Abstract: A method for generating and updating a three-dimensional representation of a surgical site based on imaging data from an imaging system is disclosed. The method comprises the steps of generating a first image of the surgical site based on structured electromagnetic radiation emitted from the imaging system, receiving a second image of the surgical site, aligning the first image and the second image, generating a three-dimensional representation of the surgical site based on the first image and the second image as aligned, displaying the three-dimensional representation on a display screen, receiving a user selection to manipulate the three-dimensional representation, and updating the three-dimensional representation as displayed on the display screen from a first state to a second state according to the received user selection.

Abstract: A system and method for transmyocardial laser revascularization (TMLR) in patients in need thereof, such as patients suffering from coronary artery disease. The system includes a Laser unit, an Electrocardiogram (EKG) unit, Vectorcardiography (VCG) unit, an Echocardiography unit, a spectrum Infrared sensor unit, and a control unit. The control unit can receive investigational data from different units and use the same to optimize the laser parameters. The Control unit can further include an AI module that can further analyze patient-related data, such as age and medical condition to further optimize the laser parameters. The laser unit can operate based on the optimized parameters to prevent unnecessary damage to the heart and allow maintaining the patency of the channels made by the laser for a longer duration.

Abstract: The invention relates to a method and an arrangement for the cleaning of a circumferentially closed canal by means of a light guide conducting a laser beam, wherein the entry of the laser beam into the light guide is interrupted when the free end of the light guide is outside of the canal and/or the movement of the light guide within the canal is monitored and if there is no movement or the movement is below a first threshold value then a signal is triggered and/or the laser radiation is turned off or its output is reduced, and wherein the turning off of the laser radiation or its reducing is controlled in dependency of at least one signal change and/or a second threshold and/or a signal change relative to the second threshold determined during at least one course of time starting before and including the entry of the light guide into the canal.

Abstract: A photo detector is selectively coupled to a first integrator or a second integrator with switching circuitry when the laser pulses. An integration time of the signal from the photo detector can be substantially greater than an amount of time between successive laser beam pulses in order to provide an accurate measurement of each laser beam pulse of a high repetition rate pulsed laser. The laser may comprise a clock coupled to an optical switch of the laser system, and control circuitry can control switching and coupling of the detector to the first integrator or the second integrator in response to the clock signal. The first integrator and the second integrator can be selectively coupled to an output such that the first integrator or the second integrator is coupled to the output of the energy detection circuitry when the other integrator is coupled to the detector.

Abstract: A cautery safety controller can include a first input to receive a cautery power signal; a first output coupled to a nerve stimulator system; a second input coupled to receive a nerve detected signal; a zero-crossing detector coupled to receive the cautery power signal via the first input and output a nerve sense enable signal via the first output to the nerve stimulator system in response to detecting a zero crossing of the cautery power signal; and a nerve detection decision unit coupled to receive the nerve detected signal via the second input, generate a stop operation signal, and output the stop operation signal via a second output. A cauterizing pencil can be provided with a tap line for providing the cautery power signal. Alternatively, a cautery pad can be provided with a sense electrode for providing the cautery power signal.

Abstract: An applicator device includes a photo-active formulation assembly and a photo-dose assembly operably coupled to the photo-active formulation assembly. The photo-active formulation assembly includes one or a plurality of dispenser portions and one or more photo-activatable formulation reservoirs. The photo-active formulation assembly is operable to dispense a photo-activatable formulation from the one or more photo-activatable formulation reservoirs onto one or more regions of a biological surface. The photo-dose assembly includes at least one illuminator oriented to focus electromagnetic energy onto one or more focal regions of a biological surface. The focused electromagnetic energy is of a character and for a duration sufficient to photo-activate the photo-activatable formulation dispensed from the one or more photo-activatable formulation reservoirs.

Abstract: A method, apparatus, and system are provided to monitor and characterize the dynamics of a phase change region (PCR) created during laser welding, specifically keyhole welding, and other material modification processes, using low-coherence interferometry. By directing a measurement beam to multiple locations within and overlapping with the PCR, the system, apparatus, and method are used to determine, in real time, spatial and temporal characteristics of the weld such as keyhole depth, length, width, shape and whether the keyhole is unstable, closes or collapses. This information is important in determining the quality and material properties of a completed finished weld. It can also be used with feedback to modify the material modification process in real time.

