Isothiocyanate Esters (i.e., Compounds Containing The Isothiocyanate Group, -n=c=s, Bonded Directly To Carbon, Which Carbon May Be Single Bonded To Any Atom But May Be Multiple Bonded Only To Carbon) Patents (Class 558/17)
  • Publication number: 20150110863
    Abstract: The present invention relates to a new series of compounds having general formula (I) and the optical isomer or enantiomer forms thereof, which belong to the family of sulforaphane derivatives. The invention also relates to the production method thereof. The invention further relates to the multiple medical (pharmaceutical, homeopathic and phytotherapeutic), food, cosmetic and dietary uses of said series of compounds, especially the use thereof in the prevention and/or treatment of diseases and any type of illness or damage associated with an oxidative process or which, although not involved in said process, are mediated by the Nrf2 transcription factor, such as, for example, cancer. The compounds can be used alone or, alternatively, encapsulated in cyclodextrins.
    Type: Application
    Filed: March 6, 2013
    Publication date: April 23, 2015
    Applicants: Univerversidad De Sevilla, Consejo Superior De Investigaciones CientÍficas (CSIC)
    Inventors: Noureddine Khiar El Wahabi, Inmaculada Fernández Fernández, Rocío Recio Jiménez
  • Patent number: 8987316
    Abstract: The present invention relates to novel isocyanate and isothiocyanate compounds, to pharmaceutical compositions comprising them, and to the use thereof in the treatment of cancer diseases in humans and animals. The novel isocyanate and isothiocyanate compounds are distinguished, as compared with the known isocyanate and isothiocyanate compounds, by improved therapeutical breadth, i.e. fewer side effects while having high anti-tumor activity.
    Type: Grant
    Filed: September 18, 2012
    Date of Patent: March 24, 2015
    Assignee: DoubleHill GmbH
    Inventor: Jochen Kalbe
  • Publication number: 20150018374
    Abstract: Disclosed is a fungicidal composition comprising (a) at least one compound selected from the compounds of Formula 1, N-oxides, and salts thereof, wherein R1 is F, Cl or Br; R2 is H or F; and R3 is Cl or Br; and (b) at least one fungicidal compound selected from (b1) through (b13) as disclosed herein. Also disclosed is a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed, a fungicidally effective amount of a compound of Formula 1, an N-oxide, or salt thereof (e.g., as a component in the aforesaid composition). Also disclosed are process intermediate compounds useful for preparing compounds of Formula 1.
    Type: Application
    Filed: January 30, 2013
    Publication date: January 15, 2015
    Inventors: Andrew Edmund Taggi, Jeffrey Keith Long, James Francis Bereznak
  • Patent number: 8933119
    Abstract: A method for treating phytophotodermatitis including the steps of applying an isothiocyanate functional surfactant to an area affected by phytophotodermatitis, wherein said isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.
    Type: Grant
    Filed: January 3, 2012
    Date of Patent: January 13, 2015
    Assignee: The William M. Yarbrough Foundation
    Inventor: Michael E. Silver
  • Publication number: 20140322304
    Abstract: Anti-cancer compositions and methods are described herein. In particular, compositions including one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described. Methods for treatment of pathological conditions particularly cancer, in a subject using one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described herein.
    Type: Application
    Filed: July 10, 2014
    Publication date: October 30, 2014
    Inventors: Gavin P. Robertson, Raghavendra Gowda Chandagalu D., Subbarao V. Madhunapantula, Gajanan S. Inamdar, Omer F. Kuzu
  • Patent number: 8859798
    Abstract: Provided herein are compositions of matter and pharmaceutical compositions thereof, for use in inhibiting the growth of various microbial pathogens, including bacteria, fungi, protozoa, and viral pathogens. Also provided herein are methods of treating microbial diseases/infections and cancer with the compositions. The compositions are additionally useful in wood preservation and food preservation by inhibition of microbial growth.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: October 14, 2014
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Arkady Mustaev, Natalia Kurepina
  • Publication number: 20140228419
    Abstract: The present invention relates to novel isocyanate and isothiocyanate compounds, to pharmaceutical compositions comprising them, and to the use thereof in the treatment of cancer diseases in humans and animals. The novel isocyanate and isothiocyanate compounds are distinguished, as compared with the known isocyanate and isothiocyanate compounds, by improved therapeutical breadth, i.e. fewer side effects while having high anti-tumor activity.
