Patents Represented by Law Firm Ciotti & Murashige, Irell & Manella
  • Patent number: 4764937
    Abstract: A semiconductor laser array device comprising two or more array portions, which are composed of a plurality of main parallel waveguides with an optical phase coupling in between, and one or more branching portions, each of which is positioned between the array portions and which are composed of two branching waveguides branching symmetrically with regard to the main waveguide direction from each of the main parallel waveguides of the array portions, each of the two branching waveguides positioned at the outer sides of each of the branching portions being disconnected with the adjacent branching waveguides and the other branching waveguides from the main parallel waveguides of one of the array portions being optically connected with the corresponding branching waveguides from the main parallel waveguides of the adjacent array portion.
    Type: Grant
    Filed: August 5, 1986
    Date of Patent: August 16, 1988
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Mitsuhiro Matsumoto, Sadayoshi Matsui, Mototaka Taneya, Hidenori Kawanishi
  • Patent number: 4762016
    Abstract: A robotic manipulator provides three degrees of freedom of movement of an end effector or gripper using only motors which are mounted on a frame. Included is a first actuator assembly providing rotation of a first input link about first and second axes. A compound motor provides this rotation about two axes through a differential gear mechanism. A second actuator provides rotation of a second input link about a third axis. The two input links are each connected to an output link, which in turn are connected, with an end effector being disposed on the end of one of the output links.
    Type: Grant
    Filed: March 27, 1987
    Date of Patent: August 9, 1988
    Assignee: The Regents of the University of California
    Inventors: Robert Stoughton, Theodore Kokkinis
  • Patent number: 4762915
    Abstract: A lipid coupling reagent for use in coupling amine-containing molecules, such as proteins, to liposomes. The reagent includes phosphatidylethanolamine coupled to a 3-20 atom carbon-containing spacer arm terminating at a carboxyl or thiocarboxyl group. Also disclosed are liposomes prepared to include between about 1 and 20 mole percent of the coupling reagent, and liposomes containing surface arrays of proteins attached to the liposomes through the coupling reagent.
    Type: Grant
    Filed: January 18, 1985
    Date of Patent: August 9, 1988
    Assignee: Liposome Technology, Inc.
    Inventors: Viola T. Kung, Carl T. Redemann
  • Patent number: 4761066
    Abstract: An optical system for producing stereoscopic imaging of a subject. The system includes an objective lens for producing an image of the subject, and right and left ocular lenses for viewing the image through right and left eyes, respectively. A polarizing filter device positioned near the objective lens divides the image produced by the objective lens into left and right perspective components characterized by different polarization directions. Right and left polarizing filters positioned near the right and left ocular lenses allow these right and left perspective components to be viewed exclusively through the right and left ocular lenses, respectively. One embodiment of the invention is a high-power stereoscopic microscope. Another embodiment is a single-objective binocular telescope.
    Type: Grant
    Filed: January 14, 1986
    Date of Patent: August 2, 1988
    Inventor: William J. Carter
  • Patent number: 4760131
    Abstract: A soft tissue wound healing composition comprising an aqueous mixture of fibrillar collagen, heparin, and undegranulated platelets or platelet releasate. The composition is applied topically to the wound site in conjunction with means to keep it at the site and hydrated or in the form of an occlusive dressing.
    Type: Grant
    Filed: June 23, 1986
    Date of Patent: July 26, 1988
    Assignee: Collagen Corporation
    Inventors: John S. Sundsmo, George A. Ksander, John M. McPherson
  • Patent number: 4757639
    Abstract: Animal traps are usually difficult to sterilize in order to remove human odor therefrom and difficult to hide when setting and often contain moving parts, tubes, pins and the like. The present device consists of a pair of spring arms made of heavy wire with a hairpin spring at the junction thereof. Eye loops are formed one on each distal end of the arms and one of these has a slotted semi-circular plate welded otherwise secured into the base of the eye. A freely running snare loop is provided on one end of a standing part, in which part extends through the slot in the disk or plate and through a cotter pin assembly spanning the other eye and terminates with a ferrule outboard of the other eye. A trigger block is secured to the standing part inboard of the slotted disk when the trap is set with the two arms close together and being urged apart by the spring.
    Type: Grant
    Filed: February 26, 1987
    Date of Patent: July 19, 1988
    Inventor: Bruce H. Bertram
  • Patent number: 4758421
    Abstract: A bleomycin conjugate for use in targeting a compound to a body tumor. The conjugate includes an oxidized bleomycin/cobalt(III) complex and the compound to be targeted joined to the complex through a monodentate cobalt/sulfur coordinate bond. Also disclosed are methods for preparing the conjugate, and for targeting the compound to a body tumor, for purposes of tumor radioimaging or therapy.