Abstract: Systems, devices, and methods for identifying a target in vivo are disclosed. A target identification system for use in electrosurgery includes a probe, an optical splitter, and a spectroscopy system. The probe includes an optical pathway to pass a first optical signal to an anatomical target and at least a portion of a second optical signal from the anatomical target. The optical splitter includes a first port to direct the first optical signal to the optical pathway and to receive the at least a portion of the second optical signal from the optical pathway, a second port to receive the first optical signal, and a parabolic reflector to redirect the portion of the second optical signal. The spectroscopy system can identify a characteristic of the anatomical target based on the redirected at least a portion of the second optical signal.

Abstract: A system for ophthalmic surgery on an eye includes: a pulsed laser which produces a treatment beam; an OCT imaging assembly capable of creating a continuous depth profile of the eye; an optical scanning system configured to position a focal zone of the treatment beam to a targeted location in three dimensions in one or more floaters in the posterior pole. The system also includes one or more controllers programmed to automatically scan tissues of the patient's eye with the imaging assembly; identify one or more boundaries of the one or more floaters based at least in part on the image data; iii. identify one or more treatment regions based upon the boundaries; and operate the optical scanning system with the pulsed laser to produce a treatment beam directed in a pattern based on the one or more treatment regions.

Abstract: A light guide or beam guiding system with safety component and a method for its breakage monitoring. The present invention provides a fiber optic cable comprising a power fiber as well as first and second channels for break and plug monitoring of the power fiber, wherein the first and second channels may be separate.

Abstract: A device and method of using the device to detect the presence and composition of clots and other target objects in a circulatory vessel of a living subject is described. In particular, devices and methods of detecting the presence and composition of clots and other target objects in a circulatory vessel of a living subject using in vivo photoacoustic flow cytometry techniques is described.

Abstract: The present disclosure relates to a photodental device that can deliver specific light wavelengths to animal oral cavities, particularly dogs. The device may be provided in a variety of shapes, sizes, and materials, for breeds from under 2 kg (4.4 lbs) to over 115 kg (254 lbs). The device has a container which may protect light sources and may be used to receive light transmission, comprising an illuminating member. The device can further include replaceable housings with photoactivated compounds. The device may be configured for untethered use by an animal. Alternatively, the electro-optical components can be placed in a separate body and transmit light through a tethered connection to a member used by an animal. Sensor components may activate light generation components in predetermined conditions. Alternatively, humans may control activation. The present disclosure also relates to methods of photodentistry using the photodental device as bactericidal treatment and periodontal treatment.

Abstract: A laser processing apparatus 10 includes a continuous-wave laser oscillator 12 for generating a continuous-wave laser beam, a condenser lens 18 for concentrating a continuous-wave laser beam onto a workpiece, and a delay time setting means for calculating an energy value for each processing by a continuous-wave laser beam irradiation on the basis of processing data and accumulating the calculated energy value, and setting a predetermined delay time between the processings when the accumulated energy value exceeds a predetermined threshold.

Abstract: A scanning device for focusing a beam of rays in defined regions of a defined volume, comprising an input optics wherein the beam of rays penetrates first, having at least one first optical element; a focusing optics for focusing the beam of rays exiting from the input optics; and a deflecting device arranged between the first optical element and the focusing optics, for deflecting the beam of rays after it has passed through the first optical element, based on a position of the focus to be adjusted in lateral direction. In order to adjust the position of the focus of the beam of rays in the direction of the beam of rays, and optical element of the input optics can be displaced relative to the deflecting device.

Abstract: A waveguide, in particular an optical fiber, is coated and is of flexible configuration so that the waveguide can be laid in an adaptable manner, wherein the coating includes a light-frequency-converting substance so that in the event of UV light or IR light being coupled into the waveguide and an overbent waveguide, visible light escapes from the waveguide at a bend point.

Abstract: An irradiation device comprises a light source, an optical switch element and an image recognition module communicatively connected to the optical switch element. In some embodiments, a contour of a target area is recognized by an image recognition module and is provided by the image recognition module to the optical switch element, and a contour of an irradiation area of the light source is controlled by the optical switch element to match with the contour of the target area according to the contour of the target area provided by the image recognition module. Thus, when skin diseases are treated using the irradiation device according to some embodiments of the present disclosure, the contour of the irradiation area of the light source coincides with the contour of the target area, thereby ensuring a therapeutic effect with respect to the target area while avoiding damages to skin in a healthy area.