    Type: Application
    Filed: September 18, 2012
    Publication date: August 14, 2014
    Applicant: DoubleHill GmbH
    Inventors: Jochen Kalbe, Olaf Hansen
  • Publication number: 20140221316
    Abstract: This disclosure relates to novel compounds containing an H2S releasing moiety and a nitric oxide (NO) releasing moiety covalently linked with a core (e.g., a salicylic acid moiety) and the use of such compounds in treating inflammatory diseases, including cancers. Therapeutic potency of these compounds is significantly higher than NSAIDs containing a H2S-releasing moiety alone (HS-NSAIDs) and NSAID containing a NO-releasing moiety alone (NO-NSAIDs). The compounds, in addition, exhibit reduced side effect, e.g., reduced stomach ulcers, upon administration.
    Type: Application
    Filed: August 15, 2012
    Publication date: August 7, 2014
    Applicant: RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
    Inventors: Khosrow Kashfi, Ravinder Kodela
  • Publication number: 20140134480
    Abstract: Disclosed are an additive for a rechargeable lithium battery electrolyte including an aromatic compound having an isothiocyanate group (—NCS), and an electrolyte and rechargeable lithium battery including the same.
    Type: Application
    Filed: March 14, 2013
    Publication date: May 15, 2014
    Applicant: SAMSUNG SDI CO., LTD.
    Inventors: Makhmut Khasanov, Woo-Cheol Shin, Denis Chernyshov, Alexey Tereshchenko, Vladimir Egorov, Pavel Shatunov
  • Patent number: 8691870
    Abstract: Novel Uses of small molecules, particularly, 6-methylsulfinylhexyl isothiocyanate and 6-methylsulfonylhexyl isothiocyanate, are disclosed herein. The two isothiocyanates are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer, particularly drug-resistant cancer, in a patient.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: April 8, 2014
    Assignee: Mackay Memorial Hospital
    Inventors: Yu-Jen Chen, Hui-Fen Liao
  • Publication number: 20140021409
    Abstract: The present invention relates to a liquid-crystal medium which comprises a component A which consists of one or more compounds of the formula X in which the parameters have the respective meanings given in the claims or in the text, and to the corresponding, novel mesogenic compounds and to the preparation thereof. The present invention likewise relates to the use of these liquid-crystal media, in particular in components for high-frequency technology, and to components of this type which contain the media according to the invention, and to the production and use of these components. The components according to the invention are suitable, in particular, for phase shifters in the microwave and millimetre wave region, for microwave and millimetre wave array antennae and very particularly for so-called tuneable “reflectarrays”.
    Type: Application
    Filed: March 7, 2012
    Publication date: January 23, 2014
    Applicant: MERCK PATENT GMBH
    Inventors: Atsutaka Manabe, Christian Jasper, Volker Reiffenrath, Elvira Montenegro, Detlef Pauluth, Dagmar Klass
  • Publication number: 20130288985
    Abstract: This application discloses pharmaceutical compositions (e.g., oral, parenteral or topical ophthalmic formulations) for treating Fuchs endothelial corneal dystrophy (FECD) with one or more Nrf2 activators and/or mitochondrially targeted antioxidants. The compositions may be topically administered to the eye and are effective in the treatment of FECD. The invention further provides methods of treating FECD by in a subject in need of such treatment by topical application of one or more Nrf2 activators and/or mitochondrially of the invention.
    Type: Application
    Filed: June 30, 2011
    Publication date: October 31, 2013
    Applicant: The Schepens Eye Research Institute Inc.
    Inventor: Ula V. Jurkunas
  • Publication number: 20130259802
    Abstract: The present invention provides a process for [18F]-fluorination of biomolecules containing a primary amino group such as proteins and peptides and in particular of peptides. The invention further provides reagents for this process, in particular 18F-labelled prosthetic groups for use in the preparation as well as non-labelled intermediates useful in the preparation of the [18F]-labelled prosthetic groups. [18F]-labelled compounds useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET) are also provided.
