Means For Ejecting Solid From Holder Patents (Class 604/59)
  • Patent number: 11877771
    Abstract: A nasal implant delivery tool includes an inner handle, an outer handle, a needle, and a push rod. The inner handle includes a loading chamber configured to receive a nasal implant. The outer handle is configured to move axially relative to the inner handle. The needle extends distally from the inner handle and has a central lumen and a distal opening. The push rod is configured to move the nasal implant from the loading chamber, through the central lumen, and out the distal opening of the needle. The push rod is coupled to the outer handle such that the push rod moves axially relative to the inner handle when the outer handle is moved axially relative to the inner handle. Also described herein are nasal implant guides and methods of using nasal implant delivery tools and nasal implant guides.
    Type: Grant
    Filed: August 8, 2022
    Date of Patent: January 23, 2024
    Assignee: Spirox, Inc.
    Inventors: Michael H. Rosenthal, Scott J. Baron, Brian J. Domecus, Michael S. Mirizzi, Sergio Salinas
  • Patent number: 11701482
    Abstract: An electronic inhalation device comprising a mouthpiece and a control unit, the control unit comprising a power cell and a computer, where the computer comprises a computer processor, a memory and an input-output means; wherein the device further comprises a transmitter connected to the computer and the computer is configured in use to collect and store use data relating to a user's use of the device in the computer memory and transmit the use data.
    Type: Grant
    Filed: December 14, 2020
    Date of Patent: July 18, 2023
    Assignee: Nicoventures Trading Limited
    Inventor: Christopher Lord
  • Patent number: 11672961
    Abstract: An injection includes a tube having opposite first and second ends. A hub is coupled to the first end. A sheath is coupled to the tube and the hub. The hub is movable relative to the tube to move the sheath between a first orientation in which the sheath covers an orifice in the second end and a second orientation in which the sheath is spaced apart from the orifice. Kits and methods of use are disclosed.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: June 13, 2023
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: Brian D. Koch
  • Patent number: 11672738
    Abstract: Single dose drug dosage form dispensing devices, and methods for operating such devices are disclosed herein. In one embodiment, an apparatus includes a housing defining an actuation pathway and a pusher. At least a portion of the pusher is disposed within the actuation pathway such that distal end portions of the pusher and the housing define a volume configured to contain a drug-containing tablet. The pusher is configured to move relative to the housing in a distal direction from a first position to a second position to expel the tablet from the volume. The distal end portion of the pusher is extended from an opening in the housing when the pusher is in its second position. The housing is configured to limit movement of the pusher relative to the housing in a proximal direction towards the first position of the pusher after the tablet is expelled.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: June 13, 2023
    Assignee: Vertical Pharmaceuticals, LLC
    Inventors: Casidy Domingo, Edmond Chiu, Bradley Blackwood
  • Patent number: 11464542
    Abstract: A nasal implant delivery tool includes an inner handle, an outer handle, a needle, and a push rod. The inner handle includes a loading chamber configured to receive a nasal implant. The outer handle is configured to move axially relative to the inner handle. The needle extends distally from the inner handle and has a central lumen and a distal opening. The push rod is configured to move the nasal implant from the loading chamber, through the central lumen, and out the distal opening of the needle. The push rod is coupled to the outer handle such that the push rod moves axially relative to the inner handle when the outer handle is moved axially relative to the inner handle. Also described herein are nasal implant guides and methods of using nasal implant delivery tools and nasal implant guides.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: October 11, 2022
    Assignee: Spirox, Inc.