Abstract: The present invention relates to an ophthalmic treatment device and a method for operating the same. The present invention provides an ophthalmic treatment device and a method for operating the same, the ophthalmic treatment device comprising: a treatment beam generation unit for generating a treatment beam; a beam delivery unit for forming a path along which the treatment beam generated from the treatment generation unit is delivered to a treatment area positioned on the fundus; a monitoring unit for emitting a detecting beam along the path of delivery of the treatment beam and sensing treatment area state information on the basis of information regarding a change in speckle of the detecting beam, which is scattered and reflected from the treatment area; and a control unit for controlling the driving of the treatment beam generation unit on the basis of the treatment area state information sensed by the monitoring unit.

Abstract: An endoscope system includes an endoscope having an image pickup section and a processor device for an endoscope, and optically communicates signals through a scope-side connector and a processor-side connector. In the endoscope system, an optical communication section is constituted by an image signal transmission section and an image signal reception section, and windows and are arranged. An optical communication section is constituted by a scope-side signal transception section and a processor-side signal transception section, and windows and are arranged. The endoscope system includes: a first air blowing section and a second air blowing section for removing dirt adhered on the windows; and a control section that controls the first air blowing section and the second air blowing section.

Abstract: A system for medical diagnosis includes a fiber optic cable and a plurality of light emitters optically coupled to a first end of the fiber optic cable. Each light emitter in the plurality of light emitters emits a distinct bandwidth of light. The system also includes a controller electrically coupled to the plurality of light emitters. The controller includes logic that when executed by the controller causes the controller to perform operations including: receiving instructions including an illumination mode, and adjusting an intensity of the light emitted from each light emitter in the plurality of light emitters to match the illumination mode.

Abstract: System and method for treating hemorrhoidal piles, addressing both cause and symptoms, by endoluminal/interstitial application of energy are disclosed. The dilated blood arteries in anal/rectal region are irradiated from inside the pile using (laser) energy for minimal pain/discomfort. The center of the pile is irradiated over a certain diameter, absorbing energy; and is denatured causing volume reduction. Central vessels located in the same diameter are obliterated immediately, relieving bleeding. During treatment, new connective tissue replaces the coagulated tissue. Closing inflowing arteries further shrinks piles in weeks to three months. Complications are highly diminished. A hand-piece and a fiber with a sharp distal tip are beneficial. Including an imaging system, (ultrasound imaging, optical coherence tomography) and an intelligent system to calculate necessary laser energy parameters help address each pile individually.

Abstract: A dental tissue treatment apparatus and associated methods includes a feedback-controlled beam guidance system for directing treatment to a defined area of dental tissue.

Abstract: A wearable ophthalmic device is disclosed. The device may include an outward facing head-mounted light field camera to receive light from a user's surroundings and to generate numerical light field image data. The device may also include a light field processor to access the numerical light field image data, to obtain an optical prescription for an eye of the user, and to computationally introduce an amount of positive or negative optical power to the numerical light field image data based on the optical prescription to generate modified numerical light field image data. The device may also include a head-mounted light field display to generate a physical light field corresponding to the modified numerical light field image data.

Abstract: An optical beam scanning system for incising target tissue in a patient's eye includes a laser source configured to deliver a laser beam to produce optical breakdown and initiate a plasma-mediated process; an OCT imaging device used to create an image of eye tissue that includes the cornea; a delivery system for delivering the laser beam to the target tissue to form a cataract incision; a scanner operable to scan the focal spot of the laser beam to different locations within the patient's eye; and a controller operatively coupled to the laser source, the imaging device, and the scanner. The OCT device is configured to scan the eye tissue to generate imaging data used to define an incision pattern configured to incise one or more relaxation incisions into the cornea, so that the one or more relaxation incisions are formed starting from the inside and proceeding outward.

Abstract: The subject system provides for the generation of a three-dimensional (3D) model from optical capture including the generation of the 3D model from point cloud data migration. The subject system includes generating a point cloud based on optically captured data of a project site. The subject system also includes generating raster information from the point cloud, and creating surface contours based on the raster information. The subject system also includes creating a 3D model based on the surface contours.

