Bones; Tendons; Teeth; Cartilage Patents (Class 530/840)
  • Patent number: 9011930
    Abstract: Nutritional supplements and methods for maintaining and/or improving the condition of bones or cartilage in a mammal, particularly a human. One such supplement comprises demineralized bone matrix (DBM) wherein the DBM comprises a bone growth improving amount of at least one osteoinductive growth factor. A preferred supplement composition further comprises at least one vitamin, such as vitamin E. One method comprises orally administering to the mammal on a periodic basis a supplement comprising DBM. In a preferred method the DBM composition is periodically administered and there is a further periodic administration of a therapeutically effective amount of a calcium-containing composition; the calcium-containing composition is administered temporally spaced apart from said DBM composition for maximum effectiveness.
    Type: Grant
    Filed: May 1, 2006
    Date of Patent: April 21, 2015
    Assignee: ZyCal Bioceuticals Healthcare Company, Inc.
    Inventor: James Scaffidi
  • Patent number: 8829166
    Abstract: A method for purifying bone-derived osteoinductive proteins including a demineralization process, a protein extraction process, a high molecular weight ultrafiltration process, a low molecular weight ultrafiltration process, and a recover process. The high and low ultrafiltration processes preferably select proteins having a nominal molecular weight between approximately 8 kilodaltons and approximately 100 kilodaltons. Processes of the present invention may be used to recover osteoinductive proteins from bone demineralization waste streams.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: September 9, 2014
    Assignee: Zimmer Orthobiologics, Inc.
    Inventors: Kevin Thorne, Rama Akella
  • Patent number: 8551170
    Abstract: Disclosed are methods for producing implantable bone compositions suitable for attaching stem cells thereto, characterized in that bone particles are contacted with an albumin comprising solution. Said bone particles can be mineralized and/or lyophilized bone particles of animal or human origin. Preferably the non-immunogenic albumin comprising solution is lyophilized onto said bone particles. The invention further concerns bone compositions suitable for use in graft implantation obtainable by said methods.
    Type: Grant
    Filed: February 26, 2009
    Date of Patent: October 8, 2013
    Assignee: Lacerta Technologies, Inc.
    Inventors: Zsombor Lacza, Miklós Weszl
  • Patent number: 8452483
    Abstract: A cell-based vehicle driving control system includes a local server for obtaining road environment information on roads within a cell and target vehicle information on a target vehicle within the cell and generating local waypoints based on the road environment information and the target vehicle information; a global server for monitoring the target vehicle information, the road environment information and local server information on the local server received from the local server; and a vehicle control terminal, mounted in the target vehicle, for receiving the local waypoints from the local server and controlling the target vehicle based on the local waypoints. The road environment information is obtained by using at least one sensor installed on the roads.
    Type: Grant
    Filed: June 21, 2010
    Date of Patent: May 28, 2013
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Do Hyun Kim, Sung Won Sohn, Jong-Hyun Park, Byung Tae Jang, Jeong Dan Choi, Kyung Bok Sung, Kyoung Hwan An, Ju Wan Kim, Seong Ik Cho, Jungsook Kim
  • Patent number: 8119167
    Abstract: Use of a composition comprising cartilage or chondroitin sulphate and absorbable zinc for the preparation of a food supplement or a drug suitable for promoting iron absorption in patients suffering from lack of iron.
    Type: Grant
    Filed: February 20, 2008
    Date of Patent: February 21, 2012
    Assignee: Medestea Research & Production S.R.L.
    Inventor: Gianfranco Merizzi
  • Patent number: 7928059
    Abstract: Disclosed are a method and a corresponding pharmaceutical composition for treating damaged cartilage and subchondral bone. Neurogenic compounds in general and neuropeptides in particular have been found to be highly effective in stimulated repair of cartilage and bone damaged due to traumatic injury, ligament disease, and disuse. Preferred active ingredients for use in the method and corresponding pharmaceutical composition include calcitonin gene-related peptide (CGRP), cholecystokinin (CCK), dynorphin, enkephalin, galanin, neuropeptide Y (NPY), neurotensin, somatostatin, substance P (SP), thyrotropin-releasing hormone (TRH), vasoactive intestinal peptide (VIP).
