Patents Represented by Attorney Donald Brown
  • Patent number: 5424295
    Abstract: The compound 9-B-D-arabinofuranosyl-2-amino-6-methoxy-9H-purine along with its 5'-acetyl and 5'-(4-methoxy-4-oxobutyryl derivatives are disclosed as inhibitors of Varicella Zoster virus (VZV).
    Type: Grant
    Filed: August 23, 1993
    Date of Patent: June 13, 1995
    Assignee: Burroughs Wellcome Co.
    Inventors: Thomas A. Krenitsky, David J. T. Porter
  • Patent number: 5422373
    Abstract: Diaryl urea compounds having anti-atherosclerosis activity are disclosed. Preferred compounds include the compounds 1-[4-(1,2-dimethoxyethoxy)benzyl-3-(2,4-dimethoxyphenyl)-l-heptylumea and 1-heptyl-3-(2,4-dimethoxyphenyl)-l-[4-(2-methoxyethoxymethoxy)-benzyl]urea .
    Type: Grant
    Filed: March 23, 1993
    Date of Patent: June 6, 1995
    Assignee: Burroughs Wellcome Co.
    Inventor: Karl W. Franzmann
  • Patent number: 5420156
    Abstract: 1-Ethylphenoxathiin 10,10-dioxide (I) ##STR1## inhibits monoamine oxidase-A and is useful in the treatment of disorders such as depression.
    Type: Grant
    Filed: December 8, 1993
    Date of Patent: May 30, 1995
    Assignee: Burroughs Wellcome Co.
    Inventors: Morton Harfenist, Daniel P. C. McGee, Helen L. White, Barrett R. Cooper
  • Patent number: 5420115
    Abstract: A method for treating two specific protozoal infections, Trichomonas vaginalis and Giardia lamblia, comprising the administration to a mammal in need thereof one of the following purine nucleosides:2,6-diamino-9-(2-deoxy-2-fluoro-.beta.-D-ribofuranosyl)-9H-purine2-amino-9-(2-deoxy-2-fluoro-.beta.-D-ribofuranosyl)-9H-purine2-amino-9-(2-deoxy-2-fluoro-.beta.-D-ribofuranosyl)-6-methoxy-9H-purine.
    Type: Grant
    Filed: September 2, 1992
    Date of Patent: May 30, 1995
    Assignee: Burroughs Wellcome Co.
    Inventors: Sylvia M. Tisdale, Joel Van Tuttle, Martin J. Slater, Susan M. Daluge, Wayne H. Miller, Thomas A. Krenitsky, George W. Koszalka
  • Patent number: 5405850
    Abstract: The present invention relates to a novel ribonucleotide reductase inhibitor and new combinations comprising an antiviral compound, such as acyclovir, and a thiocarbonohydrazone ribonucleotide reductase inhibitor for the chemo-therapeutic treatment of virus infections, especially viruses of the herpes group.
    Type: Grant
    Filed: October 29, 1992
    Date of Patent: April 11, 1995
    Assignee: Burroughs Wellcome Co.
    Inventor: Todd A. Blumenkopf
  • Patent number: 5405851
    Abstract: The present invention relates to novel benzoquinazoline thymidylate synthase inhibitors, to pharmaceutical formulations containing them and to their use in medicine.
    Type: Grant
    Filed: April 16, 1992
    Date of Patent: April 11, 1995
    Assignee: Burroughs Wellcome Co.
    Inventors: William Pendergast, Scott H. Dickerson, Julius V. Johnson, Robert Ferone
  • Patent number: 5401829
    Abstract: A peptide having primary structural homology to a continuous sequence of amino acid residues of growth hormone in the region spanning positions 35 to 53 or antigenically equivalent peptides thereto or salts thereof, may be used in an antigenic formulation to potentiate the effects of growth hormone in a vertebrate.
    Type: Grant
    Filed: December 23, 1991
    Date of Patent: March 28, 1995
    Assignee: Coopers Animal Health Ltd.
    Inventors: Stephen James, Roger Aston, Robert Bomford
  • Patent number: 5395853
    Abstract: The present invention is concerned with compounds of formula (I) ##STR1## wherein m is 0 or 1;W is hydrogen, a C.sub.1-16 straight, branched, or cyclic alkyl group, or a C.sub.2-16 straight, branched, or cyclic alkenyl or alkynyl group, orPh(CH.sub.2).sub.n -- where Ph is phenyl and n is an integer of from 0 to 2, the phenyl group being optionally substituted by one or more atoms or groups independently selected from halogen, hydroxy, nitro, C.sub.1-4 alkoxy and C.sub.1-4 alkyl wherein one or more of the hydrogen atoms in said alkyl group is optionally replaced by halogen, orR.sup.1 NHCO-- where R.sup.1 is hydrogen or a C.sub.1-6 alkyl group, orR.sup.2 CONH-- where R.sup.2 is hydrogen or a C.sub.1-6 alkyl group; ##STR2## Y is --(CH.sub.2).sub.q, where q is an integer of from 1 to 3, or --CH.dbd.CH-- (E or Z);Z is a C.sub.
    Type: Grant
    Filed: November 24, 1993
    Date of Patent: March 7, 1995
    Assignee: Burroughs Wellcome Co.
