Patents Represented by Attorney Casimir Jones, S.C.
  • Patent number: 8268565
    Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
    Type: Grant
    Filed: December 2, 2008
    Date of Patent: September 18, 2012
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Stephen A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Thomas A. Hall, Yun Jiang, James C. Hannis, Neill White, Vivek Samant, Mark W. Eshoo, Jared J. Drader
  • Patent number: 8263104
    Abstract: Disclosed herein are nanofilm coatings for implantable medical devices comprising a diblock or triblock copolymer (PEO-PMMA or PMOXA-PDMS-PMOXA, respectively). Such nanofilms, may be used, for example, as amphiphilic supports for therapeutic agents. These materials are conducive towards the formation of active substrates for a suite of biological and medical applications.
    Type: Grant
    Filed: June 9, 2008
    Date of Patent: September 11, 2012
    Assignees: Northwestern University, The Regents of the University of California
    Inventors: Dean Ho, Mark Chen, Erik Pierstorff, Houjin Huang, Edward K Chow, Genhong Cheng
  • Patent number: 8263752
    Abstract: The invention relates to soluble selenium compositions and methods of production, separation and purification thereof. In particular the present invention provides methods of preparing water soluble selenoglycoproteins (e.g., via extracting selenoglycoproteins from selenium enriched yeast), methods of supplementing a selenium deficient composition via admixing water soluble selenoglycoproteins with the selenium deficient composition, compositions comprising the water soluble selenoglycoproteins and methods of administering the same.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: September 11, 2012
    Assignee: Alltech, Inc.
    Inventors: Stefan Kwiatkowski, Ronan Power, Clayton Matney, Paiman P. Ghoroghchian, Eric M. Ostertag
  • Patent number: 8265878
    Abstract: Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: September 11, 2012
    Assignee: Ibis Bioscience, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil
  • Patent number: 8257939
    Abstract: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: September 4, 2012
    Assignee: Promega Corporation
    Inventors: Keith V. Wood, Georgyi V. Los, Robert F. Bulleit, Dieter Klaubert, Mark McDougall, Chad Zimprich
  • Patent number: 8252599
    Abstract: Sample processing units useful for mixing and purifying materials, such as fluidic materials are provided. A sample processing unit typically includes a container configured to contain a sample comprising magnetically responsive particles, and one or more magnets that are in substantially fixed positions relative to the container. A sample processing unit also generally includes a conveyance mechanism configured to convey the container to and from a position that is within magnetic communication with the magnet, e.g., such that magnetically responsive particles with captured analytes can be retained within the container when other materials are added to and/or removed from the container. Further, a sample processing unit also typically includes a rotational mechanism that is configured to rotate the container, e.g., to effect mixing of sample materials disposed within the container. Related carrier mechanisms, sample processing stations, systems, and methods are also provided.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: August 28, 2012
    Assignee: Ibis Biosciences, Inc.
    Inventors: Steven A. Hofstadler, Jared J. Drader, Jose R. Gutierrez, Paul J. Gleason, Rex O. Bare, Robert D. Miller, Jeffrey C. Smith
  • Patent number: 8252581
    Abstract: Apparatus, systems, chips, and methods of performing a large number of simultaneous chemical reactions are provided herein. The chips of the invention comprise addressable units that can be addressed according to the temperature of the reaction to be run. The subject apparatus, systems, and chips are particularly suited for performing polymerase chain reactions on thousands of nucleic acid sequences, up to and including sequences of an entire genome of an organism of interest.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: August 28, 2012
    Assignee: Wafergen, Inc.
    Inventors: Victor Joseph, Amjad Huda, Alnoor Shivji
  • Patent number: 8247181
    Abstract: Compositions and methods of detecting Borrelia proteins, nucleic acid sequences encoding these proteins, and subject antibodies to these proteins in a sample are disclosed.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: August 21, 2012
    Assignee: The Regents of the University of California
    Inventors: Alan G. Barbour, Philip L. Felgner
  • Patent number: 8246983
    Abstract: The present invention relates to methods and compositions for the treatment of cancer and for research and analysis of cancer. In particular, the present invention provides encapsulated arsenic anti-cancer compositions with improved properties.
    Type: Grant
    Filed: September 5, 2006
    Date of Patent: August 21, 2012
    Assignee: Northwestern University
    Inventors: Thomas O'Halloran, Haimei Chen
  • Patent number: 8242250
    Abstract: The present invention relates to a novel nucleic acid molecule encoding an amino acid sequence, which is capable of forming a cyclic structure. Cyclization may occur within a cell or cell membrane, or linear forms of the molecules may be circularised or partially circularised, in vitro using isolated enzyme systems or chemical means. The cyclised amino acid sequence is generally in the form of a stabilized folded structure such as acyclic knotted peptide, polypeptide or protein or functional equivalent. The nucleic acid molecules and cyclic and linear peptides are useful inter alia in the generation of molecules having animal or plant therapeutic properties, as well as in a range of diagnostic, industrial and agricultural, including horticultural, applications. Of particular importance is the use of these molecules in the protection of plants, such as crop plants, from pest and/or pathogen infestation.
