing solution, 0-70.00 wt % of a non-ionic surfactant, and 0-1.00 wt % of an antioxidant. The hydrophobic solubilizing solution comprises a medium-chain monoglyceride and diglyceride, and/or a propylene glycol fatty acid monoester.

Abstract: A composition comprising from about 0.001% to about 0.4% cyclosporin A, a surfactant, and an oil having a specific gravity from 0.8 to 0.95 is disclosed herein.

Abstract: A composition comprising a therapeutically effective amount of cyclosporin A, a blend of oils having a specific gravity of from 0.90 to 1.07, and a surfactant is disclosed herein.

Abstract: Antiseptic compositions, as well as methods of making and using, wherein the compositions include: an antimicrobial agent selected from the group consisting of iodine (I2), an iodophor, and a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to provide an available iodine concentration of at least about 0.25 wt-%; a hydroxycarboxylic acid buffer in an amount of at least about 5 wt-%; water; and an optionally substantive film-forming polymer.

Abstract: Chronic wounds may be treated by debriding necrotic and other devitalized tissue from the wound, and applying to the wound an extracellular polymeric substance solvating system comprising a metal ion sequestering agent, surfactant and buffering agent. The solvating system disrupts biofilms which may be present in the wound and aids or enables the resumption of normal healing.

Abstract: Disclosed herein are ophthalmic cleaning systems and methods for their use, which comprise an ophthalmic solution and lens case, wherein the solution includes dual disinfectants and the lens case includes silver. When the lens case is combined with the solution according to the system of the present invention, it surprisingly exhibits synergistic activity which results in a faster antimicrobial activity.

Abstract: This invention provides a self-emulsifying composition comprising 50 to 95% by weight in total of at least one compound selected from the group consisting of ?3 polyunsaturated fatty acids and their pharmaceutically acceptable salts and esters; and 5 to 50% by weight of an emulsifier having a hydrophilic lipophilic balance of at least 10. The composition has no or reduced ethanol content, and exhibits excellent self-emulsifying property, dispersibility in the composition, emulsion stability, and absorption property. The composition is adapted for use as a drug.

Abstract: A biliquid foam includes from 10% to 98% by weight of a non-polar liquid other than a fuel and from 2 to 88% by weight of a continuous phase polar liquid comprising a C1-C4 alcohol, a liquid polyethylene glycol, ethylene glycol or propylene glycol, or mixtures thereof, in an amount of at least 65% by weight, relative to the weight of the continuous phase, wherein the biliquid foam is stabilized with an amount of from 0.05% to 2% by weight based on the total formulation of a surfactant which is selected from castor oil/poly(alkylene glycol) adducts containing from 20 to 50 alkoxy groups, a C8-C24 fatty acid or hydrogenated castor oil/poly(alkylene glycol) adducts containing from 20 to 60 alkoxy groups, or mixtures thereof.

Abstract: There is provided a liquid agrochemical composition having a stable water-diluted state, which comprises 0.5 to 30% by weight of one or more hydrophobic agrochemical active compounds, 1 to 20% by weight of one or more nonionic surfactants selected from the group consisting of a polyoxyethylene polyoxypropylene block copolymer and the like, 0 to 10% by weight of one or more anionic surfactant, 6 to 60% by weight of ?-butyrolactone, and 20 to 75% by weight of 1,3-dimethyl-2-imidazolidinone; and water-diluted solution obtained by diluting the liquid agrochemical composition with a 10 to 10,000-fold amount of water.

Abstract: Aqueous alkali metal glyphosate compositions are disclosed. The compositions comprise an aqueous concentrate of an alkali metal glyphosate, a surfactant blend comprising an etheramine component, and an optional water-miscible solvent. A mixture of the surfactant blend and solvent is gel-free and monophasic. Adjusting the pH of the aqueous concentrate to be within the range of 4.0 to 4.5 surprisingly enables preparation of a highly concentrated aqueous alkali metal glyphosate composition having good elevated temperature stability and a high cloud point. For instance, a 540 g.a.e./L formulation comprising the composition exhibits good stability at 54° C. Gel-free, monophasic surfactant blends useful in the glyphosate compositions are also disclosed.

Abstract: The present invention relates to a solid pharmaceutical composition for oral administration characterized in that it comprises a benzofuran derivative with antiarrhythmic activity, or one of the pharmaceutically acceptable salts thereof, as an active principle, and a pharmaceutically acceptable nonionic hydrophilic surfactant optionally in combination with one or more pharmaceutical excipients.

