Abstract: A sutureless device and methods for closing a tissue opening that minimizes the labor, cost, and skill typically required is disclosed. The apparatus comprises two anchors that attach to either side of an open tissue wound. The two anchors are connected together by a tie strip; the tie strip has a plurality of teeth and a rack. As the wound edges and anchors are brought together the ratchet system on the tie strip prevents the anchors and tissue wound from reopening. To control the distance between the two anchors, a rack and pinion system and a key or a lever system is utilized. The rack is located on the tie strip and the pinion is located on the key.

Abstract: A hair grasping device having a handle with hollow fingers, a trigger slidably attached to the handle, a number of grips slidably attached within the hollow fingers connected to the trigger. Each of the grips has a first and a second arm, a central post, and an extended position and retracted position. When in the retracted position, the arms are forced against the central post by the hollow fingers, and when in the extended position, the arms are forced away from the central post, creating a clearance between the arms and the central post.

Abstract: A lead puncture needle includes a core rod, a puncture needle, a lead mechanism and a handle. A front end of the core rod includes a blunt head and a lead slot. During puncture, the puncture needle is exposed. After the puncture, the blunt head protrudes out of the puncture needle to avoid injury to normal tissue. When a button is pressed, the core rod moves downward, and the lead slot protrudes from the puncture needle. When the button is pressed again, the core rod moves upward, and the lead slot is retracted into the puncture needle to form traction on a surgical suture. The design of the blunt head ensures that it is retracted during puncture to expose the puncture needle to facilitate puncture and the blunt head is controlled to be exposed outside the puncture needle in a separation process, thereby avoiding accidental injury to the surrounding tissue.

Abstract: Mechanisms for pulling a tensile member a predetermined distance from a medical device having an intracorporeal end and an extracorporeal end are disclosed. Such mechanisms may be safely operated using a robot, two hands, or in some embodiments, only one hand. Such mechanisms may include one or more cams, drums, or pulley-like members and a lever, and may be physically coupled to an extracorporeal portion of the medical device.

Abstract: The present disclosure is directed to a method for treating tissue in a passageway within a body. The method may include positioning a medical device adjacent a treatment site in the passageway. The medical device may include an elongate member having a proximal end and a distal end, and an energy emitting portion positioned adjacent the distal end. The method may further include supplying an amount of energy from an energy source to the energy emitting portion. A first portion of the amount of the energy may be transmitted through the energy emitting portion to the tissue and a second portion of the amount of energy may be reflected from the energy emitting portion. The method may further include monitoring a signal corresponding to one of the first portion of the amount of energy and the second portion of the amount of energy.

Abstract: Surgical instruments, implantable articles and surgical procedures disclosed for treating medical disorders, particularly incontinence. Improved surgical sling procedures are disclosed. Novel surgical instruments and kits for use in sling procedures are also disclosed. The present invention affords options for surgeons with concomitant advantages to the patient and the healthcare provider.

Abstract: An occlusion device (10) includes a cannula (24), a dilator tip (20) fixed to the cannula and a frame member formed of an occlusion member (28) and a sleeve (30). The occlusion member (28) is covered with occlusion material (26). The cannula (24) is in the form of a tube having a lumen (25) passing therethrough. The dilator tip (20) also has a lumen therethrough and a valve (32). The arrangement is such that the occluder (10) can be delivered by an over the wire method using a guide wire, whereupon the cannula and dilator tip remain in the patient as part of the occluder assembly (10).

Abstract: The various embodiments of the present inventions provide stabilization devices and methods for use of the stabilization devices with minimally invasive gynecological procedures such as methods of preventing pregnancy by inserting intrafallopian contraceptive devices into the fallopian tubes.

Abstract: An occluding system is provided that can include a first occluding device (e.g., secondary occluder) and a second occluding device (e.g., primary occluder). Providing two devices can better promote effective occlusion within the body lumen and facilitate advantageous occlusion stages, such as initial and long-term occlusion stages. In various embodiments, the two occluding devices are in operative communication with one another, such that the second occluding device is adapted to couple with or slide along a tail portion of the first occluding device.

