Patents Represented by Attorney Charles J. Knuth

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  • Biopolymer compositions having enhanced filterability
    Patent number: 4639322
    Abstract: Biopolymers comprising xanthomonas and methylene bis (thiocyanate) are disclosed.
    Type: Grant
    Filed: August 27, 1984
    Date of Patent: January 27, 1987
    Assignee: Pfizer Inc.
    Inventors: Donald Beck, James W. Miller, William C. Wernau, Thomas B. Young, III
  • Triazole antifungal agents
    Patent number: 4638007
    Abstract: Antifungal 1-[3-(substituted)-2-hydroxy-2-(perfluoroalkyl)-propyl]triazole derivatives wherein the 3-propyl substituent represents optionally substituted phenoxy, heteroaryloxy, alkylthio, alkylsulfinyl, alkylsulfonyl or optionally substituted carbamoyl.
    Type: Grant
    Filed: August 20, 1984
    Date of Patent: January 20, 1987
    Assignee: Pfizer Inc.
    Inventors: Kenneth Richardson, Peter J. Whittle
  • N-(phenoxyalkyl)imidazoles as selective inhibitors of the thromboxane synthetase enzyme and pharmaceutical compositions thereof
    Patent number: 4636500
    Abstract: N-(mono or disubstituted Phenoxyalkyl)imidazoles and the pharmaceutically acceptable acid addition salts thereof are able to selectively inhibit the action of the thromboxane synthetase enzyme without significantly inhibiting the action of the prostacycline synthetase or cyclooxygenase enzymes and are thus useful in the treatment of ischaemic heart disease, stroke, transient ischaemic attack, thrombosis migraine and the vascular complications of diabetes.
    Type: Grant
    Filed: March 21, 1985
    Date of Patent: January 13, 1987
    Assignee: Pfizer Inc.
    Inventors: Peter E. Cross, Roger P. Dickinson
  • Formulation of antiinflammatory drugs
    Patent number: 4636498
    Abstract: An improved antiinflammatory composition and method of treating inflammation which employs a combination of an antiinflammatory agent (e.g. indomethacin or an oxicam) with a histamine-H.sub.2 antagonist selected from the group consisting of 2-guanidino-4-(4-imidazolyl)thiazole, 2-guanidino-4-(2-methyl-4-imidazolyl )thiazole, 2-(N-benzyl-N'-guanidino)-4-(2-methyl-4-imidazolyl)thiazole, 2-(N-pentyl-N'-guanidino)-4-(2-methyl-4-imidazolyl)thiazole and 2-guanidino-4-[2-(hexylamino)-4-imidazolyl]thiazole.
    Type: Grant
    Filed: August 15, 1985
    Date of Patent: January 13, 1987
    Assignee: Pfizer Inc.
    Inventor: John L. LaMattina
  • 7-heterocyclic-1,4-dihydroquinolones
    Patent number: 4636506
    Abstract: 1-Alkyl-6,8-difluoro-7-heterocyclic-1,4-dihydroquinol-4-one 3-carboxylic acids having antibacterial activity are prepared by conventional cyclization methods.
    Type: Grant
    Filed: April 4, 1985
    Date of Patent: January 13, 1987
    Assignee: Pfizer, Inc.
    Inventors: Paul J. Gilligan, Paul R. McGuirk, Michael J. Witty
  • Intermediates for preparing pirbuterol and analogs
    Patent number: 4632992
    Abstract: Processes and intermediates useful in the preparation of bronchodilator compounds of the formula ##STR1## wherein R is hydrogen, methyl or hydroxymethyl are described. Those compounds wherein R is H or CH.sub.3 have been found to have further utility as intermediates for pirbuterol (wherein R is hydroxymethyl).
    Type: Grant
    Filed: August 16, 1984
    Date of Patent: December 30, 1986
    Assignee: Pfizer Inc.