    Inventors: Michael H. Rosenthal, Scott J. Baron, Brian J. Domecus, Michael S. Mirizzi, Sergio Salinas
  • Patent number: 11452850
    Abstract: In the specification and drawings a method and apparatus for delivering a drug into a nasal turbinate or nasal polyp is described and shown, which can include implanting a drug eluting implant into a nasal turbinate or nasal polyp; and leaving the drug eluting material in the nasal turbinate or nasal polyp for at least one day such that a drug is released from the drug eluting implant over a period of time.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: September 27, 2022
    Inventor: Grayson Matthew Gremillion
  • Patent number: 11439803
    Abstract: A medicant dispenser enabling the effective administration of tableted pharmaceutical products within a body cavity has a plunger, a barrel, and a deformable tip. The deformable tip provides a suitable leading element to allow the barrel to enter the body cavity, wherein the plunger may be pushed to eject the tableted pharmaceutical products into the body cavity through the deformable tip. More specifically, the deformable tip will comprise a plurality of cuspids fixed to a support ring, wherein the support ring is fitted to a terminal end of the barrel. The plurality of cuspids will collapse concentrically to form a tapered leading element of the medicant applicator while retaining the capacity to separate to allow passage of the tableted pharmaceutical products and a head of the plunger therethrough.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: September 13, 2022
    Assignee: NIVA MEDTECH LLC
    Inventor: Harsh Yogeshkumar Adhyaru
  • Patent number: 11406766
    Abstract: Described are applicators having a plunger with a plunger body, and a tube having a receptacle end for insertion of the plunger, and a connector end formed of flexible plastic material having a bull-nose shape. As an example, the plunger body can include a viewing window. As another example, the connector end has an internal surface that is free of threaded connectors. The connector end can also have a snap-fit coupling design to couple to a snap-fit nozzle. The snap-fit nozzle can be connected to an adaptor cap or an administering tool of a metering dispenser.
    Type: Grant
    Filed: June 17, 2020
    Date of Patent: August 9, 2022
    Assignee: DOSELOGIX, LLC
    Inventors: Timothy Gayle Phipps, Dale Melton Coker, Daniel Lee DeYoung, Ellen Y. Brown, Saundra D. Naughton
  • Patent number: 11382835
    Abstract: A multiple dose spoon device for scooping, retaining, and delivering to a patient a specific number of mini-tablets from a container, e.g., bottle, or bulk pile, of mini-tablets. The device comprises a top housing, a bottom housing, and one or two sliders movably positioned between top housing and bottom housing, said: a) top housing having a plurality of nests, and also having a handle with an open window and slider retention notches, and b) one or two sliders with slider tabs, having a plurality of sequential whole number markings equivalent to the plurality of nests, and a plurality minus 1 of tablet blocking ribs, wherein slider movement is regulated by the slider retention notches, and wherein the plurality of nests and the plurality of whole number markings are a same number. Alternatively, the top housing does not have slider retention notches, and the one or two sliders have slider retention notches.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: July 12, 2022
    Assignee: Merck, Sharp & Dohme LLC
    Inventors: Annaniy Berenshteyn, Mikhail Gotliboym, Christopher Granelli
  • Patent number: 10966595
    Abstract: An endoscopy auxiliary device includes an insertion tube and a clamping unit. The clamping unit has a pipe and a connector. The connector is connected to the insertion tube. The tube is configured to clamp a capsule endoscope. The pipe has an inner space configured to accommodate a part of the capsule endoscope. The pipe includes a first slit, a second slit and a third slit. The first slit extends from a free end of the pipe for a first distance toward a connection end of the pipe. The second slit extends from the free end of the pipe for the connection distance toward the connection end of the pipe. The third slit extends from the free end of the pipe for a third distance toward the connection end of the pipe. The first slit, the second slit and the third slit are separate.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: April 6, 2021
    Assignee: INSIGHT MEDICAL SOLUTIONS INC.
    Inventors: Yu-Jen Wu, Ching-Lung Kuo, Chih-Hao Chang, Ping-Chun Tsai, Shih-Chieh Lu
  • Patent number: 10791987
    Abstract: A method and system for managing a risk of medication dependence that determines a conservative estimate of the time when the patient will become dependent on a medication as a function of a medication log. The medication log includes dose information and time information for a plurality of administrations of the medication.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: October 6, 2020
    Inventor: Barry L. Jenkins
  • Patent number: 10525248
    Abstract: The invention pertains to apparatuses, means and methods to promote uptake of fluids into a reservoir of an implantable drug delivery system though a porous membrane. Embodiments of the invention promote fluid uptake by creating a pressure differential between the reservoir of the drug delivery device and the environment of the device after implantation, for instance a subcutaneous pocket.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: January 7, 2020
    Assignee: NANO PRECISION MEDICAL, INC.
