Tetrapeptides (derived From Only Four Amino Acids) (c07k-5/10) Patents (Class 930/DIG780)

Digests

Contains at least one ring formed only through peptide links (c07k 5/12b) (Class 930/DIG781)
With at least one amino acid in d-form (c07k-5/10z) (Class 930/DIG782)
The first amino acid being heterocyclic (pro) (c07k-5/10h) (Class 930/DIG783)
The first amino acid contains the same number of amino and carboxylic acid or derivative groups (neutral) (c07k-5/10a) (Class 930/DIG784)
The first amino acid contains more amino groups than carboxylic acid or derivative groups (basic) (c07k-5/10b) (Class 930/DIG787)
The first amino acid contains more carboxylic acid or derivative groups than amino groups (acidic) (c07k-5/10c) (Class 930/DIG788)
  • Inhibitors of farnesyl protein transferase
    Patent number: 5238922
    Abstract: The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
    Type: Grant
    Filed: September 30, 1991
    Date of Patent: August 24, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Samuel L. Graham, S. Jane deSolms, Victor M. Garsky