Abstract: A living tissue bonding system including: a sandwiching section for sandwiching living tissue; a power source for supplying to the living tissue treatment energy for bonding the living tissue sandwiched by the sandwiching section; a temperature measuring section for measuring a temperature of the living tissue sandwiched by the sandwiching section; a calculation section calculating, from the temperature of the living tissue measured by the temperature measuring section and a time period of applying the treatment energy, a time integral value of the temperature of the living tissue; a comparison section comparing the time integral value of the temperature of the living tissue calculated by the calculation section with a predetermined setting value; and an instruction section giving an instruction based on a result of the comparison by the comparison section.

Abstract: The procedures described herein may involve using one or more treatment beams to induce one or more therapeutic benefits. In some embodiments, a series of short duration light pulses may be delivered to ocular tissue at a plurality of target locations with a thermal relaxation time delay to limit the temperature rise of the target ocular tissue and thereby limit a thermal effect to only a desired portion of the ocular tissue. The thermal relaxation time delay may be roughly equivalent to a duration of a scan of the treatment beam between each of the target locations. Such procedures may be used to treat diabetic retinopathy, macular edema, and/or other conditions of the eye. The treatment beam may be delivered at each target location within a sufficiently short duration so as to produce a visual appearance of a treatment pattern on the ocular tissue of the patient's eye.

Abstract: A measurement probe is configured to be detachably connected to a biological optical measurement apparatus that performs an optical measurement on body tissue. The measurement probe includes an illumination fiber configured to irradiate the body tissue with illumination light, and a plurality of detection fibers configured to detect return light of at least one of the illumination light reflected from the body tissue and the illumination light scattered from the body tissue. On a plane which is away from distal ends of the illumination fiber and the plurality of detection fibers and through which the illumination light and the return light can pass, a detection area of the return light in each of the plurality of detection fibers is included in all of an illumination area of the illumination fiber or inside of the illumination area.

Abstract: The invention discloses an apparatus and method for use with Laser Induced Breakdown Spectroscopy (LIBS) systems that can be applied to the real time analysis of various materials. The invention, in one aspect, provides a layer-by-layer method to remove the undesired coating layer of a material in which a pulsed laser is coupled with high speed scanning optics. To prepare the surface for LIBS, (i) a pulsed laser beam is scanned over an area of the surface to ablate the surface coating layer; (ii) the laser parameters are changed (i.e. pulse duration is made smaller) and the area scanned again to polish the surface; and (iii) the laser parameters are changed again (i.e. pulse duration is made smaller yet again) and the area scanned again with spectrometric analysis of the plasma plume created by the laser (i.e. LIBS is performed).

Abstract: A design for dynamically adjusting parameters applied to a surgical instrument, such as an ocular surgical instrument, is presented. The method includes detecting surgical events from image data collected by a surgical microscope focused on an ocular surgical procedure, establishing a desired response for each detected surgical event, delivering the desired response to the ocular surgical instrument as a set of software instructions, and altering the surgical procedure based on the desired response received as the set of software instructions.

Abstract: A lighting system includes a light source configured to generate light toward one or more surfaces or materials to inactivate one or more pathogens on the one or more surfaces or materials. The light includes an inactivating portion having wavelengths in a range of 280 to 380 nanometers.

Abstract: In a laser produced plasma (LPP) extreme ultraviolet (EUV) system, a plasma created from droplets irradiated by a laser pulse can become destabilized. The instability of the plasma can reduce the amount of EUV energy generated over time. While other systems seek to stabilize the plasma by varying a pulse width of the laser pulses, the systems and methods described herein stabilize the plasma by varying an intensity of the laser pulses. The intensity of the laser pulses is varied based on a comparison of the amount of EUV energy generated from current pulse to an expected amount of EUV energy. The intensity of the laser pulses can be varied on a pulse-by-pulse basis by an EUV controller that instructs a pulse actuator.

