Abstract: The compound 9-B-D-arabinofuranosyl-2-amino-6-methoxy-9H-purine along with its 5'-acetyl and 5'-(4-methoxy-4-oxobutyryl derivatives are disclosed as inhibitors of Varicella Zoster virus (VZV).
Type:
Grant
Filed:
August 23, 1993
Date of Patent:
June 13, 1995
Assignee:
Burroughs Wellcome Co.
Inventors:
Thomas A. Krenitsky, David J. T. Porter
Abstract: Diaryl urea compounds having anti-atherosclerosis activity are disclosed. Preferred compounds include the compounds 1-[4-(1,2-dimethoxyethoxy)benzyl-3-(2,4-dimethoxyphenyl)-l-heptylumea and 1-heptyl-3-(2,4-dimethoxyphenyl)-l-[4-(2-methoxyethoxymethoxy)-benzyl]urea .
Abstract: A method for treating two specific protozoal infections, Trichomonas vaginalis and Giardia lamblia, comprising the administration to a mammal in need thereof one of the following purine nucleosides:2,6-diamino-9-(2-deoxy-2-fluoro-.beta.-D-ribofuranosyl)-9H-purine2-amino-9-(2-deoxy-2-fluoro-.beta.-D-ribofuranosyl)-9H-purine2-amino-9-(2-deoxy-2-fluoro-.beta.-D-ribofuranosyl)-6-methoxy-9H-purine.
Type:
Grant
Filed:
September 2, 1992
Date of Patent:
May 30, 1995
Assignee:
Burroughs Wellcome Co.
Inventors:
Sylvia M. Tisdale, Joel Van Tuttle, Martin J. Slater, Susan M. Daluge, Wayne H. Miller, Thomas A. Krenitsky, George W. Koszalka
Abstract: The present invention relates to novel benzoquinazoline thymidylate synthase inhibitors, to pharmaceutical formulations containing them and to their use in medicine.
Type:
Grant
Filed:
April 16, 1992
Date of Patent:
April 11, 1995
Assignee:
Burroughs Wellcome Co.
Inventors:
William Pendergast, Scott H. Dickerson, Julius V. Johnson, Robert Ferone
Abstract: The present invention relates to a novel ribonucleotide reductase inhibitor and new combinations comprising an antiviral compound, such as acyclovir, and a thiocarbonohydrazone ribonucleotide reductase inhibitor for the chemo-therapeutic treatment of virus infections, especially viruses of the herpes group.
Abstract: A peptide having primary structural homology to a continuous sequence of amino acid residues of growth hormone in the region spanning positions 35 to 53 or antigenically equivalent peptides thereto or salts thereof, may be used in an antigenic formulation to potentiate the effects of growth hormone in a vertebrate.
Type:
Grant
Filed:
December 23, 1991
Date of Patent:
March 28, 1995
Assignee:
Coopers Animal Health Ltd.
Inventors:
Stephen James, Roger Aston, Robert Bomford
Abstract: The present invention is concerned with compounds of formula (I) ##STR1## wherein m is 0 or 1;W is hydrogen, a C.sub.1-16 straight, branched, or cyclic alkyl group, or a C.sub.2-16 straight, branched, or cyclic alkenyl or alkynyl group, orPh(CH.sub.2).sub.n -- where Ph is phenyl and n is an integer of from 0 to 2, the phenyl group being optionally substituted by one or more atoms or groups independently selected from halogen, hydroxy, nitro, C.sub.1-4 alkoxy and C.sub.1-4 alkyl wherein one or more of the hydrogen atoms in said alkyl group is optionally replaced by halogen, orR.sup.1 NHCO-- where R.sup.1 is hydrogen or a C.sub.1-6 alkyl group, orR.sup.2 CONH-- where R.sup.2 is hydrogen or a C.sub.1-6 alkyl group; ##STR2## Y is --(CH.sub.2).sub.q, where q is an integer of from 1 to 3, or --CH.dbd.CH-- (E or Z);Z is a C.sub.
Type:
Grant
Filed:
November 24, 1993
Date of Patent:
March 7, 1995
Assignee:
Burroughs Wellcome Co.
Inventors:
William P. Jackson, Clifford J. Harris, Richard J. Arrowsmith, John G. Dann, Kevin J. O'Connor, Robert F. G. Booth
Abstract: A safety tab device coupled to an aerosol container by a connecting member, a flexible member coupled to the connecting member and a flip tab coupled to the flexible member and which can be locked to the aerosol container to make it difficult to spray chemicals from the container without unlocking the tab.
Abstract: The present invention relates to novel ribonucleotide reductase inhibitors and new combinations comprising an antiviral compound, such as acyclovir, and a thiocarbonohydrazone ribonucleotide reductase inhibitor for the chemotherapeutic treatment of virus infections, especially viruses of the herpes group.
Type:
Grant
Filed:
February 7, 1992
Date of Patent:
February 28, 1995
Assignee:
Burroughs Wellcome Co.
Inventors:
Todd A. Blumenhopf, Thomas Spector, Devron R. Averett, Robert W. Morrison, Jr., Eric C. Bigham, Virgil L. Styles
Abstract: This invention is directed to dish drainers, which have integrally formed connecting elements in the basket and pan thereof.The connector elements are used to maintain the basket and pan coupled together during shipment, when displayed for sale or when in use. The connector may be disconnected to separate the pan from the basket in order to clean the dish drainer components.
Abstract: 2',3'-Dideoxy-3'-fluoro pyrimidine nucleosides particularly 2', 3'-dideoxy-3'-fluorothymidine have been found to have particularly potent activity against adenovirus infections especially those caused by adenoviruses of scrotype 8. Such compounds are preferably presented in pharmaceutical formulations adapted for ophthalmic administration.
Type:
Grant
Filed:
December 24, 1992
Date of Patent:
December 27, 1994
Assignee:
Burroughs Wellcome Co.
Inventors:
John W. T. Selway, Joel Van Tuttle, Thomas A. Krenitsky
Abstract: An orthesis joint comprises a first support plate, a thigh attachment part hingedly connected to the first support plate through a first bearing bush, a lower leg attachment part hingedly connected to the first support plate through a second bearing bush, a connecting member hingedly connected with both attachment parts through a third and fourth bearing bush, respectively, and means for limiting the movement of the joint. It is desired to achieve a simple design for the limit means. To this end one of the attachment parts comes into engagement with the connecting member by a first and a second stop, respectively, and at least one of the stops is adjustable.
Abstract: The invention relates to a controlled release pharmaceutical formulation for oral administration which comprises discrete units comprising acrivastine or a salt thereof coated with a mixture containing:a) a copolymer or polymer containing repeating monomer units selected from alkyl esters of acrylic and methacrylic acids andb) ethyl cellulose,and a process for preparing such formulations.
Type:
Grant
Filed:
September 8, 1993
Date of Patent:
December 6, 1994
Assignee:
Burroughs Wellcome Co.
Inventors:
Harry P. Jones, Robert J. Mackey, Michael J. D. Gamlen