Patents Represented by Attorney David E. Frankhouser
  • Patent number: 5056623
    Abstract: The specification describes a new process and apparatus for the controlled release of metered quantities of lubricating liquids or suspensions for applying a coating of lubricant to mechanically stressed zones of pressing tools in tablet-making machines, wherein the lubricating solution or suspension is fed into one or more liquid valves synchronously with the cadence of the tablet-making machine from a pressureless storage container by means of a pulsation-free pump, and any pressure variations occuring in the liquid supply line to the valves are compensated by changes in the times of opening of the valves.
    Type: Grant
    Filed: March 29, 1990
    Date of Patent: October 15, 1991
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Volker I. Glasel, Gunther M. Voss
  • Patent number: 5049587
    Abstract: Disclosed are novel opthalmic solutions useful for the treatment of ocular hypertension and glaucoma. These contain mabuterol as a preferred active ingredient.
    Type: Grant
    Filed: April 21, 1989
    Date of Patent: September 17, 1991
    Assignee: Basotherm GmbH
    Inventors: Taira Okamoto, Motoyuki Yajima
  • Patent number: 5030647
    Abstract: Novel thienylbenzylamine compounds of the formula ##STR1## wherein A and R.sub.1 -R.sub.5 are defined herein. These compounds are useful for the treatment of inflammation.
    Type: Grant
    Filed: February 9, 1990
    Date of Patent: July 9, 1991
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Clara K. Miao, Karl G. Grozinger, Robert Rothlein, Ronald Faanes, Genus Possanza, John P. Devlin
  • Patent number: 5028630
    Abstract: A method for treating inflammation in a patient which comprises administering to the patient a therapeutically effective amount of a compound of the formula: ##STR1## wherein A and R.sub.1 -R.sub.6 are defined herein.
    Type: Grant
    Filed: February 9, 1990
    Date of Patent: July 2, 1991
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Robert Rothlein, Ronald Faanes, Genus Possanza
  • Patent number: 5011946
    Abstract: An improved process for the preparation of D,L-Lactide which can be used directly in polymerization reactions.
    Type: Grant
    Filed: May 25, 1990
    Date of Patent: April 30, 1991
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Joachim Hess, Klaus R. Muller, Manfred Muller
  • Patent number: 5011836
    Abstract: A method for treating abstructive respiratory passage disorders which comprises the use of 5,11-dihydro-11-[[(1-methyl-4-piperidinyl)-amino]carbonyl]-6H-dibenz[b,e]a zepin-6-one; 5,11-dihydro-11-[(1-methyl-4-piperazinyl)acetyl]-6H-dibenz[b,e]azepin-6-on e, 5,11-dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-dibenz[b,e]azepin-6-on e, alone or in combination.
    Type: Grant
    Filed: November 17, 1989
    Date of Patent: April 30, 1991
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Wolfgang Eberlein, Wolfhard Engel, Gerhard Mihm, Klaus Rudolf, Henri Doods, Norbert Mayer
  • Patent number: 5008290
    Abstract: The invention relates to new sulphonamidoethyl compounds having valuable pharmacological properties, particularly anti-thrombotic properties, and which are also thromboxane antagonists.
    Type: Grant
    Filed: March 3, 1989
    Date of Patent: April 16, 1991
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Armin Heckel, Josef Nickl, Erich Muller, Berthold Narr, Johannes Weisenberger, Wolfgang Eisert, Thomas Muller
  • Patent number: 5008273
    Abstract: Amino acid derivatives of general formula ##STR1## (the definitions of the various symbols being explained in the specification) are suitable for treating high blood pressure and for cardioprotection. The new compounds are prepared and used in the usual way.
    Type: Grant
    Filed: September 6, 1989
    Date of Patent: April 16, 1991
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Gerd Schnorrenberg, Otto Roos, Walter Losel, Ingrid Wiedemann, Wolfram Gaida, Wolfgang Hoefke, Dietrich Arndts, Ilse Streller
  • Patent number: 5006533
    Abstract: 3-Bromo-2,6-dimethoxybenzamides useful as neuroleptic agents are described.
    Type: Grant
    Filed: November 22, 1989
    Date of Patent: April 9, 1991
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Rainer Sobotta, Adolf Langbein, Herbert Merz, Rudolf Bauer, Joachim Mierau
  • Patent number: 5006522
    Abstract: Novel condensed diazepinone of general formula I are described, ##STR1## wherein B represents one of the divalent groups ##STR2## and X.sup.1, X.sup.2, A.sup.1, A.sup.2 and R.sup.1 to R.sup.10 are as defined in herein useful as vagal pacemakers for treating bradycardia and bradyarrhythmia. The novel diazepinones also have spasmolytic properties on peripheral organs, antiemetic properties and are capable of promoting cerebral blood flow.
    Type: Grant
    Filed: May 30, 1989
    Date of Patent: April 9, 1991
    Assignee: Karl Thomae GmbH
    Inventors: Wolfhard Engel, Wolfgang Eberlein, Gerhard Mihm, Gunther Trummlitz, Norbert Mayer, Adriaan De Jonge
  • Patent number: 5002932
    Abstract: Disclosed herein is a combination of bacitracin and acyclovir or equivalent derivatives thereof. The combination, as well as bacitracin itself, are useful for treating herpes viral infections.
