Patents Represented by Law Firm Ciotti & Murashige, Irell & Manella
  • Patent number: 4784952
    Abstract: Vectors suitable for effecting expression of lamB protein in a desired procaryotic host, and methods for their construction, are disclosed. Transformation with these vectors results in the ability of the procaryotic host to sustain infection by lambda phage.
    Type: Grant
    Filed: March 21, 1985
    Date of Patent: November 15, 1988
    Assignee: The Regents of the University of California
    Inventors: Robert A. Ludwig, Gert E. de Vries
  • Patent number: 4784118
    Abstract: An apparatus for viewing a region within a body cavity or the like. The apparatus includes an elongate light pipe having a distal end and a proximal end, which light pipe illuminates the region to be viewed adjacent the distal end of the pipe. An objective lens system is carried at that distal end which in a preferred embodiment forms a focused real image of the illuminated region. This image is transmitted to the viewer through a series of relay lenses and, at the proximal end of the apparatus, through a viewing lens system. The light pipe and the lenses are composed of a polymeric material such as styrene, polycarbonate, acrylic, or the like, and are preferably aspheric lenses.
    Type: Grant
    Filed: April 28, 1987
    Date of Patent: November 15, 1988
    Assignee: EndoTherapeutics
    Inventors: Steven D. Fantone, Peter F. Costa, William A. Holmes, Frederick H. Moll
  • Patent number: 4785012
    Abstract: New oxazole derivatives of formula 1 and their pharmacetically acceptable salts have anthelmintic activity: ##STR1## where R is H, OH, or acyloxy of 8 to 22 carbon atoms;R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are each independently H or acyl of 1 to 6 carbon atoms.
    Type: Grant
    Filed: April 9, 1987
    Date of Patent: November 15, 1988
    Assignees: Syntex Corporation, The Regents of the University of California
    Inventors: Philip Crews, Thomas R. Matthews, Emilio Q. Cabana, Madeline Adamczeski
  • Patent number: 4783400
    Abstract: A liposome assay reagent for determination of an analyte in a homogeneous immunoassay. The reagent includes a suspension of oligolamellar lipid vesicles containing encapsulated glucose-6-phosphate dehydrogenase (G6PD), at a specific activity of between about 1-15 units/.mu.mole vesicle lipid, and glucose-6-phosphate (G6P) at a concentration of at least about 5 mM. The encapsulated G6P protects the enzyme against inactivation on preparation, by reverse phase evaporation in the presence of organic solvent, and on storage as an aqueous suspension.
    Type: Grant
    Filed: August 20, 1986
    Date of Patent: November 8, 1988
    Assignee: Cooper Lipotech
    Inventors: Eleanor Canova-Davis, Viola T. Kung, Carl T. Redemann
  • Patent number: 4783412
    Abstract: DNA sequences and methods of obtaining DNA sequences which include a sequence encoding for mammalian epidermal growth factor are provided. The DNA sequences may be used in cloning and expression vectors for production of DNA and RNA and for producing polypeptides including mammalian epidermal growth factor.E. coli strains HB 101 (pmegf1) and HB 101 (pmegf10b), and bacteriophage .lambda.hEGF34 were deposited at the A.T.C.C. on May 10, 1983 and given Accession Nos. 39357, 39358 and 40070, respectively.
    Type: Grant
    Filed: June 3, 1987
    Date of Patent: November 8, 1988
    Assignee: Chiron Corporation
    Inventor: Graeme I. Bell
  • Patent number: 4781871
    Abstract: A method of preparing a concentrated liposome suspension having a lipid concentration of greater than about 250 .mu.m/ml and liposome sizes no greater than about 0.4 microns. A solution of vesicle-forming lipids in a chlorofluorocarbon solvent is injected under selected conditions into an aqueous medium, with continual solvent removal. During the lipid injection and solvent-removal steps, the liposomes formed in the aqueous medium are extruded through a membrane, to reduce liposome sizes to less than about 0.6 microns. The lipid injection, solvent removal, and extrusion steps are continued until a lipid concentration of at least about 150 .mu.m/ml is reached.
    Type: Grant
    Filed: September 18, 1986
    Date of Patent: November 1, 1988
    Assignee: Liposome Technology, Inc.
