Patents Represented by Attorney, Agent or Law Firm Bozicevic, Field, & Francis
  • Patent number: 8295923
    Abstract: A wearable iontophoresis device for the prolonged delivery of a positively charged pharmaceutical species from a salt formulation is disclosed that includes a readily oxidizable metal-based sacrificial anode in the form of a generally planar layer having a connecting area that has a width that is sufficient to insure complete consumption of the oxidizable metal wherein the anode is configured to have a minimum operating life of at least 6 hours under skin-safe conditions, and a drug delivery gel pad in electrical contact with said anode for accommodating a gel containing a positively charged pharmaceutical species in salt form formulated for transdermal delivery.
    Type: Grant
    Filed: August 31, 2009
    Date of Patent: October 23, 2012
    Assignee: Teikoku Pharma USA, Inc.
    Inventors: Kathleen A. Eischen, Carter R. Anderson, Russell L. Morris
  • Patent number: 8293483
    Abstract: In certain embodiments, the method may comprise: a) obtaining the antibody sequences from a population of B cells; b) grouping the antibody sequences to provide a plurality of groups of lineage-related antibodies; c) testing a single antibody from each of the groups in a bioassay and, after the first antibody has been identified, d) testing further antibodies that are in the same group as the first antibody in a second bioassay. In another embodiment, the method may comprise: a) testing a plurality of antibodies obtained from a first portion of an antibody producing organ of an animal; b) obtaining the sequence of a first identified antibody; c) obtaining from a second portion of said antibody producing organ the sequences of further antibodies that are related by lineage to said first antibody; and, c) testing the further antibodies in a second bioassay.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: October 23, 2012
    Assignee: Epitomics, Inc.
    Inventor: Guo-Liang Yu
  • Patent number: 8293685
    Abstract: Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display of proteins and peptides at the surface of bacteria by optimizing linkers and incorporating mutations at positions 165 and 166 of CPX.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: October 23, 2012
    Assignee: The Regents of the University of California
    Inventors: Patrick S. Daugherty, Jeffrey Rice
  • Patent number: 8287581
    Abstract: Methods and devices for preventing a change in the core body temperature of a mammal under cold conditions are provided. In the subject methods, a requirement for thermal energy input in said mammal is first detected. In response to the detection of this requirement for thermal energy input, a surface of a portion of the mammal is contacted with a warm temperature medium under negative pressure conditions for a period of time sufficient to introduce thermal energy into the core body of the mammal. The subject devices include at least a means for detecting a requirement for thermal energy input and a means for contacting a surface of the mammal with a warm temperature medium under negative pressure conditions. The subject methods and devices find use in a variety of applications, and are particularly suited for use in maintaining the core body temperature of a mammal substantially constant under cold conditions for an extended period of time.
    Type: Grant
    Filed: November 29, 2010
    Date of Patent: October 16, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Dennis A. Grahn, H. Craig Heller
  • Patent number: 8287851
    Abstract: The use of interleukin 17E to inhibit tumor growth in a subject is provided. The interleukin 17E can be provided to the subject exogenously, as an interleukin 17E polypeptide or a polynucleotide encoding an interleukin 17E polypeptide, or it can be provided by stimulating production of endogenous interleukin 17E. Also provided is the use of interleukin 17E in combination with one or more anti-cancer therapeutics for inhibiting tumor growth in a subject. Anti-cancer therapeutics include, for example, standard chemotherapeutic drugs, immunotherapeutics, radiation, gene therapy, hormone manipulation and antisense therapy.
    Type: Grant
    Filed: March 8, 2006
    Date of Patent: October 16, 2012
    Assignee: Lorus Therapeutics Inc.
    Inventors: Jim A. Wright, Aiping H. Young, Yoon Lee, Ming Yu Cao
  • Patent number: 8287489
    Abstract: A needle-free injector device comprising a latch having a safe position which disables the triggering of the device, and a ready position which restrains movement of a dispensing member but enables triggering and a triggered position which permits movement of the dispensing member is disclosed. An additional safety mechanism blocks the triggering of the device until removed. A cap is provided to maintain the sterility and stability of the drug formulation and is configured such that the cap removal is required prior to placing the device in a ready to trigger state.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: October 16, 2012
    Assignee: Zogenix, Inc.
    Inventors: Jeffrey A. Schuster, Paul Stuart Bridges, Graham Gibbins, Nicola Reid
  • Patent number: 8288147
    Abstract: Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl pyrophosphate. A related method comprises introducing into a host microorganism an intermediate in the mevalonate pathway and at least one heterologous nucleic acid sequence, each sequence coding for an enzyme in the mevalonate pathway necessary for converting the intermediate into isopentenyl pyrophosphate. The invention also provides nucleic acid sequences, enzymes, expression vectors, and transformed host cells for carrying out the methods.
    Type: Grant
    Filed: February 15, 2011
    Date of Patent: October 16, 2012
    Assignee: The Regents of the University of California
    Inventors: Jay D. Keasling, Vincent J.J. Martin, Douglas J. Pitera, Seon-Won Kim, Sydnor T. Withers, III, Yasuo Yoshikuni, Jack Newman, Artem Valentinovich Khlebnikov
  • Patent number: 8287454
    Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.
