Patents Represented by Attorney, Agent or Law Firm Diane E. Furman
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Patent number: 5674371Abstract: A process for providing a variety of light to medium colors of anodized aluminum or aluminum alloy which comprises the steps of anodizing an aluminum or aluminum alloy workpiece in an aqueous strong acid electrolyte solution such as a sulfuric acid solution by application of direct current at a current density of 5 to about 25 amperes per square foot and a temperature of from 55.degree. F. to 90.degree. F. to form on the workpiece a porous anodic oxide film having a thickness of at least about 3 microns; subjecting the resulting anodized workpiece to alternating current at a voltage of about 5 to about 25 volts for about 1 to 25 minutes in an aqueous strong acid electrolyte solution such as a sulfuric acid solution comprising about 1 to 15 volume percent of an organic carboxylic acid containing at least one reactive group in the alpha-position, wherein said reactive group is a hydroxy, amino, keto or carboxyl group; and electrolytically coloring the workpiece.Type: GrantFiled: June 6, 1995Date of Patent: October 7, 1997Assignee: Clariant Finance (BVI) LimitedInventor: Pinakin Patel
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Patent number: 5599536Abstract: A method for ameliorating or suppressing the acute phase response in a patient receiving IL-6 treatment comprises co-administering with the IL-6 an effective amount of granulocyte colony stimulating factor.Type: GrantFiled: December 13, 1993Date of Patent: February 4, 1997Assignee: Sandoz Ltd.Inventor: Laurie A. Myers
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Patent number: 5578301Abstract: A method for reducing or suppressing the acute phase response in a patient receiving IL-6 treatment which comprises co-administering with the IL-6 an effective amount of granulocyte macrophage colony stimulating factor (GM-CSF).Type: GrantFiled: December 14, 1993Date of Patent: November 26, 1996Assignee: Sandoz Ltd.Inventor: Laurie A. Myers
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Patent number: 5573653Abstract: An improved electrochemical process for thiocyanating aminobenzene compounds (e.g., 3,4-dichloroaniline), and in particular a process for preparing 2-aminobenzothiazole compounds, is disclosed which provides attractive yields under relatively favorable temperature conditions, and with reduced or minimal cyanide formation. In a further aspect, use of quaternary ammonium salts in the thiocyanation medium has been found to inhibit cathodic corrosion.Type: GrantFiled: April 18, 1995Date of Patent: November 12, 1996Assignee: Sandoz Ltd.Inventor: Baldev K. Bandlish
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Patent number: 5538752Abstract: Compositions comprising melanin or melanin precursors are useful for preventing or controlling decay of substrates such as cellulosic and other porous organic substrates. The compositions provide useful wood preservatives, wound dressings, and the like. In one embodiment, the compositions comprise melanin complexed with metal ions, particularly copper. The compositions may be applied as penetrating or surface treatments. Certain melanins are also particularly useful for removing metal ions from liquids.Type: GrantFiled: February 13, 1995Date of Patent: July 23, 1996Assignees: Regents of the Univ. of Minnesota, Sandoz Ltd.Inventors: Robert A. Blanchette, Theresa S. Brush, Roberta L. Farrell
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Patent number: 5405532Abstract: The invention relates to a process for treating industrial waste water which comprises either: (a) pre-treating the waste water with at least two different pre-treatments selected from adsorption, membrane filtration and oxidation and then, biologically purifying the waste water or, (b) neutralizing and biologically purifying the waste water and then after-treating the waste water either by membrane filtration in combination with adsorption or oxidation or, by oxidation optionally in combination with adsorption or filtration on a nanofiltration membrane or, by filtration on a nanofiltration membrane.Type: GrantFiled: April 29, 1994Date of Patent: April 11, 1995Assignee: Sandoz Ltd.Inventors: Richard Loew, Wolfgang Samhaber, Anton Wyss
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Patent number: 5403593Abstract: Therapeutically active sustained release dosage forms are described which are prepared from compositions which comprise (A) a hydrophilic cellulose ether polymer or mixtures thereof as a binder matrix material, (B) a granulating medium selected from the group consisting of a lipid component, polyethylene glycol polymers, and mixtures thereof, said granulating medium having a melting range higher than about 30.degree. C., and (C) a therapeutically active medicament, said components being in melt association. The compositions are prepared by a melt granulation process.Type: GrantFiled: March 31, 1992Date of Patent: April 4, 1995Assignee: Sandoz Ltd.Inventor: Alan E. Royce
