Patents Represented by Attorney BioTechnology Law Group
  • Patent number: 7657299
    Abstract: Automated methods and systems for the detection and analysis of plaque in one or more regions of a patient's vasculature are described.
    Type: Grant
    Filed: August 21, 2004
    Date of Patent: February 2, 2010
    Assignee: Ischem Corporation
    Inventors: Joel T. Huizenga, Russell W. Anderson, Thomas Woodley Brotherton
  • Patent number: 7614264
    Abstract: The present invention provides new anchored lock systems wherein the locking device (e.g., a padlock) can be rapidly detached from its anchor. The systems comprise an anchor for attachment to a structure such as a wall, portable panel, etc., or a structure a portion of which has been adapted to detachably engage the locking device. The anchor can be mounted in any desired location on a structure, and is configured such that it can be engaged by the lock body of a locking device that comprises at least two locking functionalities: releasable engagement of the anchor to prevent the locking device from being removed from the anchor when engaged by the lock; and releasable engagement of a shackle for retention of an article to be secured.
    Type: Grant
    Filed: February 13, 2004
    Date of Patent: November 10, 2009
    Inventor: John M. Mc Gettrick
  • Patent number: 7570992
    Abstract: In vivo methods are provided for using an electric field to delivery therapeutic treatment to a subject while reducing inducement of histopathological change in the target muscle tissue, such as is associated with induction or amplification of an immune response caused by the pulsed electric field. Therapeutic agents can be delivered nto cells of muscle for local and systemic treatments with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
    Type: Grant
    Filed: January 13, 2004
    Date of Patent: August 4, 2009
    Assignee: Genetronics, Inc.
    Inventors: Edward Nolan, Dietmar P. Rabussay, Georg Widera, Lei Zhang
  • Patent number: 7563459
    Abstract: The present invention is directed to methods for delivering cells to a target tissue in a mammal using glycoconjugate to traffic the cell to a desired organ in the mammal. The methods according to the present invention are especially applicable to administering stem cells such as those derived from the bone marrow or from umbilical cord tissue. The methods are also useful for targeting a gene of interest to a tissue in a mammal by introducing a cell containing the gene of interest and administering a glycoconjugate to the mammal.
    Type: Grant
    Filed: April 20, 2007
    Date of Patent: July 21, 2009
    Assignee: The United States of America as represented by the Department of Vetrans Affairs
    Inventor: Catherine A. Phillips
  • Patent number: 7497601
    Abstract: Systems, methods and devices for lighting are provided with a reflector with paraboloidal segments. One lighting system includes a reflector having one or more reflector segments. Each reflector segment is substantially paraboloidal and has a central axis of symmetry. The lighting system also includes an illumination portion having one or more light sources. Each light source corresponds to one of the reflector segments and has a central illumination axis. The central illumination axis is directed toward the corresponding segment and substantially perpendicular to the central axis of symmetry of the corresponding segment.
    Type: Grant
    Filed: September 17, 2007
    Date of Patent: March 3, 2009
    Assignee: Underwater Kinetics, Inc.
    Inventor: Alan Uke
  • Patent number: 7489017
    Abstract: A fixed parallel plate micro-mechanical systems (MEMS) based sensor is fabricated to allow a dissolved dielectric to flow through a porous top plate, coming to rest on a bottom plate. A post-deposition bake ensures further purity and uniformity of the dielectric layer. In one embodiment, the dielectric is a polymer. In one embodiment, a support layer is deposited onto the top plate for strengthening the sensor. In another embodiment, the bottom plate is dual-layered for a narrowed gap. Integrated circuit arrays of such sensors can be made, having multiple devices separated from each other by a physical barrier, such as a polycrystalline containment rim or trough, for preventing polymer material from one sensor from interfering with that of another.
    Type: Grant
    Filed: October 2, 2006
    Date of Patent: February 10, 2009
    Assignee: Xsilogy Inc.
    Inventors: Sanjay V. Patel, Bernd Fruhberger, Erno Klaassen, Todd E. Mlsna, David R. Baselt
  • Patent number: 7470420
    Abstract: The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.
