Patents Represented by Law Firm Ciotti & Murashige, Irell & Manella
  • Patent number: 4925628
    Abstract: There is disclosed a sample preparation chamber for a system for preparing samples of various compositions for assay by liquid chromatography. The sample preparation chamber is includes a container having a threaded cap and a threaded, lightweight, translucent plastic cup. A stirrer/grinder shaft driven by a motor and connected to a propeller/grinder passes through the cap. The cup has a sloped bottom with a sump region, and a fill/empty pipe passes through the cap and has its outlet at or near the sump. A nozzle/fill pipe arrangement allows the walls to be washed down as liquid is pumped into the cup. A second fill pipe with its outlet spaced up from the bottom of the cup is also used, and a sample metering valve having an inlet in said cup is present.
    Type: Grant
    Filed: July 7, 1987
    Date of Patent: May 15, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Andre Metzger, Peter Grimm, Andre J. Nohl, Vance J. Nau
  • Patent number: 4851209
    Abstract: A novel diagnostic procedure for the in vivo clinical evaluation of gastrointestinal ulcer disease and other diseases associated with loss of mucosal integrity in humans which comprises the oral administration of an effective amount of radio-labeled sucralfate or derivative or precusor thereof or a water soluble, physiologically compatible radiolabeled salt of sucrose suflate to the human host, followed by scintigraphic imaging of the gastrointestinal area of interest with scintigraphic imaging equipment.A novel radiopharmaceutical composition comprising an aqueous solution or suspension containing an amount of a radio-labeled sucralfate or derivative or precursor thereof or a water soluble, physiologically compatible radiolabeled salt of sucrose sulfate for in vivo scintigraphic imaging of the gastrointestinal or other muscosal areas in humans.
    Type: Grant
    Filed: May 16, 1985
    Date of Patent: July 25, 1989
    Assignee: The Regents of the University of California
    Inventors: Vasquez, Robert L. Bridges, Philip Braunstein, Anne-Line Jansholt
  • Patent number: 4840223
    Abstract: Conventionally, cooling systems are drained and flushed out with a gravity flow of water added through the radiator cup. The present device permits power back scrubbing and flushing through the heater core, through the engine and then through the radiator core thus removing far more scale, rust and sludge than the usual system. It can incorporate a pressure test and then can add the correct amount of antifreeze to the water within the system.
    Type: Grant
    Filed: October 30, 1987
    Date of Patent: June 20, 1989
    Assignee: Solv-X Inventions Ltd.
    Inventor: Edward Lee
  • Patent number: 4831885
    Abstract: A Coriolis-type mass flowmeter in which the flow tube is vibrated at a resonance frequency approximately equal to the frequency for forced or natural vibration in a higher anti-symmetric mode, such as the second mode. In the preferred embodiment the flowmeter is symmetrical and has sections of oval cross-section that provide low bending resistance to the vibration at the points where the amplitude of vibration is the largest. The preferred embodiment uses electronic signal detection/processing means that generates two signals proportional to flow tube velocity in the direction of vibration of equal distance but on opposite sides of the plane of symmetry of the tube, generates a sum and a difference of the two signals, integrates the sum, demodulates the integrated signal and the difference of the two signals to produce peak amplitude signals, and divides the peak amplitude signals to produce an output that is proportional to mass flow rate.
    Type: Grant
    Filed: September 24, 1987
    Date of Patent: May 23, 1989
    Inventor: Erik B. Dahlin
  • Patent number: 4826173
    Abstract: A narrow first strip of one component of "hook and loop" material is detachably secured across the face of any conventional golf club covering the striking zone. A "ball" is formed from the other component by forming a second strip into a hollow circular ring and joining the ends by any conventional manner such as adhesive. The width of the ring is substantially narrower than the diameter of the ring and the diameter of the ring is substantially equal to the diameter of a golf ball. When the club strikes the "ball" the two components coact to detachably secure one to the other so that the player can see the exact position of the engagement of the club head with the "ball". The sound of the golf club head striking the "ball" makes a sound similar to striking a conventional ball with the club, and the strip on the club head is easily removed and is reusable on the same or other clubs.