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Patent number: 5374455Abstract: Aluminum oxide sealant compositions, concentrates, and processes employing the same are described which comprise an alkaline earth metal salt and certain sulfonated compounds. Unexpected improvements in seal quality are obtained using the compositions of the invention, and in the substantial absence of smut formation. Advantageously, the aqueous sealant compositions of the invention may be cobalt and nickel-free, can be prepared from tap water, and can be employed at temperatures below the boiling point.Type: GrantFiled: December 8, 1993Date of Patent: December 20, 1994Assignee: Sandoz Ltd.Inventors: Pinakin Patel, Richard L. Ranieri
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Patent number: 5362317Abstract: Aluminum oxide sealant compositions, concentrates, and processes employing the same are described which comprise an alkaline earth metal salt and certain sulfonated compounds. Unexpected improvements in seal quality are obtained using the compositions of the invention, and in the substantial absence of smut formation. Advantageously, the aqueous sealant compositions of the invention may be cobalt and nickel-free, can be prepared from tap water, and can be employed at temperatures below the boiling point.Type: GrantFiled: July 15, 1993Date of Patent: November 8, 1994Assignee: Sandoz Ltd.Inventors: Pinakin Patel, Richard L. Ranieri
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Patent number: 5356896Abstract: A pharmaceutical dosage form comprising an HMG-CoA reductase inhibitor compound, e.g., fluvastatin sodium, is disclosed which is stabilized against pH-related degradation by an alkaline stabilizing medium capable of imparting a pH of at least 8 to an aqueous solution or dispersion of the composition.Type: GrantFiled: December 22, 1992Date of Patent: October 18, 1994Assignee: Sandoz Ltd.Inventors: Mohan B. Kabadi, Richard V. Vivilecchia
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Patent number: 5308492Abstract: The invention relates to a process for treating industrial waste water which comprises either: (a) pretreating the waste water with at least two different pretreatments selected from adsorption, membrane filtration and oxidation and then, biologically purifying the waste water or, (b) neutralizing and biologically purifying the waste water and then after-treating the waste water either by membrane filtation in combination with adsorption or oxidation or, by oxidation optionally in combination with adsorption or filtration on a nanofiltration membrane or, by filtration on a nanofiltration membrane.Type: GrantFiled: June 3, 1991Date of Patent: May 3, 1994Assignee: Sandoz Ltd.Inventors: Richard Loew, Wolfgang Samhaber, Anton Wyss
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Patent number: 5273758Abstract: Polyethylene oxide polymer is employed as a directly compressible binder matrix for therapeutically active dosage forms. Advantageously, the polyethylene oxide has an adjustable rate control effect on the release of medicament from the dosage form, enabling in particular the preparation of sustained release dosage forms.Type: GrantFiled: April 13, 1992Date of Patent: December 28, 1993Assignee: Sandoz Ltd.Inventor: Alan E. Royce
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Patent number: 5266173Abstract: An improved process for reducing aromatic nitro compounds to form the corresponding aromatic amine compounds, and intermediates therefore, and a reducing agent therefor, are disclosed. According to the process, a titanium(IV)oxy salt such as titanium(IV) oxysulfate is electrochemically reduced to form a titanium(III)oxy reducing agent, which can be employed to chemically reduce the aromatic nitro compounds, and the resulting re-oxidized titanium salts may be recycled to the electrochemical reduction step of the process. The titanium(III)oxy salt product is highly soluble in strong acid solutions and exhibits improved oxidation stability.Type: GrantFiled: May 28, 1991Date of Patent: November 30, 1993Assignee: Sandoz, Ltd.Inventors: Baldev K. Bandlish, Robert V. Casciani
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Patent number: 5189111Abstract: Water-dilutable side-chain-containing vinylic copolymers comprising groups (.gamma.) of the formula--X--Alk--Y-- (I),whereinAlk signifies alkylene with 2-6 carbon atoms or hydroxysubstituted alkylene with 3-6 carbon atoms or alkylene with 4-6 carbon atoms, interrupted by --O--,X signifies a basic amino group or an ammonium group andY signifies a basic --NH-group or an acid adduct thereof,one of X and Y being further bound to an optionally substituted aliphatic or heteroaromatic hydrocarbon radical and the other to hydrogen or an optionally substituted aliphatic hydrocarbon radical, as a constituent of a least some of the side-chains and at least one mole % of the comonomer units constituting the copolymer bearing such (.gamma.)-containing side-chains - which are obtainable by copolymerization of corresponding comonomers or by amino-alkylation of corresponding starting polymers - are particularly suitable as precipitating and/or flocculating agents, e.g.Type: GrantFiled: January 4, 1989Date of Patent: February 23, 1993Assignee: Sandoz Ltd.Inventor: Bernard Danner