    Type: Grant
    Filed: March 15, 1985
    Date of Patent: July 19, 1988
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: C. -H. Chang, Claude F. Meares, C.-H Chang
  • Patent number: 4757048
    Abstract: Compounds and compositions comprising synthetic analogs of Atrial Natriuretic Peptides are provided, together with methods for their production and use as natriuretics, diuretics and/or vasodilators, or as intermediates for or modulators of such useful compounds or of native Atrial Natriuretic Peptides.
    Type: Grant
    Filed: May 28, 1986
    Date of Patent: July 12, 1988
    Assignee: Biotechnology Research Associates J.V.
    Inventors: John A. Lewicki, Robert M. Scarborough, Jr., Lorin K. Johnson
  • Patent number: 4753246
    Abstract: Method and apparatus for producing enhanced EEG or MEG information related to a selected brain activity in a subject. The apparatus includes a two-dimensional array of at least about 16 sensors for recording EEG or MEG traces from the subject. Control and test traces recorded before and during an interval in which the brain activity is occurring, respectively, are each decomposed into a series of basis functions which may be analytic components such as temporal frequency components, generated by spectral decomposition of an ensemble average of the recorded traces, or principal components determined by principal component analysis. The control and test traces are then represented as a sum of the products of the individual basis functions times a spatial domain matrix which represents the spatial pattern of amplitudes of that basis function, as measured by the individual sensors in the array.
    Type: Grant
    Filed: March 28, 1986
    Date of Patent: June 28, 1988
    Assignee: The Regents of the University of California
    Inventor: Walter J. Freeman
  • Patent number: 4753958
    Abstract: Topical compositions for the treatment of an epithelial disease, such as psoriasis and cervical displasia, containing phototoxic derivatives of hematoporphyrin and methods for treating epithelial diseases with phototoxic derivatives of hematoporphyrin.
    Type: Grant
    Filed: June 25, 1986
    Date of Patent: June 28, 1988
    Assignee: University of CAL
    Inventors: Gerald D. Weinstein, Jerry L. McCullough
  • Patent number: 4752627
    Abstract: Contact lens compositions containing monomers or cross-linking materials which result in satisfactory moisture content but lowered protein absorption capability are described. Lenses are comfortable for extended wear, but because of lowered protein absorption do not become opaque, and present less infection risk. Included are compositions with over 10% conventional cross-linkers, with 0.1-100% cross-linkers which are unsaturated diesters of the alcohol of the formula HO(CH.sub.2 CH.sub.2 O).sub.n H wherein n is 5-300; or 10-50% copolymerizing monomer which is an ester of an alcohol of similar formula; or 0.1-90% cross-linkers which are diesters of the diol of the formula HOCH.sub.2 (CF.sub.2).sub.m CH.sub.2 OH, and compositions containing more than 10% cross-linker; or with inclusions of 1-40% polyethylene glycol or polyethylene oxide; or copolymers containing 1-60% polyethylene oxide segments.
    Type: Grant
    Filed: August 13, 1986
    Date of Patent: June 21, 1988
    Inventor: Michael Froix
  • Patent number: 4752425
    Abstract: A method of preparing a suspension of liposomes containing a water-soluble compound predominantly in liposome-encapsulated form. A solution of vesicle-forming lipids in a chlorofluorocarbon solvent is infused under selected conditions into an aqueous medium, with continual solvent removal. The lipid infusion and solvent removal steps are continued until a lipid concentration of at least about 150 .mu.m/ml is reached, at which point more than about half of the compound contained in the resultant liposome suspension is in encapsulated form.
    Type: Grant
    Filed: September 18, 1986
    Date of Patent: June 21, 1988
    Assignee: Liposome Technology, Inc.
    Inventors: Francis J. Martin, Glenn West, III
  • Patent number: 4752576
    Abstract: Methods and compositions are provided for high level production of foreign proteins in yeast. The system is exemplified by production of .alpha..sub.1 -antitrypsin in yeast strain AB110, derived from yeast strains 2150-2-3 and AB103.1.S. carlsbergensis/S. cerevisiae hybrid strain AB110 containing plasmid pCl/1GAPATi9 was deposited at the A.T.C.C. on May 9, 1984, and given Accession No. 20709.
    Type: Grant
    Filed: June 14, 1984
    Date of Patent: June 21, 1988
    Assignee: Chiron Corporation
    Inventors: Anthony J. Brake, Robert A. Hallewell, Steven Rosenberg
  • Patent number: 4751709
    Abstract: A semiconductor laser array device comprising a plurality of waveguides in a parallel manner to achieve an optical phase coupling therebetween within an active layer, wherein said device includes a region composed of a plurality of waveguide portions in the direction vertical to the waveguide direction, the effective refractive indexes of which are alternately different, whereby optical waves passing through said region attain a 180.degree. phase shift between the waveguide portions having different effective refractive indexes.
