Patents Represented by Attorney Albert H. Graddis
  • Patent number: 4180675
    Abstract: The present invention relates to 15-cycloalkyl-prostaglandins of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## W represents ethylene or trans-vinylene, X represents ethylene or cis-vinylene, Y represents ethylene or trans-vinylene, R represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.1 represents a hydrogen atom or a methyl or ethyl group, R.sup.2 represents a straight- or branched-chain alkyl group containing from 2 to 8 carbon atoms or a phenyl group unsubstituted or substituted by an alkyl group containing from 1 to 3 carbon atoms, R.sup.3 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 3 carbon atoms, and n represents 4 or 5 and cyclodextrin clathrates of such acids and esters and, when R represents a hydrogen atom, non-toxic salts thereof.These new compounds exhibit characteristic prostaglandin-like activities.
    Type: Grant
    Filed: December 5, 1977
    Date of Patent: December 25, 1979
    Assignee: Warner-Lambert Company
    Inventors: Masaki Hayashi, Seiji Kori, Isao Ohyama, Sadahiko Iguchi, Takanori Okada
  • Patent number: 4179447
    Abstract: This invention is concerned with a novel process for the production of 2-substituted chromones (I) from readily available 4-methoxycoumarins. ##STR1## These compounds are useful as antiallergy agents.
    Type: Grant
    Filed: November 30, 1978
    Date of Patent: December 18, 1979
    Assignee: Warner-Lambert Company
    Inventors: David T. Connor, Patricia A. Young, Max von Strandtmann
  • Patent number: 4179509
    Abstract: The present invention relates to (substituted 2-carboxyanilino) nicotinic acids which have the capability of inhibiting allergic reactions.
    Type: Grant
    Filed: September 18, 1978
    Date of Patent: December 18, 1979
    Assignee: Warner-Lambert Company
    Inventors: Charles F. Schwender, Brooks R. Sunday
  • Patent number: 4179513
    Abstract: This invention relates to substituted indolobenzoxazepines which act as central nervous system depressants and as such are useful as tranquillizers.
    Type: Grant
    Filed: April 10, 1978
    Date of Patent: December 18, 1979
    Assignee: Warner-Lambert Company
    Inventor: Richard E. Brown
  • Patent number: 4177945
    Abstract: Humidifier and nebulizer adapter heads and humidifier assembly for inhalation therapy wherein high moisture content can be provided in a gas stream at high flow rates. The humidifier assembly consists of a disposable bottle and the disposable humidifier adapter head. The adapter head employs a conventional nebulizer to create a dense aerosol of sterile water and/or medicament entrained in an oxygen/air stream. The stream passes through a labyrinth of wide baffles which forces the stream to take a tortuous path resulting in turbulent flow and a high removal of droplets from the gas stream, but without generating a significant back pressure. The large surface area deflectors of the labyrinth also allow higher humidity of the gas stream due to evaporation. Water removed from the gas stream drains directly to the bottle.
    Type: Grant
    Filed: March 6, 1978
    Date of Patent: December 11, 1979
    Assignee: Warner-Lambert Company
    Inventors: Charles M. Schwartz, Eugene J. Meierhoefer
  • Patent number: 4175322
    Abstract: A complete denture is disclosed for both maxillary and mandibular prostheses of the type having a hard base structure formed of acrylic plastic into which prosthetic teeth are set, the hard base structure fused to a deflectable tray layer of thermo plastic material which is deflectable when warm to adapt the denture to the general contours of the maxillary or mandibular ridges, a subsequent coating of autopolymerizing acrylic plastic being applied to the tray providing precise fitting of the denture to the oral contours of the wearer and stabilizing the soft deflectable tray in its newly achieved configuration.
    Type: Grant
    Filed: September 21, 1977
    Date of Patent: November 27, 1979
    Assignee: Warner-Lambert Company
    Inventor: Kenneth E. Tureaud
  • Patent number: 4175083
    Abstract: This invention relates to novel substituted indolopyrones which have utility in preventing allergic and asthmatic reactions in mammals.