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Patent number: 5189164Abstract: A process for synthesizing syn-(E)-3,5-dihydroxy-7-substituted hept-6-enoic and heptanoic acids and derivatives and intermediates thereof from the corresponding keto-hydroxy compounds, which process comprises: providing a reaction medium comprising sodium borohydride and an alkoxydialkylborane compound; treating the keto-hydroxy compound with said reaction medium under conditions wherein a cyclic boronate ester is formed; and cleaving the cyclic boronate ester to obtain the dihydroxy product.The product compounds, or derivatives thereof, are useful as anti-atherosclerotic agents.Type: GrantFiled: February 20, 1990Date of Patent: February 23, 1993Assignee: Sandoz Ltd.Inventors: Prasad K. Kapa, Kau-Ming Chen
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Patent number: 5039416Abstract: The invention relates to a process for treating industrial waste water which comprises either: (a) pre-treating the waste water with at least two different pre-treatments selected from adsorption, membrane filtration and oxidation and then, biologically purifying the waste water or, (b) neutralizing and biologically purifying the waste water and then after-treating the waste water either by membrane filtration in combination with adsorption or oxidation or, by oxidation optionally in combination with adsorption or filtration on a nanofiltration membrane or, by filtration on a nanofiltration membrane.Type: GrantFiled: May 3, 1989Date of Patent: August 13, 1991Assignee: Sandoz Ltd.Inventors: Richard Loew, Wolfgang Samhaber, Anton Wyss
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Patent number: 5021132Abstract: A process is disclosed for electrochemically treating p-nitrotoluene-2-sulfonic acid salts under oxidizing conditions to form 4,4'-dinitrostilbene-2,2'-disulfonic acid or the salts thereof. The process provides satisfactory yields of the stilbene compound while enabling substantial recycling of reaction materials. Substantial benefits are obtained when lithium hydroxide is employed in the reaction medium, including recovery of product of high purity, and improved recovery and recycling of lithium to the process.Type: GrantFiled: August 7, 1990Date of Patent: June 4, 1991Assignee: Sandoz Ltd.Inventor: Baldev K. Bandlish
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Patent number: 4941983Abstract: A fluid loss additive for oil-based well-working fluids, the fluid loss additive comprisingthe product of mixing in an oil or oil based liquid,(i) lignite or humic acid(ii) (a) an oil soluble or oil dispersible amine or amine salt;(b) an aliphatic amide or hydroxyamide, or a cyclic derivative thereof, containing no primary or secondary amine or amine salt groups; and/or(c) an oil soluble or oil dispersible amine salt containing at least one C.sub.1-22 alkyl, C.sub.2-22 alkenyl or C.sub.1-22 acyl group partially or fully salted with phosphoric acid; and(iii) a dimer and/or trimer fatty acid.Type: GrantFiled: August 29, 1988Date of Patent: July 17, 1990Assignee: Sandoz Ltd.Inventors: Jacqueline A. Coates, John M. Farrar, Margaret H., all of Graham
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Patent number: 4835169Abstract: The invention provides a method of combatting fungal diseases with the aid of(a) the compound of formula I ##STR1## and (b) carbendazim,and fungicidal compositions comprising said compounds.Type: GrantFiled: December 7, 1987Date of Patent: May 30, 1989Assignee: Sandoz Ltd.Inventor: Hans Wiedmer
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Patent number: 4593080Abstract: According to the present invention, an improved method for providing acrylic copolymer resins is provided in which the polymerization solvent comprises a blend of methyl isobutyl ketone and certain alkyl-substituted benzene solvents. The monomers comprise hydroxy-substituted alkyl (meth)acrylate monomers and non-hydroxy substituted alkyl (meth)acrylate monomers, and the process provides an improved method for forming low molecular weight acrylic resins useful as components in acrylic coatings. The polymerization solvent can remain in the resin to become a solvent employed in the higher solids coating containing the thus-formed acrylic resins and provides improved electrical resistivity, improved solvency and decreased surface tensions over prior art polymerization solvents.Type: GrantFiled: October 24, 1984Date of Patent: June 3, 1986Assignee: Exxon Research & Engineering Co.Inventors: Constantine J. Bouboulis, Irving Kuntz