    Type: Grant
    Filed: May 10, 2006
    Date of Patent: April 19, 2011
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ray Vanderby, Kelley W. Grorud
  • Patent number: 7847072
    Abstract: A method for purifying bone-derived osteogenic proteins including a demineralization process, a protein extraction process, a high molecular weight ultrafiltration process, a low molecular weight ultrafiltration process, and a recovery process. The high and low ultrafiltration processes preferably select proteins having a nominal molecular weight between approximately 8 kilodaltons and approximately 50 kilodaltons. Processes of the present invention may be used to recover osteogenic proteins from bone demineralization waste streams.
    Type: Grant
    Filed: June 21, 2007
    Date of Patent: December 7, 2010
    Assignee: Zimmer Orthobiologics, Inc.
    Inventor: Kevin Thorne
  • Patent number: 7758895
    Abstract: The present invention provides methods for purifying insoluble bone gelatin and uses for insoluble bone gelatin. The process for isolating insoluble bone gelatin from bone tissue includes grinding the bone tissue into bone powder; washing the bone powder with saline; demineralizing the bone tissue; contacting the bone powder with a neutral salt; and contacting the bone powder with a stabilizer. The present invention also discloses an insoluble bone gelatin including about 10 percent growth factor. Insoluble bone gelatin is useful, for example, in preparing impaction bone grafts.
    Type: Grant
    Filed: September 4, 2002
    Date of Patent: July 20, 2010
    Assignee: Perth Bone and Tissue Bank
    Inventors: Ying Fan, Ming Hao Zheng, David Wood
  • Patent number: 7632684
    Abstract: In an in vitro diagnostic test for osteoarthritis or rheumatoid arthritis, the amount or presence in a sample of anisomerised or optically inverted protein fragment is measured which derives from perlecan, bigylcan, decorin, fibrillin-1 or protocadherin or which is a specific sequence from aggrecan, type II collagen, COMP or CILP.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: December 15, 2009
    Assignee: Nordic Bioscience Diagnostics A/S
    Inventors: Stephan Christgau, Dennis B. Henriksen, Paul A. C. Cloos
  • Patent number: 7622562
    Abstract: A method for purifying bone-derived osteoinductive proteins including a demineralization process, a protein extraction process, a high molecular weight ultrafiltration process, a low molecular weight ultrafiltration process, and a recovery process. The high and low ultrafiltration processes preferably select proteins having a nominal molecular weight between approximately 8 kilodaltons and approximately 100 kilodaltons. Processes of the present invention may be used to recover osteoinductive proteins from bone demineralization waste streams.
    Type: Grant
    Filed: October 27, 2006
    Date of Patent: November 24, 2009
    Assignee: Zimmer Orthobiologics, Inc.
    Inventors: Kevin Thorne, Rama Akella
  • Patent number: 7556800
    Abstract: The current invention involves a universal fishing bait fundamentally comprised of a cord body of filaments or strips of fibrous collagen made up into any shape or design capable of attracting fish, that is 100% biodegradable and that furthermore has a good capacity to diffuse and liberate attractant substances. The bait invented presents excellent mechanical properties in terms of resistance to breakage and resistance to tearing, is easily manipulated, transported and stored. Similarly, the invention provides for the use of fibrous collagen in the preparation of said universal fishing bait.