    Inventors: Wouter E. Roorda, William G. M. Fischer, Kathleen Fischer, Adam D. Mendelsohn, Adam Monkowski
  • Patent number: 10525241
    Abstract: In the specification and drawings a method and apparatus for delivering a drug into a nasal turbinate or nasal polyp is described and shown, which can include implanting a drug eluting implant into a nasal turbinate or nasal polyp; and leaving the drug eluting material in the nasal turbinate or nasal polyp for at least one day such that a drug is released from the drug eluting implant over a period of time.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: January 7, 2020
    Inventor: Grayson Matthew Gremillion
  • Patent number: 9974900
    Abstract: A dose request device for a medicament delivery device can include a housing, a dose request button, a short-range non-contact identifier, a communication interface configured to communicate with the medicament delivery device, and a controller. The short-range non-contact identifier can be configured to be capable of reading an identification code from a tag when the tag is disposed within a first range and not to be able to read the identification code from the tag when the tag is disposed beyond a second range. The controller can be configured and programmed to determine whether the identification code read by the short-range non-contact identifier matches any authorized identification code of a set of one or more authorized identification codes, and if so, and if the dose request button is pressed, the controller can then communicate a dose request to the medicament delivery device via the communication interface.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: May 22, 2018
    Assignee: Smiths Medical ASD, Inc.
    Inventors: Grant Adams, Larry Zalesky
  • Patent number: 9585645
    Abstract: An insertion tool for a medical closure device for the sealing of an opening in a wall of a bodily organ includes a tamping force source adapted to deliver a first member to a position at the opening on one side of the wall subsequently to a second member being positioned at the opening on the opposite side of the wall. The tamping force source, which is energized prior to the tamping procedure, can be a spring, an elastic band or a pressurized gas container. A tamping spring can be compressed or extended upon loading. The tamping force source can be released in response to a manual operation or be triggered by retraction of the insertion tool.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: March 7, 2017
    Assignee: ST. JUDE MEDICAL COORDINATION CENTER BVBA
    Inventor: Dan Akerfeldt
  • Patent number: 9155859
    Abstract: A ureteral access sheath adapted for insertion into a urethra includes an elongate tube extending between a proximal end and a distal end. A handle assembly is disposed at the proximal end and includes enlarged portions which inhibit migration of the sheath into the urethra. The enlarged portions are shaped like the bell of a horn with a concave, distally-facing outer surface and a convex, proximally-facing inner surface. The inner surface functions as a funnel while the outer surface is sized and configured to receive adjacent fingers of a user's hand held in its natural position. In an associated method, this shape of the handle assembly facilitates maintaining the sheath in a stationary position during insertion and removal of instrumentation. The handle assembly can be movable on the tube to facilitate variation of the sheath length.
    Type: Grant
    Filed: September 11, 2012
    Date of Patent: October 13, 2015
    Assignee: Applied Medical Resources Corporation
    Inventors: Gary R. Dulak, Ralph V. Clayman
  • Patent number: 9066847
    Abstract: Drug storage and dispensing devices for dispensing dosage forms to the oral mucosa of a patient are disclosed. The drug storage and dispensing device is a single dose applicator or a device which includes a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.
    Type: Grant
    Filed: July 3, 2007
    Date of Patent: June 30, 2015
    Assignee: AceIRx Pharmaceuticals, Inc.
    Inventors: Andrew I. Poutiatine, Charles Rampersaud, Bruce Edwards, Edmond Chiu, Stelios Tzannis, Pamela Palmer, William Kolosi, Sascha Retailleau
  • Publication number: 20150005700
    Abstract: The invention relates to a sanitary device (1) for applying at least one active principle inside a human or animal body cavity, said device comprising at least one biodegradable film (3) containing the at least one active substance and an applicator including: a main tubular body (4); and an ejector body (2) comprising a distal portion (202), at least one part of the surface of which forms a support for the at least one biodegradable film (3) and the end (203) of which is rounded, whereby said ejector body (2) can slide inside the main body (4) between at least one position in which the distal portion (202) of the ejector body (2) is located inside the main body (4) and an application position in which the distal portion (202) is located outside same, in the axial extension of the main body (4).
    Type: Application
    Filed: January 16, 2013
    Publication date: January 1, 2015
    Applicant: SOJASUN TECHNOLOGIES
    Inventors: Theo Efstathiou, Christophe Morin
  • Patent number: 8922367
    Abstract: Various exemplary embodiments relate to a medicament storage case including: a case body securable to a wall; a door connected to the body; a sleeve to contain an epinephrine injector; a medicament lock including a hook, wherein the hook is positioned to engage the sleeve when in a first position and is positioned to disengage the sleeve when in a second position; an actuator including a solenoid, wherein the solenoid, upon activation, moves the hook from the first position to the second position; a microphone configured to receive first audio as input; a speaker configured to output second audio; a communication unit configured to provide Internet connectivity; a button; and a processor configured to: in response to pressing the button: establish communication between the local user and a remote site, receive an unlock message, and in response to receiving the unlock message, activate the solenoid to release of the sleeve.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: December 30, 2014
    Assignee: Mylan, Inc.