Abstract: A method for cleansing and treating skin exposed to a capsaicin or derivative thereof so as to inhibit capsaicin reactivation includes: providing a subject having exposure to capsaicin, oleoresin capsicum, or other capsaicinoid derivative; cleansing capsaicin, oleoresin capsicum, or other capsaicinoid derivative from skin of the subject with a cleansing composition having: a carrier; a surfactant and/or detergent; a chelating agent; and salicylic acid, acetylsalicylic acid, or ibuprofen; and treating the skin of the subject with a therapeutic composition so as to inhibit reactivation of effects of capsaicin, oleoresin capsicum, or other capsaicinoid derivative exposure, the therapeutic composition having: a carrier; aloe; a thickening agent; and salicylic acid, acetylsalicylic acid, or ibuprofen.

Abstract: The invention relates to a herbicide composition containing (A) an amino acid-based herbicide and (B) a compound having a branched structure represented by formula (1): R1CH2O—(R2O)nH??(1) wherein R1 represents a C3 to C29 branched alkyl or branched alkenyl group, R2 represents a C2 to C4 alkylene group, and n is a mean number in the range of 1 to 30.

Abstract: A biorational insecticide and fungicide and method of application on trees and plants, fruits and vegetables to enhance the growth thereof and to effectively control insects and fungi comprising at least one surfactant and at least one high terpene containing natural oil.

Abstract: Methods for disinfecting and removing smear layer from prepared tooth surfaces are provided. The methods involve irrigating the tooth surface with a disinfectant solution containing doxycycline or tetracycline, a surfactant such as polysorbate, and organic acid such as citric acid. The methods can be used in various dental treatments including, for example, endodontic and periodontic procedures as well as tooth restoration and reconstruction.

Abstract: The invention is an increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of skin and skin appendages. The allylamine active ingredient is prepared in an acidic environment; the acidic environment altering the physiochemical properties of the active ingredient resulting in the active ingredient having a positive charge. The positive charge and enhancers used in the formula allow for increased penetration of the active ingredient through skin and skin appendages. The positively charged active ingredients are either dissolved in the vehicle directly or dissolved in a plurality of beads suspended in the vehicle.

Abstract: The present invention provides a self tanning cosmetic containing 0.2-20.0 mass % of dihydroxyacetone and 0.1-10.0 mass % of an inorganic pigment powder whose surface is treated with silica coating followed by a hydrophobing treatment. The present invention provides a cosmetic that has superior storage stability, is free of discoloration and odor generation, and achieves both the decorative effect of the pigment immediately following application and the long term dyeing effect of dihydroxyacetone.

Abstract: The invention relates to compositions having enhanced post wash hydration by ensuring component or components of the composition meet selected defined criteria.

Abstract: A composition for protecting wood from decay, mildew and sapstain comprises o-phenylphenol in combination with an alkoxylated amine, wherein the weight ratio of alkoxylated amine to o-phenylphenol ranges from 1:1 to 10:1. Organic or inorganic acids may be added to enhance solubility of the alkoxylated amines.

Abstract: The present invention is an emulsified composition comprising (a) 0.01-5 wt % polysiloxane-polyoxyalkylene copolymer, (b) 0.05-1 wt % nonionic surfactant, (c) 10-30 wt % humectant, and (d) 1-50 wt % urea. The present invention provides an emulsified formulation of a urea-containing emulsified composition that has a superior emulsifying ability even with a lowered blend ratio of the surfactant, suppresses tingling due to urea, and is good feeling of use without stickiness even with a high blend ratio of the humectant.

Abstract: An adjuvant is disclosed for use with systemic herbicides, pesticides, insecticides, ovicides and fungicides for application on animals, birds, trees, plants, fruits and vegetables to enhance the action and effect of the systemic herbicides, pesticides, insecticides, ovicides and fungicides. The adjuvant comprises at least one surfactant and at least one high terpene containing natural oil.

Abstract: The present invention relates to a solid pharmaceutical composition for oral administration characterized in that it comprises a benzofuran derivative with antiarrhythmic activity, or one of the pharmaceutically acceptable salts thereof, as an active principle, and a pharmaceutically acceptable nonionic hydrophilic surfactant optionally in combination with one or more pharmaceutical excipients.

Abstract: A composition comprising from about 0.001% to about 0.4% cyclosporin A, a surfactant, and an oil having a specific gravity from 0.8 to 0.95 is disclosed herein.

Abstract: Insecticide and fungicide, and method of application on trees and plants, fruits and vegetables to enhance the growth thereof and to effectively control insects and fungi comprising at least one surfactant and at least one high terpene containing natural oil.

Abstract: A composition is disclosed herein comprising from about 0.001% to about 0.

Abstract: A composition comprising from 0.001% to about 0.4% cyclosporin A, a surfactant, and an oil selected from the group consisting of anise oil, clove oil, cassia oil, cinnamon oil, and combinations thereof, wherein said composition is an ophthalmically acceptable emulsion is disclosed herein.