    Inventors: Berkeley W. Cue, Stephen S. Massett
  • Process for making 2-guanidino-4-(2-methyl-4-imidazolyl) thiazole dihydrobromide
    Patent number: 4632993
    Abstract: 2-Guanidino-4-(2-methyl-4-imidazolyl)thiazole dihydrobromide and a one-pot, high yield process for its preparation from 2-methyl-4(or 5)-acetylimidazole.
    Type: Grant
    Filed: October 11, 1984
    Date of Patent: December 30, 1986
    Assignee: Pfizer Inc.
    Inventor: Berkeley W. Cue, Jr.
  • Cobalt-chromium superalloy
    Patent number: 4631082
    Abstract: An oxide dispersion strengthened cobalt-chromium superalloy produced by mechanical alloying containing a refractory oxide, preferably yttrium oxide, and characterized by excellent corrosion resistance, high fatigue strength and high temperature stability; and prostheses formed from said superalloy.
    Type: Grant
    Filed: February 20, 1985
    Date of Patent: December 23, 1986
    Assignee: Pfizer Hospital Products Group Inc.
    Inventors: Henry L. Andrews, Gregory E. Gardiner
  • Thiazole precursors for the preparation of biotin
    Patent number: 4631345
    Abstract: A novel process is described for preparation of biotin comprising preparation of substituted 3H, 5H-imidazo[1, 5c]tetrahydro thiazoles by contacting the boron triflouride adduct of an appropriate thiazoline with the metallic derivative of an ester enolate, reducing the ester, hydrolyzing the thiazolidine moiety and hydrolyzing or oxidizing the resultant compound. Intermediates obtained in the preparation of biotin by the above process and alternate procedures for preparing said intermediates are also presented. A novel process for preparation of d-biotin is also given.
    Type: Grant
    Filed: February 18, 1986
    Date of Patent: December 23, 1986
    Assignee: Pfizer Inc.
    Inventor: Robert A. Volkmann
  • Bone nail for the treatment of fractures
    Patent number: 4630601
    Abstract: A bone nail for the treatment of fractures in the proximal femur zone is disclosed having a distal end portion adapted to be disposed at the outer surface of the femoral condyle, said end portion being provided with a coupling portion for engagement with a driving tool, a proximal end portion adapted to be seated in the proximal femur, and an arcuately curved portion between the ends, with the proximal end portion being provided with a rounded-off thickened portion at the free end thereof.
    Type: Grant
    Filed: May 12, 1983
    Date of Patent: December 23, 1986
    Assignee: Howmedica International, Inc.
    Inventors: Hans E. Harder, Hermann Kramer
  • Antibacterial 2-amino-oxazolinones and process therefor
    Patent number: 4629794
    Abstract: A series of novel antibacterially active derivatives of indolmycin as well as some prodrug forms of indolmycin is disclosed. A novel process for the production of these compounds is also disclosed.
    Type: Grant
    Filed: January 23, 1986
    Date of Patent: December 16, 1986
    Assignee: Pfizer Inc.
    Inventor: John P. Dirlam
  • Alternate stent covering for tissue valves
    Patent number: 4629459
    Abstract: A prosthetic heart valve comprising a stent having an annular base and a plurality of legs extending upwardly from said base; a valve element circumscribing said stent and attached thereto, said valving element comprising a number of cooperating valve leaflets equal to the number of said legs; and a layer of biologically-compatible material secured to said stent and positioned between said stent and said leaflets, said layer having a smooth, non-abrasive outer surface and covering all of the surfaces of said stent that, in the absence of said layer, would contact the mobile portions of said leaflets during the normal function of the valve.
    Type: Grant
    Filed: December 28, 1983
    Date of Patent: December 16, 1986
    Assignee: Shiley Inc.
    Inventors: Marian I. Ionescu, Jay A. Lenker, Philip S. Yang
  • Novel host strain for transformation of Yarrowia lipolytica
    Patent number: 4628033
    Abstract: A Yarrowia lipolytia strain (PC-30827) ATCC 20688 which is utilized as a suitable host for cloning. The strain is a double auxotroph and requires medium supplemented with leucine and uracil for growth.
    Type: Grant
    Filed: October 6, 1983
    Date of Patent: December 9, 1986
    Assignee: Pfizer Inc.
