Abstract: A multilayer heat shrinkable film having high heat shrink, high burn-through resistance and a broad impulse sealing range including an outer and a heat sealable inner layer each of a thermoplastic polymer or copolymer, wherein said outer layer has a melting point at least 20° C. higher than said inner layer.

Abstract: The present invention relates to a release film comprising: a polyester film; a coating layer formed on one surface of said polyester film; and a release layer formed on a surface of said coating layer which exhibits a residual adhesion rate of not less than 80%, said release film satisfying all of the conditions represented by the following formulae (1) to (3): OL≦0.6 (1) TL≧80 (2) TL(H)≦8 (3)  wherein OL is an amount (mg/m2) of oligomers extracted with dimethylformamide from a surface of said release layer after the release film is heat-treated at a temperature of 180° C. for 10 minutes; TL is a total light transmittance (%) of said release film; and TL(H) is a total light transmittance (%) of a laminate prepared by interposing said release film between two polarizing plates disposed in a perpendicular relation to each other.

Abstract: There are provided articles coated with high-performance water-repellent films with high hardness that can withstand outdoor use, which are water-repellent film-coated articles that comprise a substrate and a water-repellent film composed mainly of silicon oxide and having a water-repellent group coated on the surface of the substrate, and are characterized by containing at least one type of metal oxide selected from the group consisting of magnesium oxide, calcium oxide, strontium oxide and boron oxide, as well as a process for preparation of such water-repellent film-coated articles at a high rate of productivity and a coating liquid composition for preparation of such water-repellent film-coated articles.

Abstract: This invention provides new benzoxazepine compounds represented by the formula: [wherein R stands for a lower alkyl group optionally substituted with a hydroxyl group, X stands for an optionally substituted carbamoyl group or an optionally substituted heterocyclic group having a deprotonatable hydrogen atom, R1 stands for a lower alkyl group and W stands for a halogen atom] having activities of lowering cholesterol-level and lowering trigluceride-level, and being useful for prophylaxis and therapy of hyperlipidemia.

Abstract: A novel, cost effective optical filter is employed for photosensors used in ultraviolet-based water purification systems. Optically tuned to specifically eliminate the non-germicidal wavelength polychromatic emissions from mercury lamps, this unique optical filter approach significantly reduces the cost in manufacturing reliable water purification systems employing ultraviolet light.

Abstract: This invention provides a novel process for producing optically active 3-hydroxy-&ggr;-butyrolactone in a short step, which is superior economically and in efficiency and industrially suitable by using a starting material which is inexpensive and easily available and reagents easy to handle. This invention relates to a process for producing optically active 3-hydroxy-&ggr;-butyrolactone represented by formula I: wherein the symbol * means an asymmetric carbon atom, which comprises hydrogenating an optically active 4-substituted oxy-3-hydroxybutyrate represented by formula II: wherein R1 represents a C1-4 lower alkyl group, R2 represents a protective group for a hydroxyl group deprotected by hydrogenation with a heterogeneous hydrogenation catalyst, and the symbol * has the same meaning as defined above, in the presence of a heterogeneous hydrogenation catalyst and an acidic substance followed by deprotection and simultaneous ring closure thereof.

Abstract: The invention is drawn to novel bis-aromatic a,&bgr;-unsaturated ketones. The compounds are useful in the treatment and prophylaxis of diseases caused by parasites or bacteria.

Abstract: Functions of sno gene are analyzed by constructing heterogenous or homogeneous mouse variants lacking sno gene to thereby provide heterogenous or homogeneous mouse variants lacking sno gene, cells of these animals and screening systems with the use of these animals or cells. Non-human animals, preferably mice, lacking sno gene and cells thereof. The above animals or cells thereof include both of heterogenous variants and homogeneous variants. A method for screening candidates for drugs by using the above animals or cells thereof.

Abstract: An oral pharmaceutical modified release multiple-units composition for the administration of a therapeutically and/or prophylactically effective amount of a non-steroid anti-inflammatory drug substance to obtain both a relatively fast onset of the therapeutic effect and the maintenance of a therapeutically active plasma concentration for a relatively long period of time is disclosed.