    Type: Application
    Filed: May 20, 2013
    Publication date: October 3, 2013
    Applicant: HAMMERSMITH IMANET LIMITED
    Inventors: ERIK ARSTAD, MATTHIAS EBERHARD GLASER
  • Patent number: 8541611
    Abstract: A process for preparing phenyl iso(thio)cyanates of the formula I in which a compound of the formula II or its HCl adduct is reacted with a phosgenating agent where W is oxygen or sulfur and Ar and A are as defined in claim 1 is described. Moreover, the invention relates to the use of the phenyl iso(thio)cyanates for preparing crop protection agents.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: September 24, 2013
    Assignee: BASF Aktiengesellschaft
    Inventors: Gerhard Hamprecht, Michael Puhl, Bernd Wolf, Norbert Götz, Michael Keil, Robert Reinhard, Ingo Sagasser, Werner Seitz
  • Publication number: 20130231387
    Abstract: The invention concerns the role of Glo 1 in the prevention and reversal of proteomic and genomic damage by carbonyl substrates thereof and, in particular, therapeutics that promote Glo 1 production.
    Type: Application
    Filed: June 20, 2011
    Publication date: September 5, 2013
    Applicant: THE UNIVERSITY OF WARWICK
    Inventors: Mingzhan Xue, Paul Thornalley, Naila Rabbani
  • Patent number: 8501488
    Abstract: The present invention relates to a compound for N-terminal substitution of polypeptides which is used in sequencing and quantifying amino acids and a method for sequencing and quantifying an amino acid sequence using the same. The method for sequencing and quantifying amino acids in accordance with the present invention leads to a relative quantitative analysis of proteins with very high reliability, and can distinctively discriminate between y-type ions and b-type ions on the MS/MS spectra, providing the means for realization of high-reliability protein identification.
    Type: Grant
    Filed: June 29, 2005
    Date of Patent: August 6, 2013
    Assignee: Korea University Industry and Academy Cooperation Foundation
    Inventors: Sang-Won Lee, Yong-Ho Lee
  • Publication number: 20130184342
    Abstract: The technology described herein relates to methods of inducing cell death. The technology described herein further relates to treating conditions including cancers and autoimmune diseases comprising administering inhibitors of double strand break repair. Also described herein are inhibitors of double strand break repair and methods of screening for such inhibitors.
    Type: Application
    Filed: March 13, 2013
    Publication date: July 18, 2013
    Applicant: THE JACKSON LABORATORY
    Inventor: THE JACKSON LABORATORY
  • Publication number: 20130178523
    Abstract: Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.
    Type: Application
    Filed: March 5, 2013
    Publication date: July 11, 2013
    Applicant: THE PENN STATE RESEARCH FOUNDATION
    Inventor: The Penn State Rsearch Foundation
  • Publication number: 20130143962
    Abstract: The present invention relates to adamantyl derivatives and their anti-cancer activity. Compounds of formulae I and II are provided as well as related methods of treatment and methods of synthesis.
    Type: Application
    Filed: December 6, 2012
    Publication date: June 6, 2013
    Applicant: WOMEN & INFANTS' HOSPITAL OF RHODE ISLAND
    Inventor: Women & Infants' Hospital of Rhode Island
  • Publication number: 20130079401
    Abstract: Novel Uses of small molecules, particularly, 6-methylsulfinylhexyl isothiocyanate and 6-methylsulfonylhexyl isothiocyanate, are disclosed herein. The two isothiocyanates are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer, particularly drug-resistant cancer, in a patient.
    Type: Application
    Filed: September 23, 2011
    Publication date: March 28, 2013
    Inventors: Yu-Jen CHEN, Hui-Fen Liao
  • Patent number: 8367857
    Abstract: To provide a novel method for producing an isothiocyanate compound having a carboxyl group(s) from the corresponding amino compound having a carboxyl group(s). A method for producing an isothiocyanate compound which has a carboxyl group(s) and is represented by the formula (2). And the method comprises reacting an amino compound which has a carboxyl group(s) and is represented by the formula (1) (wherein A is e.g. a C6-14 aromatic hydrocarbon group or a C1-12 saturated hydrocarbon group, and B is e.g. a single bond, a C6-14 aromatic hydrocarbon group or a C1-12 saturated hydrocarbon group), in a solvent, with carbon disulfide (CS2) and then with a halogen as a simple substance.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: February 5, 2013
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Satoshi Nakano, Daisuke Saito
  • Publication number: 20120271049
    Abstract: A process for preparing phenyl iso(thio)cyanates of the formula I in which a compound of the formula II or its HCl adduct is reacted with a phosgenating agent where W is oxygen or sulfur and Ar and A are as defined in claim 1 is described. Moreover, the invention relates to the use of the phenyl iso(thio)cyanates for preparing crop protection agents.
