Physiological Use, E.g., Pharmaceutical, Veterinary, Dental, Etc. Patents (Class 526/936)
  • Patent number: 6642334
    Abstract: Described herein is a pentaalkyldisiloxane containing polymeric surfactant prepared by the copolymerization of an alkoxypolyoxyalkylenyl acrylate and an acrylate containing a pentaalkyldisiloxane group. A method for preparing beaded polyethylene glycol-based resins in silicone oil in the presence of a polymeric surfactant containing a pentaalkyldisiloxane group is also described. The average bead size can be controlled by varying the stirring rate, the polymerization temperature, the amount of surfactant, the type of solvent, and the amount of solvent. The surfactant does not interfere with the polymerization and can be removed together with residual silicone oil by a simple washing procedure. The resins can be used, for example, as a support for solid phase organic synthesis, as a chromatographic resin, as a resin for solid phase MAS-NMR spectroscopy, and as a carrier for drug molecules, various reagents, or scavengers.
    Type: Grant
    Filed: July 9, 2001
    Date of Patent: November 4, 2003
    Assignee: Carlsberg A/S
    Inventors: Morten Grøtli, Morten Peter Meldal
  • Patent number: 6177087
    Abstract: Substantially non-antigenic polymers containing pI and/or pH optimum modulating moieties are disclosed. The polymers are useful as intermediates for synthesis of amine-based polymers and in the formation of activated polymers for conjugation with nucleophiles. Conjugates and methods of preparation and treatment with the conjugates are also disclosed.
    Type: Grant
    Filed: November 3, 1998
    Date of Patent: January 23, 2001
    Assignee: Enzon, Inc.
    Inventors: Richard B. Greenwald, Anthony Martinez, Annapurna Pendri
  • Patent number: 5902588
    Abstract: Substantially non-antigenic polymers containing pI and/or pH optimum modulating moieties are disclosed. The polymers are useful as intermediates for synthesis of amine-based polymers and in the formation of activated polymers for conjugation with nucleophiles. Conjugates and methods of preparation and treatment with the conjugates are also disclosed.
    Type: Grant
    Filed: November 19, 1997
    Date of Patent: May 11, 1999
    Assignee: Enzon, Inc.
    Inventors: Richard B. Greenwald, Anthony Martinez, Annapurna Pendri
  • Patent number: 5589157
    Abstract: Aqueous acrylic polymer compositions comprising a copolymer of an alkyl acrylate, an alkyl methacrylate and one or more acrylate acids or salts thereof are disclosed. By introducing an alkoxylated surfactant having a surface tension of greater than about 32.2 dynes/cm and less than 48.2 dynes/cm, enhanced freeze-thaw stability can be obtained with the polymer compositions of the present invention. The polymer compositions are compatible in all-aqueous hairspray compositions, as well as those which contain up to about 80 weight percent volatile organic compounds, or more.
    Type: Grant
    Filed: May 8, 1995
    Date of Patent: December 31, 1996
    Assignee: Amerchol Corporation
    Inventor: James C. Hatfield
  • Patent number: 5474780
    Abstract: Erodible bioadhesive drug delivery vehicles for use in delivering pharmaceutical compounds to the eye and similar physiological environments are disclosed. The drug delivery vehicles are formed of a homopolymer or copolymer of maleic anhydride or lower alkyl maleic anhydride incorporating a pharmaceutical compound in either a monolithic matrix or encapsulated form. The bioadhesive erodible drug delivery vehicles are configured to be retained in the eye following administration while providing specific erosion profiles allowing convenient drug delivery schedules ranging from hourly to daily or weekly intervals.
    Type: Grant
    Filed: March 30, 1993
    Date of Patent: December 12, 1995
    Assignee: Allergan, Inc.
    Inventor: James N. Chang
  • Patent number: 5413775
    Abstract: Aqueous, anionic, acrylic polymer compositions comprising a copolymer of an alkyl acrylate, an alkyl methacrylate and one or more acrylate acids or salts thereof is disclosed. By controlling the particle size of the copolymer and introducing a surfactant, enhanced freeze-thaw stability can be obtained with the polymer compositions of the present invention. The polymer compositions are compatible in all-aqueous hairspray compositions, as well as those which contain up to about 80 weight percent volatile organic compounds, or more.