    Inventor: John R. DeZeeuw
  • Stabilized injectable solutions of piroxicam
    Patent number: 4628053
    Abstract: Stable aqueous solutions of piroxicam suitable for pharmaceutical use are disclosed. These solutions all contain piroxicam in conjunction with a sub-stoichiometric amount of D-(-)-N-methylglucamine and have proplyene glycol, ethanol and water as the solvent, with the pH of said solutions being in the range of from about pH 8 to about pH 9. These particular pharmaceutical compositions possess excellent chemical stability properties and are especially suitable for parenteral administration.
    Type: Grant
    Filed: October 7, 1985
    Date of Patent: December 9, 1986
    Assignee: Heinrich Mack Nachf.
    Inventor: Walter F. Fries
  • Calcium-aluminum briquettes
    Patent number: 4627961
    Abstract: Calcium-aluminum briquettes comprising a mechanically compressed mixture of 65 to 80% by weight of calcium granules and 20 to 35% by weight of aluminum granules are added to molten lead to obtain a lead alloy containing about 0.1% by weight of calcium and 0.03% by weight of aluminum.
    Type: Grant
    Filed: September 4, 1985
    Date of Patent: December 9, 1986
    Assignee: Pfizer Inc.
    Inventor: David M. Dudek
  • Dual lumen subclavian cannula
    Patent number: 4626240
    Abstract: A dual lumen subclavian cannula is disclosed for use in hemodialysis where the lumens are formed by a septum dividing an essentially circular tube longitudinally. The blood return lumen is closed at its distal end by a blunt point and has openings in its side wall proximal to the point. The blood inlet lumen has an open distal end plus openings in the side wall which are proximal to the analogous openings in the blood return lumen. A manifold at the proximal end of the tube separately distributes blood into the return lumen and collects blood from the inlet lumen.
    Type: Grant
    Filed: September 8, 1983
    Date of Patent: December 2, 1986
    Assignee: Shiley Incorporated
    Inventors: William Edelman, Michael Baranowski
  • Iron deficiency chlorosis resistant soybean variety
    Patent number: 4626610
    Abstract: A soybean variety which is a high yielder and resistant to iron deficiency chlorosis.
    Type: Grant
    Filed: January 11, 1985
    Date of Patent: December 2, 1986
    Assignee: DeKalb-Pfizer Genetics
    Inventor: Paul Sun
  • Aiming apparatus
    Patent number: 4625718
    Abstract: An aiming apparatus for making transverse bores in a patient's bone in register with the holes or bores of an osteosynthesis aid in the bone, especially an interlocking nail, comprises an elongated holder for the accommodation of an aiming member adapted to be brought into the beam path of an X-ray apparatus, a reception head for receivig a drill or wire drill rotatably supported in the holder, and a power drive supported by the holder for rotatably driving the reception head. The reception head is made of a material transparent to X-ray radiation.
    Type: Grant
    Filed: June 7, 1985
    Date of Patent: December 2, 1986
    Assignee: Howmedica International, Inc.
    Inventors: Sven E. Olerud, Karl M. Richter
  • Antiprotozoal 1,4-di(p-amidinophenyl)imidazoles
    Patent number: 4624958
    Abstract: Diamidines of the formula ##STR1## wherein X is a propylene, isobutylene, guanidine, pyrrole, tetrazole, imidazole or substituted imidazole group; and 2-[4-(2-imidazolinyl)phenyl]-6-(2-imidazolinyl)indole, are useful in the treatment of certain protozoal infections in mammals, particularly in cattle.
    Type: Grant
    Filed: August 28, 1985
    Date of Patent: November 25, 1986
    Assignee: Pfizer Inc.
    Inventor: Edward A. Glazer
  • Electrosurgical handle
    Patent number: D287879
    Type: Grant
    Filed: September 10, 1984
    Date of Patent: January 20, 1987
    Assignee: Valleylab, Inc.
    Inventors: Charles R. Braxton, Alan Z. Puszman, William A. Johnk