    Type: Grant
    Filed: August 5, 1986
    Date of Patent: June 14, 1988
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Mitsuhiro Matsumoto, Sadayoshi Matsui, Mototaka Taneya
  • Patent number: 4751180
    Abstract: Novel methods and compositions are provided for enhanced yield of heterologous proteins in fungi. The method and compositions involve employing fusion sequences involving a sequence encoding a heterologous product produced in relatively large amount as a stable polypeptide in the host fused to a second sequence in open reading frame with the prior sequence coding for a different heterologous polypeptide, where the two polypeptides are joined by a selectively cleavable linkage. In particular, a sequence coding for superoxide dismutase is joined to another polypeptide of interest at either terminus of the superoxide dismutase in a yeast expression vector under transcriptional control of an active promoter and the vector introduced into a yeast host and the host grown. High yields of the fusion product are obtained in this manner, where the fusion product can be selectively cleaved so as to produce both the superoxide dismutase and the other polypeptide in high yield.The S.
    Type: Grant
    Filed: March 28, 1986
    Date of Patent: June 14, 1988
    Assignee: Chiron Corporation
    Inventors: Lawrence S. Cousens, Patricia A. Tekamp-Olson, Jeffrey R. Shuster, James P. Merryweather
  • Patent number: 4751292
    Abstract: The present invention comprises novel adamantyl purine derivatives, in which the purine ring is substituted at the 6-position with a moiety incorporating an adamantane ring system. The purine may also be substituted at the 9-position with a carbohydrate, to give a nucleoside analog, or may be unsubstituted at that position.The substituent at the 6-position contains an adamantane ring system, either substituted or unsubstituted, in which a linker connects a carbon atom in the adamantane ring system with the 6-carbon of the purine ring. This linker consists of a combination of a heteroatom such as N, O or S, which is directly connected to the purine, and a short (five or less) atom chain, consisting either of carbon or other atoms such as N, O or S, with or without additional pendant moieties, which is connected either to the secondary or tertiary carbon of the adamantane ring system. The adamantane ring system itself may be unsubstituted, or substituted with a wide variety of non-ionic groups.
    Type: Grant
    Filed: July 2, 1985
    Date of Patent: June 14, 1988
    Assignee: The Plant Cell Research Institute, Inc.
    Inventor: Juan E. Fox
  • Patent number: 4749706
    Abstract: Stereoisomerically pure forms of normorphine analogs which have superior analgesic and nonaddicting qualities are described. In addition, a method of separating diastereomeric forms of N-sec-alkyl-substituted analogs utilizes the hydrocarbyl(1-8C) diesters of the normorphine derivatives. A new method for preparing the N-methylalkylmethyl derivatives of normorphine and norcodeine and their conventional analogs is also disclosed. This method employs the corresponding methyl alkyl ketones and a reducing agent.
    Type: Grant
    Filed: March 24, 1986
    Date of Patent: June 7, 1988
    Assignee: SRI International
    Inventors: John A. Lawson, Joseph I. DeGraw, Gilda H. Loew
  • Patent number: 4750183
    Abstract: An active layer for laser oscillation and optical guiding layers for guiding laser light sandwiching the active layer therebetween are included in the device. At least one of the optical guiding layers is formed by a superlattice, the optical refractive index of which is lower than that of the active layer. Further, the optical refractive index is gradually decreased in the direction from the portion of the optical guiding layer adjacent to the active layer, to the outside of the optical guiding layer.
    Type: Grant
    Filed: February 18, 1987
    Date of Patent: June 7, 1988
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Kohsei Takahashi, Toshiro Hayakawa, Takahiro Suyama, Masafumi Kondo, Saburo Yamamoto
  • Patent number: 4748674
    Abstract: A pattern learning and recognition device. The device includes a parallel processing network for receiving and processing an N-dimensional vector input, and a control system for calculating, and storing output signal correlation information during the learning mode of the device, and for distributing the learned information to the network, in the form of feedback gain, during the pattern-recognition mode of the device. The network is preferably composed of an array of N oscillatory units designed to bifurcate from a rest to an active state when stimulated with a threshold input voltage surge.
    Type: Grant
    Filed: October 7, 1986
    Date of Patent: May 31, 1988
    Assignee: The Regents of the University of Calif.
    Inventor: Walter J. Freeman
  • Patent number: D296789
    Type: Grant
    Filed: November 5, 1986
    Date of Patent: July 19, 1988
    Assignee: Linkopings Kontrollhonseri AB
    Inventor: Lars G. Larsson