Patents Represented by Attorney Cheryl K. Kilpatrick & Cody Zalesky
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Patent number: 5602245Abstract: A process for the preparation of 2',3' dideoxynucleosides, 2'-deoxynucleosides, and 2',3'-dideoxy-2',3'-didehydronucleosides is provided that includes the synchronous addition of a stereoselecting moiety (a directing group) and a protected purine or pyrimidine base to 5-(S)-6-(protected-oxy)-4,5-dihydrofuran in the presence of a Lewis acid. This one vessel reaction eliminates the need to separately prepare and purify a 2'-substituted ribose derivative that in a second step is condensed with a purine or pyrimidine base. The process can be easily modified to increase the stereoselectivity of formation of the .beta.-anomeric nucleoside as necessary.Type: GrantFiled: November 4, 1992Date of Patent: February 11, 1997Assignee: Emory UniversityInventors: Julie Wurster, Dennis C. Liotta, Jianying Wang, Lawrence J. Wilson
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Patent number: 5587514Abstract: A process for the synthesis of hydroxyethylene dipeptide isosteres from .alpha.-N,N-di(protected)-amino(alkyl or substituted alkyl)methyl ketones that can be efficiently carried out on an industrial scale. The process proceeds with excellent diastereoselectivity and chemical efficiency, and can be used to prepare a wide variety of hydroxyethylene dipeptide isosteres for a variety of uses, including as HIV-1 protease inhibitors and renin inhibitors.Type: GrantFiled: November 8, 1993Date of Patent: December 24, 1996Assignee: Emory UniversityInventors: Dennis C. Liotta, Bharat R. Lagu
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Patent number: 5587362Abstract: A compound, and a pharmaceutical composition comprising an effective mount to treat HBV or EBV of a compound, of the formula: ##STR1## wherein R is selected from the group consisting of 5-methyluracil, adenine and cytosine, and R' is hydrogen, acyl, or alkyl or a monophosphate, diphosphate or triphosphate ester, or its pharmaceutically acceptable salt.Type: GrantFiled: January 28, 1994Date of Patent: December 24, 1996Assignees: Univ. of GA Research Foundation, Yale UniversityInventors: Chung K. Chu, Yung-Chi Cheng, Balakrishna S. Pai, Gang-Qing Yao
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Patent number: 5587407Abstract: A biocidal protective coating for heat exchanger coils formed by applying a polymeric composition containing an organic water resistant polymer that has associated with it an effective amount of a biocidal compound to inhibit corrosion, fouling, and biocidal buildup on the coils.Type: GrantFiled: June 6, 1995Date of Patent: December 24, 1996Assignee: Interface, Inc.Inventors: Claude E. Terry, Douglas E. Triestman, Daniel L. Price
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Patent number: 5583225Abstract: A method is provided for the synthesis of synthesis of acyclic purine nucleosides, particularly 9-(2-hydroxyethoxymethyl)-guanine (acyclovir) and 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine ("DHPG") where the N.sup.2,N.sup.9 -diprotected guanine is reacted with CH.sub.3 C(O)OCH.sub.2 O(CH.sub.2).sub.2)OC(O)CH.sub.3 or diacetoxypropane, respectively, in the presence of a mixture of an acid and acetic anhydride, or in the presence of an acid, where the acid can be phosphoric acid or polyphosphoric acid.Type: GrantFiled: May 17, 1994Date of Patent: December 10, 1996Assignee: University of Georgia Research Foundation, Inc.Inventors: Chung K. Chu, Jinfa Du
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Patent number: 5574041Abstract: A method for suppressing an immune response in a mammal by treating the mammal with an effective amount of spiperone derivative that is without significant neuroleptic effect due to decreased binding to serotonin and/or dopamine receptors as compared with unmodified or uncomplexed spiperone, or due to topical application which maximizes local immunosuppression while limiting systemic absorption and neuroleptic effects. The spiperone derivatives are capable of inhibiting classic contact hypersensitivity reactions.Type: GrantFiled: June 4, 1992Date of Patent: November 12, 1996Assignee: Beth Israel Hospital AssociationInventors: Richard J. Sharpe, Kenneth A. Arndt, Stephen J. Galli, Peter C. Meltzer, Raj K. Razdan, Howard P. Sard
