Patents Represented by Attorney Alan D. Lourie

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  • Antitumor compounds
    Patent number: 4857549
    Abstract: Compounds, pharmaceutical compositions and a method for treating tumors by administering an effective tumor cell growth-inhibiting amount of a .alpha.,.omega.-bis(disubstitutedphosphino)hydrocarbon compound or a [.alpha.,.omega.-bis(disubstitutedphosphino)hydrocarbon] digold(I), digold(III, disiliver(I) or dicopper(I) complex to an animal afflicted by such tumor cells.
    Type: Grant
    Filed: February 26, 1988
    Date of Patent: August 15, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: David T. Hill, Randall K. Johnson, Christopher K. Mirabelli
  • Process for the extraction and purification of proteins from culture media producing them
    Patent number: 4857317
    Abstract: The process is applicable to the supernatant of engineered yeast cells disrupted in the presence of a non-ionic detergent; it comprises the precipitation of contaminants by polyethylene glycol and the treatment of this latter supernatant with either a bivalent metal cation or, after eventual ultrafiltration, with ammonium sulfate.
    Type: Grant
    Filed: April 27, 1987
    Date of Patent: August 15, 1989
    Assignee: SmithKline Biologicals
    Inventors: Frans V. Wijnendaele, Daniel Gilles, Guy Simonet
  • Carboxylic acid amides, compositions and medical use thereof
    Patent number: 4851443
    Abstract: Amide derivatives of non-steroidal anti-inflammatory carboxylic acids which have anti-inflammatory activity in their own right as well as being effective as pro-drugs of the carboxylic acids.
    Type: Grant
    Filed: July 5, 1988
    Date of Patent: July 25, 1989
    Assignee: Smith Kline Dauelsberg, GmbH
    Inventor: Kay Brune
  • Fluorescent intracellular calcium indicators
    Patent number: 4849362
    Abstract: Invented are new tetracarboxylate compounds which are chelators for calcium ions. Also invented is a useful method of measuring intracellular calcium concentrations using these novel compounds as an optical indicator.
    Type: Grant
    Filed: May 19, 1988
    Date of Patent: July 18, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: Robert M. DeMarinis, Haralambos E. Katerinopoulos, Katharine A. Muirhead
  • Certain 3-(2-phenethyl)-1-carbamoyloxypyridinium halide intermediates
    Patent number: 4843163
    Abstract: 3-(2-Phenethyl)-1-carbamoyloxypyridinium halide is an intermediate for the preparation of the antihistamine azatadine.
    Type: Grant
    Filed: December 2, 1987
    Date of Patent: June 27, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: Raymond E. Dagger, Linda A. Motyka
  • Polynucleotide hybridization probes
    Patent number: 4840892
    Abstract: Polynucleotide hybridization probes are labeled in non-probe regions but not in probe regions by selectively protecting probe regions prior to modification of the polynucleotide.
    Type: Grant
    Filed: April 15, 1985
    Date of Patent: June 20, 1989
    Assignee: Smithkline Beckman Corporation
    Inventors: Craig W. Adams, Jeffry J. Leary, Martin Rosenberg
  • 3-aralkyl-2-mercaptoyridines as dopamine-.beta.-hydroxylase inhibitors
    Patent number: 4839371
    Abstract: Disclosed are novel substituted 3-aralkyl-2-mercaptopyridines of the structure: ##STR1## processes for their preparation, intermediates useful in their preparation, pharmaceutical compositions containing them and their use in therapy in particular as dopamine-.beta.-hydroxylase inhibitors.
    Type: Grant
    Filed: September 17, 1987
    Date of Patent: June 13, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: Lawrence I. Kruse, Stephen T. Ross
  • Dopamine-.beta.-hydroxylase inhibitors
    Patent number: 4837353
    Abstract: 2-(N-Phenylakyl-N-formyl)amino-3-hydroxy-2-propenoic acids are intermediates for mercaptoimidazolecarboxylic acids which are dopamine-.beta.-hydroxylase inhibitors.
    Type: Grant
    Filed: January 21, 1988
    Date of Patent: June 6, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: Joseph A. Finkelstein, Lawrence I. Kruse, Thomas B. Leonard
  • 1-aralykyl-5-piperazinylmethyl-2-mercaptoimidazoles and 2-alkylthioimidazoles and their use as dopamine-.beta.hydroxylase inhibitors
    Patent number: 4835154
    Abstract: Potent dopamine-.beta.-hydroxylase inhibitors having the Formula ##STR1## that are useful to inhibit dopamine-.beta.-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopamine-.beta.-hydroxylase activity in mammals. Also disclosed are novel intermediates useful in preparing the presently invented inhibitors.
    Type: Grant
    Filed: June 1, 1987
    Date of Patent: May 30, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: Joseph A. Finkelstein, Lawrence I. Kruse
  • Polyene antibiotic emulsion formulation
    Patent number: 4831018
    Abstract: A polyene antibiotic emulsion formulation comprising a therapeutically effective amount of the antibiotic incorporated into an oil-in-water emulsion, and a method of treating an active infection in an animal caused by a microorganism with sterols in its cell membrane by parenterally administering the emulsion formulation to such animal.
