Abstract: The present invention relates to 15-cycloalkyl-prostaglandins of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## W represents ethylene or trans-vinylene, X represents ethylene or cis-vinylene, Y represents ethylene or trans-vinylene, R represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.1 represents a hydrogen atom or a methyl or ethyl group, R.sup.2 represents a straight- or branched-chain alkyl group containing from 2 to 8 carbon atoms or a phenyl group unsubstituted or substituted by an alkyl group containing from 1 to 3 carbon atoms, R.sup.3 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 3 carbon atoms, and n represents 4 or 5 and cyclodextrin clathrates of such acids and esters and, when R represents a hydrogen atom, non-toxic salts thereof.These new compounds exhibit characteristic prostaglandin-like activities.
Abstract: This invention is concerned with a novel process for the production of 2-substituted chromones (I) from readily available 4-methoxycoumarins. ##STR1## These compounds are useful as antiallergy agents.
Type:
Grant
Filed:
November 30, 1978
Date of Patent:
December 18, 1979
Assignee:
Warner-Lambert Company
Inventors:
David T. Connor, Patricia A. Young, Max von Strandtmann
Abstract: This invention relates to substituted indolobenzoxazepines which act as central nervous system depressants and as such are useful as tranquillizers.
Abstract: Humidifier and nebulizer adapter heads and humidifier assembly for inhalation therapy wherein high moisture content can be provided in a gas stream at high flow rates. The humidifier assembly consists of a disposable bottle and the disposable humidifier adapter head. The adapter head employs a conventional nebulizer to create a dense aerosol of sterile water and/or medicament entrained in an oxygen/air stream. The stream passes through a labyrinth of wide baffles which forces the stream to take a tortuous path resulting in turbulent flow and a high removal of droplets from the gas stream, but without generating a significant back pressure. The large surface area deflectors of the labyrinth also allow higher humidity of the gas stream due to evaporation. Water removed from the gas stream drains directly to the bottle.
Type:
Grant
Filed:
March 6, 1978
Date of Patent:
December 11, 1979
Assignee:
Warner-Lambert Company
Inventors:
Charles M. Schwartz, Eugene J. Meierhoefer
Abstract: A complete denture is disclosed for both maxillary and mandibular prostheses of the type having a hard base structure formed of acrylic plastic into which prosthetic teeth are set, the hard base structure fused to a deflectable tray layer of thermo plastic material which is deflectable when warm to adapt the denture to the general contours of the maxillary or mandibular ridges, a subsequent coating of autopolymerizing acrylic plastic being applied to the tray providing precise fitting of the denture to the oral contours of the wearer and stabilizing the soft deflectable tray in its newly achieved configuration.
Abstract: The present invention relates to prostaglandin analogues of the general formula: ##STR1## [wherein X represents cis or trans-vinylene or ethylene, R represents ##STR2## R.sup.1 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.2 represents a hydrogen atom or a methyl group, R.sup.3 represents a straight- or branched-chain alkylene group containing from 1 to 7 carbon atoms and R.sup.4 represents a cycloalkyl group containing from 5 to 7 carbon atoms, a grouping of the formula: ##STR3## (wherein R.sup.5 and R.sup.6, which may be the same or different, each represent a hydrogen atom or halogen atom, a trifluoromethyl group or a straight- or branched-chain alkyl group containing from 1 to 4 carbon atoms), or a grouping of the formula: ##STR4## (wherein R.sup.5 and R.sup.6 are as hereinbefore defined), or R.sup.3 and R.sup.
Abstract: This invention is concerned with a novel process for the production of 2-substituted chromones (I) from readily available 4-methoxycoumarins. ##STR1## These compounds are useful as antiallergy agents.
Type:
Grant
Filed:
March 31, 1978
Date of Patent:
June 19, 1979
Assignee:
Warner-Lambert Company
Inventors:
David T. Connor, Patricia A. Young, Max VON Strandtmann
Abstract: The disclosure relates to a sugarless center-filled gum wherein the sugarless chewing gum formulation can be extruded to form a hollow-centered rope and wherein the sugarless center-fill is not absorbed into the chewing gum. Both the chewing gum and the liquid fill have incorporated therein a composition comprising a natural or synthetic gum, glycerin humectant and an additional humectant which may be sorbitol solution or a combination of sorbitol solution and propylene glycol. Suitable synthetic or natural gums include carboxymethylcellulose, pectin, propylene glycol alginates, agar and gum tragacanth. The preferred composition which is incorporated into both the sugarless chewing gum formulation and the sugarless liquid fill contains sodium carboxymethylcellulose, glycerin and sorbitol solution.
Abstract: This invention relates to novel amides of 4-hydroxy-6H-thieno[2,3-b]thiopyran-5-carboxylic acid-7,7-dioxide having the Formula I: ##STR1## wherein R.sub.1 is hydrogen, halogen or lower alkyl; R.sub.2 is hydrogen, lower alkyl or aryl; Ar is aryl or heterocyclic; to the pharmaceutically acceptable salts thereof; and to processes for their preparation. The compounds of this invention exhibit antiinflammatory activity.
Type:
Grant
Filed:
December 27, 1977
Date of Patent:
May 15, 1979
Assignee:
Warner-Lambert Company
Inventors:
Jagadish C. Sircar, Stephen J. Kesten, Harold Zinnes
Abstract: A blood collection assembly and closure therefor, for the collection, separation, isolation and storage of serum from blood. The closure is constructed of a cannula penetrable self-sealing elastomer and includes a thixotropic barrier material in a hollow central portion of the closure, so that the barrier material is sealed within the closure until blood has been collected in the collection container and centrifuged. Centrifugation forces the barrier material into a collecton container through the passageway created by the cannula.
Abstract: A safety razor contains a blade cartridge in which two blades are rigidly secured. The cartridge has a seat member with an integral blade edge guard disposed transversely along its forward margin. A first razor blade is disposed on a planar surface of the seat member and has its cutting edge located rearwardly of the guard. A second razor blade having a cutting edge located parallel to and rearwardly of the first blade edge is in contact with a mating surface of a cap member. The cap member is secured to the seat member thereby clamping the blades in desired position. The blades are maintained at a predetermined distance apart by spacing means and the guard member has a plurality of projecting teeth transversely arrayed across the guard member forming a comb guard.
Type:
Grant
Filed:
October 15, 1976
Date of Patent:
April 3, 1979
Assignee:
Warner-Lambert Company
Inventors:
Evan N. Chen, Edward A. Beddall, Bryan J. Goddard
Abstract: The present invention relates to prostaglandin analogues of the general formula: ##STR1## ?wherein X represents cis or trans-vinylene or ethylene, Z represents ##STR2## R.sup.1 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.2 represents a hydrogen atom or a methyl group, R.sup.3 represents a straight- or branched-chain alkylene group containing from 1 to 7 carbon atoms and R.sup.4 represents a cycloalkyl group containing from 5 to 7 carbon atoms, a grouping of the formula: ##STR3## (wherein R.sup.5 and R.sup.6, which may be the same or different, each represent a hydrogen atom or halogen atom, a trifluoromethyl group or a straight- or branched-chain alkyl group containing from 1 to 4 carbon atoms), or a grouping of the formula: ##STR4## (wherein R.sup.5 and R.sup.6 are as hereinbefore defined), or R.sup.3 and R.sup.