Abstract: Inflammatory acne is treated topically with a non-aqueous gel of 13-cis retinoic acid.

Abstract: Anti-smoking oral preparations are provided containing a silver compound as the anti-smoking agent and a sweetener in which the silver compound is present in amounts of from 0.1 mg. to 2.5 mg. and the ratio of sweetness intensity based on sucrose to silver compound content is from 100:1 to 2500:1.

Abstract: Derivatives of N-[4-(N-[2-amino-4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-ylme thyl]-amino)benzoyl]-L-glutamic acid are antineoplastic agents. Their preparation and use, and intermediates useful for their preparation are described.

Abstract: This invention provides a semi-continuous fermentation process which is operated in a repeated fed-batch mode to maintain cell bioconversion productivity at a high level without product inhibition of enzymatic activity. The process is illustrated by the bioconversion of toluene or catechol via the ortho pathway to muconic acid which accumulates in the fermentation medium in a quantity up to about 50 grams per liter.

Abstract: Compounds of formula X ##STR1## in which R.sub.6 is aryl, R.sub.7 is hydrogen, --OH or alkyl, R.sub.8 is alkyl, R.sub.9 is hydrogen, alkyl, alkenyl, aryl, furyl or --CCl.sub.3, when n is 1, R.sub.10 is alkyl, aryl, camphoryl, --CF.sub.3 or fluoro, or when n is 2, R.sub.10 is alkylene or arylene are latent curing catalysts for acid-curable stoving varnishes. On irradiation, the active curing catalysts which lead to acid-catalysed curing of the resins are formed from the compounds of the formula x.

Abstract: N-[4-(N'-[2-amino-4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-ylme thyl]-N'-acylamino)benzoyl]-L-glutamic acid derivatives are antineoplastic agents. The compounds are prepared through acylation of the corresponding N'-amino compound or hydrolysis of a protected N'-acylamino compound. A typical embodiment is N-[4-(N'-[2-amino-4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-ylm ethyl]-N'-formylamino)benzoyl]-L-glutamic acid.

Abstract: 2-Amino-4-hydroxy-6-[2-(4-carboxyphenyl)alk-1-en-1-yl]pyrido[2,3,-d]pyrimid ines and 2-amino-4-hydroxy-6-[2-(4-carboxyphenyl)alk-1-yn-1-yl]pyrido[2,3-d]pyrimid ines are prepared through the reaction of a haloaromatic compound and an unsaturated compound in the presence of a palladium catalyst. The products are chemical intermediates for the preparation of antineoplastic agents.A typical embodiment is the reaction of a protected 2-amino-4-hydroxy-6-ethynylpyrido[2,3-d]pyrimidine and an ester of 4-iodobenzoic acid.

Abstract: N-Acylated N-phenyl-aminotetrahydro-2-furanones of the formula ##STR1## wherein R represents C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy or halogen,R.sub.1 represents C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.4 -alkoxy or halogen,R.sub.2 represents hydrogen, C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.4 -alkoxy or halogen,R.sub.3 represents hydrogen or methyl, with the total number of C atoms of the substituents R, R.sub.1, R.sub.2 and R.sub.3 in the phenyl ring not exceeding the number 8,R.sub.4 represents hydrogen or methyl, whileR.sub.5 represents one of the following groups: an alkylthioalkyl or alkoxyalkyl group having 2 to 5 carbon atoms or an alkoxyalkoxymethyl group having a maximum of 6 carbon atoms, a 2-furanyl or 2-tetrahydrofuranyl group optionally substituted by halogen, a 1,2,4-trizolylmethyl group, a 1,2-pyrazolylmethyl group, or a group --CH.sub.2 --OR.sub.6 in which R.sub.6 represents a 5- or 6-membered heterocyclic having oxygen as the hetero atom,are valuable fungicidal active substances.

Abstract: Propiophenones of the formula I ##STR1## in which R.sup.1 is hydrogen or C.sub.1 -C.sub.4 -alkyl, --Si(CH.sub.3).sub.3, allyl or benzyl, R.sup.2 is hydrogen, C.sub.1 -C.sub.8 -alkyl, C.sub.1 -C.sub.4 -alkyl which is substituted by C.sub.1 -C.sub.4 -alkoxy or --OH, --(CH.sub.2 --CH.sub.2 --O).sub.n --R.sup.5 where n is 2 to 20 and R.sup.5 is H or C.sub.1 -C.sub.4 -alkyl, --Si(CH.sub.3).sub.3, benzyl, C.sub.3 -C.sub.6 -alkenyl, C.sub.3 -C.sub.4 -alkynyl or 2-tetrahydrofuranyl, or R.sup.1 and R.sup.2 together are a C.sub.1 -C.sub.6 -alkylidene radical or a C.sub.2 -C.sub.6 -alkylidene radical which is substituted by hydroxyl, C.sub.1 -C.sub.4 -alkoxy or phenyl, a linear or branched C.sub.2 -C.sub.6 -alkanediyl radical, a benzylidene, cyclopentylidene or cyclohexylidene radical or a 2,2,2-trichloroethylidene, 2-furylimethylidene or dimethylsilylidene radical, R.sup.3 is phenyl which is unsubstituted or substituted by one or more --Cl, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy or C.sub.1 -C.sub.

