Means For Ejecting Solid From Holder Patents (Class 604/59)
  • Patent number: 9585645
    Abstract: An insertion tool for a medical closure device for the sealing of an opening in a wall of a bodily organ includes a tamping force source adapted to deliver a first member to a position at the opening on one side of the wall subsequently to a second member being positioned at the opening on the opposite side of the wall. The tamping force source, which is energized prior to the tamping procedure, can be a spring, an elastic band or a pressurized gas container. A tamping spring can be compressed or extended upon loading. The tamping force source can be released in response to a manual operation or be triggered by retraction of the insertion tool.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: March 7, 2017
    Assignee: ST. JUDE MEDICAL COORDINATION CENTER BVBA
    Inventor: Dan Akerfeldt
  • Patent number: 9155859
    Abstract: A ureteral access sheath adapted for insertion into a urethra includes an elongate tube extending between a proximal end and a distal end. A handle assembly is disposed at the proximal end and includes enlarged portions which inhibit migration of the sheath into the urethra. The enlarged portions are shaped like the bell of a horn with a concave, distally-facing outer surface and a convex, proximally-facing inner surface. The inner surface functions as a funnel while the outer surface is sized and configured to receive adjacent fingers of a user's hand held in its natural position. In an associated method, this shape of the handle assembly facilitates maintaining the sheath in a stationary position during insertion and removal of instrumentation. The handle assembly can be movable on the tube to facilitate variation of the sheath length.
    Type: Grant
    Filed: September 11, 2012
    Date of Patent: October 13, 2015
    Assignee: Applied Medical Resources Corporation
    Inventors: Gary R. Dulak, Ralph V. Clayman
  • Patent number: 9066847
    Abstract: Drug storage and dispensing devices for dispensing dosage forms to the oral mucosa of a patient are disclosed. The drug storage and dispensing device is a single dose applicator or a device which includes a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.
    Type: Grant
    Filed: July 3, 2007
    Date of Patent: June 30, 2015
    Assignee: AceIRx Pharmaceuticals, Inc.
    Inventors: Andrew I. Poutiatine, Charles Rampersaud, Bruce Edwards, Edmond Chiu, Stelios Tzannis, Pamela Palmer, William Kolosi, Sascha Retailleau
  • Publication number: 20150005700
    Abstract: The invention relates to a sanitary device (1) for applying at least one active principle inside a human or animal body cavity, said device comprising at least one biodegradable film (3) containing the at least one active substance and an applicator including: a main tubular body (4); and an ejector body (2) comprising a distal portion (202), at least one part of the surface of which forms a support for the at least one biodegradable film (3) and the end (203) of which is rounded, whereby said ejector body (2) can slide inside the main body (4) between at least one position in which the distal portion (202) of the ejector body (2) is located inside the main body (4) and an application position in which the distal portion (202) is located outside same, in the axial extension of the main body (4).
    Type: Application
    Filed: January 16, 2013
    Publication date: January 1, 2015
    Applicant: SOJASUN TECHNOLOGIES
    Inventors: Theo Efstathiou, Christophe Morin
  • Patent number: 8922367
    Abstract: Various exemplary embodiments relate to a medicament storage case including: a case body securable to a wall; a door connected to the body; a sleeve to contain an epinephrine injector; a medicament lock including a hook, wherein the hook is positioned to engage the sleeve when in a first position and is positioned to disengage the sleeve when in a second position; an actuator including a solenoid, wherein the solenoid, upon activation, moves the hook from the first position to the second position; a microphone configured to receive first audio as input; a speaker configured to output second audio; a communication unit configured to provide Internet connectivity; a button; and a processor configured to: in response to pressing the button: establish communication between the local user and a remote site, receive an unlock message, and in response to receiving the unlock message, activate the solenoid to release of the sleeve.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: December 30, 2014
    Assignee: Mylan, Inc.
    Inventors: John W. Denny, Kevin Ostrander
  • Patent number: 8905964
    Abstract: Drug storage and dispensing devices for dispensing a drug dosage form to a patient are disclosed. A cartridge includes a cartridge housing and a pusher. The cartridge housing defines a channel within which multiple tablets are disposed. The cartridge housing is configured to be removably coupled to a tablet dispensing device. A first portion of the pusher is disposed outside of the channel. A second portion of the pusher is movably disposed within the channel, and is configured to exert a force on the plurality of tablets to convey a first tablet from the channel into the tablet delivery device when the force is exerted on the first portion of the pusher.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: December 9, 2014
    Assignee: AcelRx Pharmaceuticals, Inc.
