Patents Represented by Attorney, Agent or Law Firm Charlotte L. Barney
  • Amino and nitro containing tricyclic compounds useful as inhibitors of ace
    Patent number: 5389628
    Abstract: The present invention relates to compounds of the formula ##STR1## wherein A is methylene, oxygen, sulfur or N--B wherein B is R.sub.1 or COR.sub.2 wherein R.sub.1 is hydrogen, a C.sub.1 -C.sub.4 alkyl or an Ar--Z-- group wherein Ar is aryl and Z is a C.sub.0 -C.sub.4 alkyl and R.sub.2 is a --CF.sub.3, a C.sub.1 -C.sub.10 alkyl or an Ar--Z group;R is hydrogen or a C.sub.1 -C.sub.4 alkyl; andX and Y are each independently hydrogen, nitro or amino, with the proviso that when X is nitro or amino, Y must be hydrogen, and when Y is nitro or amino, X must be hydrogen; andpharmaceutically acceptable salts thereof, which are inhibitors of Angiotensin Converting Enzyme.
    Type: Grant
    Filed: December 8, 1993
    Date of Patent: February 14, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Douglas W. Beight
  • Mercaptoacetylamido pyridazo [1,2]pyridazine, pyrazolo[1,2]pyridazine pyrazolo[1,2]pyridazine, pyridazol[1,2-a][1,2]diazepine and pyrazolol[1,2-a][1,2]diazepine
    Patent number: 5366973
    Abstract: The present invention relates to certain novel mercaptoacetylamido pyridazo[1,2]pyridazine, pyrazolo[1,2]pyridazine, pyridazo[1,2- a] [1,2]diazepine and pyrazolo[1,2- a ][1,2]diazepine derivatives useful as inhibitors of enkephalinase and of ACE.
    Type: Grant
    Filed: November 3, 1993
    Date of Patent: November 22, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Patrick W. Shum
  • Piperidyl sulfonamides and sulfoxamides as inhibitors of cholesterol biosynthesis
    Patent number: 5350758
    Abstract: The present invention relates to piperidyl sulfonamides and sulfoxamides which are useful as inhibitors of cholesterol biosynthesis and as agents which lower total serum cholesterol in patients in need thereof.
    Type: Grant
    Filed: December 18, 1992
    Date of Patent: September 27, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Marion W. Wannamaker, William A. VanSickle, William R. Moore
  • Piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis
    Patent number: 5348964
    Abstract: The present invention relates to certain novel piperidyl ethers and thioethers which are useful as inhibitors of cholesterol biosynthesis and as agents which lower total serum cholesterol in patients in need thereof.
    Type: Grant
    Filed: July 15, 1993
    Date of Patent: September 20, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Charlotte L. Barney, James R. McCarthy, Marion W. Wannamaker
  • Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
    Patent number: 5308841
    Abstract: The present invention relates to compounds of the formula ##STR1## wherein A is methylene, oxygen, sulfur or N-B wherein B is R.sub.1 or COR.sub.2 wherein R.sub.1 is hydrogen, a C.sub.1 -C.sub.4 alkyl or an Ar-Z-group wherein Ar is aryl and Z is a C.sub.0 -C.sub.4 alkyl and R.sub.2 is a --CF.sub.3, a C.sub.1 -C.sub.10 alkyl or an Ar-Z group;R is hydrogen or a C.sub.1 -C.sub.
    Type: Grant
    Filed: April 12, 1993
    Date of Patent: May 3, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Douglas W. Beight
  • 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors
    Patent number: 5252601
    Abstract: The present invention relates to novel 2-mercaptomethylene-tetrahydronaphthalene derivatives which are useful as enkephalinase inhibitors.
    Type: Grant
    Filed: April 3, 1992
    Date of Patent: October 12, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Douglas W. Beight
  • Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
    Patent number: 5238932
    Abstract: The present invention relates to novel mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase.
    Type: Grant
    Filed: May 20, 1992
    Date of Patent: August 24, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Alan M. Warshawsky
  • Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
    Patent number: 5208230
    Abstract: The present invention relates to compounds of the formula ##STR1## wherein A is methylene, oxygen, sulfur or N-B wherein B is R.sub.1 or COR.sub.2 wherein R.sub.1 is hydrogen, a C.sub.1 -C.sub.4 alkyl or an Ar--Z-- group wherein Ar is aryl and Z is a C.sub.0 -C.sub.4 alkyl and R.sub.2 is a --CF.sub.3, a C.sub.1 -C.sub.10 alkyl or an Ar--Z group;R is hydrogen or a C.sub.1 -C.sub.4 alkyl; andX and Y are each independently hydrogen, nitro or amino, with the proviso that when X is nitro or amino, Y must be hydrogen, and when Y is nitro or amino, X must be hydrogen; andpharmaceutically acceptable salts thereof, which are inhibitors of Angiotensin Converting Enzyme.
    Type: Grant
    Filed: June 25, 1992
    Date of Patent: May 4, 1993
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Gary A. Flynn, Douglas W. Beight