    Type: Grant
    Filed: September 27, 2010
    Date of Patent: October 16, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Howard Wolpert, Adam Heller
  • Patent number: 8288097
    Abstract: The present invention provides methods and compositions for asymmetrically tagging a nucleic acid fragment using asymmetric adapters.
    Type: Grant
    Filed: September 1, 2011
    Date of Patent: October 16, 2012
    Assignee: Population Genetics Technologies Ltd.
    Inventor: Gi Mikawa
  • Patent number: 8282631
    Abstract: A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the undesirable tissue. The electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body immune system. The amount of tissue ablation achievable through the use of irreversible electroporation without inducing thermal damage is considerable.
    Type: Grant
    Filed: September 20, 2011
    Date of Patent: October 9, 2012
    Assignee: The Regents of the University of California
    Inventors: Rafael Davalos, Boris Rubinsky
  • Patent number: 8282578
    Abstract: Integrated lancing and analyte measurement systems are provided which minimize the number of actions required to operate the systems, accomplished in part by combining two or more user steps into one.
    Type: Grant
    Filed: October 2, 2009
    Date of Patent: October 9, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Benjamin M. Rush, Benjamin J. Feldman
  • Patent number: 8277797
    Abstract: Mutant Listeria bacteria that modulate interferon-? production are provided. The subject bacteria are characterized by having a mutation in a gene chosen from a TetR gene, a LadR gene, a VirR gene, a MarR gene a MdrL gene, a MdrT gene and a MdrM gene. The subject bacteria find use in a variety of applications, where representative applications of interest include, but are not limited to: (a) use of the subject bacteria as adjuvants; (b) use of the subject bacteria as delivery vectors for introducing macromolecules into a cell; (c) use of the subject bacteria as vaccines for eliciting or boosting a cellular immune response; etc.
    Type: Grant
    Filed: November 21, 2007
    Date of Patent: October 2, 2012
    Assignee: The Regents of the University of California
    Inventors: Daniel A. Portnoy, Anat A. Herskovits, Gregory Crimmins
  • Patent number: 8280474
    Abstract: The present application provides Ag/AgCl based reference electrodes having an extended lifetime that are suitable for use in long term amperometric sensors. Electrochemical sensors equipped with reference electrodes described herein demonstrate considerable stability and extended lifetime in a variety of conditions.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: October 2, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Zenghe Liu, Benjamin J. Feldman, Brian Cho, Udo Hoss
  • Patent number: 8278063
    Abstract: The invention relates to bacteria, bacterial extracts, supernatants obtained from the culturing of said bacteria, polypeptides and compositions for degrading benzimidazole carbamate fungicides, carbanilate fungicides, sulfonamide herbicides, thioamide herbicides and/or synthetic pyrethroid insecticides. In particular, the invention relates to the identification of Nocardioides sp. which degrades benzimidazole carbamate fungicides, carbanilate fungicides, sulfonamide herbicides, thioamide herbicides and/or synthetic pyrethroid insecticides.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: October 2, 2012
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Gunjan Pandey, Chris M. Coppin, Susan J. Dorrian, Robyn Russell, John Oakeshott
  • Patent number: 8277496
    Abstract: Methods and devices for manipulating the thermoregulatory status of a mammal are provided. In the subject methods, thermal energy is transferred between the environment and both of the thoracic/abdominal core body and head of the mammal. In general, thermal energy transfer between thoracic/abdominal core body and the environment occurs under negative pressure conditions. The subject methods and devices can be used to increase the thoracic/abdominal core body temperature of a mammal, in which case thermal energy is introduced into the thoracic/abdominal core body of the mammal and removed from the head of the mammal or cold is merely applied thereto. The subject methods and devices can also be used to reduce the thoracic/abdominal core body temperature of a mammal, in which case thermal energy is removed from the thoracic/abdominal core body of the mammal and introduced into the head of the mammal or heat is merely applied thereto.
    Type: Grant
    Filed: January 23, 2007
    Date of Patent: October 2, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Dennis A. Grahn, H. Craig Heller
  • Patent number: 8275699
    Abstract: Provided in some embodiments is a method for conducting an honorary credit transaction.
    Type: Grant
    Filed: February 25, 2010
    Date of Patent: September 25, 2012
    Assignee: PayNearMe, Inc.
    Inventors: Danny Shader, Kurt Thams, Steve Capps
  • Patent number: 8273526
    Abstract: The present invention provides methods of cryopreserving stem and progenitor cells in a mammalian placenta; and methods of obtaining fetal stem and progenitor cells from a cryopreserved mammalian placenta. Cells obtained by carrying out the methods can be used in a variety of therapeutic applications.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: September 25, 2012
    Assignee: Children's Hospital & Research Center at Oakland
    Inventors: Frans A. Kuypers, Vladimir B. Serikov
  • Patent number: 8273241
    Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: September 25, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
  • Patent number: 8273349
    Abstract: The invention relates to the use of a binding member which binds to LewisY and Lewisb haptens in the treatment of tumours and leukaemia. The binding member may be an antibody which binds to LewisY and Lewisb haptens and cancer cells and induces cells death.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: September 25, 2012
    Assignee: Cephalon Australia Pty Ltd
    Inventors: Linda Durrant, Tina Parsons
  • Patent number: D668508
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: October 9, 2012
    Inventor: John Zox