    Inventors: Andrew I. Poutiatine, Charles Rampersaud, Thomas Schreck, William Kolosi, Sascha Retailleau
  • Patent number: 8888745
    Abstract: The invention pertains to an applicator (1) for inserting an implant, in particular a rod-like implant (2) containing an active substance, under the skin of a human or animal, comprising a housing (3), a cannula (6) extending from the housing (3), and a handle (15) for grasping and maneuvering the applicator (1) and the cannula (6) during insertion of an implant (2). In accordance with the invention, the handle (15) extends above at least part of the length of the cannula (6). Such a handle facilitates insertion of the cannula and/or accurate positioning of the implant.
    Type: Grant
    Filed: January 20, 2006
    Date of Patent: November 18, 2014
    Assignee: Merck Sharp & Dohme B.V.
    Inventors: Iris Epkjen Hobo Van Der Graaf, Maurice Petrus Wilhelmus Tak, Juergen Schmidt, Hendricus Johannes Vertegaal
  • Patent number: 8858593
    Abstract: An emergency medical device and method is provided for treatment of open wounds by enhancing clotting and arresting hemorrhaging, particularly in the area of the neck, abdomen, chest or groin. The devices includes an elongated delivery tube for insertion into a wound cavity and subsequent delivery of a space filling, sponge-like mass containing a polymerizable liquid sealant that polymerizes upon contact with body fluids after which the delivery tube is removed.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: October 14, 2014
    Assignee: Charles W. Kerber, M.D., Inc.
    Inventor: Charles W. Kerber
  • Patent number: 8821434
    Abstract: A method for transferring a solid body across a surface of a biological body includes (i) applying an electrical input to a controllable electromagnetic actuator; (ii) producing with the electromagnetic actuator a mechanical force corresponding to the electrical input; and (iii) applying the mechanical force to a reservoir coupled at one end to a nozzle, the mechanical force producing a pressure within the reservoir, a magnitude of the pressure varying with the mechanical force and causing ejection of a fluid from the reservoir to drive the solid body into the biological body. A method for delivering a substance to a target body includes (i) positioning a needle-free injector proximate to a surface of the target body; (ii) injecting the substance into the target body; and (iii) while injecting, moving the needle-free injector along the surface, thereby sweeping the surface.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: September 2, 2014
    Assignee: Massachusetts Institute Of Technology
    Inventors: Ian W. Hunter, Andrew J. Taberner, N. Catherine Hogan
  • Patent number: 8790293
    Abstract: Disclosed herein is an injector device for delivering an implant, the device including a retracting element, a cannula needle, and a plunger. The device may comprise an latch that, when actuated by a user, causes the retracting element to move the cannula needle away from the delivery site, allowing the plunger to eject the implant into the site. The device may be configured for intraocular drug delivery.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: July 29, 2014
    Assignee: pSivida US, Inc.
    Inventors: Martin Nazzaro, Josh York, Ron LeBlanc
  • Patent number: 8753308
    Abstract: Systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject using a device are disclosed. The dispensing device includes a lock-out feature and a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: June 17, 2014
    Assignee: AcelRx Pharmaceuticals, Inc.
    Inventors: Pamela Palmer, Andrew Poutiatine, Charles Rampersaud, Bruce Edwards, Edmond Chiu, Thomas Schreck, Stelios Tzannis, Lawrence Hamel, William Kolosi, Sascha Retailleau
  • Patent number: 8721621
    Abstract: A method delivers an implantable device through the urethra and into the bladder. A deployment instrument is inserted into the urethra, the implantable device is inserted into the deployment instrument, and a stream of fluid is injected into the deployment instrument. The stream of fluid drives the implantable device from the deployment instrument into the bladder. The deployment instrument is removed from the urethra, leaving the implantable device wholly implanted in the bladder.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: May 13, 2014
    Assignee: TARIS Biomedical, Inc.
    Inventors: Jim Boyko, Grace Kim, Heejin Lee, Michael J. Cima, Jennie Kwo
  • Patent number: 8715223
    Abstract: Drug depot delivery devices and methods are provided for delivering one or more drug depots in close proximity to the nerve of a patient with or without repositioning the cannula. The device includes an electronic monitor for detecting the proximity of the tip of the cannula to a nerve. In some embodiments, a method of delivering a drug depot is provided by detecting the nerve and delivering the drug depot near the nerve.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: May 6, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Patent number: 8702684
    Abstract: A device (10) for receiving implanted biological material includes a mechanoprotective surface (16) defining an adjacent space, an assembly (26, 28) for locally delivering media to said space, and a pump or slow/sustained release reservoir structure (14) operatively coupled to the assembly. The device may comprise an additional plunger body for being disposed in said space. The implanted biological material may be encapsulated or non-encapsulated.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: April 22, 2014
    Assignees: University of Miami, Converge Biotech Inc.