    Type: Grant
    Filed: August 26, 2009
    Date of Patent: August 14, 2012
    Assignees: The University of Queensland, Hexima Limited
    Inventors: David James Craik, Marilyn Anne Anderson, Cameron Victor Jennings
  • Patent number: 8241862
    Abstract: The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: August 14, 2012
    Assignees: Northwestern University, Cold Spring Harbor Laboratory
    Inventors: Sui Huang, Rajesh V. Kamath, David L. Spector, Ann D. Thor, Chen Wang
  • Patent number: 8236335
    Abstract: The present invention relates to compositions and methods for decreasing the infectivity, morbidity, and rate of mortality associated with a variety of pathogenic organisms and viruses. The present invention also relates to methods and compositions for decontaminating areas colonized or otherwise infected by pathogenic organisms and viruses. Moreover, the present invention relates to methods and compositions for decreasing the infectivity of pathogenic organisms in foodstuffs.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: August 7, 2012
    Assignee: The Regents of the University of Michigan
    Inventors: James R. Baker, Jr., Tarek Hamouda, Amy Shih, Andrzej Myc
  • Patent number: 8236777
    Abstract: The present invention relates to a promoter region of a microRNA, the use of a microRNA, in particular miR-21, and related elements for the diagnosis and for the manufacture of a medicament for the treatment and/or prevention of fibrosis and/or fibrosis related diseases. Additionally, the invention concerns antisense oligonucleotides against targets of miR-21. A cell deficient for miR-21, the promoter region and targets of miR-21 and a knock-out organism thereof are also encompassed. Finally, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis.
    Type: Grant
    Filed: February 26, 2009
    Date of Patent: August 7, 2012
    Assignee: Julius-Maximilians-Universitat Wurzburg
    Inventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
  • Patent number: 8230635
    Abstract: The present invention relates to target acquisition and related devices, and more particularly to telescopic gunsights and associated equipment used to achieve shooting accuracy at, for example, close ranges, medium ranges and extreme ranges.
    Type: Grant
    Filed: December 27, 2010
    Date of Patent: July 31, 2012
    Assignee: Horus Vision LLC
    Inventors: Dennis J. Sammut, Dickinson Buell, Lawrence Chao
  • Patent number: 8232320
    Abstract: The present invention relates to compositions and methods for decreasing the infectivity, morbidity, and rate of mortality associated with a variety of pathogenic organisms and viruses. The present invention also relates to methods and compositions for decontaminating areas colonized or otherwise infected by pathogenic organisms and viruses. Moreover, the present invention relates to methods and compositions for decreasing the infectivity of pathogenic organisms in foodstuffs.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: July 31, 2012
    Assignee: The Regents of the University of Michigan
    Inventors: James R. Baker, Jr., Tarek Hamouda, Amy Shih, Andrzej Myc
  • Patent number: 8222188
    Abstract: The present invention relates to the production of antibody libraries. In particular, the present invention relates to the use of integrating retroviral vectors to generate libraries comprising a plurality of combinations of antibody light chains and heavy chains. The present invention thus provides improved methods of generating and screening antibody libraries comprising large numbers of unique antibodies.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: July 17, 2012
    Assignee: Catalent Pharma Solutions, LLC
    Inventors: Robert D. Bremel, Kurt Eakle, Michael Imboden
  • Patent number: 8217020
    Abstract: Methods and compositions for reducing viral genome amounts in a target cell are provided. In the subject methods, the activity of a miRNA is inhibited in a manner sufficient to reduce the amount of viral genome in the target cell, e.g., by introducing a miRNA inhibitory agent in the target cell. Also provided are pharmaceutical compositions, kits and systems for use in practicing the subject methods. The subject invention finds use in a variety of applications, including the treatment of subjects suffering from a viral mediated disease condition, e.g., an HCV mediated disease condition.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: July 10, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Peter Sarnow, Catherine L. Jopling, Alissa M. Lancaster
  • Patent number: 8219180
    Abstract: The present invention provides systems, devices, and methods employing fiber optic shape and position tracking. The systems, devices, and methods permit measurement of and continuous tracking of the shape and position of objects whose shape dynamically changes with time. Applications include tracking and monitoring of endoscopes for diagnostic and surgical procedures.
    Type: Grant
    Filed: October 9, 2008
    Date of Patent: July 10, 2012
    Assignees: Tufts University, University Health Network, The Governing Council of the University of Toronto
    Inventors: Caroline G. L. Cao, Peter Y. Wong, Lothar Lilge, Paul Milgram
  • Patent number: 8216567
    Abstract: The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease.
    Type: Grant
    Filed: September 13, 2011
    Date of Patent: July 10, 2012
    Assignee: Quintessence Biosciences, Inc.
    Inventors: Tony Klink, John Kink, Laura Strong
  • Patent number: D665757
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: August 21, 2012
    Assignee: Raffel Systems, LLC
    Inventors: Kenneth G. Seidl, Edward Nowak, Paul F. Stangl