    Type: Grant
    Filed: October 21, 1987
    Date of Patent: May 2, 1989
    Inventor: Edgar W. Brown
  • Patent number: 4826666
    Abstract: Preparation of metal carbides, nitrides, borides, silicides and phosphides, also metal alloys and pure metals, by providing a precursor in which there are organic ligands bonded to the metal or metals, such precursor having the element X also bonded directly or indirectly to the metal or metals, the ligand-metal bonding being weaker than the X-metal bonding whereby on pyrolysis the product M.sub.a X.sub.b results in which M represents the metal or metals, X represents C, N, B, Si, P and a and b represent the atomic proportions of M and X. The subscript b may be zero if an alloy or pure metal is to be prepared. The product M.sub.a x.sub.b can be prepared by relatively low temperature pyrolysis and the precursor can be used as a solution or a low melting solid. This enables one to apply a surface coating or to shape the precursor into a fiber, rod or other shape and to pyrolyze the coating or shaped article. M is a transition, lanthanide or actinide metal or tin.
    Type: Grant
    Filed: March 22, 1988
    Date of Patent: May 2, 1989
    Assignee: SRI International
    Inventor: Richard M. Laine
  • Patent number: 4823614
    Abstract: A Coriolis-type mass flowmeter in which the flow tube is vibrated at a resonance frequency approximately equal to the frequency for forced or natural vibration in a higher anti-symmetric mode, such as the second mode. In the preferred embodiment the flowmeter is symmetrical and has sections of oval cross section that provide low bending resistance to the vibration at the points where the amplitude of vibration is the largest. The preferred embodiment uses electronic signal detection/processing means that generates two signals proportional to flow tube velocity in the direction of vibration at equal distance but on opposite sides of the plane of symmetry of the tube, generates a sum and a difference of the two signals, integrates the sum, demodulates the integrated signal and the difference of the two signals to produce peak amplitude signals, and divides the peak amplitude signals to produce an output that is proportional to mass flow rate.
    Type: Grant
    Filed: June 11, 1986
    Date of Patent: April 25, 1989
    Inventor: Dahlin, Erik B.
  • Patent number: 4823353
    Abstract: A semiconductor laser array apparatus comprising a semiconductor laser array device having a plurality of active waveguides in a parallel manner with an optical phase-coupling between the adjacent waveguides and an optical phase-shifting means attaining a 180.degree. phase-shift between the adjacent laser beams emitted from the adjacent waveguides of the laser array device, the phase-shifting means being disposed in the vicinity of one of the facets of the laser array device.
    Type: Grant
    Filed: October 8, 1987
    Date of Patent: April 18, 1989
    Assignee: 501 Sharp Kabushiki Kaisha
    Inventors: Mototaka Taneya, Mitsuhiro Matsumoto, Sadayoshi Matsui
  • Patent number: 4820666
    Abstract: The invention consists of zirconia base with high hydrothermal stability which:(a) consists essentially of at least 40 weight % of partially stabilized zirconia of the ZrO.sub.2 -Y.sub.2 O.sub.3 -CeO.sub.2 system wherein the proportion of ZrO.sub.2, Y.sub.2 O.sub.3, and CeO.sub.2 is within the range defined by the line connecting points F, G, L, M, N and K in a ternary diagram (ZrO.sub.2, YO.sub.1.5, CeO.sub.2), the vertices of said points being given by the following molar % of ZrO.sub.2, YO.sub.1.5, and CeO.sub.2, respectively:F (88, 10, 2),G (89, 10, 1),L (93.5, 4, 2.5),M (93, 2, 5),N (88, 1, 11), andK (86, 1,13),and 3 to 60 weight % of at least one of Al.sub.2 O.sub.3, MgO.Al.sub.2 O.sub.3, spinel and mullite, and(b) has a mean crystal grain size not exceeding 2 micrometers and a bending strength of at least 100 kgf/mm.sup.2, said ZrO.sub.2 containing a minimum of 50 volume % tetragonal crystal structure and a maximum of 5 volume % monoclinic crystal structure when tested in steam of 180.degree. C.