    Type: Grant
    Filed: July 9, 2004
    Date of Patent: July 7, 2009
    Assignee: Viscofan, S.A
    Inventors: Vicente Etayo Garralda, Ion Inaki Garcia Martinez
  • Patent number: 7534422
    Abstract: The current invention involves a universal fishing bait fundamentally comprised of a matrix of fibrous collagen made up into any shape or design capable of attracting fish, that is 100% biodegradable and innocuous, that has physico-chemical properties that confer it with the capacity to accommodate liberate and diffuse attractant substances, and whose physico-mechanical properties confer it a soft and flexible texture, as well as making it resistant to breakage. Likewise, the invention outlines a procedure to prepare such a bait, and a precursor paste employed in the preparation, as well as the use of fibrous collagen in the preparation of said universal fishing bait.
    Type: Grant
    Filed: July 9, 2004
    Date of Patent: May 19, 2009
    Assignee: Viscofan, S.A.
    Inventors: Vicente Etayo Garralda, Ion Inaki Garcia Martinez
  • Patent number: 7410770
    Abstract: A method for improving the diagnostic assessment of cartilage degenerative processes, and to provide means of monitoring the effects of therapeutical measures taken towards arthritic diseases in most mammals utilizes an immunoassay to detect fragments of collagen type II resulting from collagenase activity comprising an antibody directed against an epitope comprised in the amino acid sequence HRGYPGLDG, located in the helical region of collagen type II.
    Type: Grant
    Filed: March 12, 2003
    Date of Patent: August 12, 2008
    Assignee: Universite De Liege
    Inventors: Jean-Yves Reginster, Michelle Deberg, Yves Henrotin, Stephan Christgau
  • Patent number: 7393649
    Abstract: Methods are described for improving the diagnostic possibilities of diseases where oxidative NO-modifications occur, for example inflammatory conditions, cancer, Parkinson's or Alzheimer's disease, and to provide means of monitoring the effects of therapeutical measures taken towards such diseases. The invention enables the detection of disease specific catabolic markers related to oxidative NO-modifications, utilizing an immunoassay comprising antibodies directed against nitrated and non-nitrated epitopes characteristic of a specific protein.
    Type: Grant
    Filed: March 12, 2003
    Date of Patent: July 1, 2008
    Assignee: Universite de Liege
    Inventors: Jean-Yves Reginster, Michelle Deberg, Yves Henrotin, Stephan Christgau
  • Patent number: 7354723
    Abstract: Disclosed are compositions and methods for performing an immuno-assay that includes measuring the amount of an isomerised or optically inverted non-collagen protein derived from cartilage.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: April 8, 2008
    Assignee: Nordic Bioscience Dagnostics A/S
    Inventors: Stephan Christgau, Dennis B. Henriksen, Paul A. C. Cloos
  • Patent number: 7258999
    Abstract: This invention relates to a novel PTH gene. The invention further relates to methods of screening, diagnosis and development of therapies for bone related disorders.
    Type: Grant
    Filed: November 10, 2003
    Date of Patent: August 21, 2007
    Assignee: Wyeth
    Inventors: John Allen Robinson, Vedrana Stojanovic-Susulic, Philip Babij, Richard John Murrills
  • Patent number: 7241874
    Abstract: A method for purifying bone-derived osteogenic proteins including a demineralization process, a protein extraction process, a high molecular weight ultrafiltration process, a low molecular weight ultrafiltration process, and a recovery process. The high and low ultrafiltration processes preferably select proteins having a nominal molecular weight between approximately 8 kilodaltons and approximately 50 kilodaltons. Processes of the present invention may be used to recover osteogenic proteins from bone demineralization waste streams.
    Type: Grant
    Filed: June 25, 2003
    Date of Patent: July 10, 2007
    Assignee: Zimmer Ortho Biologics, Inc.
    Inventor: Kevin Thorne
  • Patent number: 7208469
    Abstract: We claim a method of treating a patient to stimulate chondrocyte proliferation comprising administering to said patient an adrenomedullin analog that is adrenomedullin-(27–52) wherein said patient is suffering from cartilage disorders, and a method of stimulating chondrocyte proliferation comprising administering to chondrocyte cells adrenomedullin-(27–52).