    Inventors: Nicholas Bodor, Peter Buchwald, Christopher A. Fraker, Jeffrey Hubbell, Luca Inverardi, Norma Sue Kenyon, Paul Latta, Antonello Pileggi, Cheryl Stabler Anderson, Fabio Grassi, Camillo Ricordi
  • Publication number: 20140107423
    Abstract: An apparatus for insertion in an ear is provided in one example and includes a drug delivery device for insertion into an external auditory canal, wherein the drug delivery device contains one or more pharmaceutically active agents that can be released from the drug delivery device into the external auditory canal. In more particular instances, the drug delivery device can conform to the profile of the external auditory canal.
    Type: Application
    Filed: September 14, 2012
    Publication date: April 17, 2014
    Inventor: Yoseph Yaacobi
  • Patent number: 8679072
    Abstract: The invention relates to a process for producing a bone-regeneration material. According to the method, a bio-compatible, open-pored body is exposed to a vacuum and osteoinductive and/or osteogenic substances are absorbed into the pores of the body, for example by means of a vacuum generated therein. It is thus possible to produce a bone-regeneration material, which contains osteoinductive and/or osteogenic substances in the pores of the bio-compatible body, said substances acting as a network structure for new somatic cells that are to grow into the porous body.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: March 25, 2014
    Assignee: DePuy Synthes Products, LLC
    Inventor: Thierry Stoll
  • Patent number: 8652092
    Abstract: The invention relates to applicators (1) for implantation of an implant, having a cylinder (2) and a plunger (3) displaceably mounted therein, which plunger (3) has a pusher plunger (31) for pushing the implant out of a cannula, the cannula being mounted on a cylinder part, the cylinder part (4) being movably guided in the cylinder (2), there being provided a gear mechanism (5) which couples the plunger (3) to the cylinder part (4), a movement of the plunger (3) relative to the cylinder (2) being converted into an opposite movement of the cylinder part (4).
    Type: Grant
    Filed: May 4, 2006
    Date of Patent: February 18, 2014
    Assignee: Acino AG
    Inventor: Oliver Bussmann
  • Publication number: 20140018725
    Abstract: The present invention relates to novel drug delivery technology in the form of solid dose injection devices and methods which utilise a blade that is pushed into the skin to a predetermined depth before the before a solid drug formulation is pushed into the cut made by the blade. Thus the present invention also relates to delivering a therapeutic compound to a human or animal in the form of a solid dose injection comprising: providing an injection device comprising a casing; an actuation mechanism capable of ei generating a force, a blade, a solid drug formulation; and a means for pushing said solid drug formulation; wherein the blade is inser ted to a predetermined depth in the skin and, following insertion of the blade, the device is actuated such that the actuation mechanism capable of generating a force acts on the means for pushing to push the solid drug formulation out of the casing and into the human or animal body.
    Type: Application
    Filed: January 20, 2012
    Publication date: January 16, 2014
    Applicant: GLIDE PHARMACEUTICAL TECHNOLOGIES LIMITED
    Inventors: Charles Potter, John Watson
  • Publication number: 20130331777
    Abstract: Devices and methods for delivering therapeutic agents use an inverted member to deliver a therapeutic agent with little or no shear stress. The inverted member may have a movable continuous surface, the movable continuous surface having a first section and a second section opposing the first section, the second section surrounding an inner cavity that is configured to hold the therapeutic agent, the inverting member being configured to deliver the therapeutic agent by inverting at least a portion of the second section.
