Patents Represented by Attorney Casimir Jones, S.C.
  • Patent number: 8178506
    Abstract: Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
    Type: Grant
    Filed: December 30, 2008
    Date of Patent: May 15, 2012
    Assignee: Regulus Therapeutics Inc.
    Inventors: Bridget Lollo, C. Frank Bennett, Susan M. Freier, Richard H. Griffey
  • Patent number: 8173957
    Abstract: The methods described herein generally relate to characterization of large analytes, such as biomolecules, by molecular mass analysis. Specifically, the methods are directed to molecular mass analysis of singly- or multiply-charged ions by selective ion filtering carried out by a digital thresholding process.
    Type: Grant
    Filed: January 26, 2010
    Date of Patent: May 8, 2012
    Assignee: Ibis Biosciences, Inc.
    Inventors: Steven A. Hofstadler, Jared J. Drader, Amy L. Schink
  • Patent number: 8168405
    Abstract: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two amino acid substitutions relative to the wild-type hydrolase. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: May 1, 2012
    Assignee: Promega Corporation
    Inventors: Aldis Darzins, Lance Encell, Dieter Klaubert, Georgyi V. Los, Mark McDougall, Keith V. Wood, Monika G. Wood, Chad Zimprich
  • Patent number: 8168675
    Abstract: The present invention relates to compositions and methods for treating neurodegenerative diseases. In some embodiments, the present invention provides compositions for treating and preventing presbycusis.
    Type: Grant
    Filed: December 31, 2008
    Date of Patent: May 1, 2012
    Assignee: Marin Bio Co., Ltd.
    Inventor: Shinichi Someya
  • Patent number: 8163895
    Abstract: Oligonucleotide primers and compositions and kits containing the same for rapid identification of orthopoxviruses by amplification of a segment of viral nucleic acid followed by molecular mass analysis are provided.
    Type: Grant
    Filed: August 24, 2005
    Date of Patent: April 24, 2012
    Assignee: Ibis Biosciences, Inc.
    Inventors: Rangarajan Sampath, Thomas A. Hall, David J. Ecker, Steven A. Hofstadler
  • Patent number: 8158354
    Abstract: The present invention provides a method for rapid solution capture purification of nucleic acids for subsequent analysis by electrospray mass spectrometry which is efficient and cost-effective relative to existing methods. The present invention also provides kits useful for practicing rapid solution capture of nucleic acids so that purified samples are in condition for analysis by electrospray mass spectrometry.
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: April 17, 2012
    Assignee: Ibis Biosciences, Inc.
    Inventors: Steven A. Hofstadler, Lendell L. Cummins
  • Patent number: 8158936
    Abstract: The invention relates generally to sample ionization, and provides ionization probe assemblies, systems, computer program products, and methods useful for this purpose.
    Type: Grant
    Filed: February 12, 2010
    Date of Patent: April 17, 2012
    Assignee: Ibis Biosciences, Inc.
    Inventors: Steven A. Hofstadler, Jose R. Gutierrez, James C. Hannis, Jared J. Drader, Rex O. Bare, Jeffrey C. Smith, Paul J. Gleason, Jared Nathanson
  • Patent number: 8153592
    Abstract: This description provides methods and materials related to modulating Toll-like receptor activity. For example, methods and materials for increasing or decreasing the responsiveness of a TLR4 polypeptide are provided.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: April 10, 2012
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Jeffrey L. Platt, Gregory J. Brunn
  • Patent number: 8153737
    Abstract: The present invention relates generally to molecularly imprinted polymers (MIPs). In particular, the present invention relates to reusable, ecologically friendly MIPs that can be produced in relatively large quantities, methods of producing the same, and methods of utilizing the same (e.g., to sequester and/or adsorb target compounds (e.g., mycotoxins)). Compositions and methods of the invention find use in a variety of applications including dietary therapeutic, prophylactic, food and beverage processing and manufacture, as well as research, quality control and traceability applications.
    Type: Grant
    Filed: August 27, 2010
    Date of Patent: April 10, 2012
    Assignee: Alltech, Inc.
    Inventors: Alexandros Yiannikouris, Stefan Kwiatkowski, Manoj Bojappa Kudupoje, Clayton Matney
  • Patent number: 8148163
    Abstract: Sample processing units useful for mixing and purifying materials, such as fluidic materials are provided. A sample processing unit typically includes a container configured to contain a sample comprising magnetically responsive particles, and one or more magnets that are in substantially fixed positions relative to the container. A sample processing unit also generally includes a conveyance mechanism configured to convey the container to and from a position that is within magnetic communication with the magnet, e.g., such that magnetically responsive particles with captured analytes can be retained within the container when other materials are added to and/or removed from the container. Further, a sample processing unit also typically includes a rotational mechanism that is configured to rotate the container, e.g., to effect mixing of sample materials disposed within the container. Related carrier mechanisms, sample processing stations, systems, and methods are also provided.
    Type: Grant
    Filed: September 16, 2009
    Date of Patent: April 3, 2012
    Assignee: Ibis Biosciences, Inc.