    Inventors: John W. Denny, Kevin Ostrander
  • Patent number: 8905964
    Abstract: Drug storage and dispensing devices for dispensing a drug dosage form to a patient are disclosed. A cartridge includes a cartridge housing and a pusher. The cartridge housing defines a channel within which multiple tablets are disposed. The cartridge housing is configured to be removably coupled to a tablet dispensing device. A first portion of the pusher is disposed outside of the channel. A second portion of the pusher is movably disposed within the channel, and is configured to exert a force on the plurality of tablets to convey a first tablet from the channel into the tablet delivery device when the force is exerted on the first portion of the pusher.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: December 9, 2014
    Assignee: AcelRx Pharmaceuticals, Inc.
    Inventors: Andrew I. Poutiatine, Charles Rampersaud, Thomas Schreck, William Kolosi, Sascha Retailleau
  • Patent number: 8888745
    Abstract: The invention pertains to an applicator (1) for inserting an implant, in particular a rod-like implant (2) containing an active substance, under the skin of a human or animal, comprising a housing (3), a cannula (6) extending from the housing (3), and a handle (15) for grasping and maneuvering the applicator (1) and the cannula (6) during insertion of an implant (2). In accordance with the invention, the handle (15) extends above at least part of the length of the cannula (6). Such a handle facilitates insertion of the cannula and/or accurate positioning of the implant.
    Type: Grant
    Filed: January 20, 2006
    Date of Patent: November 18, 2014
    Assignee: Merck Sharp & Dohme B.V.
    Inventors: Iris Epkjen Hobo Van Der Graaf, Maurice Petrus Wilhelmus Tak, Juergen Schmidt, Hendricus Johannes Vertegaal
  • Patent number: 8858593
    Abstract: An emergency medical device and method is provided for treatment of open wounds by enhancing clotting and arresting hemorrhaging, particularly in the area of the neck, abdomen, chest or groin. The devices includes an elongated delivery tube for insertion into a wound cavity and subsequent delivery of a space filling, sponge-like mass containing a polymerizable liquid sealant that polymerizes upon contact with body fluids after which the delivery tube is removed.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: October 14, 2014
    Assignee: Charles W. Kerber, M.D., Inc.
    Inventor: Charles W. Kerber
  • Patent number: 8821434
    Abstract: A method for transferring a solid body across a surface of a biological body includes (i) applying an electrical input to a controllable electromagnetic actuator; (ii) producing with the electromagnetic actuator a mechanical force corresponding to the electrical input; and (iii) applying the mechanical force to a reservoir coupled at one end to a nozzle, the mechanical force producing a pressure within the reservoir, a magnitude of the pressure varying with the mechanical force and causing ejection of a fluid from the reservoir to drive the solid body into the biological body. A method for delivering a substance to a target body includes (i) positioning a needle-free injector proximate to a surface of the target body; (ii) injecting the substance into the target body; and (iii) while injecting, moving the needle-free injector along the surface, thereby sweeping the surface.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: September 2, 2014
    Assignee: Massachusetts Institute Of Technology
    Inventors: Ian W. Hunter, Andrew J. Taberner, N. Catherine Hogan
  • Patent number: 8790293
    Abstract: Disclosed herein is an injector device for delivering an implant, the device including a retracting element, a cannula needle, and a plunger. The device may comprise an latch that, when actuated by a user, causes the retracting element to move the cannula needle away from the delivery site, allowing the plunger to eject the implant into the site. The device may be configured for intraocular drug delivery.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: July 29, 2014
    Assignee: pSivida US, Inc.
    Inventors: Martin Nazzaro, Josh York, Ron LeBlanc
  • Patent number: 8753308
    Abstract: Systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject using a device are disclosed. The dispensing device includes a lock-out feature and a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: June 17, 2014
    Assignee: AcelRx Pharmaceuticals, Inc.