    Type: Grant
    Filed: December 7, 2005
    Date of Patent: December 30, 2008
    Assignee: The Regents of the University of California
    Inventors: Bakthan Singaram, Ritchie A. Wessling
  • Patent number: 7437942
    Abstract: Sensors for outputting signals indicative of a magnetic drag force between a ferromagnetic sample that is or has been in motion relative to one or more measurement magnets are described. Such sensors include at least one measurement magnet and a sensing element operably associated therewith, such that upon or after exposure of the measurement magnet(s) to a ferromagnetic sample in motion relative thereto, the sensor can sense the drag force, if any, or changes therein, experienced by the measurement magnet. Devices for detecting and/or measuring magnetic drag force that employ one or more of these sensors are also described, as are various applications for such devices.
    Type: Grant
    Filed: October 27, 2006
    Date of Patent: October 21, 2008
    Assignee: MagCanica, Inc.
    Inventors: Ivan J. Garshelis, Stijn P. L. Tollens
  • Patent number: 7417037
    Abstract: Inflammatory bowel diseases are represented by two idiopathic disorders, which include ulcerative colitis and Crohn's disease. Ulcerative colitis is restricted to the colon and involves uncertain and inflammation of the lining (mucosa) of the large intestine. Crohn's disease, on the other hand, can involve the mucosa of the small and/or large intestine and may involve deeper layers of the bowel wall. The present invention is a combination of 5-aminosalicylic acid and one or more antioxidants (e.g., N-acetylcysteine) for treating such inflammatory bowel diseases.
    Type: Grant
    Filed: December 28, 2004
    Date of Patent: August 26, 2008
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Richard F. Harty
  • Patent number: 7393740
    Abstract: A fixed parallel plate micro-mechanical systems (MEMS) based sensor is fabricated to allow a dissolved dielectric to flow through a porous top plate, coming to rest on a bottom plate. A post-deposition bake ensures further purity and uniformity of the dielectric layer. In one embodiment the dielectric is a polymer. In one embodiment, a support layer is deposited onto the top plate for strengthening the sensor. In another embodiment, the bottom plate is dual-layered for a narrowed gap. Integrated circuit arrays of such sensors can be made, having multiple devices separated from each other by a physical barrier, such as a polycrystalline containment rim or trough, for preventing polymer material from one sensor from interfering with that of another.
    Type: Grant
    Filed: March 20, 2007
    Date of Patent: July 1, 2008
    Assignee: Xsilogy Inc.
    Inventors: Sanjay V. Patel, Bernd Fruhberger, Erno Klaassen, Todd E. Mlsna, David R. Baselt
  • Patent number: 7340941
    Abstract: Sensors for determining the ambient amount (e.g., concentration) of a chemical (e.g., molecular hydrogen in a gas or vapor) are disclosed. Preferred embodiments of these sensors comprise a dense thin metal (e.g., palladium or a palladium alloy) film disposed on a microcantilever beam that is suspended above a stationary baseplate. The dense thin metal film is configured to absorb, for example, hydrogen, thereby causing the film to expand which in turn causes the microcantilever beam to deform. The deformation can be measured, for example, as a change in capacitance between the microcantilever beam and the stationary baseplate. The measured change in capacitance is indicative of the ambient hydrogen concentration.
    Type: Grant
    Filed: October 1, 2003
    Date of Patent: March 11, 2008
    Assignee: Xsilogy, Inc.
    Inventors: Bernd Fruhberger, David R. Baselt
  • Patent number: 7328064
    Abstract: An apparatus is provided for injecting a fluid into body tissue, the apparatus comprising: a hollow needle; and fluid delivery means, wherein the apparatus is adapted to actuate the fluid delivery means in use so as to automatically inject fluid into body tissue during insertion of the needle into the said body tissue.
    Type: Grant
    Filed: July 3, 2003
    Date of Patent: February 5, 2008
    Assignee: Inovio AS
    Inventors: Iacob Mathiesen, Torunn Tjelle, Knut Arvid Sørensen Rekdahl, Bjøm David-Andersen
  • Patent number: 7282222
    Abstract: The present invention is directed to methods for delivering cells to a target tissue in a mammal using glycoconjugate to traffic the cell to a desired organ in the mammal. The methods according to the present invention are especially applicable to administering stem cells such as those derived from the bone marrow or from umbilical cord tissue. The methods are also useful for targeting a gene of interest to a tissue in a mammal by introducing a cell containing the gene of interest and administering a glycoconjugate to the mammal.