    Inventors: Steven A. Hofstadler, Jared J. Drader, Jose R. Gutierrez, Paul J. Gleason, Rex O. Bare, Robert D. Miller, Jeffrey C. Smith
  • Patent number: 8148147
    Abstract: The present invention relates to the field of oncology and provides novel compositions and methods for diagnosing and treating pancreatic cancer. In particular, the present invention provides pancreatic cancer stem cells useful for the study, diagnosis, and treatment of solid tumors.
    Type: Grant
    Filed: January 24, 2008
    Date of Patent: April 3, 2012
    Assignee: The Regents of the University of Michigan
    Inventors: Diane M. Simeone, Michael F. Clarke
  • Patent number: 8143232
    Abstract: The present invention relates to compositions and methods for cancer therapy, including but not limited to, targeted inhibition of cancer markers. In particular, the present invention relates to recurrent gene fusions as clinical targets for prostate cancer.
    Type: Grant
    Filed: March 3, 2010
    Date of Patent: March 27, 2012
    Assignee: The Regents of the University of Michigan
    Inventors: Arul M. Chinnaiyan, Jindan Yu, Ram Shankar Mani
  • Patent number: 8137911
    Abstract: The present invention provides methods, compositions and kits for using an RNA polymerase for making transcription products corresponding to a target sequence by obtaining single-stranded DNA transcription substrates that comprise a single-stranded promoter that is operably joined to a single-stranded target sequence. The invention has broad applicability for research, diagnostic and therapeutic applications, such as preparing cDNA corresponding to full-length mRNA, making sense or anti-sense probes, detecting gene- or organism-specific sequences, cloning, cell signaling or making RNA for use in RNAi.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: March 20, 2012
    Assignee: CellScript, Inc.
    Inventors: Gary A. Dahl, Jerome J. Jendrisak, Elena K. Davydova, Lucia B. Rothman-Denes, Svetalana Y. Gerdes
  • Patent number: 8136668
    Abstract: The present invention relates to articles of manufacture for the packaging of brittle, elongated, and/or asymmetrically-shaped retail items for retail display to consumers. In some embodiments, the article of manufacture serves to protect the retail items from breakage during display or transit while allowing ready visual inspection by the consumer. In a preferred embodiment, the retail items are candy canes.
    Type: Grant
    Filed: June 22, 2009
    Date of Patent: March 20, 2012
    Assignee: Atico International, USA
    Inventors: Gerald I. Katz, Marlen Rosales
  • Patent number: 8138909
    Abstract: A method and apparatus for providing assay information to a portable detection unit, by way of a remote server in communication with the portable detection unit or a consumable with stored information for use with the portable detection unit. Global Positioning System (GPS) information is provided to a portable detection unit having a GPS receiver, so that the unit can determine its current position, including altitude. Based on the determined position, assays and parameters, such as PCR melt temperatures, can be selected. Assays to be performed by the portable detection unit can be selected based on the results of a prior assay.
    Type: Grant
    Filed: July 2, 2008
    Date of Patent: March 20, 2012
    Assignees: Smiths Detection Inc., Smiths Detection—Watford Limited
    Inventors: Jay Lewington, John Walter Czajka, Douglas Jason Green, Carmelo Volpe
  • Patent number: 8133496
    Abstract: The present invention relates to methods and compositions for treating urinary tract infections. In particular, the present invention relates to vaccines and immune modulators for treating urinary tract infections.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: March 13, 2012
    Assignee: The Regents of the University of Michigan
    Inventor: Harry L. T. Mobley
  • Patent number: 8133876
    Abstract: Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
    Type: Grant
    Filed: December 30, 2008
    Date of Patent: March 13, 2012
    Assignee: Regulus Therapeutics Inc.
    Inventors: C. Frank Bennett, Susan M. Freier, Richard H. Griffey, Eric G. Marcusson
  • Patent number: 8119348
    Abstract: The present invention relates generally to biomarkers for macular degeneration. In particular, the present invention provides a plurality of biomarkers for monitoring and diagnosing macular degeneration. The compositions and methods of the present invention find use in diagnostic, therapeutic, research, and drug screening applications.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: February 21, 2012
    Assignees: The Regents of the University of Michigan, The Trustees of the University of Pennsylvania, Mayo Foundation for Medical Education and Research
    Inventors: Anand Swaroop, Goncalo Abecasis, Wei Chen, Dwight Stambolian, Albert O. Edwards
  • Patent number: 8119336
    Abstract: The present invention provides oligonucleotide primers and compositions and kits containing the same for rapid identification of alphaviruses by amplification of a segment of viral nucleic acid followed by molecular mass analysis.
    Type: Grant
    Filed: March 2, 2005
    Date of Patent: February 21, 2012
    Assignee: Ibis Biosciences, Inc.
    Inventors: Rangarajan Sampath, Thomas A. Hall, Mark W. Eshoo
  • Patent number: 8119742
    Abstract: The invention describes families of compounds that utilize multihydroxyl phenyl groups to provide adhesive properties. Selection of the multihydroxy phenyl group along with linkers or linking groups and the linkages between the linkers or linking groups with polyalkylene oxides, provides materials that can be engineered to afford controllable curing time, biodegradation and/or swelling.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: February 21, 2012
    Assignee: KNC Ner Acquisition Sub, Inc.
    Inventors: Jeffrey L. Dalsin, Bruce P. Lee, Laura Vollenweider, Sunil Silvary, John L. Murphy, Fangmin Xu, Amanda Spitz, Arinne Lyman