    Type: Application
    Filed: June 28, 2012
    Publication date: October 25, 2012
    Applicant: BASF AKTIENGESELLSCHAFT
    Inventors: Gerhard Hamprecht, Michael Puhl, Bernd Wolf, Norbert Götz, Michael Keil, Robert Reinhard, Ingo Sagasser, Werner Seitz
  • Publication number: 20120214786
    Abstract: This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R6, R7, R8 have meanings given in the description.
    Type: Application
    Filed: August 17, 2011
    Publication date: August 23, 2012
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Henning PRIEPKE, Henri DOODS, Raimund KUELZER, Roland PFAU, Dirk STENKAMP, Benjamin PELCMAN, Robert ROENN
  • Publication number: 20120214742
    Abstract: A GABA (gamma-aminobutyric acid) release-inhibiting agent in the cerebellum and a composition for treating pathological symptoms caused by over-release of GABA in the cerebellum, each comprising a Bestrophin 1(Best1) channel inhibitor as an active ingredient; a GABA release-promoting agent in the cerebellum and a composition for treating pathological symptoms caused by the deficit of GABA in the cerebellum, each comprising a Best1 channel activator as an active ingredient; and a method for screening a GABA release-regulating agent in the cerebellum, which uses Best1 channel as target, are provided.
    Type: Application
    Filed: August 24, 2010
    Publication date: August 23, 2012
    Inventors: Changjoon Justin Lee, Soo-Jung Lee, Bo-Eun Yoon
  • Patent number: 8232421
    Abstract: A process for preparing phenyl iso(thio)cyanates of the formula I in which a compound of the formula II or its HCl adduct is reacted with a phosgenating agent where W is oxygen or sulfur and Ar and A are as defined in claim 1 is described. Moreover, the invention relates to the use of the phenyl iso(thio)cyanates for preparing crop protection agents.
    Type: Grant
    Filed: September 21, 2010
    Date of Patent: July 31, 2012
    Assignee: BASF Aktiengesellschaft
    Inventors: Gerhard Hamprecht, Michael Puhl, Bernd Wolf, Norbert Götz, Michael Keil, Robert Reinhard, Ingo Sagasser, Werner Seitz
  • Publication number: 20120182200
    Abstract: The present invention relates to a component for high-frequency technology or for the microwave range and millimetre wave range of the electromagnetic spectrum, characterised in that it contains a liquid-crystal compound of the formula I in which the parameters have the respective meanings given in the claims or in the text, or a liquid-crystal medium which itself comprises one or more compounds of this formula I, and to the corresponding, novel liquid-crystal media, to the use and preparation thereof, and to the production and use of the components. The components according to the invention are particularly suitable as phase shifters in the microwave and millimetre wave range, for microwave and millimetre wave array antennae and very particularly for so-called tuneable reflectarrays.
    Type: Application
    Filed: September 14, 2010
    Publication date: July 19, 2012
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Atsutaka Manabe, Mark Goebel, Dagmar Klass, Elvira Montenegro, Detlef Pauluth
  • Publication number: 20120171117
    Abstract: The present invention provides a process for [18F]-fluorination of biomolecules containing a primary amino group such as proteins and peptides and in particular of peptides. The invention further provides reagents for this process, in particular 18F-labelled prosthetic groups for use in the preparation as well as non-labelled intermediates useful in the preparation of the [18F]-labelled prosthetic groups. [18F]-labelled compounds useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET) are also provided.
    Type: Application
    Filed: March 8, 2012
    Publication date: July 5, 2012
    Applicant: HAMMERSMITH IMANET LIMITED
    Inventors: ERIK ARSTAD, MATTHIAS EBERHARD GLASER
  • Publication number: 20120148690
    Abstract: A novel skin barrier function recovery acceleration method and accelerator are provided. The present invention provides a skin barrier function recovery accelerator that comprises a TRPA1 agonist capable of activating TRPA1 in epidermal cells.
    Type: Application
    Filed: December 10, 2010
    Publication date: June 14, 2012
    Inventors: Mitsuhiro Denda, Moe Tsutsumi, Sumiko Denda
  • Publication number: 20120064002
    Abstract: Enantiomer-pure compounds of general formulas VIIa and VIIb in which A stands for a group —COO—, and Z and R have different meanings, as well as use thereof are described.