Abstract: The various embodiments of the present inventions provide stabilization devices and methods for use of the stabilization devices with minimally invasive gynecological procedures such as methods of preventing pregnancy by inserting intrafallopian contraceptive devices into the fallopian tubes.

Abstract: The present disclosure relates to a device for use with an operating end of a uterine manipulator for sealing tissue that includes a shaft having a handle at an operating end thereof and a ring-like snare at a distal end thereof. The handle has an actuator operable to selectively cinch the snare from a first configuration to a second configuration. An electrode is operably coupled to the snare and is connected to an energy source to energize tissue to create a tissue seal. The shaft is positionable within a surgical cavity such that the snare encircles tissue and operably engages and cinches the operating end of the uterine manipulator under a sealing pressure. Energy is applied to the electrode to seal the tissue disposed between the uterine manipulator and the snare under a working pressure. The tissue may then be resected and removed from the body.

Abstract: A delivery catheter with a plug ejection mechanism with a fluid filled actuator incorporated in the catheter's handle is disclosed. After delivery of RF energy, the clinician deploys the plug within the region of the lesion by activating the plug ejection mechanism.

Abstract: A device for occluding the fallopian tube including a wire composed of a shape memory material and an outer material encapsulating at least a portion of the wire. The device has a first elongated configuration for delivery and a second configuration for placement. In the second configuration, the wire moves toward its shape memory position and has a U-shape defined by a curved portion and first and second leg portions extending from the curved portion, the first and second leg portions extending downwardly from the curved portion and laterally outwardly.

Abstract: The various embodiments of the present inventions provide stabilization devices and methods for use of the stabilization devices with minimally invasive gynecological procedures such as methods of preventing pregnancy by inserting intrafallopian contraceptive devices into the fallopian tubes.

Abstract: A delivery system for deploying an occlusion device comprises a piston having a threaded proximal end, an elongated delivery catheter having a proximal end, a distal end, and an inner lumen extending between the proximal and distal ends of the delivery catheter, and a drive mechanism comprising an internally threaded nut member and a spring member. The piston is moveable between a first axial position and a second axial position. The internally threaded nut member receives the threaded proximal end of the piston. The spring member, which is coupled to the internally threaded nut member, rotates the nut member to drive the piston from the first axial position toward the nut member to the second axial position. Driving the piston toward the nut member retracts the attached delivery catheter and deploys an occlusion device from within the inner lumen and through the distal end of the delivery catheter.

Abstract: Systems and methods of visibly marking a reproductive tract, e.g., at least one ostium of the Fallopian tubes accessed transvaginally and transcervically, to indicate delivery of an occlusion device into the corresponding at least one Fallopian tube to effect contraception are disclosed. Marking is effected by delivery of a dye that stains the ostium and/or extension of the marking member from the delivered occlusion device into view in the uterine cavity or ostium. A catheter (or catheters) preferably introduced through a hysteroscope that illuminates and provides visualization of the uterine cavity and the ostia of the Fallopian tubes is employed to insert each contracted, stent-like, occluding device into each Fallopian tube and to mechanically expand or release to self-expand the occluding device.

Abstract: The various embodiments of the present inventions provide stabilization devices and methods for use of the stabilization devices with minimally invasive gynecological procedures such as methods of preventing pregnancy by inserting intrafallopian contraceptive devices into the fallopian tubes.

Abstract: Apparatus for sterilisation of a female mammal comprising at least one separation member for separation of a fallopian tube from a uterine cavity of the female mammal, a circulation assembly which is operatively connected to said at least one separation member, and at least one sterilisation lumen which is operatively connected to said circulation assembly and debouching at a distal side of said at least one separation member, said at least one sterilisation lumen being adapted for injection in use of a tissue necrotising fluid capable of necrotising a lining of at least a part of said fallopian tube, wherein said circulation assembly is adapted to circulate said tissue necrotising fluid within said sterilisation lumen and said fallopian tube. The apparatus allows quick, simple, safe and reliable sterilisation.

Abstract: A device for occluding the fallopian tube having a wire composed of a shape memory material and an outer material encapsulating at least a portion of the wire. The device has a first elongated configuration for delivery and a second configuration for placement. In the second configuration, the wire moves toward its shape memory position and has a U-shape defined by a curved portion and first and second leg portions extending from the curved portion, the first and second leg portions extending downwardly from the curved portion and laterally outwardly.