    Inventors: Pamela Palmer, Andrew Poutiatine, Charles Rampersaud, Bruce Edwards, Edmond Chiu, Thomas Schreck, Stelios Tzannis, Lawrence Hamel, William Kolosi, Sascha Retailleau
  • Patent number: 8721621
    Abstract: A method delivers an implantable device through the urethra and into the bladder. A deployment instrument is inserted into the urethra, the implantable device is inserted into the deployment instrument, and a stream of fluid is injected into the deployment instrument. The stream of fluid drives the implantable device from the deployment instrument into the bladder. The deployment instrument is removed from the urethra, leaving the implantable device wholly implanted in the bladder.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: May 13, 2014
    Assignee: TARIS Biomedical, Inc.
    Inventors: Jim Boyko, Grace Kim, Heejin Lee, Michael J. Cima, Jennie Kwo
  • Patent number: 8715223
    Abstract: Drug depot delivery devices and methods are provided for delivering one or more drug depots in close proximity to the nerve of a patient with or without repositioning the cannula. The device includes an electronic monitor for detecting the proximity of the tip of the cannula to a nerve. In some embodiments, a method of delivering a drug depot is provided by detecting the nerve and delivering the drug depot near the nerve.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: May 6, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Patent number: 8702684
    Abstract: A device (10) for receiving implanted biological material includes a mechanoprotective surface (16) defining an adjacent space, an assembly (26, 28) for locally delivering media to said space, and a pump or slow/sustained release reservoir structure (14) operatively coupled to the assembly. The device may comprise an additional plunger body for being disposed in said space. The implanted biological material may be encapsulated or non-encapsulated.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: April 22, 2014
    Assignees: University of Miami, Converge Biotech Inc.
    Inventors: Nicholas Bodor, Peter Buchwald, Christopher A. Fraker, Jeffrey Hubbell, Luca Inverardi, Norma Sue Kenyon, Paul Latta, Antonello Pileggi, Cheryl Stabler Anderson, Fabio Grassi, Camillo Ricordi
  • Publication number: 20140107423
    Abstract: An apparatus for insertion in an ear is provided in one example and includes a drug delivery device for insertion into an external auditory canal, wherein the drug delivery device contains one or more pharmaceutically active agents that can be released from the drug delivery device into the external auditory canal. In more particular instances, the drug delivery device can conform to the profile of the external auditory canal.
    Type: Application
    Filed: September 14, 2012
    Publication date: April 17, 2014
    Inventor: Yoseph Yaacobi
  • Patent number: 8679072
    Abstract: The invention relates to a process for producing a bone-regeneration material. According to the method, a bio-compatible, open-pored body is exposed to a vacuum and osteoinductive and/or osteogenic substances are absorbed into the pores of the body, for example by means of a vacuum generated therein. It is thus possible to produce a bone-regeneration material, which contains osteoinductive and/or osteogenic substances in the pores of the bio-compatible body, said substances acting as a network structure for new somatic cells that are to grow into the porous body.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: March 25, 2014
    Assignee: DePuy Synthes Products, LLC
    Inventor: Thierry Stoll
  • Patent number: 8652092
    Abstract: The invention relates to applicators (1) for implantation of an implant, having a cylinder (2) and a plunger (3) displaceably mounted therein, which plunger (3) has a pusher plunger (31) for pushing the implant out of a cannula, the cannula being mounted on a cylinder part, the cylinder part (4) being movably guided in the cylinder (2), there being provided a gear mechanism (5) which couples the plunger (3) to the cylinder part (4), a movement of the plunger (3) relative to the cylinder (2) being converted into an opposite movement of the cylinder part (4).
    Type: Grant
    Filed: May 4, 2006
    Date of Patent: February 18, 2014
    Assignee: Acino AG
    Inventor: Oliver Bussmann
  • Publication number: 20140018725
    Abstract: The present invention relates to novel drug delivery technology in the form of solid dose injection devices and methods which utilise a blade that is pushed into the skin to a predetermined depth before the before a solid drug formulation is pushed into the cut made by the blade. Thus the present invention also relates to delivering a therapeutic compound to a human or animal in the form of a solid dose injection comprising: providing an injection device comprising a casing; an actuation mechanism capable of ei generating a force, a blade, a solid drug formulation; and a means for pushing said solid drug formulation; wherein the blade is inser ted to a predetermined depth in the skin and, following insertion of the blade, the device is actuated such that the actuation mechanism capable of generating a force acts on the means for pushing to push the solid drug formulation out of the casing and into the human or animal body.