    Type: Application
    Filed: March 31, 2011
    Publication date: March 15, 2012
    Inventors: Lutz LEHMANN, Matthias FRIEBE, Thomas BRUMBY, Detlev SUELZLE, Johannes PLATZEK
  • Publication number: 20120034266
    Abstract: The present invention provides a new means of restoring the immune system in aging and immunocompromised individuals using an antioxidant nutraceutical. The nutraceutical stimulates the aging immune system through the Nrf2 master gene regulatory pathway. The invention is based in part on the discovery that the Nrf2 has antioxidant and immune restorative activity. The nutraceutical improves function of both the innate and adaptive immune systems.
    Type: Application
    Filed: March 3, 2009
    Publication date: February 9, 2012
    Inventors: Andre E. Nel, Hyon-Jeen Kim
  • Publication number: 20110263457
    Abstract: We describe herein a cell-based multiplexing technique called detectable cell barcoding (DCB). In DCB, each individual sample is labeled with a different DCB signature that distinguishes each sample by one or both of detected intensity or type of detection characteristic. The samples are then combined and analyzed for a detectable characteristic of interest (e.g., presence of an analyte). By employing multiple distinct DCB labels at varying concentrations, one can perform multiplex analyses on up to hundreds or thousands (or more) of cell samples in a single reaction tube. DCB reduces reagent consumption by factors of 100-fold or more, significantly reduces data acquisition times and allows for stringent control sample analysis.
    Type: Application
    Filed: July 1, 2011
    Publication date: October 27, 2011
    Inventors: Peter O. Krutzik, Garry Nolan
  • Publication number: 20110250300
    Abstract: The present invention features methods for treating or preventing conditions, diseases, or disorders related to oxidative stress. In one embodiment, the method increases Nrf2 biological activity or expression. In particular, the invention provides for the treatment or prevention of diseases relating to oxidative stress including emphysema, sepsis, septic shock, ischemic injury, cerebral ischemia and neurodegenerative disorders, meningitis, encephalitis, hemorrhage, cerebral ischemia, heart ischemia, cognitive deficits and neurodegenerative disorders.
    Type: Application
    Filed: May 14, 2010
    Publication date: October 13, 2011
    Applicant: The Johns Hopkins University
    Inventors: Shyam Biswal, Rajesh K. Thimmulappa
  • Publication number: 20110245213
    Abstract: The present invention concerns compositions that may be used in the prevention or treatment of medical conditions characterised by having an inflammatory component. The compositions comprise a therapeutically effective amount of an isothiocyanate (ITC). The composition may comprise further anti-inflammatory agents (e.g. plant-derived polyphenols).
    Type: Application
    Filed: June 25, 2009
    Publication date: October 6, 2011
    Applicants: PROVEXIS NATURAL PRODUCTS LIMITED, PLANT BIOSCIENCE LIMITED
    Inventors: Niamh O'Kennedy, Richard Mithen
  • Publication number: 20110245262
    Abstract: Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also, disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: August 20, 2007
    Publication date: October 6, 2011
    Inventors: Lijun Sun, Keizo Koya, Shoujun Chen, Zachary Demko, Zhi-Qiang Xia
  • Publication number: 20110201836
    Abstract: The invention relates to a process for the extraction of actives from botanical materials using a series of silicone compounds having different partition coefficients. The botanical extracts are used in a wide range of applications, including in dermatocosmetic products. The selection of silicone-based products over solvents heretofore used allows for more efficient as well as more specific extraction of desired active-containing fractions from the plant material in a carrier that not only is more skin substantive but also enhances the retention of the dermatocosmetically-active constituents from botanical materials on the skin.
    Type: Application
    Filed: February 12, 2010
    Publication date: August 18, 2011
    Inventor: Anthony J. O'Lenick, JR.
  • Publication number: 20110009640
    Abstract: A process for preparing phenyl iso(thio)cyanates of the formula I in which a compound of the formula II or its HCl adduct is reacted with a phosgenating agent where W is oxygen or sulfur and Ar and A are as defined in claim 1 is described. Moreover, the invention relates to the use of the phenyl iso(thio)cyanates for preparing crop protection agents.