Abstract: The present disclosure relates to a device for use with an operating end of a uterine manipulator for sealing tissue that includes a shaft having a handle at an operating end thereof and a ring-like snare at a distal end thereof. The handle has an actuator operable to selectively cinch the snare from a first configuration to a second configuration. An electrode is operably coupled to an the snare and is connected to an energy source to energize tissue to create a tissue seal. The shaft is positionable within a surgical cavity such that the snare encircles tissue and operably engages and cinches the operating end of the uterine manipulator under a sealing pressure. Energy is applied to the electrode to seal the tissue disposed between the uterine manipulator and the snare under a working pressure. The tissue may then be resected and removed from the body.

Abstract: A reversible vasectomy device includes a first and a second connector piece for attachment to the severed ends of the vas deferens. Each connector piece has an outer vas deferens attaching end, an opposite inner end, and a passage from the outer to the inner end. A midpiece has end portions that are connectable to the inner ends of the connector pieces, a passage in one end portion and a vent from the passage to an exterior surface. When the connector pieces are connected to the end portions, the passage in one of the connector pieces is in fluid communication with the vent, but is not in fluid communication with the passage in the other connector piece.

Abstract: This invention is directed to a surgical isolator and cradle, suitable for the use in a surgical method involving the removal of prematura eggs from birds in order to generate germ-free eggs and birds. In particular, the surgical isolator is used in the generation of birds of specified germ-free status.

Abstract: A transuterine cannula through which an endoscope can be advanced into the peritoneal space to provide visualization of tissue cutting in the peritoneal space pursuant to a vaginal hysterectomy.

Abstract: Novel therapies for the treatment of Fabry disease by using androgen/androgen receptor (AR) pathway-related molecules as biomarkers and use of approaches targeting androgen/AR pathway are presented herein. The involvement of aberrant androgen/AR pathway in Fabry disease has never been previously described. The present invention describes, (i) use of approaches that target androgen/AR pathway as therapeutic treatments for Fabry disease and (2) use of the levels of androgen/AR pathway-related molecules in body fluids or tissues as biomarkers for evaluation of disease progression and efficacy of treatments in Fabry patients.

Abstract: Systems and methods of visibly marking a reproductive tract, e.g., at least one ostium of the Fallopian tubes accessed transvaginally and transcervically, to indicate delivery of an occlusion device into the corresponding at least one Fallopian tube to effect contraception are disclosed. Marking is effected by delivery of a dye that stains the ostium and/or extension of the marking member from the delivered occlusion device into view in the uterine cavity or ostium. A catheter (or catheters) preferably introduced through a hysteroscope that illuminates and provides visualization of the uterine cavity and the ostia of the Fallopian tubes is employed to insert each contracted, stent-like, occluding device into each Fallopian tube and to mechanically expand or release to self-expand the occluding device.

Abstract: The various embodiments of the present inventions provide stabilization devices and methods for use of the stabilization devices with minimally invasive gynecological procedures such as methods of preventing pregnancy by inserting intrafallopian contraceptive devices into the fallopian tubes.

Abstract: A ring to assist in use of an animal ligation device has an inner diameter dimensioned for easy passage around a part of an animal to be removed by the ligation device, an outer diameter of the ring having an outer peripheral groove dimensioned for receipt of a ligature of the ligation device so as to assist in use of the ligation device relative to the animal. The ring is preferably made from a plastic material having the groove dimensioned for easy removal of the ligature after positionment of the ligature relative to the animal, so that completion of use of the ligation device is facilitated.

Abstract: The present disclosure provides methods for preventing or treating illness, improving responsiveness to immunization, and improving the efficacy of gene therapy in a patient by disrupting sex steroid signalling in the patient, wherein the bone marrow and other immune cell functionality is improved without, prior to, or concurrently with, thymic regeneration. In some embodiments, sex steroid signalling is interrupted or ablated in the patient by the administration of LHRH agonists, LHRH antagonists, anti-LHRH receptor antibodies, anti-LHRH vaccines, anti-androgens, anti-estrogens, selective estrogen receptor modulators (SERMs), selective androgen receptor modulators (SARMs), selective progesterone response modulators (SPRMs), ERDs, aromatase inhibitors, or various combinations thereof.