Abstract: A novel, cost effective optical filter is employed for photosensors used in ultraviolet-based water purification systems. Optically tuned to specifically eliminate the non-germicidal wavelength polychromatic emissions from mercury lamps, this unique optical filter approach significantly reduces the cost in manufacturing reliable water purification systems employing ultraviolet light.

Abstract: The present invention provides a human c-Ha-ras proto-oncogene transgenic rat and the methods of the screening of many carcinogens and the screenings of promoters of carcinogenesis and preventive and inhibitory agents of tumors, and additionally enables the analysis of the carcinogenesis mechanism of a number of tumors.

Abstract: The present invention relates to methods for modulating calcium sensitivity of cardiac muscle. In preferred aspects, the invention provides methods for enhancing myocardial contractility and cardiac performance, and methods for treatment of heart failure and other disorders associated with cardiac contractility by administration of one or more xanthine oxidase inhibitor compounds.

Abstract: The invention provides a compound recognizing the minor group of hydrogen bonds between base pairs and being capable of forming a covalent bond with bases. The inventive compound can recognize a specific nucleotide sequence and can strongly bind to adjacent bases via covalent bonding, to regulate the expression of a DNA with the nucleotide sequence. The invention provides a DNA alkylating agent comprising a compound represented by the general formula I: wherein R represents a lower amyl group or a polyamide group; and X represents nitrogen or CH.

Abstract: The present invention provides an apparatus that lifts, secures, splits and/or crushes tree stumps or other materials, particularly wooden materials and other materials that may be present at an excavation site. The apparatus is characterized in part by a two pivot point design. A first pivot point allows for the pivotable operation of an engaging unit which grabs and lifts the tree stump. The engaging unit further acts a durable and secure support member for the tree stump during the splitting and crushing process. The second pivot point allows for the pivotable operation of a cutting device which facilitates splitting and crushing of the stumps.

Abstract: The present invention relates to a novel process for preparing pyrrole ester compounds, which are key intermediates in the preparation of farnesyl transferase inhibitors, an anti-cancer agent Horner-Emmons reaction of aldehyde compounds provides the corresponding &agr;,&bgr;-unsaturated esters, which without any separation and/or purification steps, are treated with toluenesutfonyl-methylisocyanate in the presence of base to give pyrrole esters in one-pot fashion.

Abstract: A microsphere is prepared containing a compound possessing physiological activity coupled to a styrene-glycidyl methacrylate polymer through a spacer. Compounds that may be used include receptors such as proteins, and 3-[(5-(2,3-dimethoxy-6-methyl-benzoquinonyl)]-2-nonyl-2-propionic acid. A preferred spacer is an ethylene glycol diglycidyl ether derivative. Preferably, the whole surface of the styrene-glycidyl methacrylate polymer is covered with glycidyl methacrylate. The microsphere may be used for isolating and detecting substances such as proteins that bind to the coupled compound.

Abstract: An analogue frontend, such as is used, for example, in receivers for communications equipment, comprises a plurality of analogue components (1-3) which are connected upstream of an analogue/digital converter (4). In order to control the drive level of the individual analogue components (1-3) precisely, the input of the analogue/digital converter (4) can optionally be connected via a switch-over device (8) to the output of any one of the analogue components (1-3) and a drive level control signal for the respective analogue component (1-3) can be generated by a digital control device (5) by evaluating the sampled value which is then supplied by the analogue/digital converter (4).

Abstract: A flip-flop circuit comprises a master latch circuit (2), which receives an input signal (D), and, connected in series therewith, a slave latch circuit (3), the two latch circuits (2, 3) being actuated complementarily-to one another by a clock signal. The output signal value (Q,{overscore (Q)}) of the flip-flop circuit is emitted from the output of the slave latch circuit (3) not directly but via a non-differential output driver circuit (4), e.g. an inverter circuit.