    Type: Application
    Filed: September 21, 2010
    Publication date: January 13, 2011
    Applicant: BASF AKTIENGESELLSCHAFT
    Inventors: Gerhard Hamprecht, Michael Puhl, Bernd Wolf, Norbert Götz, Michael Keil, Robert Reinhard, Ingo Sagasser, Werner Seitz
  • Publication number: 20100215574
    Abstract: The invention relates to a method for producing injectable medicament preparations containing a therapeutically and/or diagnostically effective substance which is comprised of an active agent, of a spacer molecule and of at least one protein-binding molecule. After being brought into contact with the body, said therapeutically and/or diagnostically effective substance covalently bonds to the body fluid constituents or tissue constituents via the protein-binding molecule, thus providing a form of transport of the active agent that an be hydrolytically or enzymatically cleaved, according to pH, in the body while releasing the active agent.
    Type: Application
    Filed: October 22, 2009
    Publication date: August 26, 2010
    Inventor: FELIX KRATZ
  • Patent number: 7741359
    Abstract: The present invention relates to derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) having improved anti-inflammatory properties useful in the treatment of inflammation, pain and fever. More particularly, NSAIDs are derivatized with a hydrogen sulfide (H2S) releasing moiety to produce novel anti-inflammatory compounds having reduced side effects.
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: June 22, 2010
    Assignee: Antibe Therapeutics Inc.
    Inventors: John Wallace, Giuseppe Cirino, Vincenzo Santagada, Giuseppe Caliendo
  • Patent number: 7667048
    Abstract: The present invention provides novel fluorescent compounds and covalent attachment chemistries which facilitate the use of these compounds as labels for ultrasensitive and quantitative fluorescent detection of low levels of biomolecules. In a preferred embodiment, the fluorescent labels of this invention are novel derivatives of the hydroxy-pyrene trisulphonic and disulphonic acids which may be used in any assay in which radioisotopes, colored dyes or other fluorescent molecules are currently used. Thus, for example, any assay using labeled antibodies, proteins, oligonucleotides or lipids, including fluorescent cell sorting, fluorescence microscopy (including dark-field microscopy), fluorescence polarization assays, ligand, receptor binding assays, receptor activation assays and diagnostic assays can benefit from use of the compounds disclosed herein.
    Type: Grant
    Filed: December 29, 2007
    Date of Patent: February 23, 2010
    Assignee: Aries Associates, Inc.
    Inventors: Ram Bhatt, Michael J. Conrad, Azzouz Bencheikh, Yifeng Xiong
  • Publication number: 20090087379
    Abstract: The present invention provides a process for [18F]-fluorination of biomolecules containing a primary amino group such as proteins and peptides and in particular of peptides. The invention further provides reagents for this process, in particular 18F-labelled prosthetic groups for use in the preparation as well as non-labelled intermediates useful in the preparation of the [18F]-labelled prosthetic groups. [18F]-labelled compounds useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET) are also provided.
    Type: Application
    Filed: April 20, 2007
    Publication date: April 2, 2009
    Inventors: Erik Arstad, Matthias Eberhard Glaser
  • Publication number: 20080312164
    Abstract: The present invention provides glucosinolate and isothiocyante compounds and related methods for synthesizing these compounds and analogs. In certain embodiments, these glucosinolate and isothiocyanate compounds are useful and chemopreventive and or chemotherapeutic agents.
    Type: Application
    Filed: July 13, 2007
    Publication date: December 18, 2008
    Inventors: Scott R. Rajski, Jared Rae Mays
  • Publication number: 20080227995
    Abstract: A process of producing a compound of the following formula (3): wherein R1 is a C1-5 alkyl group, R2 is a halogen atom, a C1-5 alkyl group, a C2-5 alkenyl group, a C2-5 alkynyl group, a C1-5 alkyl group, a C1-5 alkoxy group, a nitro group, or a hydroxy group, wherein multiple R2 may be the same or may be different, and a is an integer of from 0 to 4, comprising reacting a compound of the following formula (2): wherein R2 and a are as defined above with a C1-5-alkanesulfonyl chloride or C1-5-alkanesulfonic acid anhydride followed by hydrolyzing an N,N-disulfonated derivative of compound (3) to the compound of formula (3).