Abstract: A device for verifying occlusion of the fallopian tube in a female subject includes an elongate gas delivery member having a lumen disposed therein, the elongate gas delivery member adapted for sealing engagement with the subject's uterus. The device includes a pressurized insufflation gas source coupled to the elongate gas delivery member, the insufflation gas source being in communication with the lumen of the elongate gas delivery member. The insufflation gas may includes for example, carbon dioxide. In one aspect, the device includes a pressure sensor or gauge to measure intra-uterine pressure to verify occlusion of the fallopian tube(s). In another aspect, the flow rate of insufflation gas into the uterus may be measured using a flow meter to verify occlusion of the fallopian tube(s).

Abstract: An easily operated castrating tool that allows placement of an improved continuous elastic band for ligation and removal of an appendage. The present invention includes a tool that allows such bands to be placed in a manner that is significantly more easy to use, and less fatiguing to the parties that utilize the device. The instant invention is also an improved elastic band which allows for better compressive ligation about a body part as well as a simple, but effective, spreading tool that allows for quicker and easier placement of the improved elastic band about a body part to be ligated.

Abstract: An apparatus for sterilizing a female patient in a transcervical procedure comprises an elongated catheter with a piezoelectric ultrasound transducer at its distal end. The catheter is inserted transcervically into the uterus and guided to the intramural region of a fallopian tube. The transducer is inserted into the intramural region in direct contact with the surrounding tissue. The transducer produces a radially dispersing acoustical wave front, heating the adjacent tissue and forming a thermal lesion therein. A fibrous tissue forms during the healing process, sealing the fallopian tube. An embodiment of the apparatus includes a movable thermal sensor for monitoring the tissue temperature at multiple locations along the lesion. Another embodiment of the apparatus includes a spring that centers the distal end of the catheter at the opening of the fallopian tube and provides a tactile means to determine that the catheter and transducer have been correctly positioned.

Abstract: A device for sterilizing females by occluding the uterotubal junction. The device includes a catheter with a releasable heat generating plug which is used to thermally damage the uterotubal junction and cause it to constrict around the plug, after which the plug is released from the catheter and left in place in the uterotubal junction.

Abstract: Contraceptive methods, systems, and devices generally improve the ease, speed, and reliability with which a contraceptive device can be deployed transcervically into an ostium of a fallopian tube. The contraceptive device may remain in a small profile configuration while a sheath is withdrawn proximally, and is thereafter expanded to a large profile configuration engaging the surrounding tissues, by manipulating one or more actuators of a proximal handle with a single hand. This leaves the other hand free to manipulate a hysteroscope, minimizing the number of health care professional required to deploy the contraceptive device.

Abstract: A clip for sexual sterilization is provided. The clip includes resilient upper and a lower jaw members, and may be readily assembled by means of cooperating aperture and finger members on the upper and lower jaws.

Abstract: A sterilization device (10) is provided having a flexible housing element (12) that is smaller in diameter than the diameter of the lumen of the isthmic portion of the fallopian tube, a heating element (14) carried by the housing element adjacent to its distal end, and an energy source (18) coupled to the heating element such that when the energy source is energized the temperature of the heating element will be increased. A procedure is described for inserting the sterilization device (10) through the uterus and into the isthmic portion of the fallopian tube where the heating element (14) is energized and the heat generated destroys the mucosal layer and damages the muscular layer of the fallopian tube wall inducing sufficient scarification to occlude the fallopian tube.

Abstract: A localized heat applying medical device is provided for applying heat to tissue adjacent a patient's tubal ostia in order to close the patient's fallopian tubes and sterilize the patient. Procedures of performing sterilizations are also disclosed.