Abstract: The present invention provides a closure for a container, preferably a plastic aerosol container on which there is provided a specially designed neck. A metal cup having vent slots is fittable on the container top and neck. The cup has formed at its periphery an inwardly curled tuck and a rounded top portion which fits over a rounded annular shoulder on the neck. The radius of the rounded annular shoulder of the neck is larger than the radius of the rounded top portion of the cup. The neck further includes a tuck support member having a horizontal ledge. A tuck pocket is formed between the annular shoulder and the tuck support member to accomodate the tuck in the cup. Sealing of the cup to the container occurs at the annular shoulder of the neck by pressure of a pressure ring in concert with a pilot of a closure die on the cup top portion.

Abstract: In a method of bonding a mirror to a rigid backing by means of a solvent-based adhesive, the solvent vapor from the bond line is extracted by interposing a porous layer between the mirror and the backing and extracting the solvent vapor through the porous layer by suction.Apparatus for this purpose includes first and second work stations 2,4 for supporting a rigid sheet of material 8, and means 39,40,44,46,56 for advancing the sheet from one station to the other through a third station equipped with means 34 for dispensing liquid adhesive on the sheet as it passes through. The support surface 16 of the second station is gas-permeable 18 and this station also includes a flexible and substantially gas-impermeable lid 22 adapted to close over a sheet lying on the support surface and means 21 for sucking gas through the support surface from the space between the lid and the support surface whereby to evacuate the space.

Abstract: In a method of bonding a mirror to a rigid backing by means of a solvent-based adhesive, the solvent vapour from the bond line is extracted by interposing a porous layer between the mirror and the backing and extracting the solvent vapour through the porous layer by suction.Apparatus for this purpose includes first and second work stations 2,4 for supporting a rigid sheet of material 8, and means 39,40,44,46,56 for advancing the sheet from one station to the other through a third station equipped with means 34 for dispensing liquid adhesive on the sheet as it passes through. The support surface 16 of the second station is gas-permeable 18 and this station also includes a flexible and substantially gas-impermeable lid 22 adapted to close over a sheet lying on the support surface and means 21 for sucking gas through the support surface from the space between the lid and the support surface whereby to evacuate the space.

Abstract: Anthraquinone is produced by reacting phthalic anhydride in the vapor phase over a catalyst which may be an oxide of the Group 4b metals zirconium, hafnium, and titanium, the Group 5b metals niobium, tantalum, and vanadium, or the rare earths cerium and thorium such oxides, preferably being treated with sulfuric acid and calcined. Substituted anthraquinones may be produced by employing the corresponding substituted phthalic anhydrides.

Abstract: Prop-1-ynyl-3-phenoxybenzyl-2,2-dimethyl-3-(2',2'-dihalovinyl)-cyclopropane -1-carboxylates of the formula ##STR1## in which X.sub.1 if fluorine, chlorine or bromine, and their use in combating pests.

Abstract: Oral or parenteral administration of 10 to 30 mg/kg/day of L-carnitine (or an equivalent amount of a pharmacologically acceptable salt thereof) both during preanesthesia and post-operative phase antagonizes the toxic effects (particularly on kidneys and liver) induced by inhalation of halogen-containing general anesthetics such as, typically, halotane.

Abstract: The present invention relates to pharmaceutical administration systems containing phosphatidylserine and phosphatidylcholine or phosphatidylethanolamine derivatives in the form of liposomes which encapsulate water soluble muramyldipeptide derivatives in combination with gamma-interferon. The liposomes are prepared by conventional dispersion methods. The pharmaceutical administration systems when applied in the form of liposomes are especially useful in the cancer chemotherapy for combating metastatic tumor cells.

Abstract: Stable salts of S-adenosyl-L-methionine with water-soluble polyanions, such as polyphosphates, polyvinylsulfonates -sulfates or -phosphates, polyacrylates, polystyrene sulfonates, are described.The salts according to the invention, prepared by precipitation from aqueous solutions of pH not exceeding 3.5, possess peculiar stability, solubility, nonhygroscopicity and are valuable for use as active constituents in pharmaceutical compositions.

Abstract: A cough drop is provided comprising a hard candy outer shell and a powdered centerfill containing a rapidly-dissolving powder such as dextrose monohydrate and an active ingredient such as menthol and eucalyptus which is preferably in the form of a liquid blend and a spray-dried powder. The hard candy outer shell also contains menthol and eucalyptus as a liquid blend.When the outer shell is dissolved in the mouth or the centerfill is bitten into, the rapidly-dissolving powder acts to enhance the active-ingredient's activity in the mouth so that a discernible vaporization of active-ingredient is felt.

Abstract: Carnitine acetyl carnitate dichloride, a precursor of carnitine and acetyl carnitine, is prepared by condensing noncarnitine tert-butyl ester with the acid chloride of acetyl carnitine chloride and methylating the product of the condensation with methyl iodide, thereby obtaining acetyl carnitate of carnitine chloride iodide. This product is hydrolized with trifluoroacetic acid, thereby eliminating the tert-butyl ester. The so-obtained acetyl carnitate of carnitine chloride iodide is converted into the desired compound by eluting a solution of the chloride iodide on a strongly basic ion-exchange resin activated in Cl.sup.- form.

Abstract: N-Sulfonyliminothiocarbonic acid diesters protect rice crops from phytotoxic damage caused by herbicides.