    Type: Application
    Filed: March 19, 2012
    Publication date: December 12, 2013
    Applicants: CELL PRECISION, LLC, EMORY UNIVERSITY
    Inventors: W. Robert Taylor, Raymond P. VIto, Michael L. Wach, Jack Griffis
  • Patent number: 8579852
    Abstract: Methods and devices to process harvested skin tissue and to immediately reintroduce the ground tissue into the patient to repair a tissue defect are disclosed. A hand-held portable tissue grinder comprising a housing and a grinding element are disclosed. The tissue grinder is used for grinding skin and subcutaneous tissue and includes a sterile polymer housing having a first opening adapted to receive the skin and subcutaneous tissue. The tissue grinder also includes a sterile grinding element disposed substantially within the housing. The grinding element includes a plurality of cutting surfaces adapted to operably engage with the housing to provide ground tissue and further includes a handle mechanism coupled to the grinding element to move the grinding element with respect to the housing to grind the skin and subcutaneous tissue, wherein the ground tissue can be removed from the housing.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: November 12, 2013
    Inventor: Omeed Memar
  • Patent number: 8574189
    Abstract: Dispensing devices and systems for oral transmucosal administration of small volume drug dosage forms to the oral mucosa are provided. The dispensing device may be a single dose applicator (SDA), or an electromechanical device comprising a means for patient identification such as a wrist worn RFID tag and annular bidirectional antenna together with a lock-out feature.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: November 5, 2013
    Assignee: AcelRx Pharmaceuticals, Inc.
    Inventors: Andrew Poutiatine, Bruce Edwards, Charles Rampersaud, Pamela Palmer, Bradley Blackwood, Benjamin K. Yaffe
  • Patent number: 8574188
    Abstract: The invention relates to a novel drug delivery technology. More particularly the invention relates to a method of delivering at least one therapeutic compound or a formulation comprising the at least one therapeutic compound to a patient; to a throwaway or reusable device for delivering at least one therapeutic compound or a formulation comprising the at least one therapeutic compound to a patient in a manner as set out by the method; to a pioneer projectile for use in said method; to formulations for use in said method and to an injectate comprising a pioneer projectile and formulation. It also relates to a disposable component containing either a pioneer projectile or an injectate. The invention also relates to a throwaway or reusable device for delivering at least one therapeutic compound, or a formulation comprising the at least one therapeutic compound (hereafter drug) to a patient, and a method for administering a drug to a patient using said device.
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: November 5, 2013
    Assignee: Glide Pharmaceutical Technologies Limited
    Inventors: David Stuart Potter, Charles David Ogilvy Potter
  • Patent number: 8545377
    Abstract: A magazine for chain components of a chain with radiation sources comprises a housing as well as a first means for receiving chain components that is mounted in a pivotal manner in the housing and has recesses for receiving the chain components, a tension spring for driving the means for receiving the chain components, a sprocket being coupled in a pivotal manner to the means for receiving the chain components and being mounted in a pivotal position in the housing, and an ejector for ejection of the radiation sources. Furthermore, the magazine comprises an ejection lever which is mounted in a pivotal manner in the housing, whereby, in a first position, the ejection lever engages the sprocket, and in a second position it blocks the ejector.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: October 1, 2013
    Assignee: Eckert & Ziegler Bebig GmbH
    Inventors: Axel Hentrich, Christoph Lederer
  • Patent number: 8535701
    Abstract: The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: September 17, 2013
    Assignee: Intarcia Therapeutics, Inc.
    Inventors: John R. Peery, Keith E. Dionne, Felix A. Landrau, Bonnie J. Eckenhoff, Scott D. Lautenbach, Judy A. Magruder, Jeremy C. Wright
  • Patent number: 8529550
    Abstract: Catheter systems and methods for implanting helical or dart-like implants into the myocardium or other body tissue. The catheter system includes a helix for fixing the distal end of the catheter to the myocardium, an implant held by the helix, mechanisms for driving the fixation helix into the myocardium, and mechanisms for driving the implant into the myocardium, removing the fixation helix and leaving the implant behind. The implant may be coated, filled, or made of a drug or drug eluting compound, or drug delivery matrix of any composition.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: September 10, 2013
    Assignee: BioCardia, Inc.
    Inventors: Daniel C. Rosenman, Peter A. Altman, Mark A. Lovich, Michael A. Schwartz, Aaron J. Miller
  • Patent number: 8499966
    Abstract: A method of administering small, bioadhesive drug tablets includes moving an end portion of a delivery member. A surface of the delivery member can be positioned to prevent movement of the drug tablet from a tablet cartridge channel to a delivery passage of a delivery device when the end portion of the delivery member is in a first stopped position. The end portion of the delivery member can be moved to a second position within the delivery passage such that the tablet cartridge channel is in communication with the delivery passage. The drug tablet can be conveyed into the delivery passage via the tablet cartridge channel. The end portion of the delivery member can be moved to a third position within the delivery passage to convey the drug tablet through an exit opening of the delivery device.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: August 6, 2013
    Assignee: AcelRx Pharmaceuticals, Inc.