    Inventors: William P. Jackson, Clifford J. Harris, Richard J. Arrowsmith, John G. Dann, Kevin J. O'Connor, Robert F. G. Booth
  • Patent number: 5393883
    Abstract: The present invention relates to novel ribonucleotide reductase inhibitors and new combinations comprising an antiviral compound, such as acyclovir, and a thiocarbonohydrazone ribonucleotide reductase inhibitor for the chemotherapeutic treatment of virus infections, especially viruses of the herpes group.
    Type: Grant
    Filed: February 7, 1992
    Date of Patent: February 28, 1995
    Assignee: Burroughs Wellcome Co.
    Inventors: Todd A. Blumenhopf, Thomas Spector, Devron R. Averett, Robert W. Morrison, Jr., Eric C. Bigham, Virgil L. Styles
  • Patent number: 5392961
    Abstract: A safety tab device coupled to an aerosol container by a connecting member, a flexible member coupled to the connecting member and a flip tab coupled to the flexible member and which can be locked to the aerosol container to make it difficult to spray chemicals from the container without unlocking the tab.
    Type: Grant
    Filed: June 18, 1993
    Date of Patent: February 28, 1995
    Assignee: Casco International, Inc.
    Inventor: Paul D. Starrett
  • Patent number: 5385261
    Abstract: This invention is directed to dish drainers, which have integrally formed connecting elements in the basket and pan thereof.The connector elements are used to maintain the basket and pan coupled together during shipment, when displayed for sale or when in use. The connector may be disconnected to separate the pan from the basket in order to clean the dish drainer components.
    Type: Grant
    Filed: July 2, 1991
    Date of Patent: January 31, 1995
    Assignee: Sterilite Corporation
    Inventors: Hangwind F. Lippisch, Cory J. Kruger
  • Patent number: 5380759
    Abstract: Methyl N-[6-(3,4,5-trimethoxybenzloxy) imidazo [1,2-6]pyridazin-2-yl]carbamate is disclosed which is used to treat leukemia.
    Type: Grant
    Filed: September 17, 1993
    Date of Patent: January 10, 1995
    Assignee: Burroughs Wellcome Co.
    Inventor: Simon T. Hodgson
  • Patent number: 5376644
    Abstract: 2',3'-Dideoxy-3'-fluoro pyrimidine nucleosides particularly 2', 3'-dideoxy-3'-fluorothymidine have been found to have particularly potent activity against adenovirus infections especially those caused by adenoviruses of scrotype 8. Such compounds are preferably presented in pharmaceutical formulations adapted for ophthalmic administration.
    Type: Grant
    Filed: December 24, 1992
    Date of Patent: December 27, 1994
    Assignee: Burroughs Wellcome Co.
    Inventors: John W. T. Selway, Joel Van Tuttle, Thomas A. Krenitsky
  • Patent number: 5376134
    Abstract: An orthesis joint comprises a first support plate, a thigh attachment part hingedly connected to the first support plate through a first bearing bush, a lower leg attachment part hingedly connected to the first support plate through a second bearing bush, a connecting member hingedly connected with both attachment parts through a third and fourth bearing bush, respectively, and means for limiting the movement of the joint. It is desired to achieve a simple design for the limit means. To this end one of the attachment parts comes into engagement with the connecting member by a first and a second stop, respectively, and at least one of the stops is adjustable.
    Type: Grant
    Filed: December 23, 1993
    Date of Patent: December 27, 1994
    Assignee: Biedermann Motech GmbH
    Inventor: Lutz Biedermann
  • Patent number: 5371219
    Abstract: Compounds of general formula (I) ##STR1## wherein R.sup.1 represents an optionally substituted carbocyclic or heterocyclic aryl group, or an optionally substituted alkyl, alkenyl, cycloalkyl or cycloalkenyl group; R.sup.2 represents an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl group or an optionally substituted carbocyclic or heterocyclic aryl or aralkyl group; R.sup.3 represents a hydrogen atom or an alkyl group; and either X represents an oxygen or sulphur atom, a group --CH.sub.2 -- or a group NR.sup.4 where R.sup.4 represents a hydrogen atom of a C.sub.1-4 alkyl group; and Y represents a group --CH.sub.2 -- or --CH.sub.2 CH.sub.2 -- or X--Y together represent the group --CH.dbd.CH--; and salts and physiologically functional derivatives thereof are useful in the treatment of tumours. Processes for preparing the compounds, intermediates useful in their preparation, pharmaceutical compositions containing them and their use in the treatment of tumours are also described.
    Type: Grant
    Filed: September 17, 1993
    Date of Patent: December 6, 1994
    Assignee: Burroughs Wellcome Co.
    Inventor: Simon T. Hodgson
  • Patent number: D353537
    Type: Grant
    Filed: May 19, 1993
    Date of Patent: December 20, 1994
    Assignee: Casco International, Inc.
    Inventor: Paul D. Starrett
  • Patent number: D353921
    Type: Grant
    Filed: July 2, 1991
    Date of Patent: December 27, 1994
    Assignee: Sterilite Corporation
    Inventors: Hangwind F. Lippisch, Cory J. Kruger
  • Patent number: D356497
    Type: Grant
    Filed: February 11, 1993
    Date of Patent: March 21, 1995
    Assignee: Sterilite Corporation
    Inventor: Larry G. Zimmerman
  • Patent number: D359322
    Type: Grant
    Filed: July 12, 1994
    Date of Patent: June 13, 1995
    Inventor: Chi K. Lo
  • Patent number: D359338
    Type: Grant
    Filed: May 28, 1993
    Date of Patent: June 13, 1995
    Assignee: Monadnock Lifetime Products, Inc.
    Inventor: Paul D. Starrett