    Type: Grant
    Filed: September 8, 1978
    Date of Patent: November 20, 1979
    Assignee: Warner-Lambert Company
    Inventors: Richard E. Brown, Paul C. Unangst
  • Patent number: 4165437
    Abstract: The present invention relates to prostaglandin analogues of the general formula: ##STR1## [wherein X represents cis or trans-vinylene or ethylene, R represents ##STR2## R.sup.1 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.2 represents a hydrogen atom or a methyl group, R.sup.3 represents a straight- or branched-chain alkylene group containing from 1 to 7 carbon atoms and R.sup.4 represents a cycloalkyl group containing from 5 to 7 carbon atoms, a grouping of the formula: ##STR3## (wherein R.sup.5 and R.sup.6, which may be the same or different, each represent a hydrogen atom or halogen atom, a trifluoromethyl group or a straight- or branched-chain alkyl group containing from 1 to 4 carbon atoms), or a grouping of the formula: ##STR4## (wherein R.sup.5 and R.sup.6 are as hereinbefore defined), or R.sup.3 and R.sup.
    Type: Grant
    Filed: August 17, 1978
    Date of Patent: August 21, 1979
    Assignee: Ono Pharmaceutical Company, Ltd.
    Inventors: Masaki Hayashi, Seiji Kori, Yoshinobu Arai, Takanori Okada, Yoshitaka Konishi
  • Patent number: 4158663
    Abstract: This invention is concerned with a novel process for the production of 2-substituted chromones (I) from readily available 4-methoxycoumarins. ##STR1## These compounds are useful as antiallergy agents.
    Type: Grant
    Filed: March 31, 1978
    Date of Patent: June 19, 1979
    Assignee: Warner-Lambert Company
    Inventors: David T. Connor, Patricia A. Young, Max VON Strandtmann
  • Patent number: 4156740
    Abstract: The disclosure relates to a sugarless center-filled gum wherein the sugarless chewing gum formulation can be extruded to form a hollow-centered rope and wherein the sugarless center-fill is not absorbed into the chewing gum. Both the chewing gum and the liquid fill have incorporated therein a composition comprising a natural or synthetic gum, glycerin humectant and an additional humectant which may be sorbitol solution or a combination of sorbitol solution and propylene glycol. Suitable synthetic or natural gums include carboxymethylcellulose, pectin, propylene glycol alginates, agar and gum tragacanth. The preferred composition which is incorporated into both the sugarless chewing gum formulation and the sugarless liquid fill contains sodium carboxymethylcellulose, glycerin and sorbitol solution.
    Type: Grant
    Filed: February 2, 1978
    Date of Patent: May 29, 1979
    Assignee: Warner-Lambert Company
    Inventors: Michael Glass, Wayne J. Puglia
  • Patent number: 4154734
    Abstract: This invention relates to novel amides of 4-hydroxy-6H-thieno[2,3-b]thiopyran-5-carboxylic acid-7,7-dioxide having the Formula I: ##STR1## wherein R.sub.1 is hydrogen, halogen or lower alkyl; R.sub.2 is hydrogen, lower alkyl or aryl; Ar is aryl or heterocyclic; to the pharmaceutically acceptable salts thereof; and to processes for their preparation. The compounds of this invention exhibit antiinflammatory activity.
    Type: Grant
    Filed: December 27, 1977
    Date of Patent: May 15, 1979
    Assignee: Warner-Lambert Company
    Inventors: Jagadish C. Sircar, Stephen J. Kesten, Harold Zinnes
  • Patent number: 4152269
    Abstract: A blood collection assembly and closure therefor, for the collection, separation, isolation and storage of serum from blood. The closure is constructed of a cannula penetrable self-sealing elastomer and includes a thixotropic barrier material in a hollow central portion of the closure, so that the barrier material is sealed within the closure until blood has been collected in the collection container and centrifuged. Centrifugation forces the barrier material into a collecton container through the passageway created by the cannula.