    Type: Grant
    Filed: March 21, 2005
    Date of Patent: April 24, 2007
    Assignee: Auckland UniServices Limited
    Inventors: Ian Reginald Reid, Jillian Cornish
  • Patent number: 7186811
    Abstract: The present invention is related to an osteogenic device and its preparation. Said device comprises a bone morphogenetic protein (BMP), preferably a modified BMP complex obtainable by a modification of the conventional guanidum hydrochloride extraction method and collagens, preferably collagen I or collagen IV, impregnated in and/or adsorbed on a bioceramic carrier, preferably a shapable body (block) originating from a coral skeleton. The method of isolating said modified BMP complex which lacks an immunogenic component and consists essentially of a 100–700 kD and a 15–25 kD protein with osteoinductive properties and preferably of the 15–25 kD protein which has improved storage properties as well as its use in the osteogenic device with improved osteoinductive properties is also disclosed.
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: March 6, 2007
    Assignee: Bioactive Bone Substitutes Oy, AB
    Inventors: Sam T. Lindholm, Aulis Marttinen
  • Patent number: 7081240
    Abstract: A protein mixture that is useful in the treatment of wounds, where the mixture is isolated from bone or is produced from recombinant proteins and may include two or more of BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-7, TGF-?1, TGF-?2, TGF-?3, and FGF-1.
    Type: Grant
    Filed: June 28, 2000
    Date of Patent: July 25, 2006
    Assignee: Zimmer OrthoBioLogics, Inc.
    Inventors: Rama Akella, John P. Ranieri
  • Patent number: 6841644
    Abstract: Disclosed are modified naturally occurring biocompatible biopolymers of plant and animal origin made by subjecting same to ionizing radiation in the presence of a mediating gas, typically acetylene to enable one to selectively enhance and modify one or more of the physiochemical properties of the starting materials which have a wide range of uses in medicine, food technology and other industrial applications. Notwithstanding the modifications, the biocompatibility of the biopolymer remains unchanged and no new or additional functional groups are introduced into the starting biopolymer.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: January 11, 2005
    Assignee: Phillips Hydrocolloids Research Limited
    Inventors: Glyn Owen Phillips, Tjaart Andries Du Plessis, Saphwan Al-Assaf, Peter Anthony Williams
  • Patent number: 6746865
    Abstract: Nucleic acid sequences encoding for endostatin protein. Ribonucleic and deoxyribonucleic acid sequences that encode for endostatin protein are useful for gene therapy or recombinant expression for the treatment of angiogenesis-related diseases, specifically angiogenesis-dependent cancer.
    Type: Grant
    Filed: October 16, 1998
    Date of Patent: June 8, 2004
    Assignee: The Children's Medical Center Corporation
    Inventors: Michael S. O′Reilly, M. Judah Folkman
  • Patent number: 6645485
    Abstract: A process for treating inflammation in a joint whether heat, redness, pain, swelling and/or stiffness, and for increasing motion and increasing joint space and correcting malalignment, comprising the steps of dissolving a quantity of growth hormone (somatotropin), preferably in purified form, in a buffer solution, and injecting one time or multiple repeat times, a single dosage of the mixture of purified growth hormone and buffer solution into the joint of a body so as to initiate the treatment process.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: November 11, 2003
    Inventor: Allan R. Dunn
  • Patent number: 6589590
    Abstract: A method of making artificial bone comprises providing a membrane of collagen with solutions of calcium ions and of phosphate ions on opposite sides of the membrane. The calcium ions and phosphate ions diffuse through the membrane and precipitate as a hydroxyapatite material. Control of ionic concentrations ensures that precipitation takes place within the fibrils of the membrane. The result is an artificial bone material comprising a matrix of collagen and a hydroxyapatite material deposited within the matrix.