Abstract: This invention provides a microemulsion pre-concentrate comprising a difficultly soluble active agent and a carrier medium comprising 1) a hydrophilic phase which comprises dimethylisosorbide and/or a lower alkyl alkanoic ester, 2) a lipophilic phase, and 3) a surfactant. The active agent may be a cyclosporin or a macrolide. In another aspect, this invention provides a pharmaceutical composition for enteral or parenteral administration comprising a macrolide and an acid.

Abstract: A composition comprising a therapeutically effective amount of cyclosporin A, a blend of oils having a specific gravity of from 0.90 to 1.07, and a surfactant is disclosed herein.

Abstract: An aqueous composition suitable for applying fungicides to plant propagation materials is provided, comprising water and a blend of the following components, by weight: a) 2–10% of a surface-active agent comprising a1) at least one anionic surfactant; b) 0.5–10% of at least one polymer selected from water-dispersible polymers and water-soluble film-forming polymers; c) 4–20% of at least one inorganic solid carrier; and d) 3–20% of at least one antifreeze agent. In one embodiment, the composition comprises a fungicidally effective amount of at least one fungicidally active compound. The inventive composition is storage stable, ready-to-apply (RTA), ecologically and toxicologically favorable and has good fungicidal efficacy.

Abstract: The present invention relates to cosmetic and pharmaceutical oil-in-water emulsions which have a mattifying effect when applied to the skin. The invention comprises a hydrophilic, non-organically modified magnesium aluminum silicate or a bentonite clay and a polyol in the water phase; and a volatile, skin-compatible, lipophilic solvent and a high melting point lipophilic plasticizer in the oil phase. A preferred surfactant system to stabilize the emulsion includes non-toxic metal alkyl sulfates and/or sucrose esters.

Abstract: A pharmaceutical composition for parenteral delivery, comprising a retinide such as fenretinide in combination with a solvent capable of dispersing or solubilizing the retinide. The solvent comprises an alcohol, such as ethanol, in combination with an alkoxylated castor oil, such as CREMOPHOR® EL, or comprising a retinide, such as fenretinide, in an emulsion composed of a lipoid dispersed in an aqueous phase, a stabilizing amount of a non-ionic surfactant, optionally a solvent, and optionally an isotonic agent. In addition, a method of use in the treatment of hyperproliferative disorders, such as cancers is described.

Abstract: Antiseptic compositions, as well as methods of making and using, wherein the compositions include: an antimicrobial agent selected from the group consisting of iodine (I2), an iodophor, and a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to provide an available iodine concentration of at least about 0.25 wt-%; a hydroxycarboxylic acid buffer in an amount of at least about 5 wt-%; water; and an optionally substantive film-forming polymer.

Abstract: The present invention is an orally administered liquid pharmaceutical composition that demonstrates excellent physical stability while delivering concentrated levels of the pharmaceutical active(s). Specifically, these compositions for extended periods do not allow the active to precipitate or settle out of solution. Among the advantages of this invention is that the compositions do not require agitation/shaking prior to use as a method to re-suspend or dissolve active drug material to insure even and consistent dosing.

Abstract: The present invention provides a pharmaceutical composition comprising at least one pharmaceutically acceptable bismuth-containing compound, at least one pharmaceutically acceptable non-clay-derived suspending agent, and water. The suspension exhibits reduced upward pH drift by comparison with an otherwise similar suspension which comprises a clay-derived suspending agent. Such compositions are useful in the prevention and treatment of gastrointestinal diseases and/or disorders.

Abstract: An aqueous pharmaceutical composition which is capable of being sprayed into the nasal cavity of an individual and which comprises: (A) a pharmaceutically effective amount of solid particles of medicament which is effective in treating a bodily condition by virtue of its being present on the mucosal surfaces of the nasal cavity; and (B) a suspending agent in an amount effective to maintain said particles dispersed uniformly in the composition and to impart to the composition the following thixotropic properties: (i) the viscosity of the position in unsheared form is relatively high, with the composition being in gel-like form; (ii) as the composition is subjected to shear (shaken) in preparation for spraying, the viscosity of the composition becomes relatively low and such that the composition in the form of a mist flows readily into the nasal passages for deposit on the mucosal surfaces of the nasal cavity; and (D) in deposited form on the mucosal surfaces, the viscosity of the composition is relatively high

Abstract: A system for delivering a chemical agent in the form of a spray or foam, which in a preferred embodiment involves the use of an aerosol dispenser to deliver a formulation containing both an anionic surface active agent such as sodium lauryl sulfate as a foaming agent and a chemical agent such as either hydrogen peroxide as a disinfecting chemical agent or natural sea water.

Abstract: A composition is disclosed comprising a polymer and a surfactant in a solvent exhibiting a common solubility for the polymer and the surfactant. The composition provides a dosage form for administering a drug over time.