    Type: Grant
    Filed: February 1, 1977
    Date of Patent: May 1, 1979
    Assignee: Warner-Lambert Company
    Inventor: Arthur L. Babson
  • Patent number: 4152326
    Abstract: The present invention is concerned with new cyclic sulphonyloxyimides and their preparation.
    Type: Grant
    Filed: March 7, 1977
    Date of Patent: May 1, 1979
    Assignee: Warner-Lambert Company
    Inventors: Johannes Hartenstein, Gerhard Satzinger
  • Patent number: 4148806
    Abstract: This invention relates to a novel process for preparing a group of novel substituted indolopyrones.
    Type: Grant
    Filed: December 14, 1977
    Date of Patent: April 10, 1979
    Assignee: Warner-Lambert Company
    Inventors: Richard E. Brown, Paul C. Unangst, Frank Fontsere, Arthur C. Fabian
  • Patent number: 4146958
    Abstract: A safety razor contains a blade cartridge in which two blades are rigidly secured. The cartridge has a seat member with an integral blade edge guard disposed transversely along its forward margin. A first razor blade is disposed on a planar surface of the seat member and has its cutting edge located rearwardly of the guard. A second razor blade having a cutting edge located parallel to and rearwardly of the first blade edge is in contact with a mating surface of a cap member. The cap member is secured to the seat member thereby clamping the blades in desired position. The blades are maintained at a predetermined distance apart by spacing means and the guard member has a plurality of projecting teeth transversely arrayed across the guard member forming a comb guard.
    Type: Grant
    Filed: October 15, 1976
    Date of Patent: April 3, 1979
    Assignee: Warner-Lambert Company
    Inventors: Evan N. Chen, Edward A. Beddall, Bryan J. Goddard
  • Patent number: 4145555
    Abstract: The present invention relates to prostaglandin analogues of the general formula: ##STR1## ?wherein X represents cis or trans-vinylene or ethylene, Z represents ##STR2## R.sup.1 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.2 represents a hydrogen atom or a methyl group, R.sup.3 represents a straight- or branched-chain alkylene group containing from 1 to 7 carbon atoms and R.sup.4 represents a cycloalkyl group containing from 5 to 7 carbon atoms, a grouping of the formula: ##STR3## (wherein R.sup.5 and R.sup.6, which may be the same or different, each represent a hydrogen atom or halogen atom, a trifluoromethyl group or a straight- or branched-chain alkyl group containing from 1 to 4 carbon atoms), or a grouping of the formula: ##STR4## (wherein R.sup.5 and R.sup.6 are as hereinbefore defined), or R.sup.3 and R.sup.
    Type: Grant
    Filed: March 7, 1977
    Date of Patent: March 20, 1979
    Assignee: Ono Pharmaceutical Company
    Inventors: Masaki Hayashi, Seiji Kori, Yoshinobu Arai, Takanori Okada, Yoshitaka Konishi
  • Patent number: D252157
    Type: Grant
    Filed: April 14, 1977
    Date of Patent: June 19, 1979
    Assignee: Warner-Lambert Company
    Inventors: Donald P. Kronish, William D. Young, Walter E. Jacobson, Doris B. Taylor
  • Patent number: D253375
    Type: Grant
    Filed: December 30, 1977
    Date of Patent: November 6, 1979
    Assignee: Warner-Lambert Company
    Inventor: Evan N. Chen
  • Patent number: D253515
    Type: Grant
    Filed: May 10, 1977
    Date of Patent: November 27, 1979
    Assignee: Warner-Lambert Company
    Inventor: Eugene J. Meierhoefer
  • Patent number: D253516
    Type: Grant
    Filed: May 10, 1977
    Date of Patent: November 27, 1979
    Assignee: Warner-Lambert Company
    Inventor: Eugene J. Meierhoefer