    Type: Grant
    Filed: March 25, 1987
    Date of Patent: May 16, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: Richard L. Kirsh, Louis J. Ravin
  • Hybrid polypeptides comprising somatocrinine and alpha.sub.1 -antitrypsin, method for their production from bacterial clones and use thereof for the production of somatocrinine
    Patent number: 4828988
    Abstract: A fusion between DNA sequences coding for hAT and hGRF via a synthetic adaptor coding for an in vitro cleavable amino acid sequence is used to express hGRF at high levels in E. coli.
    Type: Grant
    Filed: May 15, 1986
    Date of Patent: May 9, 1989
    Assignee: Smith Kline - RIT
    Inventors: Alex J. Bollen, Paul Jacobs
  • 4'-Methyl-.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid vasopressin antagonists
    Patent number: 4826813
    Abstract: Vasopressin antagonists which have a 4'-methyl-.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid group have vasopressin antagonist activity without substantial agonist activity. A species of the invention is [1-(4'-methyl-.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)-2-(O-ethyl)-D-tyrosine-4-valine-8-arginine]vasopressin.
    Type: Grant
    Filed: May 21, 1987
    Date of Patent: May 2, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: William F. Huffman, Nelson C. F. Yim
  • Chemical compounds having selective thyromimetic activity
    Patent number: 4826876
    Abstract: This invention relates to chemical compounds which have selective thyromimetic activity. A compound of this invention is 3,5-dibromo-3'-[6-oxo-3(1H)-pyridazinyl-methyl]-thyronine.
    Type: Grant
    Filed: December 21, 1987
    Date of Patent: May 2, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: David Ellis, John C. Emmett, Anthony H. Underwood, Paul D. Leeson
  • Effervescent couples, histamine H.sub.2 -antagonist effervescent compositions containing them and their preparation
    Patent number: 4824664
    Abstract: The invention relates to an effervescent couple which comprises a mixture of mono-and di-alkali metal citrate as well as to a process for preparing same. The process comprises partially neutralizing citric acid by reacting an alkali metal carbonate or bicarbonate with citric acid and water and controlling the amount of carbon dioxide released during the reaction by stopping the reaction when a certain amount of citric acid has been neutralized. In a preferred embodiment the reaction is stopped when from about 24% to about 54% of the potential amount of carbon dioxide has been released.
    Type: Grant
    Filed: January 20, 1987
    Date of Patent: April 25, 1989
    Assignee: Laboratoires Smith Kline & French
    Inventors: Rene Tarral, Jacky Mention
  • Sulfinyl and sulfonyl substituted 2,3,4,5 tetrahydro-1H-3-benzazepines and their use in treating gastrointestinal motility disorders
    Patent number: 4824839
    Abstract: Sulfinyl and sulfonyl substituted 3-benzazepine compounds are useful in treating gastrointestinal motility disorders and emesis. A particular compound of this invention is 7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine.
    Type: Grant
    Filed: March 14, 1988
    Date of Patent: April 25, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: William E. Bondinell, Herbert S. Ormsbee, III
  • Pyrrolidone derivatives and memory enhancement use thereof
    Patent number: 4824861
    Abstract: The invention relates to 4-hydroxy pyrrolidone derivatives which help restore learning and memory difficulties associated with ageing. A compound of the invention is 2-(4-hydroxy-2-oxo-1-pyrrolidineacetamido)acetamide.
    Type: Grant
    Filed: December 11, 1987
    Date of Patent: April 25, 1989
    Assignee: ISF Societa Per Azioni
    Inventors: Mario Pinza, Carlo Farina, Silvano Banfi, Ugo Pfeiffer
  • Treatment of Parkinsons disease
    Patent number: 4824860
    Abstract: The present invention relates to the use of certain indolone derivatives in particular, 4-(2-di-n-propyl-aminoethyl)-2-(3H)-indolone in a method of treatment of Parkinsons disease.
    Type: Grant
    Filed: May 19, 1988
    Date of Patent: April 25, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: David A. A. Owen
  • Leukotriene antagonists
    Patent number: 4820719
    Abstract: This invention relates to alkanoic acid compounds having phenyl and thio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to methods of treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.
    Type: Grant
    Filed: May 16, 1988
    Date of Patent: April 11, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: John G. Gleason, Ralph F. Hall, Thomas Wen-Fu Ku, Carl D. Perchonock
  • Pyrimidylalkylthio benzimidazole compounds, pharmaceutical compositions and use
    Patent number: 4820708
    Abstract: This invention relates to 2- and 4-pyrimidinylmethylsulphinyl(and thio)benzimidazoles in which the pyrimidyl group is substituted by an optionally substituted amino group. These compounds inhibit exogenously and endogenously stimulated gastric acid secretion.
    Type: Grant
    Filed: July 22, 1988
    Date of Patent: April 11, 1989
    Assignee: Smith Kline & French Laboratories
    Inventors: Robert J. Ife, Thomas H. Brown
  • Tablet
    Patent number: D301637
    Type: Grant
    Filed: December 19, 1986
    Date of Patent: June 13, 1989
    Assignee: Smith Kline & French Laboratories Ltd
    Inventor: Geoffrey D. Tovey