Abstract: The invention provides acidic cosmetic, dermatological, and pharmaceutical agents comprising at least one copolymer obtainable by free-radical copolymerization of A) acryloyldimethyltaurine and/or acryloyldimethyltaurates, B) optionally, one or more further olefinically unsaturated, noncationic comonomers, C) optionally, one or more olefinically unsaturated, cationic comonomers, D) optionally, one or more silicon-containing component(s), E) optionally, one or more fluorine-containing component(s), F) optionally, one or more macromonomers, G) the copolymerization taking place if desired in the presence of at least one polymeric additive, H) with the proviso that component A) is copolymerized with at least one component selected from one of the groups D) to G).

Abstract: An emulsion of ?-tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans via various routes is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated ?-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of ?-tocopherol.

Abstract: Spray-dried particles having improved protein stability are produced by spray-drying a mixture including a protein, a phospholipid and an organic-aqueous co-solvent. Spray-dried particles which include at least 1 weight % phospholipid, having a tap density of less than 0.4 g/cm3 can be prepared. The particles can be delivered to the pulmonary system of a patient.

Abstract: Aerosol formulations suitable for use in pressurised metered dose inhalers comprise a hydrofluoroalkane propellant, an medicament for inhalation and a surfactant which is a a C8–C16 fatty acid or salt thereof, a bile salt, a phospholipid, or an alkyl saccharide.

Abstract: An aqueous composition suitable for applying fungicides to plant propagation materials is provided, comprising water and a blend of the following components, by weight: a) 2-10% of a surface-active agent comprising a1) at least one anionic surfactant; b) 0.5-10% of at least one polymer selected from water-dispersible polymers and water-soluble film-forming polymers; c) 4-20% of at least one inorganic solid carrier; and d) 3-20% of at least one antifreeze agent. In one embodiment, the composition comprises a fungicidally effective amount of at least one fungicidally active compound. The inventive composition is storage stable, ready-to-apply (RTA), ecologically and toxicologically favorable and has good fungicidal efficacy.

Abstract: Disclosed is both a method and composition for controlling deleterious organisms, such as insects, nematodes and weeds by applying a compound comprised of a liquid medium comprising an azide and an azide stabilizer. The azide can be selected from the group consisting of sodium azide and potassium azide or a combination of the two. The composition provides an effective pesticide, without causing significant harm to the environment. The composition may be applied to soil to control a population of a deleterious organism.

Abstract: A wiping article is provided which includes an effervescent cleanser composition held within a pouch formed from a first and second substrate sheet. At least one of the substrate sheets must be water permeable. The effervescent composition is an intimate mixture of an acid material such as citric acid and an alkaline material such as sodium bicarbonate. Water contact causes the combination to effervesce. A dry surfactant such as sodium cocoyl isethionate in contact with the water and effervescing carbon dioxide results in a highly pleasant sudsing system. Skin benefit agents may be included within the composition. The effervescent action may improve deposition of the skin benefit agents onto the skin.

Abstract: Composition which is useful in particular for the treatment and protection of domestic animals which are infested with parasites or are likely to be infested with them, these compositions comprising, in the form of a ready-to-use solution: a) an insecticidal active substance of formula (I), b) a crystallization inhibitor, c) an organic solvent having a dielectric constant of between 10 and 35, preferably of between 20 and 30, d) an organic co-solvent having a boiling point below 100° C., preferably below 80° C., and a dielectric constant of between 10 and 40, preferably of between 20 and 30.

Abstract: Free-flowing granular dispersing agents for use in water-dispersible granule (WDG) agricultural chemical formulations are a composite substance comprised of an alkyl polyglycoside and a polymeric anionic dispersant. The granular composite dispersing agents can be used in granular or liquid agricultural chemical formulations, exhibit outstanding attrition resistance, excellent dispersional stability after accelerated aging and low moisture content when made into a paste. The composite dispersing agents are useful as primary dispersants in dry agricultural formulations (wettable powders and water-dispersible granules) and in aqueous suspension concentrates.

Abstract: A storage-stable aqueous agrochemical concentrate formulation comprises a) an agrochemical electrolyte such as glyphosate b) a water-insoluble agrochemical system such as diuron c) an alkylglycoside and d) a co-surfactant which interacts with the alkylglycoside to form a structured aqueous system. Examples of the co-surfactant include: i) a linear or branched chain aliphatic or aromatic alcohol or ii) an alcohol alkoxylate or ester alkoxylate or alkyl phenol alkoxylate iii) a glyceryl alkyl or alkenyl ester and iv) a sorbitan alkyl or alkenyl ester. The composition optionally contains an additional ionic surfactant.

Abstract: The invention concerns a phytosanitary fungicide, bactericidal or bacteriostatic composition comprising at least a mineral salt, a copper oxide or hydroxide suspended in an aqueous emulsion of at least a terpene derivative.