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Patent number: 5567688Abstract: A method for the treatment of a human infected with HBV that includes administering an HBV-treatment amount of an L-nucleoside of the formula: ##STR1## wherein R is selected from the group consisting of 5-methyluracil, adenine and cytosine, and R' is hydrogen, acyl, alkyl or a monophosphate, diphosphate or triphosphate ester, or its pharmaceutically acceptable salt.Type: GrantFiled: June 6, 1995Date of Patent: October 22, 1996Assignees: Univ. of GA Research Foundation, Yale UniversityInventors: Chung K. Chu, Yung-Chi Cheng, Balakrishna S. Pai, Gang-Oing Yao
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Patent number: 5565438Abstract: A method for the treatment of a human infected with EBV that includes administering an EBV-treatment amount of an L-nucleoside of the formula: ##STR1## wherein R is 5-methyluracil, and R' is hydrogen, acyl, alkyl or a monophosphate, diphosphate or triphosphate ester, or its pharmaceutically acceptable salt.Type: GrantFiled: June 6, 1995Date of Patent: October 15, 1996Assignees: University of GA Research Foundation, Yale UniversityInventors: Chung K. Chu, Yung-Chi Cheng, Balakrishna S. Pai, Gang-Oing Yao
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Patent number: 5560972Abstract: A fusion bonded carpet in which the pile yarn is secured in a non hot-melt latex adhesive base and methods of manufacture of such carpet.Type: GrantFiled: September 6, 1994Date of Patent: October 1, 1996Assignee: Interface, Inc.Inventors: Lawrence W. Blakely, Michael A. Howe
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Patent number: 5548060Abstract: A method for the alkylsulfonation of polymeric and cyclic trimer phosphazenes that includes reacting the phosphazene with a sultone. This method can be used to prepare sulfonated phosphazenes that are useful as biomedical materials, membranes, reversibly cross-linkable polymers, surfactants, and polyelectrolytes.Type: GrantFiled: August 8, 1994Date of Patent: August 20, 1996Assignee: Penn State Research Foundation, Inc.Inventors: Harry R. Allcock, Eric H. Klingenberg, Mark P. Weller
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Patent number: 5545367Abstract: Methods and apparatus are disclosed for the production of high precision large scale, micro and mini structures using three dimensional stereolithography. The objects formed using these methods have minimal stress between layers and low curl distortion. The objects also have low warpage because no post-cure treatment is necessary. The methods include the use of elevated pressure, elevated temperature, or sequential polymerization of polymer precursor fluid, or a combination of these, in the three dimensional stereolithographic process.Type: GrantFiled: May 27, 1993Date of Patent: August 13, 1996Assignee: Soane Technologies, Inc.Inventors: Young C. Bae, David S. Soane, Charles Crocker
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Patent number: 5539116Abstract: The present invention relates to a method of preparing BCH-189 and various analogs of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds, .beta.-BCH-189 and related compounds. Furthermore, the steochemistry at the nucleoside 4' position can be controlled to produce enantiomerically-enriched .beta.-BCH-189 and its analogs.Type: GrantFiled: February 10, 1993Date of Patent: July 23, 1996Assignee: Emory UniversityInventors: Dennis C. Liotta, Woo-Baeg Choi
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Patent number: 5530141Abstract: 2,4-Diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammatory or immune response. The compounds exhibit this biological activity by acting as PAF receptor antagonists, by inhibiting the enzyme 5-lipoxygenase, or by exhibiting dual activity, i.e., by acting as both a PAF receptor antagonist and inhibitor of 5-lipoxygenase.A method to treat disorders mediated by PAF or leukotrienes is also disclosed, that includes administering an effective amount of one or more of the above-identified compounds or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier.Type: GrantFiled: September 14, 1992Date of Patent: June 25, 1996Assignee: Center for Innovative TechnologyInventors: T. Y. Shen, David M. Goldstein
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Patent number: 5527384Abstract: The instant invention concerns a wood preservative composition comprising a synergistically effective amount of (a) a cuprammonium compound and (b) tebuconazole to preserve wood.Type: GrantFiled: April 4, 1994Date of Patent: June 18, 1996Assignee: Hickson International, PlcInventors: Gareth Williams, Judith A. Cornfield, Janet Brown, Neil P. Ryan