    Type: Application
    Filed: January 20, 2012
    Publication date: January 16, 2014
    Applicant: GLIDE PHARMACEUTICAL TECHNOLOGIES LIMITED
    Inventors: Charles Potter, John Watson
  • Publication number: 20130331777
    Abstract: Devices and methods for delivering therapeutic agents use an inverted member to deliver a therapeutic agent with little or no shear stress. The inverted member may have a movable continuous surface, the movable continuous surface having a first section and a second section opposing the first section, the second section surrounding an inner cavity that is configured to hold the therapeutic agent, the inverting member being configured to deliver the therapeutic agent by inverting at least a portion of the second section.
    Type: Application
    Filed: March 19, 2012
    Publication date: December 12, 2013
    Applicants: CELL PRECISION, LLC, EMORY UNIVERSITY
    Inventors: W. Robert Taylor, Raymond P. VIto, Michael L. Wach, Jack Griffis
  • Patent number: 8579852
    Abstract: Methods and devices to process harvested skin tissue and to immediately reintroduce the ground tissue into the patient to repair a tissue defect are disclosed. A hand-held portable tissue grinder comprising a housing and a grinding element are disclosed. The tissue grinder is used for grinding skin and subcutaneous tissue and includes a sterile polymer housing having a first opening adapted to receive the skin and subcutaneous tissue. The tissue grinder also includes a sterile grinding element disposed substantially within the housing. The grinding element includes a plurality of cutting surfaces adapted to operably engage with the housing to provide ground tissue and further includes a handle mechanism coupled to the grinding element to move the grinding element with respect to the housing to grind the skin and subcutaneous tissue, wherein the ground tissue can be removed from the housing.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: November 12, 2013
    Inventor: Omeed Memar
  • Patent number: 8574188
    Abstract: The invention relates to a novel drug delivery technology. More particularly the invention relates to a method of delivering at least one therapeutic compound or a formulation comprising the at least one therapeutic compound to a patient; to a throwaway or reusable device for delivering at least one therapeutic compound or a formulation comprising the at least one therapeutic compound to a patient in a manner as set out by the method; to a pioneer projectile for use in said method; to formulations for use in said method and to an injectate comprising a pioneer projectile and formulation. It also relates to a disposable component containing either a pioneer projectile or an injectate. The invention also relates to a throwaway or reusable device for delivering at least one therapeutic compound, or a formulation comprising the at least one therapeutic compound (hereafter drug) to a patient, and a method for administering a drug to a patient using said device.
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: November 5, 2013
    Assignee: Glide Pharmaceutical Technologies Limited
    Inventors: David Stuart Potter, Charles David Ogilvy Potter
  • Patent number: 8574189
    Abstract: Dispensing devices and systems for oral transmucosal administration of small volume drug dosage forms to the oral mucosa are provided. The dispensing device may be a single dose applicator (SDA), or an electromechanical device comprising a means for patient identification such as a wrist worn RFID tag and annular bidirectional antenna together with a lock-out feature.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: November 5, 2013
    Assignee: AcelRx Pharmaceuticals, Inc.
    Inventors: Andrew Poutiatine, Bruce Edwards, Charles Rampersaud, Pamela Palmer, Bradley Blackwood, Benjamin K. Yaffe
  • Patent number: 8545377
    Abstract: A magazine for chain components of a chain with radiation sources comprises a housing as well as a first means for receiving chain components that is mounted in a pivotal manner in the housing and has recesses for receiving the chain components, a tension spring for driving the means for receiving the chain components, a sprocket being coupled in a pivotal manner to the means for receiving the chain components and being mounted in a pivotal position in the housing, and an ejector for ejection of the radiation sources. Furthermore, the magazine comprises an ejection lever which is mounted in a pivotal manner in the housing, whereby, in a first position, the ejection lever engages the sprocket, and in a second position it blocks the ejector.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: October 1, 2013
    Assignee: Eckert & Ziegler Bebig GmbH
    Inventors: Axel Hentrich, Christoph Lederer
  • Patent number: 8535701
    Abstract: The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: September 17, 2013
    Assignee: Intarcia Therapeutics, Inc.