    Type: Grant
    Filed: March 21, 1986
    Date of Patent: April 11, 1989
    Assignee: Noritake Co., Limited
    Inventors: Masanori Hirano, Hiroshi Inada
  • Patent number: 4820642
    Abstract: A DNA expression vector which contains the trp promotor is described. The expression vector provides for the overproduction of .beta.-lactamase. Insertion of a gene or cDNA into the .beta.-lactamase gene of the expression vector results in the over-production of a fusion protein comprising a part of the .beta.-lactamase as the N-terminal end and the protein coded for by the inserted DNA as the C-terminal end. Using the expression vector described herein, it is possible to obtain large amounts of the fusion protein. A fusion protein containing the surface antigen of Hepatitis B virus and a vaccine containing this fusion protein are also described.
    Type: Grant
    Filed: April 4, 1983
    Date of Patent: April 11, 1989
    Assignee: The Regents of the University of California
    Inventors: Jeffrey C. Edman, William J. Rutter, Robert A. Hallewell, Pablo D. T. Valenzuela, Howard M. Goodman
  • Patent number: 4819244
    Abstract: A V-channel inner stripe semiconductor laser device comprising a multi-layered growth crystal having an active layer for laser oscillation but no substrate, with a buffer layer formed on the multi-layered growth crystal thicker than all of the layers of the growth crystal, where the multi-layered growth crystal and buffer layer are sandwiched between an n-sided electrode and a p-sided electrode, wherein a pair of mesa-striped channels are formed outside of the V-channel to remove the outside of the optical waveguide formed in the active layer corresponding to the V-channel.
    Type: Grant
    Filed: June 4, 1986
    Date of Patent: April 4, 1989
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Saburo Yamamoto, Hiroshi Hayashi, Taiji Morimoto
  • Patent number: 4818753
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is H, methyl, ethyl, or chloro and R.sup.2 is hydrocarbyl of 1-12 C are useful as antifungal agents. Compounds of this series wherein R.sup.2 is 7-12 C are novel. A new synthetic method for the compounds is also described.
    Type: Grant
    Filed: September 18, 1987
    Date of Patent: April 4, 1989
    Assignee: SRI International
    Inventors: William T. Colwell, Joseph I. DeGraw
  • Patent number: 4816442
    Abstract: Polypeptides called cartilage-inducing factors (CIFs) that are found in bone and have heretofore been identified as having in vitro cartilage-inducing activity. TGF-.beta. activity, and anti-inflammatory activity have now been found to possess potent oncostatic activity. The CIFs showed oncostatic activity on human and animal tumors, including carcinomas, adenocarcinomas, lymphomas, and melanomas.
    Type: Grant
    Filed: November 7, 1986
    Date of Patent: March 28, 1989
    Assignee: Collagen Corporation
    Inventors: John M. McPherson, Danile R. Twardzik, George J. Todaro, Karl A. Piez, Jane E. Ranchalis
  • Patent number: 4816249
    Abstract: Monoclonal anti-idiotype antibodies against cell surface Ig of human B-cell tumors, labeled conjugates of such antibodies, immunotherapeutic compositions containing such antibodies, and a process for making such antibodies. The nodular lymphoma of a patient treated with a monoclonal anti-idiotype antibody against the cell surface IgM of the patient's tumor went into complete remission.