Abstract: Systems and methods for assisting the placement of a catheter within the body of a patient through the use of an ultrasound imaging system are disclosed. In particular, the systems and methods described herein enable a clinician to determine, prior to insertion of the medical device, how much of the device will be disposed within the vessel, thus enabling the clinician to choose a catheter with suitable length. In one embodiment, an ultrasound imaging system for assisting with placement of the medical device comprises a console, a probe for producing an image of a target location, and a processor. The processor provides to a user proximity information relating to the anticipated proximity of the medical device to the target location prior to insertion of the medical device. A display is included for depicting the image, target location depth, and the proximity information of the medical device to the target location.

Abstract: A lighting system includes a light source configured to generate light toward one or more surfaces or materials to inactivate one or more pathogens on the one or more surfaces or materials. The light includes an inactivating portion having wavelengths in a range of 280 to 380 nanometers.

Abstract: An ablation procedure. The ablation procedure may be applied to tooth buds 120 and result in tooth agenesis. The ablation procedure may be applied to lesions or tumors. A tooth bud ablation system for use in a tooth bud ablation procedure that results in tooth agenesis. A method for volume scanning both hard tissues and soft tissues of a patient. A method for manufacturing or fabricating a custom surgical stent 110. A custom surgical stent 110 for use in a tooth bud ablation procedure that results in tooth agenesis, the custom surgical stent 110 for use with an ablation probe tip 108 having a center of ablation 130a.

Abstract: The present invention provides a method for indicating differentiation between tissues. For each tissue amongst multiple tissues, a magnetization vector corresponding to each tissue is generated on the basis of a random scan sequence; on the basis of the magnetization vector corresponding to each of the multiple tissues, a differentiation-indicating value between each pair of the multiple tissues is calculated. Thus, a physician can select a suitable random scan sequence, according to the method provided in the present invention, and generate a magnetic resonance image comprising multiple brightness curves corresponding to multiple tissues, such that the trends of the brightness curves corresponding to the multiple tissues in the magnetic resonance image differ significantly. The present invention also provides a device for indicating differentiation between tissues.

Abstract: Methods and arrangements for distinguishing between target areas and non-target areas during a laser surgical procedure involve coating or otherwise providing the non-target areas with a phosphorescent material that emits radiation, upon stimulation when a predetermined condition occurs, that is distinguishable from the treatment radiation.

Abstract: A method for determining the total refractive power of the cornea is based on a combination of keratometric or topographic measurements using the measured values obtained from depth scans or sectional images. The radius (Ra) of the front side of the cornea is ascertained keratometrically or topographically, the radius (Rp) of the rear side of the cornea is determined from depth scans or sectional images, and the refractive power (Ka) of the front side of the cornea, the refractive power (Kp) of the rear side of the cornea, and the total refractive power (K) of the cornea are determined. The method is used to determine the total refractive power of the cornea of an eye and is not just applicable to eyes with normal vision but in particular also to astigmatic eyes.

Abstract: A catheter is adapted to ablate tissue and provide lesion qualitative information on a real time basis, having an ablation tip section with a generally omni-directional light diffusion chamber with one openings to allow light energy in the chamber to radiate the tissue and return to the chamber. The chamber is irrigated at a positive pressure differential to continuously flush the opening with fluid. The light energy returning to the chamber from the tissue conveys a tissue parameter, including without limitation, lesion formation, depth of penetration of lesion, cross-sectional area of lesion, formation of char during ablation, recognition of char during ablation, recognition of char from non-charred tissue, formation of coagulum around the ablation site, differentiation of coagulated from non-coagulated blood, differentiation of ablated from healthy tissue, tissue proximity, and recognition of steam formation in the tissue for prevention of steam pop.

Abstract: A coating removal apparatus utilizing a common optics path to provide laser pulses to a coated surface and to direct a light illumination reflected from the coated surface to a photosensitive detector and analyzer. The apparatus is an integrated device including a laser source, a beam splitter, scanning optics, a waste removal apparatus, one or more light illuminators, a photosensitive detector, a comparator, and a control logic circuit. Alternatively, the laser source is external to the integrated device and a fiber optic cable is used to connect the laser source to the integrated device.

Abstract: A coupling device for an optical waveguide includes an optical waveguide connection for a first optical waveguide. The coupling device includes an optical filter arranged in a beam path between a laser light source and the optical waveguide connection which reflects light of a first wavelength range or a first polarization direction and transmits light of a second wavelength range or a second polarization direction.