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Patent number: 5492681Abstract: A method for producing copper oxide. In the method, a copper bearing material, aqueous ammonia, and a sufficient amount of an ammonium salt to double the rate of production of copper oxide in the absence of the salt are placed in a single vessel. The vessel is closed, and oxygen is fed into the vessel. The mixture is stirred and heated to a temperature of between approximately 70.degree. and 130.degree. C. to dissolve the copper bearing material into aqueous ammoniacal copper ion. The aqueous ammoniacal copper ion is reacted with the oxygen in the vessel to form solid copper oxide particles, which are then recovered.Type: GrantFiled: March 22, 1993Date of Patent: February 20, 1996Assignee: Hickson CorporationInventors: Eugene A. Pasek, Craig R. McIntyre
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Patent number: 5484788Abstract: A method for suppressing an immune response in a mammal by systemically treating the mammal with an effective amount of buspirone that is capable of inhibiting classic contact hypersensitivity reactions.Type: GrantFiled: March 26, 1993Date of Patent: January 16, 1996Assignee: Beth Israel Hospital AssociationInventors: Richard J. Sharpe, Kenneth A. Arndt, Stephen L. Galli, Peter C. Meltzer, Raj K. Razdan, Howard P. Sard
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Patent number: 5464932Abstract: Chalcone and cinnamate bearing polyphosphazenes are disclosed. The polyphusphazenes contain a sufficient number of chalcone or cinnamate groups, or a combination thereof, to achieve a photocrosslinkable material. The phosphazene backbone is transparent from the near and mid-UV to the near infrared region, minimizing degradation of the skeleton both under the high intensity UV irradiation required for the photo-crosslinking reaction and during subsequent exposure to light disclosed. These photosensitive polyphosphazenes are useful for a variety of purposes, including in photolithography, photocurable coatings, for the stabilization of certain non-linear optical properties, and for use in the construction of biocompatible semi-permeable membranes which can be used to encapsulate living cells or other substances of implantation.Type: GrantFiled: April 15, 1994Date of Patent: November 7, 1995Assignee: The Penn State Research FoundationInventors: Harry R. Allcock, Charles G. Cameron, Dawn E. Smith
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Patent number: 5463083Abstract: 2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammatory or immune response. The compounds exhibit this biological activity by acting as PAF receptor antagonists, by inhibiting the enzyme 5-lipoxygenase, or by exhibiting dual activity, i,e., by acting as both a PAF receptor antagonist and inhibitor of 5-lipoxygenase. Also disclosed is a method to treat disorders mediated by PAF and/or leukotrienes that includes administering an effective amount of one or more of the above-identified compounds or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier, to a patient in need of such therapy.Type: GrantFiled: January 6, 1994Date of Patent: October 31, 1995Assignee: Cytomed, Inc.Inventors: Tesfaye Biftu, Xiong Cai, Sajjet Hussion, Gurmit Grewal, T. Y. Shen
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Patent number: 5459188Abstract: Permanently soil resistant polymeric compositions that have fluorochemical dispersed throughout the polymer are prepared by melt extrusion of the fluorochemical with the desired polymer. Preferred polymers for extrusion with the fluorochemical are polyester, polypropylene, polyethylene, and polyamide.Type: GrantFiled: June 30, 1993Date of Patent: October 17, 1995Assignee: Peach State Labs, Inc.Inventors: R. Richard Sargent, Jeffrey R. Alender
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Patent number: 5457160Abstract: Polymer blends of the following:(i) poly[bis(methylamino)phosphazene] and poly[bis(2-(2-methoxyethoxy)ethoxy)phosphazene;(ii) poly[bis(methylamino)phosphazene] with poly(vinyl chloride), poly(methyl methacrylate), poly(ethylene oxide), or polystyrene;(iii) poly[bis(2-(2-methoxyethoxy)ethoxy)phosphazene with poly(vinyl alcohol) or poly(acrylic acid); and(iv) poly[bis(phenoxy)phosphazene] with polystyrene or poly(methyl methacrylate).Type: GrantFiled: November 24, 1993Date of Patent: October 10, 1995Assignee: The Penn State Research FoundationInventors: Harry R. Allcock, Karyn B. Visscher