    Inventors: Glenn West, III, Francis J. Martin
  • Patent number: 4782476
    Abstract: An objective lens-driving unit comprising a lens supporting means for supporting the objective lens having an optical axis vertical to a recording medium on which light beams converge through the objective lens so as to attain optical recording, optical playing and optical erasing of information on the recording medium; at least one driving means for driving said lens supporting means in the tracking direction; a driving means for driving said intermediate supporting means in the focusing direction, wherein said tracking direction-driving means comprises a magnetic circuit that produces magnetic flux in the circumferential direction of the recording medium, and a tracking direction-driving coil that is positioned to cross a gap formed in the magnetic circuit to thereby receive an electro-magnetic force due to an interaction between the magnetic field of the magnetic circuit and the current passing through said coil, said tracking direction-driving coil being positioned within the excitation area of the magnet
    Type: Grant
    Filed: June 22, 1987
    Date of Patent: November 1, 1988
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Yoshihiro Sekimoto, Toshihisa Deguchi, Mitsuo Ishii, Masaru Nomura
  • Patent number: 4779579
    Abstract: A bank of piston and cylinder assemblies is formed in a cylinder block and is mounted for rotation within bearings. The piston rods are operatively connected to the pistons and bearing supports on an angled plate journalled for rotation at one end of the block and shafts extend axially from the block and the plate and are connected together by a universal joint for rotation as a unit. A centrally located fuel/air chamber is formed axially through the block and fuel/air compression and vaporizing fans rotate with the chamber as the block rotates and feeds fuel/air mixtures through inlet ports to the cylinders successively as the pistons uncover the inlet ports. An exhaust ring surrounds the block and is adjustable radially and exhaust ports from the cylinders coincide with an exhaust outlet in the ring also successively. The engine operates on the two stroke principle, each cylinder firing every 360.degree. of rotation but splash lubrication is provided thus eliminating fuel/oil mixture.
    Type: Grant
    Filed: July 29, 1987
    Date of Patent: October 25, 1988
    Inventors: Sulo Sukava, Larry Sukava
  • Patent number: 4779780
    Abstract: Conventional film wrap dispensers have an exit slot adjacent the cutting blade so that the film end is difficult to grasp and pull out of the dispenser. The present device has a dispensing slot in the base adjacent the rear thereof and spaced from the cutter blade so that there is a two or three inch strip of plastic film extending from the slot after the previous length has been detached by said cutter blade. Furthermore, the transverse portion between the dispensing slot and the cutter blade is formed from a material which inhibits the usual adhesion of the plastic film so that the strip of plastic film extending from the dispenser slot normally hangs downwardly clear of the dispenser and does not adhere to the portion of the base between the slot and the blade as is usual. Even if some light adhesion does take place, the strip is easily detached so that it may be grasped easily for withdrawal, remote from the cut-off blade.
    Type: Grant
    Filed: April 23, 1987
    Date of Patent: October 25, 1988
    Inventor: James E. Scharf
  • Patent number: 4780175
    Abstract: A method for the production of an optical phase-shifting board comprising laying two or more layer-elements with different etching rates therebetween upon a substrate and then subjecting the substrate to an etching treatment so as to remove given portions of the layer-element with the highest etching rate that is disposed on the top of the layer-elements, resulting in the optical phase-shifting board, and a method for the fixation of the optical phase-shifting board to the stem comprising disposing molten light-sensitive or thermosetting resin in or on a guiding rail of the stem positioned in front of the light-emitting face of a semiconductor laser device, placing the optical phase-shifting board in or on the guiding rail of the stem, sliding the optical phase-shifting board in or on the guiding rail along the guiding rail while the far-field pattern of the semiconductor laser device is being monitored, stopping the sliding of the optical phase-shifting board in or on the guiding rail at the position where t
    Type: Grant
    Filed: October 26, 1987
    Date of Patent: October 25, 1988
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Mototaka Taneya, Mitsuhiro Matsumoto, Sadayoshi Matsui
  • Patent number: 4780421
    Abstract: An improvement in an assay method which relies on the detection of a labeled, solubilized specific binding complex is achieved by linking the label to a component of the complex through a bond cleavable under conditions compatible with the assay and with the complex in solution.
    Type: Grant
    Filed: April 3, 1986
    Date of Patent: October 25, 1988
    Assignee: Sclavo Inc.
    Inventors: Naomi Kameda, Gerald L. Rowley
  • Patent number: 4777239
    Abstract: A series of seventeen synthetic peptides which are capable of raising antibodies specific for certain desired human papilloma virus (HPV) are useful in diagnosis and therapy of conditions associated with HPV infection.
    Type: Grant
    Filed: July 10, 1986
    Date of Patent: October 11, 1988
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Gary K. Schoolnik, Joel M. Palefsky
  • Patent number: 4776890
    Abstract: An improved process for obtaining a matrix of mineral particles in reconstituted atelopeptide collagen comprises reconstituting a mixture of mineral particles with collagen in solution. This process results in a matrix of collagen containing the mineral particles which, when wetted, is malleable and retains its integrity.
