Abstract: This invention is a system and method for a system and method for scheduling the harvesting of information associated with one or more end users from one or more information providers. A host computer, including a processor, is in communication with a user data store for storing data associated with users and an information provider store for storing data associated with information providers. For each end user, a profile of past access times, login times, is maintained in the user data store. For each information provider, a profile of update times and criteria are maintained in the information provider store. For a selected information provider, the host computer processor determines an update time for information stored by the selected information provider and a set of end users whose information could be modified by an update at that update time.

Abstract: Described are mutant Nav1.7 sodium channel alpha-subunits and nucleic acid sequences encoding such mutants. Further described are methods for characterizing a nucleic acid sequence that encodes a Nav1 sodium channel alpha-subunit, methods for determining a Nav1.7 haplotype, methods for determining a subject's predisposition to a neurologic disorder associated with a sodium channel mutation, and methods of identifying a compound that modulates mutant Nav1.7 sodium channels. Other materials, compositions, articles, devices, and methods relating to mutant Nav1.7 sodium channels are also described herein.

Abstract: A replacement light fixture for directing light emitted from a light source toward an area to be illuminated, including a base member upon with the light source is positioned and a reflector assembly detachably secured to a first and second mounting brackets that are mounted to a portion of the preexisting light fixture housing such that a lens portion of the reflector assembly overlies the light source and such that substantially all of the light emitted from the light source passes through the lens portion.

Abstract: A monoaxially-oriented polymeric film material formed from an impact copolymer and having increased toughness relative to films that are monoaxially-oriented at conventional temperatures. A process for imparting high cross machine toughness to polymer films comprises forming a film; subjecting the film to monoaxial orientation, drawing the film; tempering the film, and annealing the film.

Abstract: The present invention relates to a novel truncated form of heptocyte growth factor (HGF) which specifically antagonizes the activity of HGF and to a novel truncated form of HGF that is a partial HGF agonist. In particular, the present invention relates to the purification, molecular cloning, recombinant expression of the truncated HGF variants and related pharmaceutical compositions. The present invention further relates to the utilization of the small HGF variants to either inhibit HGF mitogenesis or stimulate HGF mitogenesis in cells expressing the receptor for HGF.

Abstract: Stable protein conformational isomers and methods for producing and isolating such isomers are disclosed. Methods of using such isomers, and products and compositions comprising such isomers are also disclosed.

Abstract: The invention relates to active agents from parasitic worms, in particular Schistosoma mansoni, which induce a T-helper type 2 response (Th2 immune response).

Abstract: A process is provided for the preparation of albumin from a yeast culture medium which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins, fragments of albumin, polymers or aggregates of albumin and viruses, and which is essentially non-glycated, relatively high in free thiol and with an intact C-terminus. The process comprises separating the yeast from the culture medium to yield an albumin solution; subjecting the albumin solution to positive mode cation exchange, affinity, and positive mode anion exchange chromatography; and concentrating and formulating the albumin with sodium octanoate and sodium chloride.

Abstract: A retirement planning method for computing possible future values of a portfolio of an investor.

Abstract: Embodiments according to the present invention provide an Impedance-based Arc-Fault Determination Device (IADD) and method that, when attached to an electrical node on the power system and through observations on voltage, current and phase shift with a step load change, determine the effective Thevenin equivalent circuit or Norton equivalent circuit at the point of test. The device and method determine the expected bolted fault current at the test location of interest, which enables calculation of incident energy and the assignment of a flash-hazard risk category.

Abstract: Disclosed is a method for producing a pigmented composite comprising contacting a microporous material with a tin compound to form a composite then contacting the composite with a pigment comprising an elemental metal, a metal oxide, a metal alloy, a metal salt, or a combination thereof to produce the pigmented composite. The pigmented composites described herein are useful for separating one or more analytes present in a fluid sample.

Abstract: A preassembled mechanical pipe coupling for joining pipe elements in end-to-end relationship is disclosed. The coupling is formed from a plurality of interconnectable segments that are initially maintained in spaced apart relation. The segments have arcuate surfaces that project inwardly. Connection members in the form of lugs and fasteners are mounted on the segments. The connection members are adjustably tightenable for drawing the coupling segments together and forcing the arcuate surfaces into engagement with the outer surfaces of the pipe elements. Notches are formed at ends of the arcuate surfaces to provide clearance allowing the pipe elements to be inserted between the segments when they are in the pre-assembled, spaced apart configuration.

Abstract: The crystal structure of ligand-bound EGLN1 catalytic domain of prolyl hydroxylase is disclosed. These coordinates are useful in computer aided drug design for identifying compounds that regulate EGLN1 prolyl hydroxylase and thereby regulate HIF-regulated disorders.

Abstract: A system designed to assist with the therapeutic treatment of subjects who have difficulty in walking, specifically those with a lack of sensation due to nerve damage or amputation, who are unable to tell when the foot makes contact with the floor. The system comprises a removable insole placed inside the shoe with proportionally senses touchdown; a miniature wireless transmitter which can be worn unobtrusively on the shoe; a miniature wireless receiver with tone generator which feeds an earpiece worn by the user; and a separate wireless receiver used by the therapist to monitor the same signal receiver by the user, in order to facilitate initial set-up and adjustments.

Abstract: The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-?) inhibitors thereby regulating angiogenesis. The present disclosure further relates to compositions comprising one or more human protein tyrosine phosphatase beta (HPTP-?) inhibitors, and to methods for regulating angiogenesis.

Abstract: The invention relates to medicaments for treating cardiac power failure. The medicaments contain a therapeutically effective quantity of one or more S100 protein(s) or one or more mutant or fragments of the same, or contain one or more nucleic acid sequence(s) which code(s) for these amino acid sequences and which are optionally integrated in one or more gene transfer vectors.