    Inventors: Pamela Palmer, Andrew I. Poutiatine, Charles Rampersaud, Bruce Edwards, Edmond Chiu, Thomas Schreck, Stelios Tzannis, Larry Hamel
  • Patent number: 8480630
    Abstract: A modular injection device for administration of dermal filler compositions is provided. The injection device may include a handheld injector unit including a drive unit, the drive unit configured to apply an extrusion force to a fluid; a control unit remote from the injector unit, the control unit configured to control the drive unit; and a cable configured to connect the control unit to the injector unit.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: July 9, 2013
    Assignee: Allergan, Inc.
    Inventors: Christopher S. Mudd, Ahmet Tezel, Shaohui Qiu, Lee F. Powers
  • Patent number: 8479742
    Abstract: Medical devices and related methods are disclosed for delivering an implant into the body of a patient. The devices include a damping assembly having an internal chamber with a varying inner diameter, and a piston slideably disposed therein. The piston is operably connected with a catheter portion such that movement of the piston is associated with concurrent movement of the catheter for implant delivery. The varying inner diameter of the damping assembly results in a decrease in damping force during implant delivery, thus providing a substantially constant velocity of implant delivery.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: July 9, 2013
    Assignee: Hologic, Inc.
    Inventor: Matthew LaPlaca
  • Publication number: 20130131586
    Abstract: Drug storage and dispensing devices for dispensing a drug dosage form to a patient are disclosed. The dispensing device has a programmable lock-out feature for locking the dispensing device and is capable of detecting the identity of a user. The invention further provides a method for the treatment of subject, by administering to the subject a drug dosage form using a dispensing device of the invention.
    Type: Application
    Filed: January 18, 2013
    Publication date: May 23, 2013
    Applicant: AcelRx Pharmaceuticals, Inc.
    Inventor: AcelRx Pharmaceuticals, Inc.
  • Patent number: 8419722
    Abstract: An apparatus for percutaneous delivery of a sealant comprising: at least two fluid reservoirs, an introducer needle having a distal tip that is in fluid communication with at least one reservoir, a fluid delivery tube that is in fluid communication with a second reservoir, wherein the fluid delivery tube has a tip and wherein the fluid delivery tube is configured so that the tip of the fluid delivery tube does not extend past the distal tip of the introducer needle during use.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: April 16, 2013
    Assignee: Spinal Restoration, Inc.
    Inventors: Mark Richards, Brian D. Burkinshaw, Kevin Pauza, James B. Rogan, John Wheeler
  • Patent number: 8419712
    Abstract: Rectal suppositories are used to administer a predetermined drug dosage to treat a variety of diseases and symptoms in a variety of patient populations. Certain medical conditions, such as digestive disorders, may be more effectively treated when the suppository is placed in a particular location of the patient's anal canal or rectum. A method and apparatus for inserting a suppository into an animal or human may include an applicator having a barrel and plunger. The barrel maintains a first gas flow path during insertion of a suppository and the plunger maintains a second gas flow path during withdrawal of the plunger. By maintaining the first and second gas flow paths, trapped air and suction effects on the suppository are minimized or eliminated. Furthermore, patients may immediately resume day-to-day activities. These benefits may encourage patients to maintain a course of treatment thereby potentially avoiding additional complications, hospitalization, and costs.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: April 16, 2013
    Assignee: Christcot Medical Company
    Inventor: Jennifer Davagian Ensign
  • Patent number: 8409184
    Abstract: The resorbable cryoprobe device and process is a novel approach for treating localized disease allowing for the precise combined application of freezing temperatures and cytotoxic or cryosensitizing agents within a self-contained matrix/package for optimized tissue destruction. The cryopellet is comprised of a list of components including a source of cryogen to produce the sub-zero temperatures, a porous matrix to contain the cytotoxic agent, cytotoxic agent, and a delivery packet. Data presented herein demonstrates the efficacy of this approach in destroying cancerous tissue. For example, the application of freezing temperatures to ?10° C. results in approximately 15% cell death, while exposure to cytotoxic agents such as TRAIL produces minimal cell death. The utilization of the cryopellet approach results in a synergistic effect yielding complete cell death at the same temperature.
    Type: Grant
    Filed: October 28, 2009
    Date of Patent: April 2, 2013
    Assignee: CPSI Holdings LLC
    Inventors: John M. Baust, John G. Baust, Anthony T. Robilotto, Kristi K. Snyder, Robert G. Van Buskirk
  • Patent number: 8403923
    Abstract: A method and kit for treating a disc that is leaking nucleus pulposus through at least one defect in the annulus fibrosus. The method includes injecting a fibrin sealant into the disc to reduce at least a portion of the at least one defect, wherein the fibrin sealant injected into the disc comprises fibrinogen and an activating compound, wherein at least a portion of the fibrin forms after injection, with the proviso that a corticosteroid is absent from the fibrin sealant injected into the disc.