    Inventors: John R. Peery, Keith E. Dionne, Felix A. Landrau, Bonnie J. Eckenhoff, Scott D. Lautenbach, Judy A. Magruder, Jeremy C. Wright
  • Patent number: 8529550
    Abstract: Catheter systems and methods for implanting helical or dart-like implants into the myocardium or other body tissue. The catheter system includes a helix for fixing the distal end of the catheter to the myocardium, an implant held by the helix, mechanisms for driving the fixation helix into the myocardium, and mechanisms for driving the implant into the myocardium, removing the fixation helix and leaving the implant behind. The implant may be coated, filled, or made of a drug or drug eluting compound, or drug delivery matrix of any composition.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: September 10, 2013
    Assignee: BioCardia, Inc.
    Inventors: Daniel C. Rosenman, Peter A. Altman, Mark A. Lovich, Michael A. Schwartz, Aaron J. Miller
  • Patent number: 8499966
    Abstract: A method of administering small, bioadhesive drug tablets includes moving an end portion of a delivery member. A surface of the delivery member can be positioned to prevent movement of the drug tablet from a tablet cartridge channel to a delivery passage of a delivery device when the end portion of the delivery member is in a first stopped position. The end portion of the delivery member can be moved to a second position within the delivery passage such that the tablet cartridge channel is in communication with the delivery passage. The drug tablet can be conveyed into the delivery passage via the tablet cartridge channel. The end portion of the delivery member can be moved to a third position within the delivery passage to convey the drug tablet through an exit opening of the delivery device.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: August 6, 2013
    Assignee: AcelRx Pharmaceuticals, Inc.
    Inventors: Pamela Palmer, Andrew I. Poutiatine, Charles Rampersaud, Bruce Edwards, Edmond Chiu, Thomas Schreck, Stelios Tzannis, Larry Hamel
  • Patent number: 8480630
    Abstract: A modular injection device for administration of dermal filler compositions is provided. The injection device may include a handheld injector unit including a drive unit, the drive unit configured to apply an extrusion force to a fluid; a control unit remote from the injector unit, the control unit configured to control the drive unit; and a cable configured to connect the control unit to the injector unit.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: July 9, 2013
    Assignee: Allergan, Inc.
    Inventors: Christopher S. Mudd, Ahmet Tezel, Shaohui Qiu, Lee F. Powers
  • Patent number: 8479742
    Abstract: Medical devices and related methods are disclosed for delivering an implant into the body of a patient. The devices include a damping assembly having an internal chamber with a varying inner diameter, and a piston slideably disposed therein. The piston is operably connected with a catheter portion such that movement of the piston is associated with concurrent movement of the catheter for implant delivery. The varying inner diameter of the damping assembly results in a decrease in damping force during implant delivery, thus providing a substantially constant velocity of implant delivery.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: July 9, 2013
    Assignee: Hologic, Inc.
    Inventor: Matthew LaPlaca
  • Publication number: 20130131586
    Abstract: Drug storage and dispensing devices for dispensing a drug dosage form to a patient are disclosed. The dispensing device has a programmable lock-out feature for locking the dispensing device and is capable of detecting the identity of a user. The invention further provides a method for the treatment of subject, by administering to the subject a drug dosage form using a dispensing device of the invention.
    Type: Application
    Filed: January 18, 2013
    Publication date: May 23, 2013
    Applicant: AcelRx Pharmaceuticals, Inc.
    Inventor: AcelRx Pharmaceuticals, Inc.
  • Patent number: 8419722
    Abstract: An apparatus for percutaneous delivery of a sealant comprising: at least two fluid reservoirs, an introducer needle having a distal tip that is in fluid communication with at least one reservoir, a fluid delivery tube that is in fluid communication with a second reservoir, wherein the fluid delivery tube has a tip and wherein the fluid delivery tube is configured so that the tip of the fluid delivery tube does not extend past the distal tip of the introducer needle during use.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: April 16, 2013
    Assignee: Spinal Restoration, Inc.