    Type: Grant
    Filed: March 14, 2003
    Date of Patent: October 16, 2007
    Assignee: The United States of America as Represented by the Department of Veterans Affairs
    Inventor: Catherine Phillips
  • Patent number: 7270956
    Abstract: Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor polynucleotide complementary to the target polynucleotide. The sensor polynucleotide comprises a signaling chromophore to receive energy from the excited multichromophore and increase emission in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: September 18, 2007
    Assignee: The Regents of the University of California
    Inventors: Guillermo C. Bazan, Brent S. Gaylord, Shu Wang
  • Patent number: 7235194
    Abstract: Disclosed are highly efficient multiphoton absorbing compounds and methods of their use. The compounds generally include a bridge of pi-conjugated bonds connecting electron donating groups or electron accepting groups. The bridge may be substituted with a variety of substituents as well. Solubility, lipophilicity, absorption maxima and other characteristics of the compounds may be tailored by changing the electron donating groups or electron accepting groups, the substituents attached to or the length of the pi-conjugated bridge. Numerous photophysical and photochemical methods are enabled by converting these compounds to electronically excited states upon simultaneous absorption of at least two photons of radiation. The compounds have large two-photon or higher-order absorptivities such that upon absorption, one or more Lewis acidic species, Lewis basic species, radical species or ionic species are formed.
    Type: Grant
    Filed: May 20, 2003
    Date of Patent: June 26, 2007
    Assignee: California Institute of Technology
    Inventors: Brian Cumpston, Matthew Lipson, Seth R Marder, Joseph W Perry
  • Patent number: 7230533
    Abstract: Devices for locating misplaced keys are described. Such devices include a housing in which is disposed a cell phone receiver, a ringer, associated circuitry, a power supply, and an “on/off” switch”. Such devices may also include a battery life indicator disposed in the housing, which indicator is visible to a user.
    Type: Grant
    Filed: August 8, 2005
    Date of Patent: June 12, 2007
    Inventor: Sharon Lee Hamolsky
  • Patent number: 7198893
    Abstract: Fast and highly accurate mass spectrometry-based processes for detecting a particular nucleic acid sequence in a biological sample are provided. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.
    Type: Grant
    Filed: October 10, 2000
    Date of Patent: April 3, 2007
    Assignee: Sequenom, Inc.
    Inventors: Hubert Köster, Andreas Braun, Dirk van den Boom, Christian Jurinke, Andreas Ruppert, Franz Hillenkamp, Daniel P. Little
  • Patent number: 7172219
    Abstract: Embodiments include a collapsible utility pole that snowboarders can carry easily in their pants pocket and can be quickly pulled out and extended to a completely rigid pole to push themselves over flat sections of downhill runs. The utility pole can also being useful when getting off the chair lift to move toward the slopes. Embodiments of the device have the capability of being converted into a small shovel or ice pick by detaching the snow basket and attaching a desired device.
    Type: Grant
    Filed: October 1, 2004
    Date of Patent: February 6, 2007
    Assignee: Sparker International, Inc.
    Inventors: Justin M. Spragg, Joseph M. Parker
  • Patent number: 7169390
    Abstract: Methods and compositions are disclosed that are useful for the prevention and/or treatment of cancer, angiogenesis, and inflammation. The beneficial effects of the compositions and methods are achieved through the use of pharmaceutical compositions that include agents that bind spingolipids or sphingolipid metabolites. In one embodiment the agent is an antibody or antibody derivative. In some embodiments, the agent is a receptor of a sphingolipid or a sphingolipid metabolite. Also disclosed are methods for identifying and isolating therapeutic agents.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: January 30, 2007
    Assignee: Lpath Therapeutics, Inc.
    Inventor: Roger A. Sabbadini
  • Patent number: 7171264
    Abstract: Methods are proved for introducing a biologically active agent into cells of a subject by introducing the agent in a form suitable for electrotransport into a region of tissue of the subject using one or more needle-free injectors, and applying a pulsed electric field to the region of tissue, thereby causing electroporation of the region of tissue. The combination of needle-free injection and electroporation is sufficient to introduce the agent into cells in skin, muscle or mucosa. For example, the region of tissue can be contacted with two oppositely charged injectors, one acting as the donor electrode and one acting as the counter electrode, or a single injector and one or more electrodes can be used. In addition, needle-free injection may be used in combination with suitable non-invasive electrode configurations. The active agents delivered into cells using the invention method can be small molecules, polynucleotides, polypeptides, and the like.
    Type: Grant
    Filed: January 8, 2003
    Date of Patent: January 30, 2007
    Assignee: Genetronics, Inc.
    Inventors: Gunter A. Hofmann, Dietmar P. Rabussay, Lei Zhang