Abstract: A golf glove of man-made (synthetic) material and two leather sections, wherein a first leather section is positioned on the palm side of the golf glove and extends from the three of the outer fingers down into a heel and a separate leather thumb portion is also positioned on the palm side of the glove.The backside of the golf glove, as well as the other portions of the glove on the palm side are of synthetic material, e.g., plastic.
Abstract: The present invention relates to compounds of formula (I)ArCH.sub.2 R.sup.1 (I)or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 30 carbon atoms in total); ethers, esters, thereof; acid addition salts thereof; wherein Ar is a C.sub.15-18 fused tetracarbocyclic ring system containing 3 or 4 aromatic rings or a C.sub.17-22 fused pentacarbocyclic ring system containing 4, or 5 aromatic rings, or a substituted derivative thereof; the ring system Ar should be planar or deviate only slightly from planarity. Thus, the ring system contains a maximum of two non-aromatic carbon atoms which may be in the same ring, in which case they are adjacent, or in different rings;Ar is not perylene, fluoranthene, chrysene, pyrene, or triphenylene;R.sup.1 contains not more than eight carbon atoms and is a group ##STR1## wherein m is 0 or 1; R.sup.5 is hydrogen;R.sup.6 and R.sup.7 are the same or different and each is hydrogen or C.sub.
Abstract: This invention describes the preparation and use of anticonvulsant agents. In particular, triazolopyridine compounds are described which have utility in the treatment of epilepsy in mammals.
Abstract: The present invention is concerned with the use of a compound of formula (I) ##STR1## wherein --W-- is ##STR2## wherein Z is --V(CH.sub.2).sub.b CO.sub.2 H where b is 1 or 2 and V is oxygen when b is 1 or methylene when b is 2;X is hydrogen, cyano, or --C.tbd.CH; andthe dotted line represents an optional double bond;and physiologically functional derivatives thereof,in the treatment of congestive heart failure.
Abstract: Synergistic combinations of nucleoside derivatives, pharmaceutical formulations containing said combinations and use of the combinations in the treatment of retroviral infections are disclosed.
Type:
Grant
Filed:
March 5, 1992
Date of Patent:
August 10, 1993
Assignee:
Burroughs Wellcome Co.
Inventors:
Phillip A. Furman, Jr., George R. Painter, III
Abstract: The present invention relates to the treatment and prophylaxis of Pneumocystis carinii infections with 2-[4-(4-chlorophenyl)cyclohexyl-3-hydroxy-1,4-naphthoquinone.
Type:
Grant
Filed:
November 29, 1990
Date of Patent:
July 6, 1993
Assignee:
Burroughs Wellcome Co.
Inventors:
Victoria S. Latter, Winston E. Gutteridge
Abstract: The present invention is concerned with compounds of formula (I) ##STR1## wherein R, R.sup.1 and R.sup.2 are independently selected from hydrogen and C.sub.1-4 alkyl;R.sup.3 and R.sup.4 are independently selected from hydrogen, C.sub.1-6 alkyl (including cycloalkyl) and aryl (wherein the alkyl or aryl group, which latter includes benzyl, is optionally substituted by one or more atoms or groups independently selected from halogen, C.sub.1-4 alkyl and aryl), provided R.sup.3 benzyl or substituted benzyl when R.sup.4 =H;m is an integer of from 0 to 2;n is an integer of from 0 to 3;(W) is a group of formula (i), (ii), (iii), or (iv) ##STR2## wherein Y is selected from oxygen, methylene and >N--R.sup.5, where R.sup.5 is hydrogen, C.sub.1-4 alkyl, or benzyl, Z and Z' are independently selected from >C.dbd.O, >C.dbd.
Type:
Grant
Filed:
February 26, 1991
Date of Patent:
July 6, 1993
Assignee:
Burroughs Wellcome Co.
Inventors:
Alan D. Robertson, Graeme R. Martin, Janet S. Buckingham
Abstract: Compositions for treating timber, especially timber to be exposed to the ground, comprising creosote and a compound of formula I: ##STR1## wherein Z and Z.sup.1 are the same or different and are each halo, halophenyl or haloalkyl, X is hydrogen or cyano, and Y is hydrogen or a fluorine atom.The preferred pyrethroid is Permethrin.The compositions are unusually stable and have a prolonged protective action against termites, beetles, molluscs, woodworm and the like.
Type:
Grant
Filed:
February 12, 1991
Date of Patent:
June 8, 1993
Assignee:
Burroughs Wellcome Co.
Inventors:
Barry A. Richardson, Timothy R. G. Cox, Stuart W. Carter
Abstract: A tube separator comprises an inlet and an outlet to define a flow direction from the inlet to the outlet, shut-off means arranged between the inlet and the outlet for connecting the inlet with the outlet in a first position thereof and for disconnecting the inlet from the outlet in a second position thereof, control means for operating the shut-off means and a non-return valve at the outlet for blocking or allowing fluid flow from the inlet to the outlet. The shut-off means comprises a shut-off member being arranged in the shut-off means for rotation around an axis perpendicular to the flow direction from a first rotational position to a second rotational position thereof, and a bore is provided in the shut-off member for connecting the inlet with the outlet in the first rotational position and for disconnecting the inlet from the outlet in the second rotational position.