    Type: Grant
    Filed: August 17, 2005
    Date of Patent: March 26, 2013
    Assignee: Spinal Restoration, Inc.
    Inventors: Steven I. Whitlock, Brian D. Burkinshaw, Kevin Pauza
  • Patent number: 8389023
    Abstract: Novel methods for the chemical ablation of tissue (e.g. prostatic tissue) are described. These methods include the steps of: (a) providing one or more solid salt dosage form comprising 50-100% w/w salt; and (b) inserting one or more of such solid salt dosage forms into the tissue. The solid salt dosage form is optionally inserted into the tissue under real-time ultrasonic observation. An advantage of the present invention is its ability to eliminate toxic byproducts. For example, where NaCl-based solid salt dosage forms are used to effect localized chemical ablation, the concentration is ultimately reduced to the level of normal saline (i.e., about 0.9%) upon absorption by the body of the subject being treated.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: March 5, 2013
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Joseph V. DiTrolio
  • Patent number: 8377032
    Abstract: Methods and apparatus are provided for delivering a bioactive agent in a needle track formed in a target tissue mass, following formation of the needle track, by avoiding impingement of the agent against target tissue at high velocity or by using capillary action to draw the bioactive agent out of the needle during needle withdrawal. The apparatus comprises a catheter and a needle disposed within the catheter and configured to be selectively extended into the tissue mass to a predetermined depth, while dispensing the agent simultaneously with retraction of the needle along the needle track. Alternatively, or in addition, the needle may be configured to create a tissue space surrounding a distal or lateral surface of the needle, into which the bioactive agent to be infused.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: February 19, 2013
    Assignee: Nexeon MedSystems, Inc.
    Inventor: Mark C. Bates
  • Patent number: 8357114
    Abstract: Drug storage and dispensing devices for dispensing a drug dosage form are disclosed. Devices having a housing defining a nonlinear passageway and a flexible push rod to move within the nonlinear passageway are disclosed. Devices having a flexible push rod coupled to a rotation actuating member at at an end portion thereof are also disclosed.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: January 22, 2013
    Assignee: AcelRx Pharmaceuticals, Inc.
    Inventors: Andrew I. Poutiatine, Charles Rampersaud, Thomas Schreck, William Kolosi, Sascha Retailleau
  • Patent number: 8357147
    Abstract: A method of repairing a defect in an annulus fibrosus of an intervertebral disc, without excising the entire nucleus pulposus of the disc. The method includes inserting an introducer needle through the annulus fibrosus by puncturing the annulus fibrosus with the introducer needle, injecting an in situ curable, bio-compatible polymerizable or polymeric material composition into the disc through the introducer needle directly or indirectly so that the in situ curable composition contacts a defect in the annulus fibrosus; and curing said material in situ.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: January 22, 2013
    Assignee: Spinal Restoration, Inc.
    Inventors: Brian D. Burkinshaw, John L. Wheeler, James B. Rogan, Steven I. Whitlock
  • Patent number: 8353863
    Abstract: Embodiments described herein provide a skin penetrating device and method for the subcutaneous delivery of therapeutic agents in solid form. One embodiment provides such a device comprising an elongated shaft having proximal and distal ends and a skin penetrating element detachably coupled to the shaft. At least a portion of the penetrating element is fabricated from a solid form therapeutic agent composition that dissolves in body tissue and is absorbed into the blood stream so as to produce a therapeutic effect. The penetrating element has shape for penetrating and lodging beneath the skin when inserted through the skin by force applied from the shaft. The penetrating element is configured to detach from the shaft when the shaft is pulled away from the skin so as to leave the element in place beneath the skin where it is absorbed by body tissue and the therapeutic agent is released.
    Type: Grant
    Filed: February 12, 2010
    Date of Patent: January 15, 2013
    Assignee: InCube Labs, Inc.