Abstract: A device for occluding a body lumen, and particularly contraceptive or sterilization device for occluding a reproductive tract or lumen to prevent the passage of reproductive cells through the tract or lumen, generally comprising a tubular member, and a mesh member, transversely disposed on the tubular member lumen. The mesh member is permeable to allow for tissue ingrowth, which produces a tissue impregnated mesh occluding the body lumen. The occluding device of the invention can be used in the fallopian tubes of a female patient, the vas deferens of a male patient, or other body lumen.

Abstract: An apparatus for transcervical sterilization or transcatheter embolization with a controlled bipolar RF catheter for creating thermal lesions in the fallopian tubes or thrombosing vessels has a catheter elongate along an axis thereof with a patient end. The catheter is circular and sized for transcervical insertion into the fallopian tube or transcatheter vessel insertion, respectively. A connector on an end of the catheter opposite the patient end has the terminations for RF and monitoring and is shaped for the surgeon to manipulate during placement and withdrawal. Two or more bipolar electrodes on the patient end are placed so each electrode is spaced from another with each circumscribing the catheter. A mucosa or thrombus sensor responsive to applied RF energy passing between the two or more bipolar electrodes determines the condition of the transmural formation of a lesion or the thrombus between each of the electrodes.

Abstract: A sterilization device (10) is provided having a flexible housing element (12) that is smaller in diameter than the diameter of the lumen of the isthmic portion of the fallopian tube, a heating element (14) carried by the housing element adjacent to its distal end, and an energy source (18) coupled to the heating element such that when the energy source is energized the temperature of the heating element will be increased. A procedure is described for inserting the sterilization device (10) through the uterus and into the isthmic portion of the fallopian tube where the heating element (14) is energized and the heat generated destroys the mucosal layer and damages the muscular layer of the fallopian tube wall inducing sufficient scarification to occlude the fallopian tube.

Abstract: An apparatus and method for occluding a lumen, such as a vessel, in a mammal using alternating current and monitoring reflected power from the occlusion site to determine vessel constriction and/or electrocoagulation. The apparatus is provided with an alternating current (AC) power generator, a first electrode electrically coupled to the generator, a dispersive electrode electrically coupled to the generator and forming in-part with the generator and the first electrode a drive circuit and a reflected power monitoring circuit coupled to the drive circuit for monitoring power reflected back toward the generator from the first electrode. With this construction, occlusion and/or thermocoagulation can be accurately detected so that the power delivered to the first electrode when positioned in the mammal can be terminated. In this manner, the risk of overheating tissue in the vicinity of the constricted vessel is minimized or eliminated.

Abstract: An apparatus and method for human female sterilization. The apparatus includes an occlusive device configured from an elongate tubular member having a central lumen and a flange formed at the proximal end. The occlusive device is formed with a plurality of flexible ribs configured to provide a plurality of seals within the interstitial portion of a Fallopian tube. A valve member is preferably disposed within the lumen of the tubular member. The occlusive device may further include a plurality of copper rings disposed between the ribs of the tubular member, or ribs may be coated with a material containing copper. The method includes placing the occlusive device within a delivery catheter having a lumen and placing the distal end of the delivery catheter within the uterus. After the occlusive device and distal end of the delivery catheter are placed in the Fallopian tube, the occlusive device is removed from the delivery catheter and ejected into the Fallopian tube.

Abstract: A tool and method for continuous elastomeric band ligation type castration of larger sexually mature animals with an elastic band that must be enlarged by stretching for placement provides an elongate body having a handle at a first rearward end to aid manipulation and an elastic band supporting yoke at a second forward end. The band supporting yoke provides spaced forwardly extending legs for releasable support of the elastic band at two spaced points. Band stretching mechanism carried by the body provides an elongate stretching rod that releasably interconnects one course of the elastic band carried by the yoke at a third point between the two yoke support points to stretch the band rearwardly responsive to motion of an associated compound lever mechanism to enlarge the medial orifice defined by the elastic band sufficiently to allow the band to pass over the scrotal pouch and contained testicular structure of a large animal.

Abstract: A method and apparatus (10) for applying a preformed endless band (18) of elastomeric ligature material to an animal body part is provided, such method employing a motor to facilitate the winding of ligature material. The apparatus (10) includes a winding assembly (14) for winding the band (18), wherein a loop (20) of the band (18) is tightened by winding the band (18). A crimping assembly (16) for crimping a grommet (32) to secure the loop (20) is also disclosed. The invention allows the loop (20) to be quickly and tightly secured using pneumatic/electric tools or motors.