    Inventors: Mark Richards, Brian D. Burkinshaw, Kevin Pauza, James B. Rogan, John Wheeler
  • Patent number: 8419712
    Abstract: Rectal suppositories are used to administer a predetermined drug dosage to treat a variety of diseases and symptoms in a variety of patient populations. Certain medical conditions, such as digestive disorders, may be more effectively treated when the suppository is placed in a particular location of the patient's anal canal or rectum. A method and apparatus for inserting a suppository into an animal or human may include an applicator having a barrel and plunger. The barrel maintains a first gas flow path during insertion of a suppository and the plunger maintains a second gas flow path during withdrawal of the plunger. By maintaining the first and second gas flow paths, trapped air and suction effects on the suppository are minimized or eliminated. Furthermore, patients may immediately resume day-to-day activities. These benefits may encourage patients to maintain a course of treatment thereby potentially avoiding additional complications, hospitalization, and costs.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: April 16, 2013
    Assignee: Christcot Medical Company
    Inventor: Jennifer Davagian Ensign
  • Patent number: 8409184
    Abstract: The resorbable cryoprobe device and process is a novel approach for treating localized disease allowing for the precise combined application of freezing temperatures and cytotoxic or cryosensitizing agents within a self-contained matrix/package for optimized tissue destruction. The cryopellet is comprised of a list of components including a source of cryogen to produce the sub-zero temperatures, a porous matrix to contain the cytotoxic agent, cytotoxic agent, and a delivery packet. Data presented herein demonstrates the efficacy of this approach in destroying cancerous tissue. For example, the application of freezing temperatures to ?10° C. results in approximately 15% cell death, while exposure to cytotoxic agents such as TRAIL produces minimal cell death. The utilization of the cryopellet approach results in a synergistic effect yielding complete cell death at the same temperature.
    Type: Grant
    Filed: October 28, 2009
    Date of Patent: April 2, 2013
    Assignee: CPSI Holdings LLC
    Inventors: John M. Baust, John G. Baust, Anthony T. Robilotto, Kristi K. Snyder, Robert G. Van Buskirk
  • Patent number: 8403923
    Abstract: A method and kit for treating a disc that is leaking nucleus pulposus through at least one defect in the annulus fibrosus. The method includes injecting a fibrin sealant into the disc to reduce at least a portion of the at least one defect, wherein the fibrin sealant injected into the disc comprises fibrinogen and an activating compound, wherein at least a portion of the fibrin forms after injection, with the proviso that a corticosteroid is absent from the fibrin sealant injected into the disc.
    Type: Grant
    Filed: August 17, 2005
    Date of Patent: March 26, 2013
    Assignee: Spinal Restoration, Inc.
    Inventors: Steven I. Whitlock, Brian D. Burkinshaw, Kevin Pauza
  • Patent number: 8389023
    Abstract: Novel methods for the chemical ablation of tissue (e.g. prostatic tissue) are described. These methods include the steps of: (a) providing one or more solid salt dosage form comprising 50-100% w/w salt; and (b) inserting one or more of such solid salt dosage forms into the tissue. The solid salt dosage form is optionally inserted into the tissue under real-time ultrasonic observation. An advantage of the present invention is its ability to eliminate toxic byproducts. For example, where NaCl-based solid salt dosage forms are used to effect localized chemical ablation, the concentration is ultimately reduced to the level of normal saline (i.e., about 0.9%) upon absorption by the body of the subject being treated.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: March 5, 2013
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Joseph V. DiTrolio
  • Patent number: 8377032
    Abstract: Methods and apparatus are provided for delivering a bioactive agent in a needle track formed in a target tissue mass, following formation of the needle track, by avoiding impingement of the agent against target tissue at high velocity or by using capillary action to draw the bioactive agent out of the needle during needle withdrawal. The apparatus comprises a catheter and a needle disposed within the catheter and configured to be selectively extended into the tissue mass to a predetermined depth, while dispensing the agent simultaneously with retraction of the needle along the needle track. Alternatively, or in addition, the needle may be configured to create a tissue space surrounding a distal or lateral surface of the needle, into which the bioactive agent to be infused.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: February 19, 2013
    Assignee: Nexeon MedSystems, Inc.
    Inventor: Mark C. Bates
  • Patent number: 8357114
    Abstract: Drug storage and dispensing devices for dispensing a drug dosage form are disclosed. Devices having a housing defining a nonlinear passageway and a flexible push rod to move within the nonlinear passageway are disclosed. Devices having a flexible push rod coupled to a rotation actuating member at at an end portion thereof are also disclosed.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: January 22, 2013
    Assignee: AcelRx Pharmaceuticals, Inc.
    Inventors: Andrew I. Poutiatine, Charles Rampersaud, Thomas Schreck, William Kolosi, Sascha Retailleau