    Type: Grant
    Filed: November 25, 1988
    Date of Patent: March 26, 1991
    Inventors: Yves Langelier, Pierrette Gaudreau, Paul Brazeau
  • Patent number: 5001122
    Abstract: A method for treating shock in a patient, which comprises administering to the patient a therapeutically effective amount of a diazepinone of the general formula: ##STR1## wherein A represents a 5,11-dihydro-6H-pyrido[2,3-b] [1,4] benzodiazepin-6-one group bound in the 11-position; a 5,10-dihydro-11H-dibenzo [b,e] [1,4] diazepin-11-one group bound in the 5-position; a 5,11-dihydro-10H-pyrido [3-2b] [1-4] benzodiazepin-10-one group bound in the 5-position; a 4,9-dihydro-10H-thieno [3,4-b] [1,5] benzodiazpin-10-one group bound in the 4-position, unsubstituted or substituted at the 1- or 3-position or both in the 1- and 3-position by an alkyl group having from 1 to 4 carbon atoms, or in the 3-positionby chlorine, fluorine or bromine; a 6-11-dihydro-5H-pyrido [2,3-b] [1,5] benzodiazepin-5-one group bound in the 11-position; or a 1-methyl-1,4,9,10-tetrahydropyrrolo-[3,2-b] [1,5] benzodiazepin-10-one group bound in the 4-position, unsubstituted or substituted at the 3-position by methyl or methyl or chlorine;R.sub.
    Type: Grant
    Filed: May 17, 1989
    Date of Patent: March 19, 1991
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Wolfgang Eberlein, Volker Trach, Wolfhard Engel, Gerhard Mihm, Norbert Mayer, Henri Doods, Richard Reichl
  • Patent number: 4997833
    Abstract: Aryloxy-aminoalkanes useful as antihypertensive agents are described and disclosed.
    Type: Grant
    Filed: July 5, 1989
    Date of Patent: March 5, 1991
    Assignee: Boehringer Ingelheim K G
    Inventors: KoHerbert, Franz Esser, Wolfram Gaida, Wolfgang Hoefke, Georg Speck
  • Patent number: 4990222
    Abstract: The invention relates to a new process for the purification, by distillation, of thermolabile compounds wherein a thermolabile compound is introduced into a twin screw extruder which is heated, in at least one zone, to the boiling temperature of the compound. The volatilized compound is drawn off and condensed.
    Type: Grant
    Filed: October 23, 1987
    Date of Patent: February 5, 1991
    Assignee: Boehringer Ingelheim KG
    Inventors: Michael Aigner, Wolfgang Dersch, Dieter Reichert, Horst Schwall, Werner Warth
  • Patent number: 4970208
    Abstract: By using .alpha.-mimetics, particularly compounds of general formulae I to III and the compounds listed in Table I, as feed additives in fattening animals, it has surprisingly been possible to improve the daily weight gain, the utilization of fodder and the ratio of muscle to fat in favour of the proportion of muscle and protein.
    Type: Grant
    Filed: October 25, 1988
    Date of Patent: November 13, 1990
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Werner Bomann, Franz Esser, Ulrich Hamel, Helmut Stable
  • Patent number: 4954516
    Abstract: The invention relates to the use of 1-benzyl-aminoalkyl-pyrrolidinones as antidepressants.
    Type: Grant
    Filed: July 20, 1989
    Date of Patent: September 4, 1990
    Assignee: Boehringer Ingelheim KG
    Inventors: Erich Lehr, Wolf-Dietrich Bechtel, Karin Boke-Kuhn, Claus Schneider, Gerhard Walther, Karl-Heinz Weber
  • Patent number: 4954505
    Abstract: Oxoquinazoline derivatives of formulae ##STR1## (the symbols are defined in the specification) are well-tolerated drugs for treating hyperuricaemia.
    Type: Grant
    Filed: September 25, 1989
    Date of Patent: September 4, 1990
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Gerhard Rauber, Roland Stechert
  • Patent number: 4948812
    Abstract: Compounds of formula ##STR1## (the substituents R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are explained in the specification) may be prepared by conventional methods.Owing to their favorable activity profile the compounds may advantageously be used to treat certain heart and circulatory disorders.
    Type: Grant
    Filed: November 25, 1987
    Date of Patent: August 14, 1990
    Assignee: Boehringer Ingelheim KG
    Inventors: Herbert Koppe, Franz Esser, Walter Kobinge, Christian Lillie
  • Patent number: 4948890
    Abstract: The invention relates to an improved process for the catalytic hydrogenation of DAHNP and a new process for preparing 2,4-diamino-5-formylamino-6-hydroxypyrimidine.
    Type: Grant
    Filed: July 12, 1989
    Date of Patent: August 14, 1990
    Assignee: Boehringer Ingelheim KG
    Inventor: Heinrich Schneider
  • Patent number: 4945187
    Abstract: The invention relates to a process for preparing enantiomerically pure S(+)-propan-1,2-diol and R(-)-propan-1,2-diol from L(-)-lactide or D(+)-lactide, respectively.
    Type: Grant
    Filed: July 14, 1989
    Date of Patent: July 31, 1990
    Assignee: Karl Thomae GmbH
    Inventor: Klaus R. Muller