    Type: Grant
    Filed: February 27, 2002
    Date of Patent: July 8, 2003
    Assignee: Isis Innovation Limited
    Inventors: Jan Tadeusz Czernuszka, Alison Christina Lawson, Alasdair Hamish Robert Wallace Simpson
  • Publication number: 20030109686
    Abstract: The present invention is based on the discovery that a true tissue morphogen such as OP-1 provided systemically, alone in its mature dimeric form, or as part of a soluble complex, can induce new replacement tissue regeneration at a localized, permissive defect site distal to the site of administration. Specifically, systemically administered protein is sufficient to induce formation of new functional replacement tissue, sufficient to repair a local defect in a tissue, including skeletal or orthopedic tissues, liver, pancreas, lung, cardiac, renal, uterine, intestinal, gastrointestinal _____ tissue. (As used herein, “orthopedic” or “skeletal” or “joint” or “chondrogenic” tissue is understood to encompass the skeletal and skeletal joint tissues: bone, cartilage, tendon, ligament, and synovial membrane tissues.
    Type: Application
    Filed: March 8, 2000
    Publication date: June 12, 2003
    Inventors: KUBER T. SAMPATH, CHARLES M. COHEN
  • Publication number: 20030069401
    Abstract: Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel polypeptide chains and host cells transfected with these vectors; (4) methods of producing these polypeptide chains using recombinant DNA technology; (5) antibodies specific for these novel polypeptide chains; (6) osteogenic devices comprising these recombinantly produced proteins in association with an appropriate carrier matrix; and (7) methods of using the osteogenic devices to mimic the natural course of endochondral bone formation in mammals.
    Type: Application
    Filed: October 24, 1997
    Publication date: April 10, 2003
    Inventors: HERMANN OPPERMANN, ENGIN OZKAYNAK, THANGAVEL KUBERASAMPATH, DAVID C. RUEGER, ROY H. L. PANG
  • Publication number: 20030026786
    Abstract: Disclosed are a composition of chemically defined components having elevated levels of simple sugars which support the enhanced in vitro chondrogenesis of mesenchymal progenitor cells, a method for in vitro chondrogenic induction of such progenitor cells and a method of forming human chondrocytes in vitro from such progenitor cells.
    Type: Application
    Filed: June 4, 1999
    Publication date: February 6, 2003
    Inventors: MARK F. PITTENGER, ALASTAIR M. MACKAY, J. MARY MURPHY, FRANCIS P. BARRY
  • Patent number: 6511958
    Abstract: Disclosed is a cartilage repair product that induces both cell ingrowth into a bioresorbable material and cell differentiation into cartilage tissue. Such a product is useful for regenerating and/or repairing both vascular and avascular cartilage lesions, particularly articular cartilage lesions, and even more particularly mensical tissue lesions, including tears as well as segmental defects. Also disclosed is a method of regenerating and repairing cartilage lesions using such a product.
    Type: Grant
    Filed: February 16, 2000
    Date of Patent: January 28, 2003
    Assignee: Sulzer Biologics, Inc.
    Inventors: Brent Atkinson, James J. Benedict
  • Patent number: 6461630
    Abstract: Disclosed are terminally sterilized osteogenic devices for implantation into a mammal. The devices contain a combination of a biologically active osteogenic protein and an insoluble carrier which after being combined are sterilized by exposure to ionizing radiation, for example, by exposure to gamma rays or an electron beam. The terminally sterilized devices of the invention are characterized in that they induce bone formation following implantation into a mammal. Also disclosed is a method for inducing bone formation in a mammal by implanting a terminally sterilized device of the invention into a preselected locus in a mammal. Also disclosed is a method for preparing the terminally sterilized device of the invention.
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: October 8, 2002
    Assignee: Stryker Corporation
    Inventors: Marjorie M. Tucker, David C. Rueger, Kuber T. Sampath
  • Publication number: 20020143159
    Abstract: Purified BMP-17 and BMP-18 proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-17 and BMP-18 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, epithelium, brain, spleen, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.