Abstract: Apparatus and surgical procedures are provided for completely coagulating endometrial tissue of the uterus by means of heated liquid in the distended uterus under direct view of a thermally insulated hysteroscope or under indirect view fluoroscopically using a thermally insulated hysterographic cannula and a radiopaque heated liquid.

Abstract: A ligature tool, of the type having a handle carrying an elongate body defining a fastening clip chamber in its forward part with ligature tubing holding and tensioning means carried on the body, provides improved crimping and tubing holding means. The crimping element provides a single pivotally mounted crimping dog that contacts a slit portion of an annular ligation tube clip carried in the fastening clip chamber and is movable into that chamber to crimp the sides defining the slit toward the adjacent inner surfaces of the annular clip body to fasten ligation material therebetween. The tubing holding means provide a body supporting similar laterally opposed tubing holders each having a headed vertical post about which the end portion of tubing is wound under tension before placement in an adjacent wedge-shaped slot for releasable fastening. The tubing holding body also provides tubing cutting structure.

Abstract: A method and apparatus (10) for applying a band (18) of ligature material to an animal body part is provided, such method employing a motor to facilitate the winding of ligature material. The apparatus (10) includes a winding assembly (14) for winding the band (18), wherein a loop (20) of the band (18) is tightened by winding the band (18). A crimping assembly (16) for crimping a grommet (32) to secure the loop (20) is also disclosed. The invention allows the loop (20) to be quickly and tightly secured using pneumatic/electric tools or motors.

Abstract: Percutaneous suture externalizer devices are disclosed which grasp, secure and externalize sutures from within an abdominal or thoracic cavity. The suture externalizer devices include a thin tubular sheath with a penetrating point and a hook rod slidable within the sheath. The hook rod is slidable between an extended position and a retracted position. The hook rod is biased to the extended position. In the retracted position, a suture grasped within the hook is snugly held between the hook rod and the inner wall of the sheath, providing a positive means of securing the suture during externalization. An alternative embodiment utilizes a hollow tubular hook rod that can also be used to insufflate the abdominal or thoracic cavity. The alternative embodiment utilizes a valve to control the flow of gas through the hook rod, into and out of the cavity.

Abstract: An instrument for grasping and incising the scrotum of an animal. The instrument has a barrel, a spring-loaded rod within the barrel, a pair of forceps members attached to the rod and a knife housing with a spring-loaded knife at the forward end of the barrel. A spring-biased latch member is provided to hold the knife in a cocked position. A trigger is attached to the barrel to cock the rod in a forward position with the forceps members extending forward through the knife housing and to release the rod for rapid movement rearward in the barrel. With the knife and rod cocked, the forceps members are applied to the scrotum of an animal. The trigger is then pressed to release the rod and forceps members rearward. The rearward movement of the forceps members draws a portion of the scrotum into the knife housing behind the knife. The final rearward movement of the rod causes the latch member to be tripped, and the knife is released to incise the scrotum.

Abstract: A method and apparatus (10) for applying a band (18) of ligature material to an animal body part is provided. The apparatus (10) includes a winding assembly (14) for winding the band (18), wherein a loop (20) of the band (18) is tightened by winding the band (18). A crimping assembly (16) for crimping a grommet (32) to secure the loop (20) is also disclosed. The invention allows the loop (20) to be quickly and tightly secured.

Abstract: An arrangement including a suction pump, a pipette, an application tip and a plurality of ligating rings which are carried on the application tip. The application tip is disposed in cooperative relation with the pipette so that the ligating rings may be transferred from the adapter tip to the pipette while being gradually stretched. The pipette is disposed in an incision exposing the ovarian sack of a small mammalian creature, whereupon a suction or vacuum is generated by the pump to capture the ovarian sack, after which a ligating ring is slipped off of the pipette and contracts to ligate said captured sack. This enables resorption of the ligated ovarian sack into the creature and stabilization of hormonal activity as is desired for experimental purposes.