    Type: Grant
    Filed: September 29, 1992
    Date of Patent: May 9, 1995
    Assignee: Amerchol Corporation
    Inventors: James C. Hatfield, Steven I. Cochran, David R. Bassett, Raymond Rigoletto, Jr.
  • Patent number: 5306490
    Abstract: A cyanoacrylate adhesive is applied to the skin areas prone to blistering prior to blister formation.
    Type: Grant
    Filed: April 20, 1992
    Date of Patent: April 26, 1994
    Assignee: Medlogic, Inc.
    Inventor: Leonard V. Barley, Jr.
  • Patent number: 5279821
    Abstract: Here is disclosed a water-insoluble pyrogen adsorbent composed of a polymer possessing amide groups optionally modified, said polymer being, e.g., a poly amino acid, a nylon, on a polyacrylamide.
    Type: Grant
    Filed: August 30, 1991
    Date of Patent: January 18, 1994
    Assignees: Chuichi Hirayama, Hirotaka Ihara, Ajinomoto Co., Inc.
    Inventors: Chuichi Hirayama, Hirotaka Ihara, Shunsei Tsunoda, Katsutoshi Aihara, Kazufumi Yagyu, Masao Honma
  • Patent number: 5262171
    Abstract: A pharmaceutical tablet is provided herein having an effective dissolution rate. The tablet contains a pharmaceutically-active ingredient and a substantially linear, i.e. non-crosslinked K-30 to K-120 PVP as a binding agent. The PVP used herein is made by an initiated polymerization process in which vinyl pyrrolidone monomer is polymerized in the presence of an initiator which produces a linear PVP polymerization, i.e. is a poor hydrogen abstractor of PVP polymer backbones, which would produce a disadvantageous crosslinked PVP product. Suitable initiators include low energy peroxyester free radical initiators, such as t-amylperoxy pivalate, an azo initiator, or a redox initiator which can perform at low temperatures.Preferably the residual initiator level in the PVP is reduced to less than 500 ppm, thereby further precluding the possibility of crosslinking of the PVP polymer during the shelf-life of the tablet.
    Type: Grant
    Filed: November 25, 1991
    Date of Patent: November 16, 1993
    Assignee: ISP Investments Inc.
    Inventors: Robert B. Login, Mohammed Tazi, Jui-Chang Chuang, Rama K. Haldar, Dinesh Jaiswal, Chi-San Wu
  • Patent number: 5241081
    Abstract: The invention relates to new N-alkyl-N-(meth)acryloyloxyalkylcarboxamides of aromatic carboxylic acids and aromatic carboxylic acid anhydrides, their preparation and formulations of these compounds for use as adhesives for the treatment of dental hard substance.
    Type: Grant
    Filed: August 9, 1991
    Date of Patent: August 31, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Michael Muller, Wolfgang Podszun, Werner Finger, Jens Winkel
  • Patent number: 5221722
    Abstract: Polycarbophil or crosslinked acrylic acid polymer is prepared in a solvent selected from acetone, alkyl acetates, and mixtures thereof, in the presence of an effective amount of divinyl glycol crosslinker, and in the presence of an effective amount of a suitable initiator allowing for polymerization to proceed at a temperature below 100.degree. C. at atmospheric pressure. The polymer produced has average particle size of less than 10 microns without grinding, its viscosity is greater than about 20,000 cPs when measured in water at 1% concentration, and it adheres to mucous membranes. By preparing the polymer in a non-aqueous solvent, the need for aqueous washing is avoided and the subsequent and enormous swelling of the polymer is avoided which means that prolonged and excessive drying inherent in the known processes is avoided.
    Type: Grant
    Filed: October 22, 1992
    Date of Patent: June 22, 1993
    Assignee: The B. F. Goodrich Company
    Inventor: Eugene J. Sehm
  • Patent number: 5188821
    Abstract: An oral composition mouthwash or liquid dentifrice containing an aqueous vehicle acceptable vehicle, a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2'-hydroxy-diphenyl ether (triclosan) and an antibacterial-enhancing agent which enhances delivery of said antibacterial agent to, and retention thereof on, oral surfaces.