    Type: Application
    Filed: November 12, 1999
    Publication date: October 3, 2002
    Inventors: ANTHONY J. CELESTE, BETH L. MURRAY
  • Patent number: 6368787
    Abstract: The present invention relates generally to methods and compositions for identifying morphogenic protein analogs. In one embodiment, this invention relates to an osteogenic protein reponsive transcription inhibitory element. This invention also relates to the identified morphogenic protein analogs which can mimic the biological effects of morphogenic proteins, particularly those relating to the BMP family such as osteogenic protein (OP-1), on the regulation of gene expression and tissue inductive capabilities.
    Type: Grant
    Filed: December 16, 1999
    Date of Patent: April 9, 2002
    Assignee: Stryker Corporation
    Inventors: Lee-Chuan C. Yeh, John C. Lee
  • Patent number: 6287816
    Abstract: Purified bone morphogenetic protein-9 (BMP-9) proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: June 6, 1994
    Date of Patent: September 11, 2001
    Assignee: Genetics Institute, Inc.
    Inventors: Vicki A. Rosen, John M. Wozney, Anthony J. Celeste, R. Scott Thies, Jeffrey R. Song
  • Publication number: 20010016646
    Abstract: Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art. Defects susceptible to repair with the instant invention include, but are not limited to: critical size defects, non-critical size defects, non-union fractures, fractures, osteochondral defects, subchondral defects, and defects resulting from degenerative diseases such as osteochondritis dessicans.
    Type: Application
    Filed: March 20, 1998
    Publication date: August 23, 2001
    Inventors: DAVID C. RUEGER, MARJORIE A. TUCKER, AN-CHENG CHANG
  • Publication number: 20010014662
    Abstract: Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art. Defects susceptible to repair with the instant invention include, but are not limited to: critical size defects, non-critical size defects, non-union fractures, fractures, osteochondral defects, subchondral defects, and defects resulting from degenerative diseases such as osteochondritis dessicans.
    Type: Application
    Filed: March 20, 1997
    Publication date: August 16, 2001
    Inventors: DAVID C RUEGER, MARJORIE A TUCKER
  • Publication number: 20010011127
    Abstract: The present application relates to a compositions comprising a compound which modulates the activity of T1-M protein, the use of compounds which modulate the activity of T1-M protein, and an in vitro method for influencing the proliferation and/or differentiation potential of bone cells.
    Type: Application
    Filed: March 20, 1998
    Publication date: August 2, 2001
    Inventors: ANNE KATRIN WERENSKIOLD, JORG SCHMIDT
  • Patent number: 6261586
    Abstract: A bone graft substitute including a composition of natural selectively deactivated bone material which has been processed to remove associated non-collagenous bone proteins, said bone material containing native collagen materials and naturally associated bone minerals and substantially free from native non-collagenous protein, and a therapeutically effective amount to stimulate bone growth of a bone growth factor in a pharmaceutically acceptable carrier in synergistic combination with said bone material. Spacers composed of the bone graft substitute composition methods for using the spacers are also provided.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: July 17, 2001
    Assignee: SDGI Holdings, Inc.
    Inventor: William F. McKay
  • Patent number: 6180605
    Abstract: The present invention provides improved osteogenic compositions having enhanced by the sorption of growth factors, of nutrient factors, or drugs onto or into the compositions. Compositions may consist of collagen and demineralized bone materials onto and into which growth factors, antimicrobial agent,s nutrient factors, or other soluble factors may be sorbed to enhance the osteogenic factor. These materials can be used in a wide range of clinical procedures to replace and restore osseous or periodontal defects.
    Type: Grant
    Filed: January 5, 1998
    Date of Patent: January 30, 2001
    Assignee: GenSci OrthoBiologics, Inc.
    Inventors: Charles C. Chen, Steven R. Jeffries
  • Patent number: 6180606
    Abstract: Osteogenic compositions, and methods for preparing same, which compositions comprise a porous or semi-porous matrix, an osteogenic factor and an agent such as growth factors, nutrient factors, drugs, calcium-containing compounds, blood products, large molecular weight proteins, or combinations thereof. These materials can be used in a wide range of clinical procedures to replace and restore osseous or periodontal defects.