    Type: Application
    Filed: July 20, 2006
    Publication date: September 18, 2008
    Applicant: Schwarz Pharma AG
    Inventors: Jorg Hamann, Ralf Kanzler, Youxin Li
  • Publication number: 20080220483
    Abstract: The present invention relates to a compound for N-terminal substitution of polypeptides which is used in sequencing and quantifying amino acids and a method for sequencing and quantifying an amino acid sequence using the same. The method for sequencing and quantifying amino acids in accordance with the present invention leads to a relative quantitative analysis of proteins with very high reliability, and can distinctively discriminate between y-type ions and b-type ions on the MS/MS spectra, providing the means for realization of high-reliability protein identification.
    Type: Application
    Filed: June 29, 2005
    Publication date: September 11, 2008
    Inventors: Sang-Won Lee, Yong-Ho Lee
  • Publication number: 20080176942
    Abstract: A method of stabilizing sulforaphane is provided. The method includes contacting sulforaphane, or an analog thereof, and a cyclodextrin to form a complex between the sulforaphane, or analog thereof, and the cyclodextrin.
    Type: Application
    Filed: January 23, 2008
    Publication date: July 24, 2008
    Applicant: PharmAgra Labs, Inc.
    Inventors: Ido Dov Dagan, Albert Roger Frisbee, Peter Wyatt Newsome, Michel Pierre Baudet
  • Patent number: 7317111
    Abstract: The present invention provides novel fluorescent compounds and covalent attachment chemistries which facilitate the use of these compounds as labels for ultrasensitive and quantitative fluorescent detection of low levels of biomolecules. In a preferred embodiment, the fluorescent labels of this invention are novel derivatives of the hydroxy-pyrene trisulphonic and disulphonic acids which may be used in any assay in which radioisotopes, colored dyes or other fluorescent molecules are currently used. Thus, for example, any assay using labeled antibodies, proteins, oligonucleotides or lipids, including fluorescent cell sorting, fluorescence microscopy (including dark-field microscopy), fluorescence polarization assays, ligand, receptor binding assays, receptor activation assays and diagnostic assays can benefit from use of the compounds disclosed herein.
    Type: Grant
    Filed: September 23, 2003
    Date of Patent: January 8, 2008
    Assignee: Aries Associates, Inc.
    Inventors: Ram Bhatt, Michael J. Conrad, Azzouz Bencheikh, Yifeng Xiong
  • Publication number: 20070207087
    Abstract: A cycloalkyl triamine pentacarboxylate compound coordinating to a metal ion to form a high stability metal complex in serum is provided. The metal complex of the present invention can be used as a contrast agent for magnetic resonance imaging (MRI).
    Type: Application
    Filed: September 21, 2006
    Publication date: September 6, 2007
    Applicant: Kaohsiung Medical University
    Inventors: Yun-Ming Wang, Chih-Wei Chiu, Gin-Chung Liu
  • Patent number: 7091341
    Abstract: A method is described of preparing (poly)isocyanurate polyisocyanates by catalytic cyclotrimerization of isocyanates. A catalytic system is used which includes a cyclotrimerization catalyst based on a quatemary ammonium salt and imidazole as a cocatalyst.
    Type: Grant
    Filed: August 14, 2003
    Date of Patent: August 15, 2006
    Assignee: Rhodia Chimie
    Inventors: Denis Revelant, Jean-Marie Bernard
  • Patent number: 7041844
    Abstract: The present invention relates to an antiandrogen compound and a method of treating prostate cancer in a patient utilizing the compound. The present invention also relates to a pharmaceutical composition which includes the compound.
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: May 9, 2006
    Assignee: The University Of Tennessee Research Corporation
    Inventors: Duane D. Miller, Leonid I. Kirkovsky, James T. Dalton, Arnab Mukherjee
  • Publication number: 20040242905
    Abstract: Aldehydes containing a difluorooxymethylene bridge, of the general formula I
    Type: Application
    Filed: May 27, 2004
    Publication date: December 2, 2004
    Inventors: Eike Poetsch, Werner Binder, Volker Meyer, Stephen Gurtler, Juergen Eckstein, Michael Schwarz
  • Publication number: 20040147736
    Abstract: Novel arylisothiocyanate compounds are described that are useful for activating alcohol-containing macromolecules, for example polyethyleneglycols and cellulose, for covalent linkage to amino-groups of biomolecules, for example polypeptides such as antibodies, enzymes, and proteins.
    Type: Application
    Filed: December 19, 2003
    Publication date: July 29, 2004
    Inventor: Paul K. Smith