Abstract: A bone screw (1) has a threaded portion (2) and a head (3). Such screws are used in particular as pedicle screws. In order that the bone screw can be anchored securely also in soft bone tissue, the screw is provided with a longitudinal bore (5) extending along the longitudinal axis of the threaded portion (2), the longitudinal bore (5) being provided with a tapered portion (7) opposite to the head (3). In this region of the screw, slits are extending parallel to the threaded portion and an interior thread is provided. An expander part (12) having a tip (14) forming the point of the screw and a shaft (16) having a threaded portion (17) cooperating with said interior thread are provided.
Abstract: For a pedicle screw a receiver member is provided for hingedly connecting a screw (2) comprising a threaded shaft portion (3) and a spherical-segment-shaped head (4) on the one hand and a rod (16) on the other hand. In order to improve the stocking costs for screws of different shaft lengths and shaft diameters, the receiver member has a receiver chamber (7) therein, the receiver chamber has a bore (8) at one end thereof for passing the threaded shaft portion (3) followed by an inner hollow spherical-segment-shaped portion (9) for supporting the head of the screw (2) to be received, and an aperture (10) on the side opposite to the bore (8) for inserting the screw (2). Further, a compression member (18) is provided which exerts, in assembled state, a force onto the head such that the head is pressed against the hollow spherical-segment-shaped portion (9).
Abstract: The present invention relates to 6-substituted purine carbocyclic nucleosides and their use in medical therapy particularly in the treatment of HIV and HBV infections. The invention also relates to pharmaceutical formulations and processes for the preparation of compounds according to the invention.
Abstract: A method for treating or preventing a Pneumocystis carinii infection in a mammal by administering a certain naphthoquinone compound or physiologically acceptable salts thereof.
Type:
Grant
Filed:
August 15, 1989
Date of Patent:
April 27, 1993
Assignee:
Burroughs Wellcome Co.
Inventors:
Victoria S. Latter, Winston E. Gutteridge, Alan T. Hudson
Abstract: A reproducing optical device for a magneto-optical recording medium related to the present invention having light sources that emit linearly polarized lights towards a magneto-optical recording medium, polarization directions of the linearly polarized lights being mutually orthogonal. A quarter wavelength plate disposed between the recording medium and the light sources converts each of the linearly polarized lights into right and left circularly polarized lights respectively. Corresponding to recorded information, the recording medium has magnetized sections that are magnetized in a perpendicularly upward and downward direction with respect to a medium surface. Moreover, the recording medium displays the property of circular dichroism.
Abstract: The present invention relates to a 3'-substituted pyrimidine nucleoside and its use in medical therapy, particularly in the treatment of HIV infections. Also provided are pharmaceutical formulations.
Abstract: A bone screw to be used in combination with a correction and supporting apparatus is provided. With such correction and supporting device the problem arises that when two vertebrae are expanded, the vertebra in between the vertebrae is shifted to the inside of the curvature of the spinal column. To correct or prevent such lateral shifting a bone screw is provided having a threaded shaft (60) and a segmented or fully spherically shaped head (61), an extension (62) having a support face (64) fitting on the head (61) being provided. An element (66) is connected to the extension (62). The element (66) serves to connect the extension with a rod (29, 30) at the correction and supporting apparatus. Element (66) and extension (62) are connected such that the distance between the support face and the element may be adjusted.
Abstract: A stackable bulk-material packing or container is disclosed, which can have a simple opening for pouring out the contents. The packing uses a folding-box carton with a bag inside it. The bag has an opening for pouring out the contents. The opening has an annular shoulder and is located behind a removable section of the carton. Removal of this section produces an opening in the carton giving access to the opening in the bag. The removal section of the carton is located at one of the upper corners or one of the upper edges of the carton. Because the removable section of the carton and the opening in the bag are co-located at one of the upper corners or one of the upper edges of the carton, the contents do not exert any pressure on them, and the closure can thus be of a simple design.
Abstract: The present invention is concerned with compounds of formula (I) ##STR1## wherein R.sup.1 is hydrogen or C.sub.1-4 alkoxy;R.sub.2 is carbonyl, hydroxymethylene, or methylene; andR.sub.3 is hydrogen or hydroxy;and salts thereof, provided that when R.sub.1 is hydrogen and R.sub.2 is carbonyl, R.sub.3 is not hydroxy, with processes for preparing same and with their use in medicine for the treatment of hypertension.
Type:
Grant
Filed:
October 28, 1991
Date of Patent:
March 16, 1993
Assignee:
Burroughs Wellcome Co.
Inventors:
John D. McDermed, Anjaneyulu S. Tadepalli, Vincent H. Chang, Kevin P. Hurley, Harold S. Freeman
Abstract: This invention relates to certain 6-substituted 2',3'-dideoxypurine nucleosides and pharmaceutically acceptable derivatives thereof and their use in the treatment of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections. Also provided are pharmaceutical formulations and processes for the production of the compounds of the invention.
Type:
Grant
Filed:
August 31, 1991
Date of Patent:
February 9, 1993
Assignee:
Burroughs Wellcome Co.
Inventors:
George W. Koszalka, Charlene L. Burns, Thomas A. Krenitsky, Janet L. Rideout