    Type: Grant
    Filed: January 13, 1998
    Date of Patent: January 30, 2001
    Assignee: GenSci Orthobiologics, Inc.
    Inventors: Charles C. Chen, Steven R. Jefferies
  • Patent number: 6117979
    Abstract: Bioprosthetic devices made of collagen-based material having collagen amine groups and collagen carboxyl groups are provided as well as methods for their formation. The methods comprise combining an epoxy functionalized crosslinking agent with the collagen-based material in an aqueous medium at an acidic pH to react a portion of the collagen carboxyl groups with the epoxy functionalized crosslinking agent to form crosslinked collagen-based material comprising residual collagen carboxyl groups.
    Type: Grant
    Filed: August 18, 1997
    Date of Patent: September 12, 2000
    Assignee: Medtronic, Inc.
    Inventors: Marc Hendriks, Michel Verhoeven, Patrick Cahalan, Raymond Zeeman, Piet Dijkstra, Jan Feijen
  • Patent number: 6034061
    Abstract: Purified Bone Morphogenetic Protein (BMP)-9 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair, and in hepatic growth and function.
    Type: Grant
    Filed: December 4, 1996
    Date of Patent: March 7, 2000
    Assignee: Genetics Institute, Inc.
    Inventors: Vicki A. Rosen, John M. Wozney, Anthony J. Celeste, Scott R. Thies, Jeffrey R. Song
  • Patent number: 5972368
    Abstract: A bone graft substitute including a composition of natural selectively deactivated bone material which has been processed to remove associated non-collagenous bone proteins, said bone material containing native collagen materials and naturally associated bone minerals and substantially free from native non-collagenous protein, and a therapeutically effective amount to stimulate bone growth of a bone growth factor in a pharmaceutically acceptable carrier in synergistic combination with said bone material. Spacers composed of the bone graft substitute composition methods for using the spacers are also provided.
    Type: Grant
    Filed: June 11, 1997
    Date of Patent: October 26, 1999
    Assignee: SDGI Holdings, Inc.
    Inventor: William F. McKay
  • Patent number: 5948766
    Abstract: Tasteless, hydrolyzed collagen from gelatin, gelatin or animal collagenic connective tissue having an average molecular weight of from 1 to 40 kD for the preparation of agents for the treatment of osteoporosis. It may be combined with conventional agents for combatting osteoporosis, such as calcitonin, calcium salts, and/or progesterone.
    Type: Grant
    Filed: April 25, 1997
    Date of Patent: September 7, 1999
    Assignee: DGF Stoess AG
    Inventors: Adam Milan, Bernd Eggersgluss, Klaus Braumer, Reinhard Schrieber
  • Patent number: 5936035
    Abstract: Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a multifunctionally activated synthetic hydrophilic polymer. A particularly preferred composition comprises fibrillar collagen, a fiber disassembly agent, and a multifunctionally activated synthetic hydrophilic polymer. Methods are disclosed for using the compositions to effect the attachment of a native tissue to the surface of another native tissue, a non-native tissue, or a synthetic implant. Also disclosed are methods of using the compositions to prevent the formation of surgical adhesions.
    Type: Grant
    Filed: December 18, 1995
    Date of Patent: August 10, 1999
    Assignee: Cohesion Technologies, Inc.