Abstract: Provided herein are methods of evaluating efficacy of a treatment in a subject having eye inflammation (e.g., a subject having dry eye syndrome) and selecting a subject for participation in a clinical study. Also provided are methods of treating a subject having eye inflammation (e.g., a subject having dry eye syndrome).

Abstract: A monitoring and detection system for use on high power laser systems, long distance high power laser systems and tools for performing high power laser operations. In particular, the monitoring and detection systems provide break detection and continuity protection for performing high power laser operations on, and in, remote and difficult to access locations.

Abstract: An improved apparatus and method for deep tissue laser therapy, in which the phase of the laser light is spatially modulated to produce a modulated laser beam. The modulated laser beam is able to restore its intensity profile even after being scattered by the skin or the superficial layer of the tissue, allowing it to penetrate deep into the tissue to provide efficient therapeutic treatment.

Abstract: Apparatus and methods are described for laser ablation of tissue. The apparatus and methods utilize a laser source coupled to a fiberoptic laser delivery device and a laser driver and control system with features for protection of the laser delivery device, the patient, the operator and other components of the laser treatment system. Advantageously, the laser source may utilize laser diodes operating at approximately 975 nm, 1470 nm, 1535 nm or 1870 nm wavelengths with a laser power output of at least 60 watts, preferably greater than 80 watts and most preferably 120-150 watts or higher. The invention, which has broad medical and industrial applications, is described in relation to a method for treatment of benign prostatic hyperplasia (BPH) by contact laser ablation of the prostate (C-LAP).

Abstract: An apparatus for applying electro-magnetic radiations to a sample is provided. The apparatus can include an arrangement which has a specific portion with a plurality of channels. One channel(s) can facilitate a first radiation to be forwarded to the sample within an anatomical structure, and another channel(s) can facilitate a second radiation to be forwarded to the sample. The first radiation can have a first wavelength band, and the second radiation can have a second wavelength band, which can be substantially different from the first wavelength band. The first radiation can be delivered to a first area of the sample, and the second radiation can be delivered to a second area of the sample. Each of the channels can facilitate a particular radiation(s) to be forwarded to the sample that is within an anatomical structure of the sample, the radiations being delivered to different areas of the sample.

Abstract: A sensor probe comprises a tube, a sensor element and an absorber mass. The tube is for placement in a process fluid flow within a fluid conduit and comprises a first end for coupling to the fluid conduit and a second end for insertion into the process fluid flow. The sensor element is in communication with the tube. The absorber mass is coupled to the tube and is configured to dampen vibration of the tube when inserted in the process fluid flow.

Abstract: Headache treatment methods are described and include providing an energy delivery device; locating a secondary or higher-order branch of a postganglionic nerve that provides innervation for a patient's head, by identifying a target region of the patient's head that includes the nerve branch; positioning, within the target region, a portion of the energy delivery device; and applying, from the positioned portion of the energy delivery device to the target region, an amount of energy effective to result in a stimulation activity of the nerve branch; and, after observing the stimulated nerve branch activity, delivering, from the energy delivery device to the nerve branch, energy in an amount effective to reduce a headache severity in the patient.

Abstract: The invention provides systems and method for the removal of diseased cells during surgery.

Abstract: A laser ablation method and apparatus uses a laser device to generate a pulsed laser using a laser device and to project the pulsed laser onto an ablation target to be ablated. A probe is then used to measure an indicative property of the ablation target or of the pulsed laser projected on the ablation target. A control loop is used to optimize ablation effect by generating a feedback signal according to the measured indicative property, sending the feedback signal to a control unit, and adjusting an output parameter of the pulsed laser according to the feedback signal. The measured indicative property may be a size of the laser beam spot or a material composition. The ablation, the feedback and the adjustment may be performed dynamically.

Abstract: A system and method of estimating a distance between the distal end of an optical fiber and treated tissue, to improve treatment efficiency, is provided herein. The estimation is achieved by modulating the numerical aperture of a light beam transmitted through the fiber to receive reflections from the tissue and distinguish them from other reflections in the fiber, and further by calculating the distance by comparing reflection intensities of beams having different numerical aperture values that illuminate the tissue over a very short period, so that tissue and environment conditions do not change much. Distance estimation may be carried out by modulating the treatment beam itself, or by a light beam transmitted between pulses of a pulsed treatment beam.