    Type: Grant
    Filed: August 28, 1989
    Date of Patent: February 23, 1993
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, Nuran Nabi, John Afflitto, Orum Stringer
  • Patent number: 5180578
    Abstract: An oral composition such as a dentifrice, mouthwash, lozenge or chewing gum containing a polyphosphate anticalculus agent, such as tetraalkali metal pyrophosphate and antibacterial antiplaque agent compatible therewith. The antiplaque agent is a substantially water-insoluble noncationic antibacterial agent such as 2,4,4'-trichloro-2'-hydroxydiphenyl ether (Triclosan). Antiplaque effectiveness is optimized by the presence of an antibacterial-enhancing agent which enhances delivery of said antibacterial agent to, and retention thereof on, oral surfaces.
    Type: Grant
    Filed: February 19, 1991
    Date of Patent: January 19, 1993
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, Nuran Nabi, John Afflitto, Orum Stringer
  • Patent number: 5178851
    Abstract: An oral composition dentifrice comprising an orally acceptable vehicle, about 5-30% by weight of a siliceous polishing agent, about 0.25-0.35% by weight of a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2'-hydroxydiphenyl ether (triclosan) and an antibacterial-enhancing agent which enhances the delivery of said antibacterial agent to, and retention thereof on, oral surfaces.
    Type: Grant
    Filed: February 14, 1991
    Date of Patent: January 12, 1993
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, Nuran Nabi, John Afflitto, Orum Stringer
  • Patent number: 5126381
    Abstract: A process and apparatus are disclosed for producing polymerized beads containing actives such as perfumes and pesticides, by forming droplets from a solution of monomers and the actives. The solution is subjected to ultraviolet light to initiate polymerization. The droplets are caused to fall through a reaction vessel as polymerization continues so as to polymerize substantially spherical beads containing the actives. In one embodiment, the droplets are irradiated as they fall through the reaction vessel. In a second embodiment, the solution is irradiated prior to droplet formation and the fall. The beads are collected and can be cured if necessary. The process is preferably performed in an inert gas environment which most preferably is nitrogen. A nitrogen stream can serve as a carrier for the monomers and active ingredients. The nitrogen environment is maintained in the reaction vessel, and in the curing structure, if present.
    Type: Grant
    Filed: December 19, 1988
    Date of Patent: June 30, 1992
    Assignee: Dow Corning Corporation
    Inventor: Cristina Liscomb
  • Patent number: 4914140
    Abstract: An acrylic copolymer of ethyl acrylate and methacrylic acid wherein the weight ratio of ethyl acrylate to methacrylic acid is in a range between 75:25 and 95:5, containing therein a residual monomer content of 50 ppm or less, but substantially no surfactants, and which is useful as agents for protecting the skin and manufactured from the following essential components:a. an acrylic copolymer of ethyl acrylate and methacrylic acid wherein the weight ratio of ethyl acrylate to methacrylic acid is in a range between 75:25 and 95:5, containing therein residual monomers in an amount of 50 ppm or less, but substantially no surfactants--approximately 2 to 10%;b. cellulose derivative--approximately 0.2 to 2%; andc. a necessary amount of an aqueous alcohol to make the whole 100%.
    Type: Grant
    Filed: May 18, 1989
    Date of Patent: April 3, 1990
    Assignees: Shinonogi and Co., Ltd., Nisshin Chemical Co., Ltd.
    Inventors: Izumi Saitoh, Shigeru Kido, Yoshio Sasaki, Syuichiro Shinohara
  • Patent number: 4739025
    Abstract: A product and method for obtaining a radiation-resistant polyolefin-containing product, by handling and processing the corresponding homopolymer or copolymer melt and resulting extrudate in a manner favoring retention of a high smectic and less than about 20 wt % monoclinic configuration.
    Type: Grant
    Filed: May 5, 1986
    Date of Patent: April 19, 1988
    Assignee: Hercules Incorporated
    Inventor: George N. B. Burch