    Inventors: Woonza M. Rhee, Prema R. Rao, George H. Chu, Frank A. DeLustro, Carol F. H. Harner, Naomi Sakai, Jacqueline A. Schroeder
  • Patent number: 5849880
    Abstract: Purified bone morphogenetic protein (BMP)-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 15, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: John M. Wozney, Elizabeth A. Wang, Vicki A. Rosen, Anthony J. Celeste
  • Patent number: 5741895
    Abstract: Disclosed herein is a novel proteinaceous cell density signal molecule (CDS) between 25 and 35 kD, which is secreted by fibroblastic primary avian tendon cells in culture, and causes the cells to self-regulate their proliferation and the expression of differentiated function. It effects an increase of procollagen production in avian tendon cell cultures of ten fold while proliferation rates are decreased. CDS, and the antibodies which recognize them, are important for the development of diagnostics and treatments for injuries and diseases involving connective tissues, particularly tendon. Also disclosed are methods of production and use.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: April 21, 1998
    Assignee: The Regents of the University of California
    Inventor: Richard I. Schwarz
  • Patent number: 5714589
    Abstract: Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel polypeptide chains and host cells transfected with these vectors; (4) methods of producing these polypeptide chains using recombinant DNA technology; (5) antibodies specific for these novel polypeptide chains; (6) osteogenic devices comprising these recombinantly produced proteins in association with an appropriate carrier matrix; and (7) methods of using the osteogenic devices to mimic the natural course of endochondral bone formation in mammals.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: February 3, 1998
    Assignee: Stryker Corporation
    Inventors: Hermann Oppermann, Engin Ozkaynak, Thangavel Kuberasampath, David C. Rueger, Roy H. L. Pang
  • Patent number: 5707962
    Abstract: The present invention provides improved osteogenic compositions having enhanced by the sorption of growth factors, of nutrient factors, or drugs onto or into the compositions. Compositions may consist of collagen and demineralized bone materials onto and into which growth factors, antimicrobial agent, a nutrient factors, or other soluble factors may be sorbed to enhance the osteogenic factor. These materials can be used in a wide range of clinical procedures to replace and restore osseous or periodontal defects.
    Type: Grant
    Filed: September 28, 1994
    Date of Patent: January 13, 1998
    Assignee: GenSci Regeneration Sciences Inc.
    Inventors: Charles C. Chen, Steven R. Jefferies
  • Patent number: 5693615
    Abstract: A method for generating new bone growth in a mammal comprising administrating to the mammal a safe and effective amount of a Vitamin D compound in combination with a safe and effective amount of osteoinductive extract or at least one BMP.
    Type: Grant
    Filed: January 23, 1995
    Date of Patent: December 2, 1997
    Assignee: The Procter & Gamble Company
    Inventor: Roger Lee Stone
  • Patent number: 5656598
    Abstract: The present invention provides therapeutic compositions for the prevention and treatment of pathological conditions involving bone and dental tissue. The present invention also provides a method to promote bone repair and/or growth for the treatment of pathological conditions involving bone tissue, for example, osteoporosis, Paget's disease, osteopetrosis, and periodontal disease and fracture repair, and healing of bone defects by administering FGF-1 to an animal or human in need of such treatment.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: August 12, 1997
    Assignees: Rhone-Poulenc Rorer Pharmaceuticals Inc., Osteosa Inc.
    Inventors: Colin R. Dunstan, Elzbieta Izbicka, Gregory R. Mundy, Wilson Burgess, Michael C. Jaye
  • Patent number: 5637466
    Abstract: A method of detecting bone acidic glycoprotein-75 (BAG-75) antigen includes the steps incubating a serum or synovial fluid sample with anti-BAG antibody, reacting the incubated sample with a signal generating antibody to the anti-BAG-75 antibody, and detecting the signal as an indication of BAG-75 antigen in the serum. Antibodies for use in the test for detecting BAG-75 antigen in serum and synovial fluid samples includes BAG-75 #3-13 peptide anti-serum, anti-BAG-75 protein anti-serum, and monoclonal antibodies against the BAG-75 protein, the antibodies recognizing the 75,000 molecular weight BAG-75 precursor protein and the 50,000 molecular weight BAG-75 fragment in serum and synovial fluid. Molecular weight assignments are based upon electrophoretic mobilities under denaturing conditions.
    Type: Grant
    Filed: September 3, 1993
    Date of Patent: June 10, 1997
    Assignee: Curators of the University of Missouri
    Inventor: Jeffrey P. Gorski