    Type: Grant
    Filed: February 19, 1987
    Date of Patent: March 28, 1989
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ronald Levy, Jeanette Dilley, David G. Maloney, Richard A. Miller
  • Patent number: 4816405
    Abstract: Vectors and procedures are provided that enable genetic manipulation of the filamentous ascomycetes such as Aspergillus nidulans and Aspergillus niger. The systems of the invention permit transformation of various Aspergillus strains as well as the production and secretion of desired foreign proteins. Also provided are cosmid vectors which enable the isolation, cloning, sequencing and modifications of genes from the filamentous ascomycetes.
    Type: Grant
    Filed: October 16, 1987
    Date of Patent: March 28, 1989
    Assignee: The Regents of the University of California
    Inventors: William E. Timberlake, John E. Hamer, M. Melanie Yelton
  • Patent number: 4816491
    Abstract: p-Allyl or cycloalkyl phenoxy alkanols and esters are provided having the structure: ##STR1## in which: R.sub.1 is an alkyl group having from one to six carbon atoms, preferably tertiary, and still more preferably tertiary-butyl; or a bivalent cycloalkylene group condensed with the phenyl group at adjacent ring carbons thereof, such as in indane;R.sub.2 is lower alkyl having from one to three carbon atoms or hydrogen;R.sub.3 is hydroxyl or an ester group selected from the group consisting of COOR.sub.4 and OOCR.sub.4 derived from unsubstituted and hydroxy-substituted monocarboxylic acids and COOR.sub.5 OOC and OOCR.sub.
    Type: Grant
    Filed: May 7, 1987
    Date of Patent: March 28, 1989
    Assignee: Frank M. Berger
    Inventors: Frank M. Berger, Joseph I. Degraw, Howard L. Johnson
  • Patent number: 4815744
    Abstract: The device includes a gravity ball feed to an elevator component having a tee on the upper end thereof. The raising of the tee is operated electrically and the lowering thereof is by gravity. The electric motor turns a gear engaging a rack on the elevator component and a player actuated switch causes the elevator component with a ball on the tee to rise into the desired position. When fully raised, a further, internal switch actuated by the gear stops the motor while the golfer strikes the ball. The first switch is again actuated by the player and the gear having a segment of the teeth removed, disengages from the rack which falls by gravity to pick up another ball whereupon the teeth once again engage the rack and re-commence the tee raising sequence.
    Type: Grant
    Filed: September 4, 1987
    Date of Patent: March 28, 1989
    Inventor: Manolis Diamandis
  • Patent number: 4815088
    Abstract: A semiconductor laser array device with a waveguide structure comprising waveguides designed such that the widths thereof gradually increase from the center waveguide to the waveguides positioned at both sides of the array portions.
    Type: Grant
    Filed: October 5, 1987
    Date of Patent: March 21, 1989
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Mitsuhiro Matsumoto, Sadayoshi Matsui, Mototaka Taneya
  • Patent number: 4814966
    Abstract: There is disclosed a diode snubber for the voltage transients generated in the parasitic inductance of a switched resistor when current therethrough is interrupted. Also disclosed is the use of such a diode snubber in: a series switched resistor regulator; a shunt switched resistor regulator; a hybrid switched resistor regulator and a passbank switched resistor regulator. Also disclosed is the use of a linear dissipative regulator in all these forms of switched resistor regulators to maximize the efficiency of power delivery to the load.
    Type: Grant
    Filed: September 30, 1987
    Date of Patent: March 21, 1989
    Assignee: Spectra-Physics, Inc.
    Inventor: John Ekstrand
  • Patent number: 4811785
    Abstract: Designed primarily for use in the production of heavy and medium oil in conjunction with a screw-type pump in relatively shallow or medium wells, the device comprises an inner mandrel within an outer casing situated below the pump and connected to the pump casing and prevents right-hand rotation in the event that the torque reaction of the pump increases due to sand, for example, and attempts to rotate the pump stator together with the production string tubing, but at the same time allows vertical movement of the string to take place for withdrawal purposes.
    Type: Grant
    Filed: July 31, 1987
    Date of Patent: March 14, 1989
    Assignee: Halbrite Well Services Co. Ltd.
    Inventor: James L. Weber