    Type: Grant
    Filed: April 3, 1987
    Date of Patent: October 11, 1988
    Assignee: Collagen Corporation
    Inventor: George Chu
  • Patent number: 4777143
    Abstract: A method for detecting the presence of carboxylic acids in a specimen is provided. A specimen is contacted with a developing system containing a metal salt reactive with carboxylic acids present in the specimen to form metal-carboxylic acid complexes. Any such complexes are colorimetrically detected by their activity in catalyzing oxidation of a chromogen such as guaiac. The method is useful in detecting intestinal helminth infestation.
    Type: Grant
    Filed: December 12, 1986
    Date of Patent: October 11, 1988
    Assignee: Litmus Concepts Inc.
    Inventors: Neil H. Price, Paul J. Lawrence
  • Patent number: 4777245
    Abstract: A stable trioma cell line capable of secreting a non-human primate monoclonal antibody specific against a selected antigen. An exemplary cell line secretes chimpanzee monoclonal antibody specific against an antigen associated with hepatitis nonA/nonB infection. The cell line is produced, in the method of the invention, by isolating lymphocytes from a primate immunized with the selected antigen, and immortalizing the lymphocytes by fusion with a stable, non-antibody-secreting murine myeloma/human hybridoma cell line having selected-for human characteristics. The trioma fusion products are selected for secretion of the desired antibody, which has a variety of diagnostic and/or therapeutic uses.
    Type: Grant
    Filed: August 19, 1985
    Date of Patent: October 11, 1988
    Assignee: Genelabs Incorporated
    Inventors: Steven K. H. Foung, Judith A. Blunt, Linda B. Rabin, F. Carl Grumet, Edgar G. Engleman
  • Patent number: 4775619
    Abstract: Methods for diagnosis employing polynucleotides having oligonucleotide sequences substantially homologous to a sequence of interest, where the presence or absence of hybridization at a predetermined stringency provides for the release of a label from a support. Particularly, various techniques are employed for binding a label to a support, whereupon cleavage of either a single or double strand, a label may be released from a support, where the release of the label can be detected as indicative of the presence of a particular oligonucleotide sequence in a sample. The method finds use in diagnosis of disease, genetic monitoring, and analyzing nucleic acid mixtures.
    Type: Grant
    Filed: October 16, 1984
    Date of Patent: October 4, 1988
    Assignee: Chiron Corporation
    Inventor: Mickey S. Urdea
  • Patent number: 4774589
    Abstract: An image stabilizer for optical systems is disclosed as are its use with optical systems and its combination with such systems. The stabilizer measures the torque applied to the visual system about an axis and applies a reactive countertorque. More than one such device can be employed to stabilize along more than one axis.
    Type: Grant
    Filed: March 3, 1986
    Date of Patent: September 27, 1988
    Inventor: David A. Rowland
  • Patent number: 4774227
    Abstract: A composition which combines autogenic bone marrow with a suspension of purified atelopeptide reconstituted collagen is used to repair bone defects in mammals.
    Type: Grant
    Filed: February 14, 1986
    Date of Patent: September 27, 1988
    Assignees: Collagen Corporation, Ramot Ltd.
    Inventors: Karl A. Piez, Shlomo Weintraub
  • Patent number: 4774322
    Abstract: Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. Each is reduced to a single polypeptide indicating that the proteins are probably homodimers. One has an N-terminal sequence identical to that of human placenta-derived TGF-.beta. whereas the other has an N-terminal sequence that is different from that of TGF-.beta. derived from human placenta. The two proteins may be purified to homogeneity using RP-HPLC or acetic acid-urea gel electrophoresis.
    Type: Grant
    Filed: December 10, 1987
    Date of Patent: September 27, 1988
    Assignee: Collagen Corporation
    Inventors: Saeid Seyedin, Thomas Thomas, Hanne Bentz, Larry Ellingsworth, Rosa Armstrong
  • Patent number: 4774228
    Abstract: Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. Each is reduced to a single polypeptide indicating that the proteins are probably homodimers. One has an N-terminal sequence identical to that of human placenta-derived TGF-.beta. whereas the other has an N-terminal sequence that is different from that of TGF-.beta. derived from human placenta. The two proteins may be purified to homogeneity using RP-HPLC or acetic acid-urea gel electrophoresis.
    Type: Grant
    Filed: December 10, 1987
    Date of Patent: September 27, 1988
    Assignee: Collagen Corporation
    Inventors: Saeid Seyedin, Thomas Thomas, Hanne Bentz, Larry Ellingsworth, Rosa Armstrong