    Inventor: Mir Imran
  • Patent number: 8348882
    Abstract: An instrument with a covered bore for subcutaneous implantation is provided. An incising body defines a non-circular coaxial bore and includes a sharpened cutting edge that extends from a bottom distal end beyond the opening of the coaxial bore and an attachment point at a top distal end. A plunger is non-fixedly contained within the coaxial bore and slides longitudinally therein. A cover is pivotally attached at the attachment point and extends down to the bottom distal end and, when closed, the cover encloses the opening proximal to the cutting edge.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: January 8, 2013
    Assignee: Cardiac Science Corporation
    Inventor: Gust H. Bardy
  • Patent number: 8337453
    Abstract: A pellet loading apparatus has a pellet housing configured to receive and hold a plunger so that a cavity is formed by an interior surface of the pellet housing and the plunger. A pellet is located or formed in the cavity. A dispensing chamber housing is located in a disposable drug delivery device. The dispensing chamber housing is configured to couple with the pellet housing so that the plunger and the pellet can be loaded into the dispensing chamber housing.
    Type: Grant
    Filed: December 3, 2008
    Date of Patent: December 25, 2012
    Assignee: Alcon Research, Ltd.
    Inventor: Casey Jean Lind
  • Patent number: 8328753
    Abstract: The bioinjection device has a housing including a pistol grip and an elongated barrel. A trigger is pivotally mounted to the housing. A plunger and needle are slidable between a first position in which the plunger and needle are slidably disposed in the barrel and a second position in which the plunger and needle extend from an opening in the end of the barrel. A retaining member is disposed about the opening at the end of the barrel. A spring-biased actuation mechanism connects the trigger with the plunger and needle. A membranous cartridge containing bone morphogenic protein, antibiotics, and/or other medication is loaded into the retaining member. A surgeon can inject the cartridge into a bone fracture or degenerative bone tissue during surgery to deliver the medicament directly to the affected site.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: December 11, 2012
    Inventors: Clifford T. Solomon, Theodore C. Solomon
  • Patent number: 8323232
    Abstract: An instrument with a two-part plunger for subcutaneous implantation is provided. An incising body defines a non-circular coaxial bore and includes a cutting edge formed on a distal end. A two-part plunger is non-fixedly contained within the coaxial bore and includes a tongue blade assembly and a plunger assembly. The tongue blade assembly is provided on a bottom surface of the coaxial bore and includes a tongue blade shaft and a thin tongue blade with a sharpened clearing edge on a distal end. The tongue blade assembly has a length exceeding the coaxial bore. The plunger assembly has a length exceeding the coaxial bore and includes a plunger shaft and a plunger affixed on a distal end. The plunger is slidably positioned on a top surface of the tongue blade.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: December 4, 2012
    Assignee: Cardiac Science Corporation
    Inventor: Gust H. Bardy
  • Patent number: 8308678
    Abstract: A device for delivering a medicated product or the like to a bodily cavity is provided. The device includes a barrel member having a distal end. The barrel member is sized to contain the medicated product. The device includes a plunger sized to extend into the barrel member. A cap is adapted to move between a sealing position, in which the cap is positioned adjacent to the barrel member and seals the distal end of the barrel member, and a dispensing position, in which the cap is moved in a direction away from the barrel member. The cap includes at least one opening sized to allow the medicated product to flow through the cap when the cap is in the dispensing position. A retainer mechanism is provided for retaining the cap on the barrel when the cap is in the dispensing position.
    Type: Grant
    Filed: September 23, 2008
    Date of Patent: November 13, 2012
    Assignee: McNeil-PPC, Inc.
    Inventor: Paul B. Swick
  • Patent number: 8308708
    Abstract: A catheter-based deployment system for deploying cellular material (22) into the heart muscle (25). The deployment system includes a guiding catheter (19) and a needle assembly (31) capable of sliding within the guiding catheter. The needle assembly (31) terminates in a tip (34) having at least one side with an opening (43) in communication with a lumen (20) disposed within the needle assembly (31). Once the guiding catheter (19) is positioned, the needle assembly (31) is advanced until the tip (34) penetrates the muscle wall (25). At a predetermined depth the cellular material (22) may be deployed into the muscle wall (25) via a push rod (46) disposed through the lumen of the needle assembly (31).
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: November 13, 2012
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Howard J Leonhardt, Robert D. Lashinski
  • Publication number: 20120238993
    Abstract: The invention provides a drug delivery device for one or more drugs. The device has a drug core which is surrounded by an internal and external sheath. The external sheath has a first cap that is permeable to at least one drug in the core. The first cap may comprise polyvinyl alcohol (PVA), and the PVA may be heat cured. In certain aspects, there are one or more additional caps on the ends of the sheaths formed from one or more polymers. In certain aspects, one or more portions of the drug delivery device are substantially impermeable to one or more drugs in the drug core. In certain aspects, the drug elutes through the first cap into a biological environment. The invention further provides methods for manufacturing the drug delivery device.
    Type: Application
    Filed: December 21, 2011
    Publication date: September 20, 2012
    Inventors: Martin Nazzaro, Josh York, Paul Ashton
  • Patent number: 8246570
    Abstract: The present invention provides a cell transplantation device which is capable of inserting cells for transplantation into a cell-deficient site without application of direct external force to the cells. The present invention discloses a cell transplantation device provided with a plate-type carrier with at least one pass-through hole formed on its side surface, a linear member to be threaded through the pass-through hole, and a pusher member which engages with the linear member that comes out from each exit of the pass-through holes.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: August 21, 2012
    Assignees: Japan Medical Materials Corporation
    Inventors: Yukihide Iwamoto, Koichi Nakayama, Hiromasa Miura, Kazuhiro Tanaka, Shuichi Matsuda
  • Publication number: 20120209170
    Abstract: Rectal suppositories are used to administer a predetermined drug dosage to treat a variety of diseases and symptoms in a variety of patient populations. Certain medical conditions, such as digestive disorders, may be more effectively treated when the suppository is placed in a particular location of the patient's anal canal or rectum. A method and apparatus for inserting a suppository into an animal or human may include an applicator having a barrel and plunger. The barrel maintains a first gas flow path during insertion of a suppository and the plunger maintains a second gas flow path during withdrawal of the plunger. By maintaining the first and second gas flow paths, trapped air and suction effects on the suppository are minimized or eliminated. Furthermore, patients may immediately resume day-to-day activities. These benefits may encourage patients to maintain a course of treatment thereby potentially avoiding additional complications, hospitalization, and costs.
    Type: Application
    Filed: April 26, 2012
    Publication date: August 16, 2012
    Applicant: Christcot Medical Company
    Inventor: Jennifer Davagian Ensign
  • Patent number: 8231565
    Abstract: A device for delivering a medicated product into a bodily cavity includes a barrel member having a dispensing end, a proximal end, which is positioned opposite the dispensing end, and a bore, which extends through the barrel member. The bore is sized and shaped so as to receive a medicated product therein and includes an opening formed in the dispensing end of the barrel member. The opening is sized and shaped so as to permit a medicated product received in the bore to be dispensed therethrough. The applicator is also provided with a plunger member movably extending through the bore of the barrel member for dispending a medicated product from the bore through the opening. The barrel member includes at least one substantially flexible section located between the dispending end and the proximal end such that the barrel member is bendable about the flexible section.
    Type: Grant
    Filed: March 23, 2007
    Date of Patent: July 31, 2012
    Assignee: McNeil-PPC, Inc.
    Inventor: Paul B. Swick
  • Patent number: 8221344
    Abstract: An apparatus for insertion of a medicine peg (3) into the skin (4) has a barrel (2) wherein the medicine peg (2) is stored and in which a plunger (8) behind said peg (2) can be moved to press the peg out through an end of the barrel (2) pressed against the skin (4) where it is intended to insert the peg (3), The plunger (8) is a part of a flexible rod construction (6, 7, 8) which can be passed from a first non rectilinear constellation, by which the plunger (8) is withdrawn in the barrel (2) to a position leaving space for the medicine peg (3) in front of the plunger (8), to a rectilinear constellation by which the plunger (8) projects from the end of the barrel (2) and further to a new non rectilinear position in which the end of the plunger (8) is withdrawn in the barrel (2).
    Type: Grant
    Filed: November 25, 2008
    Date of Patent: July 17, 2012
    Assignee: Novo Nordisk A/S
    Inventor: Mads Christian Sabra
  • Patent number: 8177738
    Abstract: Apparatus and methods for delivering a clotted biological component (such as blood, autologous conditioned plasma (ACP), platelet-rich plasma (PRP), bone marrow aspirate (BMA), demineralized bone matrix, anticoagulants and/or clotting agents, or combination of these materials) into a tissue void (for example, a bone void such as a bone tunnel, socket, opening or cavity), and then cutting the clotted biological component with a cutting or shearing mechanism at the tissue surface. The apparatus is provided with a tube and a cutting or shearing mechanism (provided on or within the distal end of the tube) that is actuated to cut or break off the clot at the desired insertion length. The tube may then be placed over the next tissue void so that the obturator drives the next clot into the next tissue void until all tissue voids are filled. Upon insertion at the defect site, the biological component advances the healing of the damaged tissue and tissue growth.
    Type: Grant
    Filed: July 21, 2010
    Date of Patent: May 15, 2012
    Assignee: Arthrex, Inc.
    Inventors: Reinhold Schmieding, Robert Benedict